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Items: 19

1.

Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.

Verdonck S, Pu SY, Sorrell FJ, Elkins JM, Froeyen M, Gao LJ, Prugar LI, Dorosky DE, Brannan JM, Barouch-Bentov R, Knapp S, Dye JM, Herdewijn P, Einav S, De Jonghe S.

J Med Chem. 2019 Jun 12. doi: 10.1021/acs.jmedchem.9b00136. [Epub ahead of print]

PMID:
31136173
2.

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.

Kumar S, Barouch-Bentov R, Xiao F, Schor S, Pu S, Biquand E, Lu A, Lindenbach BD, Jacob Y, Demeret C, Einav S.

Cell Rep. 2019 Feb 12;26(7):1800-1814.e5. doi: 10.1016/j.celrep.2019.01.075.

3.

A 20-Gene Set Predictive of Progression to Severe Dengue.

Robinson M, Sweeney TE, Barouch-Bentov R, Sahoo MK, Kalesinskas L, Vallania F, Sanz AM, Ortiz-Lasso E, Albornoz LL, Rosso F, Montoya JG, Pinsky BA, Khatri P, Einav S.

Cell Rep. 2019 Jan 29;26(5):1104-1111.e4. doi: 10.1016/j.celrep.2019.01.033.

4.

Viral journeys on the intracellular highways.

Robinson M, Schor S, Barouch-Bentov R, Einav S.

Cell Mol Life Sci. 2018 Oct;75(20):3693-3714. doi: 10.1007/s00018-018-2882-0. Epub 2018 Jul 24. Review.

PMID:
30043139
5.

Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.

Pu SY, Wouters R, Schor S, Rozenski J, Barouch-Bentov R, Prugar LI, O'Brien CM, Brannan JM, Dye JM, Herdewijn P, De Jonghe S, Einav S.

J Med Chem. 2018 Jul 26;61(14):6178-6192. doi: 10.1021/acs.jmedchem.8b00613. Epub 2018 Jul 16.

PMID:
29953812
6.

Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment.

Pu SY, Xiao F, Schor S, Bekerman E, Zanini F, Barouch-Bentov R, Nagamine CM, Einav S.

Antiviral Res. 2018 Jul;155:67-75. doi: 10.1016/j.antiviral.2018.05.001. Epub 2018 May 16.

PMID:
29753658
7.

Turning Up Your Nose for a Flaviviral Encephalitis Cure.

Barouch-Bentov R, Einav S.

Cell Host Microbe. 2018 Apr 11;23(4):427-429. doi: 10.1016/j.chom.2018.03.014.

8.

Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release.

Xiao F, Wang S, Barouch-Bentov R, Neveu G, Pu S, Beer M, Schor S, Kumar S, Nicolaescu V, Lindenbach BD, Randall G, Einav S.

MBio. 2018 Mar 13;9(2). pii: e02233-17. doi: 10.1128/mBio.02233-17.

9.

Erratum for Barouch-Bentov et al., "Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment".

Barouch-Bentov R, Neveu G, Xiao F, Beer M, Bekerman E, Schor S, Campbell J, Boonyaratanakornkit J, Lindenbach B, Lu A, Jacob Y, Einav S.

MBio. 2018 Jan 9;9(1). pii: e02234-17. doi: 10.1128/mBio.02234-17. No abstract available.

10.

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.

Bekerman E, Neveu G, Shulla A, Brannan J, Pu SY, Wang S, Xiao F, Barouch-Bentov R, Bakken RR, Mateo R, Govero J, Nagamine CM, Diamond MS, De Jonghe S, Herdewijn P, Dye JM, Randall G, Einav S.

J Clin Invest. 2017 Apr 3;127(4):1338-1352. doi: 10.1172/JCI89857. Epub 2017 Feb 27.

11.

Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment.

Barouch-Bentov R, Neveu G, Xiao F, Beer M, Bekerman E, Schor S, Campbell J, Boonyaratanakornkit J, Lindenbach B, Lu A, Jacob Y, Einav S.

MBio. 2016 Nov 1;7(6). pii: e01456-16. doi: 10.1128/mBio.01456-16. Erratum in: MBio. 2018 Jan 9;9(1):.

12.

Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.

Kovackova S, Chang L, Bekerman E, Neveu G, Barouch-Bentov R, Chaikuad A, Heroven C, Šála M, De Jonghe S, Knapp S, Einav S, Herdewijn P.

J Med Chem. 2015 Apr 23;58(8):3393-410. doi: 10.1021/jm501759m. Epub 2015 Apr 9.

13.

AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.

Neveu G, Ziv-Av A, Barouch-Bentov R, Berkerman E, Mulholland J, Einav S.

J Virol. 2015 Apr;89(8):4387-404. doi: 10.1128/JVI.02705-14. Epub 2015 Feb 4.

14.

Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly.

Neveu G, Barouch-Bentov R, Ziv-Av A, Gerber D, Jacob Y, Einav S.

PLoS Pathog. 2012;8(8):e1002845. doi: 10.1371/journal.ppat.1002845. Epub 2012 Aug 16.

15.

Mechanisms of drug resistance in kinases.

Barouch-Bentov R, Sauer K.

Expert Opin Investig Drugs. 2011 Feb;20(2):153-208. doi: 10.1517/13543784.2011.546344. Review.

16.

A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function.

Barouch-Bentov R, Che J, Lee CC, Yang Y, Herman A, Jia Y, Velentza A, Watson J, Sternberg L, Kim S, Ziaee N, Miller A, Jackson C, Fujimoto M, Young M, Batalov S, Liu Y, Warmuth M, Wiltshire T, Cooke MP, Sauer K.

Mol Cell. 2009 Jan 16;33(1):43-52. doi: 10.1016/j.molcel.2008.12.024.

17.

Integrating traditional and postgenomic approaches to investigate lymphocyte development and function.

Huang YH, Barouch-Bentov R, Herman A, Walker J, Sauer K.

Adv Exp Med Biol. 2006;584:245-76. Review. No abstract available.

PMID:
16802612
18.

Protein kinase C-theta (PKCtheta): new perspectives on its functions in T cell biology.

Barouch-Bentov R, Altman A.

Adv Exp Med Biol. 2006;584:1-13. Review. No abstract available.

PMID:
16802595
19.

Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells.

Barouch-Bentov R, Lemmens EE, Hu J, Janssen EM, Droin NM, Song J, Schoenberger SP, Altman A.

J Immunol. 2005 Oct 15;175(8):5126-34.

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