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The Pressing Need to Redefine "COPD".

Barnes PJ, Vestbo J, Calverley PM.

Chronic Obstr Pulm Dis. 2019 Nov;6(5):380-383. doi: 10.15326/jcopdf.6.5.2019.0173. No abstract available.


Predictors of Outcome in Mammary Adenoid Cystic Carcinoma: A Multi-Institutional Study.

Slodkowska E, Xu B, Kos Z, Bane A, Barnard M, Zubovits J, Iyengar P, Faragalla H, Turbin D, Williams P, Barnes PJ, Mulligan AM.

Am J Surg Pathol. 2019 Sep 26. doi: 10.1097/PAS.0000000000001378. [Epub ahead of print]


Small airway fibrosis in COPD.

Barnes PJ.

Int J Biochem Cell Biol. 2019 Nov;116:105598. doi: 10.1016/j.biocel.2019.105598. Epub 2019 Sep 6. Review.


Nitrosative stress in patients with asthma-chronic obstructive pulmonary disease overlap.

Barnes PJ.

J Allergy Clin Immunol. 2019 Oct;144(4):928-930. doi: 10.1016/j.jaci.2019.07.040. Epub 2019 Aug 16. No abstract available.


Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells.

MacDonald TM, Thomas LN, Daze E, Marignani P, Barnes PJ, Too CK.

Am J Cancer Res. 2019 Jul 1;9(7):1484-1503. eCollection 2019.


Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: a RCT.

Devereux G, Cotton S, Fielding S, McMeekin N, Barnes PJ, Briggs A, Burns G, Chaudhuri R, Chrystyn H, Davies L, Soyza A, Gompertz S, Haughney J, Innes K, Kaniewska J, Lee A, Morice A, Norrie J, Sullivan A, Wilson A, Price D.

Health Technol Assess. 2019 Jul;23(37):1-146. doi: 10.3310/hta23370.


Symptoms and perception of airway obstruction in asthmatic patients: Clinical implications for use of reliever medications.

Barnes PJ, Szefler SJ, Reddel HK, Chipps BE.

J Allergy Clin Immunol. 2019 Nov;144(5):1180-1186. doi: 10.1016/j.jaci.2019.06.040. Epub 2019 Jul 19.


Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages.

Belchamber KBR, Singh R, Batista CM, Whyte MK, Dockrell DH, Kilty I, Robinson MJ, Wedzicha JA, Barnes PJ, Donnelly LE; COPD-MAP consortium.

Eur Respir J. 2019 Oct 10;54(4). pii: 1802244. doi: 10.1183/13993003.02244-2018. Print 2019 Oct.


Evaluation of systemic absorption and bronchodilator effect of glycopyrronium bromide delivered by nebulizer or a dry powder inhaler in subjects with chronic obstructive pulmonary disease.

Leaker BR, Singh D, Nicholson GC, Hezelova B, Goodin T, Ozol-Godfrey A, Galluppi G, Barnes PJ.

Respir Res. 2019 Jun 28;20(1):132. doi: 10.1186/s12931-019-1113-z.


Isolated Tumor Cells in Sentinel Lymph Nodes of Primary Invasive Breast Carcinoma: A Cohort Analysis.

Bethune GC, Karkada MA, DeCoste R, Barnes PJ, Rayson D.

Clin Breast Cancer. 2019 Aug;19(4):286-291. doi: 10.1016/j.clbc.2019.03.002. Epub 2019 Mar 11.


Dual mechanism of action of T2 inhibitor therapies in virally induced exacerbations of asthma: evidence for a beneficial counter-regulation.

Efthimiou J, Poll C, Barnes PJ.

Eur Respir J. 2019 Jul 4;54(1). pii: 1802390. doi: 10.1183/13993003.02390-2018. Print 2019 Jul. Review.


Pulmonary Diseases and Ageing.

Barnes PJ.

Subcell Biochem. 2019;91:45-74. doi: 10.1007/978-981-13-3681-2_3. Review.


Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases.

Barnes PJ, Baker J, Donnelly LE.

Am J Respir Crit Care Med. 2019 Sep 1;200(5):556-564. doi: 10.1164/rccm.201810-1975TR.


Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019.

Singh D, Agusti A, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, Criner GJ, Frith P, Halpin DMG, Han M, López Varela MV, Martinez F, Montes de Oca M, Papi A, Pavord ID, Roche N, Sin DD, Stockley R, Vestbo J, Wedzicha JA, Vogelmeier C.

Eur Respir J. 2019 May 18;53(5). pii: 1900164. doi: 10.1183/13993003.00164-2019. Print 2019 May. Review.


Inflammatory endotypes in COPD.

Barnes PJ.

Allergy. 2019 Jul;74(7):1249-1256. doi: 10.1111/all.13760. Epub 2019 Mar 31. Review.


Can We Define Asthma-COPD Overlap (ACO) by Biomarkers?

Izuhara K, Barnes PJ.

J Allergy Clin Immunol Pract. 2019 Jan;7(1):146-147. doi: 10.1016/j.jaip.2018.07.002. No abstract available.


Bacterial load and defective monocyte-derived macrophage bacterial phagocytosis in biomass smoke-related COPD.

Ghosh B, Gaike AH, Pyasi K, Brashier B, Das VV, Londhe JD, Juvekar S, Shouche YS, Donnelly LE, Salvi SS, Barnes PJ.

Eur Respir J. 2019 Feb 28;53(2). pii: 1702273. doi: 10.1183/13993003.02273-2017. Print 2019 Feb.


Low-Dose Budesonide/Formoterol Counteracts Airway Inflammation and Improves Lung Function in Chronic Obstructive Pulmonary Disease.

Hakim A, Khan Y, Esteban I, Meah S, Miller-Larsson A, Barnes PJ, Usmani OS.

Am J Respir Crit Care Med. 2019 Mar 1;199(5):662-664. doi: 10.1164/rccm.201808-1590LE. No abstract available.


Current Controversies in Chronic Obstructive Pulmonary Disease. A Report from the Global Initiative for Chronic Obstructive Lung Disease Scientific Committee.

Criner GJ, Martinez FJ, Aaron S, Agusti A, Anzueto A, Bafadhel M, Barnes PJ, Bourbeau J, Chen R, Ewig J, Fabbri LM, Frith P, Halpin DMG, Han M, Montes de Oca M, Nishimura M, O'Donnell D, Papi A, Pavord I, Roche N, Rodriguez-Roisin R, Salvi S, Singh D, Sin DD, Stockley R, López Varela MV, Vestbo J, Vogelmeier CF, Washko G, Wedzicha JA, Celli BR.

Ann Am Thorac Soc. 2019 Jan;16(1):29-39. doi: 10.1513/AnnalsATS.201808-557PS. No abstract available.


Direct Inhibitory Effect of the PDE4 Inhibitor Roflumilast on Neutrophil Migration in Chronic Obstructive Pulmonary Disease.

Dunne AE, Kawamatawong T, Fenwick PS, Davies CM, Tullett H, Barnes PJ, Donnelly LE.

Am J Respir Cell Mol Biol. 2019 Apr;60(4):445-453. doi: 10.1165/rcmb.2018-0065OC.


Looking for Airways Periostin in Severe Asthma: Could It Be Useful for Clustering Type 2 Endotype?

Carpagnano GE, Scioscia G, Lacedonia D, Soccio P, Lepore G, Saetta M, Foschino Barbaro MP, Barnes PJ.

Chest. 2018 Nov;154(5):1083-1090. doi: 10.1016/j.chest.2018.08.1032. Epub 2018 Oct 15.


Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial.

Devereux G, Cotton S, Fielding S, McMeekin N, Barnes PJ, Briggs A, Burns G, Chaudhuri R, Chrystyn H, Davies L, De Soyza A, Gompertz S, Haughney J, Innes K, Kaniewska J, Lee A, Morice A, Norrie J, Sullivan A, Wilson A, Price D.

JAMA. 2018 Oct 16;320(15):1548-1559. doi: 10.1001/jama.2018.14432.


Ezrin, a Membrane Cytoskeleton Cross-Linker Protein, as a Marker of Epithelial Damage in Asthma.

Jia M, Yan X, Jiang X, Wu Y, Xu J, Meng Y, Yang Y, Shan X, Zhang X, Mao S, Gu W, Pavlidis S, Barnes PJ, Adcock IM, Huang M, Yao X.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):496-507. doi: 10.1164/rccm.201802-0373OC.


Comparison of fluticasone propionate and budesonide on COPD macrophage and neutrophil function.

Belchamber KB, Thomas CM, Dunne AE, Barnes PJ, Donnelly LE.

Int J Chron Obstruct Pulmon Dis. 2018 Sep 17;13:2883-2897. doi: 10.2147/COPD.S169337. eCollection 2018.


Correction: Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease.

Maneechotesuwan K, Yao X, Ito K, Jazrawi E, Usmani OS, Adcock IM, Barnes PJ.

PLoS Med. 2018 Sep 7;15(9):e1002657. doi: 10.1371/journal.pmed.1002657. eCollection 2018 Sep.


MicroRNA-570 is a novel regulator of cellular senescence and inflammaging.

Baker JR, Vuppusetty C, Colley T, Hassibi S, Fenwick PS, Donnelly LE, Ito K, Barnes PJ.

FASEB J. 2019 Feb;33(2):1605-1616. doi: 10.1096/fj.201800965R. Epub 2018 Aug 29.


Quantitative Screening Method for Erythromycin and Tylosin in Honey Using RapidFire Mass Spectrometry.

Veach BT, Mudalige TK, Barnes PJ, Baker CA.

J AOAC Int. 2018 Jul 31. doi: 10.5740/jaoacint.18-0107. [Epub ahead of print]


Adenosine 5'-triphosphate's role in bradycardia and syncope associated with pulmonary embolism.

Pelleg A, Schulman ES, Barnes PJ.

Respir Res. 2018 Jul 28;19(1):142. doi: 10.1186/s12931-018-0848-2. Review.


Pre-clinical Pharmacokinetic and Metabolomic Analyses of Isorhapontigenin, a Dietary Resveratrol Derivative.

Dai Y, Yeo SCM, Barnes PJ, Donnelly LE, Loo LC, Lin HS.

Front Pharmacol. 2018 Jul 11;9:753. doi: 10.3389/fphar.2018.00753. eCollection 2018.


Impact of Detection Method and Age on Survival Outcomes in Triple-Negative Breast Cancer: A Population-Based Cohort Analysis.

Rayson D, Payne JI, Michael JCR, Tsuruda KM, Abdolell M, Barnes PJ.

Clin Breast Cancer. 2018 Oct;18(5):e955-e960. doi: 10.1016/j.clbc.2018.04.013. Epub 2018 Apr 28.


Inhaled Combined Budesonide-Formoterol as Needed in Mild Asthma.

O'Byrne PM, FitzGerald JM, Bateman ED, Barnes PJ, Zhong N, Keen C, Jorup C, Lamarca R, Ivanov S, Reddel HK.

N Engl J Med. 2018 May 17;378(20):1865-1876. doi: 10.1056/NEJMoa1715274.


As-Needed Budesonide-Formoterol versus Maintenance Budesonide in Mild Asthma.

Bateman ED, Reddel HK, O'Byrne PM, Barnes PJ, Zhong N, Keen C, Jorup C, Lamarca R, Siwek-Posluszna A, FitzGerald JM.

N Engl J Med. 2018 May 17;378(20):1877-1887. doi: 10.1056/NEJMoa1715275.


Efficacy and safety profile of xanthines in COPD: a network meta-analysis.

Cazzola M, Calzetta L, Barnes PJ, Criner GJ, Martinez FJ, Papi A, Gabriella Matera M.

Eur Respir Rev. 2018 May 2;27(148). pii: 180010. doi: 10.1183/16000617.0010-2018. Print 2018 Jun 30. Review.


Breathomics for Assessing the Effects of Treatment and Withdrawal With Inhaled Beclomethasone/Formoterol in Patients With COPD.

Montuschi P, Santini G, Mores N, Vignoli A, Macagno F, Shoreh R, Tenori L, Zini G, Fuso L, Mondino C, Di Natale C, D'Amico A, Luchinat C, Barnes PJ, Higenbottam T.

Front Pharmacol. 2018 Apr 17;9:258. doi: 10.3389/fphar.2018.00258. eCollection 2018.


Pharmacological treatment of COPD: the devil is always in the detail.

Singh D, Barnes PJ, Stockley R, Lopez Valera MV, Vogelmeier C, Agusti A.

Eur Respir J. 2018 Apr 19;51(4). pii: 1800263. doi: 10.1183/13993003.00263-2018. Print 2018 Apr. No abstract available.


Targeting cytokines to treat asthma and chronic obstructive pulmonary disease.

Barnes PJ.

Nat Rev Immunol. 2018 Jul;18(7):454-466. doi: 10.1038/s41577-018-0006-6. Review.


Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.

Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):739-750. doi: 10.1164/rccm.201705-0903OC.


The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure.

Yanagisawa S, Baker JR, Vuppusetty C, Koga T, Colley T, Fenwick P, Donnelly LE, Barnes PJ, Ito K.

PLoS One. 2018 Mar 6;13(3):e0193921. doi: 10.1371/journal.pone.0193921. eCollection 2018.


Reduced Clearance of Fungal Spores by Chronic Obstructive Pulmonary Disease GM-CSF- and M-CSF-derived Macrophages.

Wrench C, Belchamber KBR, Bercusson A, Shah A, Barnes PJ, Armstrong-James D, Donnelly LE.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):271-273. doi: 10.1165/rcmb.2017-0351LE. No abstract available.


Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease.

Mallia P, Webber J, Gill SK, Trujillo-Torralbo MB, Calderazzo MA, Finney L, Bakhsoliani E, Farne H, Singanayagam A, Footitt J, Hewitt R, Kebadze T, Aniscenko J, Padmanaban V, Molyneaux PL, Adcock IM, Barnes PJ, Ito K, Elkin SL, Kon OM, Cookson WO, Moffat MF, Johnston SL, Tregoning JS.

J Allergy Clin Immunol. 2018 Sep;142(3):815-823.e6. doi: 10.1016/j.jaci.2017.10.017. Epub 2018 Jan 5.


ERS/ATS workshop report on respiratory health effects of household air pollution.

Sood A, Assad NA, Barnes PJ, Churg A, Gordon SB, Harrod KS, Irshad H, Kurmi OP, Martin WJ 2nd, Meek P, Mortimer K, Noonan CW, Perez-Padilla R, Smith KR, Tesfaigzi Y, Ward T, Balmes J.

Eur Respir J. 2018 Jan 4;51(1). pii: 1700698. doi: 10.1183/13993003.00698-2017. Print 2018 Jan.


TGF-β Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD.

Di Stefano A, Sangiorgi C, Gnemmi I, Casolari P, Brun P, Ricciardolo FLM, Contoli M, Papi A, Maniscalco P, Ruggeri P, Girbino G, Cappello F, Pavlides S, Guo Y, Chung KF, Barnes PJ, Adcock IM, Balbi B, Caramori G.

Chest. 2018 Apr;153(4):851-862. doi: 10.1016/j.chest.2017.12.017. Epub 2017 Dec 28.


Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study.

Wang Z, Singh R, Miller BE, Tal-Singer R, Van Horn S, Tomsho L, Mackay A, Allinson JP, Webb AJ, Brookes AJ, George LM, Barker B, Kolsum U, Donnelly LE, Belchamber K, Barnes PJ, Singh D, Brightling CE, Donaldson GC, Wedzicha JA, Brown JR; COPDMAP.

Thorax. 2018 Apr;73(4):331-338. doi: 10.1136/thoraxjnl-2017-210741. Epub 2017 Dec 21.


Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease.

Mitani A, Azam A, Vuppusetty C, Ito K, Mercado N, Barnes PJ.

Exp Lung Res. 2017 Nov - Dec;43(9-10):417-425. doi: 10.1080/01902148.2017.1393707. Epub 2017 Dec 11.


Corticosteroid plus β2-agonist in a single inhaler as reliever therapy in intermittent and mild asthma: a proof-of-concept systematic review and meta-analysis.

Wang G, Zhang X, Zhang HP, Wang L, Kang Y, Barnes PJ, Wang G.

Respir Res. 2017 Dec 6;18(1):203. doi: 10.1186/s12931-017-0687-6. Review.


Quantitation and Confirmation of Chloramphenicol, Florfenicol, and Nitrofuran Metabolites in Honey Using LC-MS/MS.

Veach BT, Anglin R, Mudalige TK, Barnes PJ.

J AOAC Int. 2018 May 1;101(3):897-904. doi: 10.5740/jaoacint.17-0262. Epub 2017 Nov 30.


Budesonide facilitates weaning from mechanical ventilation in difficult-to-wean very severe COPD patients: Association with inflammatory mediators and cells.

Hashemian SM, Mortaz E, Jamaati H, Bagheri L, Mohajerani SA, Garssen J, Movassaghi M, Barnes PJ, Hill NS, Adcock IM.

J Crit Care. 2018 Apr;44:161-167. doi: 10.1016/j.jcrc.2017.10.045. Epub 2017 Oct 31.


Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease.

Birch J, Barnes PJ, Passos JF.

Pharmacol Ther. 2018 Mar;183:34-49. doi: 10.1016/j.pharmthera.2017.10.005. Epub 2017 Oct 4. Review.


Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and Patients with Chronic Obstructive Pulmonary Disease.

Paschalaki KE, Zampetaki A, Baker JR, Birrell MA, Starke RD, Belvisi MG, Donnelly LE, Mayr M, Randi AM, Barnes PJ.

Am J Respir Crit Care Med. 2018 Mar 1;197(5):665-668. doi: 10.1164/rccm.201706-1304LE. No abstract available.


Effects of an Airway Clearance Device on Inflammation, Bacteriology, and Mucus Transport in Bronchiectasis.

Tambascio J, de Souza HCD, Martinez R, Baddini-Martinez JA, Barnes PJ, Gastaldi AC.

Respir Care. 2017 Aug;62(8):1067-1074. doi: 10.4187/respcare.05214.

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