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Elevated Cyclic AMP Inhibits Mycobacterium tuberculosis-Stimulated T-cell IFN-γ Secretion Through Type I Protein Kinase A.

Chung YT, Pasquinelli V, Jurado JO, Wang X, Yi N, Barnes PF, Garcia VE, Samten B.

J Infect Dis. 2018 May 5;217(11):1821-1831. doi: 10.1093/infdis/jiy079.


A rho GDP dissociation inhibitor produced by apoptotic T-cells inhibits growth of Mycobacterium tuberculosis.

Venkatasubramanian S, Dhiman R, Paidipally P, Cheekatla SS, Tripathi D, Welch E, Tvinnereim AR, Jones B, Theodorescu D, Barnes PF, Vankayalapati R.

PLoS Pathog. 2015 Feb 6;11(2):e1004617. doi: 10.1371/journal.ppat.1004617. eCollection 2015 Feb.


Phosphorylated STAT3 and PD-1 regulate IL-17 production and IL-23 receptor expression in Mycobacterium tuberculosis infection.

Bandaru A, Devalraju KP, Paidipally P, Dhiman R, Venkatasubramanian S, Barnes PF, Vankayalapati R, Valluri V.

Eur J Immunol. 2014 Jul;44(7):2013-24. doi: 10.1002/eji.201343680. Epub 2014 Apr 23.


Protecting against post-influenza bacterial pneumonia by increasing phagocyte recruitment and ROS production.

Subramaniam R, Barnes PF, Fletcher K, Boggaram V, Hillberry Z, Neuenschwander P, Shams H.

J Infect Dis. 2014 Jun 1;209(11):1827-36. doi: 10.1093/infdis/jit830. Epub 2013 Dec 23.


Interleukin 22 inhibits intracellular growth of Mycobacterium tuberculosis by enhancing calgranulin A expression.

Dhiman R, Venkatasubramanian S, Paidipally P, Barnes PF, Tvinnereim A, Vankayalapati R.

J Infect Dis. 2014 Feb 15;209(4):578-87. doi: 10.1093/infdis/jit495. Epub 2013 Sep 16.


Phosphorylation of mitogen-activated protein kinases contributes to interferon γ production in response to Mycobacterium tuberculosis.

Pasquinelli V, Rovetta AI, Alvarez IB, Jurado JO, Musella RM, Palmero DJ, Malbrán A, Samten B, Barnes PF, García VE.

J Infect Dis. 2013 Jan 15;207(2):340-50. doi: 10.1093/infdis/jis672. Epub 2012 Nov 2.


Early secreted antigenic target of 6-kDa protein of Mycobacterium tuberculosis primes dendritic cells to stimulate Th17 and inhibit Th1 immune responses.

Wang X, Barnes PF, Huang F, Alvarez IB, Neuenschwander PF, Sherman DR, Samten B.

J Immunol. 2012 Sep 15;189(6):3092-103. doi: 10.4049/jimmunol.1200573. Epub 2012 Aug 17.


NK1.1+ cells and IL-22 regulate vaccine-induced protective immunity against challenge with Mycobacterium tuberculosis.

Dhiman R, Periasamy S, Barnes PF, Jaiswal AG, Paidipally P, Barnes AB, Tvinnereim A, Vankayalapati R.

J Immunol. 2012 Jul 15;189(2):897-905. doi: 10.4049/jimmunol.1102833. Epub 2012 Jun 18.


Immune regulatory activities of early secreted antigenic target of 6-kD protein of Mycobacterium tuberculosis and implications for tuberculosis vaccine design.

Samten B, Wang X, Barnes PF.

Tuberculosis (Edinb). 2011 Dec;91 Suppl 1:S114-8. doi: 10.1016/ Epub 2011 Dec 9. Review.


The Mycobacterium tuberculosis early secreted antigenic target of 6 kDa inhibits T cell interferon-γ production through the p38 mitogen-activated protein kinase pathway.

Peng H, Wang X, Barnes PF, Tang H, Townsend JC, Samten B.

J Biol Chem. 2011 Jul 8;286(27):24508-18. doi: 10.1074/jbc.M111.234062. Epub 2011 May 17.


GM-CSF in the lung protects against lethal influenza infection.

Huang FF, Barnes PF, Feng Y, Donis R, Chroneos ZC, Idell S, Allen T, Perez DR, Whitsett JA, Dunussi-Joannopoulos K, Shams H.

Am J Respir Crit Care Med. 2011 Jul 15;184(2):259-68. doi: 10.1164/rccm.201012-2036OC. Epub 2011 Apr 7.


Programmed death 1 and cytokine inducible SH2-containing protein dependent expansion of regulatory T cells upon stimulation With Mycobacterium tuberculosis.

Periasamy S, Dhiman R, Barnes PF, Paidipally P, Tvinnereim A, Bandaru A, Valluri VL, Vankayalapati R.

J Infect Dis. 2011 May 1;203(9):1256-63. doi: 10.1093/infdis/jir011. Epub 2011 Mar 7.


c-Maf-dependent growth of Mycobacterium tuberculosis in a CD14(hi) subpopulation of monocyte-derived macrophages.

Dhiman R, Bandaru A, Barnes PF, Saha S, Tvinnereim A, Nayak RC, Paidipally P, Valluri VL, Rao LV, Vankayalapati R.

J Immunol. 2011 Feb 1;186(3):1638-45. doi: 10.4049/jimmunol.1003146. Epub 2011 Jan 5.


Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and Mycobacterium tuberculosis.

Feng Y, Kong Y, Barnes PF, Huang FF, Klucar P, Wang X, Samten B, Sengupta M, Machona B, Donis R, Tvinnereim AR, Shams H.

Infect Immun. 2011 Jan;79(1):229-37. doi: 10.1128/IAI.00709-10. Epub 2010 Oct 25.


Innate and adaptive immune responses to human Mycobacterium tuberculosis infection.

Vankayalapati R, Barnes PF.

Tuberculosis (Edinb). 2009 Dec;89 Suppl 1:S77-80. doi: 10.1016/S1472-9792(09)70018-6.


Mycobacterium tuberculosis ESX-1 system-secreted protein ESAT-6 but not CFP10 inhibits human T-cell immune responses.

Samten B, Wang X, Barnes PF.

Tuberculosis (Edinb). 2009 Dec;89 Suppl 1:S74-6. doi: 10.1016/S1472-9792(09)70017-4.


Progress in understanding the human immune responses to Mycobacterium tuberculosis.

Barnes PF, Samten B, Shams H, Vankayalapatib R.

Tuberculosis (Edinb). 2009 Dec;89 Suppl 1:S5-9. doi: 10.1016/S1472-9792(09)70004-6.


Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy.

Cheng L, Guo J, Sun L, Fu J, Barnes PF, Metzger D, Chambon P, Oshima RG, Amagai T, Su DM.

J Biol Chem. 2010 Feb 19;285(8):5836-47. doi: 10.1074/jbc.M109.072124. Epub 2009 Dec 2.


IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion.

Dhiman R, Indramohan M, Barnes PF, Nayak RC, Paidipally P, Rao LV, Vankayalapati R.

J Immunol. 2009 Nov 15;183(10):6639-45. doi: 10.4049/jimmunol.0902587. Epub 2009 Oct 28.


NKG2D-dependent IL-17 production by human T cells in response to an intracellular pathogen.

Paidipally P, Periasamy S, Barnes PF, Dhiman R, Indramohan M, Griffith DE, Cosman D, Vankayalapati R.

J Immunol. 2009 Aug 1;183(3):1940-5. doi: 10.4049/jimmunol.0803578. Epub 2009 Jul 8.


Vaccination strategies to enhance local immunity and protection against Mycobacteriun tuberculosis.

Klucar P, Barnes PF, Kong Y, Howard ST, Pang X, Huang FF, Tvinnereim AR, Samten B, Shams H.

Vaccine. 2009 Mar 13;27(12):1816-24.


Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth.

Wu S, Barnes PF, Samten B, Pang X, Rodrigue S, Ghanny S, Soteropoulos P, Gaudreau L, Howard ST.

Microbiology. 2009 Apr;155(Pt 4):1272-81. doi: 10.1099/mic.0.024638-0.


ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells.

Wang X, Barnes PF, Dobos-Elder KM, Townsend JC, Chung YT, Shams H, Weis SE, Samten B.

J Immunol. 2009 Mar 15;182(6):3668-77. doi: 10.4049/jimmunol.0803579.


IFN-gamma production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB.

Pasquinelli V, Townsend JC, Jurado JO, Alvarez IB, Quiroga MF, Barnes PF, Samten B, García VE.

J Infect Dis. 2009 Mar 1;199(5):661-5. doi: 10.1086/596742.


CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen.

Samten B, Townsend JC, Weis SE, Bhoumik A, Klucar P, Shams H, Barnes PF.

J Immunol. 2008 Aug 1;181(3):2056-64.


Characterization of effector functions of human peptide-specific CD4+ T-cell clones for an intracellular pathogen.

Klucar P, Barnes PF, Kong Y, Samten B, Tvinnereim A, Spallek R, Nepom GT, Singh M, Shams H.

Hum Immunol. 2008 Aug;69(8):475-83. doi: 10.1016/j.humimm.2008.05.008. Epub 2008 Jun 25.


An antibody against the surfactant protein A (SP-A)-binding domain of the SP-A receptor inhibits T cell-mediated immune responses to Mycobacterium tuberculosis.

Samten B, Townsend JC, Sever-Chroneos Z, Pasquinelli V, Barnes PF, Chroneos ZC.

J Leukoc Biol. 2008 Jul;84(1):115-23. doi: 10.1189/jlb.1207835. Epub 2008 May 1.


NK cells lyse T regulatory cells that expand in response to an intracellular pathogen.

Roy S, Barnes PF, Garg A, Wu S, Cosman D, Vankayalapati R.

J Immunol. 2008 Feb 1;180(3):1729-36.


Mannose-capped lipoarabinomannan- and prostaglandin E2-dependent expansion of regulatory T cells in human Mycobacterium tuberculosis infection.

Garg A, Barnes PF, Roy S, Quiroga MF, Wu S, García VE, Krutzik SR, Weis SE, Vankayalapati R.

Eur J Immunol. 2008 Feb;38(2):459-69. doi: 10.1002/eji.200737268.


The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells.

Gui J, Zhu X, Dohkan J, Cheng L, Barnes PF, Su DM.

Int Immunol. 2007 Oct;19(10):1201-11. Epub 2007 Sep 5.


Lymphohematopoietic progenitors do not have a synchronized defect with age-related thymic involution.

Zhu X, Gui J, Dohkan J, Cheng L, Barnes PF, Su DM.

Aging Cell. 2007 Oct;6(5):663-72. Epub 2007 Aug 6.


Vimentin expressed on Mycobacterium tuberculosis-infected human monocytes is involved in binding to the NKp46 receptor.

Garg A, Barnes PF, Porgador A, Roy S, Wu S, Nanda JS, Griffith DE, Girard WM, Rawal N, Shetty S, Vankayalapati R.

J Immunol. 2006 Nov 1;177(9):6192-8. Erratum in: J Immunol. 2008 Dec 15;181(12):8797.


Weighing gold or counting spots: which is more sensitive to diagnose latent tuberculosis infection?

Barnes PF.

Am J Respir Crit Care Med. 2006 Oct 1;174(7):731-2. No abstract available.


A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis.

Flores-Villanueva PO, Ruiz-Morales JA, Song CH, Flores LM, Jo EK, Montaño M, Barnes PF, Selman M, Granados J.

J Exp Med. 2005 Dec 19;202(12):1649-58. Epub 2005 Dec 13.


Role of NK cell-activating receptors and their ligands in the lysis of mononuclear phagocytes infected with an intracellular bacterium.

Vankayalapati R, Garg A, Porgador A, Griffith DE, Klucar P, Safi H, Girard WM, Cosman D, Spies T, Barnes PF.

J Immunol. 2005 Oct 1;175(7):4611-7.


Enzyme-linked immunospot and tuberculin skin testing to detect latent tuberculosis infection.

Shams H, Weis SE, Klucar P, Lalvani A, Moonan PK, Pogoda JM, Ewer K, Barnes PF.

Am J Respir Crit Care Med. 2005 Nov 1;172(9):1161-8. Epub 2005 Aug 4.


Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen.

Samten B, Howard ST, Weis SE, Wu S, Shams H, Townsend JC, Safi H, Barnes PF.

J Immunol. 2005 May 15;174(10):6357-63.


Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.

Shams H, Klucar P, Weis SE, Lalvani A, Moonan PK, Safi H, Wizel B, Ewer K, Nepom GT, Lewinsohn DM, Andersen P, Barnes PF.

J Immunol. 2004 Aug 1;173(3):1966-77.


Diagnosing latent tuberculosis infection: turning glitter to gold.

Barnes PF.

Am J Respir Crit Care Med. 2004 Jul 1;170(1):5-6. No abstract available.


IS6110 functions as a mobile, monocyte-activated promoter in Mycobacterium tuberculosis.

Safi H, Barnes PF, Lakey DL, Shams H, Samten B, Vankayalapati R, Howard ST.

Mol Microbiol. 2004 May;52(4):999-1012.


The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo.

Wu S, Howard ST, Lakey DL, Kipnis A, Samten B, Safi H, Gruppo V, Wizel B, Shams H, Basaraba RJ, Orme IM, Barnes PF.

Mol Microbiol. 2004 Mar;51(6):1551-62.


NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen.

Vankayalapati R, Klucar P, Wizel B, Weis SE, Samten B, Safi H, Shams H, Barnes PF.

J Immunol. 2004 Jan 1;172(1):130-7.


Molecular epidemiology of tuberculosis.

Barnes PF, Cave MD.

N Engl J Med. 2003 Sep 18;349(12):1149-56. Review. No abstract available.


Human CD8+ T cells recognize epitopes of the 28-kDa hemolysin and the 38-kDa antigen of Mycobacterium tuberculosis.

Shams H, Barnes PF, Weis SE, Klucar P, Wizel B.

J Leukoc Biol. 2003 Dec;74(6):1008-14. Epub 2003 Sep 12.


Spectrum of manifestations of Mycobacterium tuberculosis infection in primates infected with SIV.

Safi H, Gormus BJ, Didier PJ, Blanchard JL, Lakey DL, Martin LN, Murphey-Corb M, Vankayalapati R, Barnes PF.

AIDS Res Hum Retroviruses. 2003 Jul;19(7):585-95.


Immunotherapy for tuberculosis: wave of the future or tilting at windmills?

Barnes PF.

Am J Respir Crit Care Med. 2003 Jul 15;168(2):142-3. No abstract available.


The CD14 receptor does not mediate entry of Mycobacterium tuberculosis into human mononuclear phagocytes.

Shams H, Wizel B, Lakey DL, Samten B, Vankayalapati R, Valdivia RH, Kitchens RL, Griffith DE, Barnes PF.

FEMS Immunol Med Microbiol. 2003 May 15;36(1-2):63-9.


CD40 ligand trimer enhances the response of CD8+ T cells to Mycobacterium tuberculosis.

Samten B, Wizel B, Shams H, Weis SE, Klucar P, Wu S, Vankayalapati R, Thomas EK, Okada S, Krensky AM, Barnes PF.

J Immunol. 2003 Mar 15;170(6):3180-6.


Serum cytokine concentrations do not parallel Mycobacterium tuberculosis-induced cytokine production in patients with tuberculosis.

Vankayalapati R, Wizel B, Weis SE, Klucar P, Shams H, Samten B, Barnes PF.

Clin Infect Dis. 2003 Jan 1;36(1):24-8. Epub 2002 Dec 10.


Multiple Chlamydia pneumoniae antigens prime CD8+ Tc1 responses that inhibit intracellular growth of this vacuolar pathogen.

Wizel B, Starcher BC, Samten B, Chroneos Z, Barnes PF, Dzuris J, Higashimoto Y, Appella E, Sette A.

J Immunol. 2002 Sep 1;169(5):2524-35.

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