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Items: 1 to 50 of 334

1.

Analyzing receptor assemblies in the cell membrane using fluorescence anisotropy imaging with TIRF microscopy.

Erdelyi M, Simon J, Barnard EA, Kaminski CF.

PLoS One. 2014 Jun 19;9(6):e100526. doi: 10.1371/journal.pone.0100526. eCollection 2014.

2.

Activation of UTP-sensitive P2Y2 receptor induces the expression of cholinergic genes in cultured cortical neurons: a signaling cascade triggered by Ca2+ mobilization and extracellular regulated kinase phosphorylation.

Choi RC, Chu GK, Siow NL, Yung AW, Yung LY, Lee PS, Lo CC, Simon J, Dong TT, Barnard EA, Tsim KW.

Mol Pharmacol. 2013 Jul;84(1):50-61. doi: 10.1124/mol.112.084160. Epub 2013 Apr 16.

PMID:
23592515
3.

ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors.

Siow NL, Choi RC, Xie HQ, Kong LW, Chu GK, Chan GK, Simon J, Barnard EA, Tsim KW.

Mol Pharmacol. 2010 Dec;78(6):1059-71. doi: 10.1124/mol.110.066506. Epub 2010 Sep 16.

4.

The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons.

Filippov AK, Simon J, Barnard EA, Brown DA.

J Neurosci. 2010 Aug 18;30(33):11068-72. doi: 10.1523/JNEUROSCI.2597-10.2010.

5.

Constitutive and agonist-induced dimerizations of the P2Y1 receptor: relationship to internalization and scaffolding.

Choi RC, Simon J, Tsim KW, Barnard EA.

J Biol Chem. 2008 Apr 18;283(16):11050-63. doi: 10.1074/jbc.M709266200. Epub 2008 Feb 12.

6.

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.

Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA.

Pharmacol Rev. 2006 Sep;58(3):281-341. Review.

7.

Activation of P2Y1 nucleotide receptors induces inhibition of the M-type K+ current in rat hippocampal pyramidal neurons.

Filippov AK, Choi RC, Simon J, Barnard EA, Brown DA.

J Neurosci. 2006 Sep 6;26(36):9340-8.

8.

Increased susceptibility to ATP via alteration of P2X receptor function in dystrophic mdx mouse muscle cells.

Yeung D, Zablocki K, Lien CF, Jiang T, Arkle S, Brutkowski W, Brown J, Lochmuller H, Simon J, Barnard EA, Górecki DC.

FASEB J. 2006 Apr;20(6):610-20.

PMID:
16581969
9.

Potentiation of P2Y receptors by physiological elevations of extracellular K+ via a mechanism independent of Ca2+ influx.

Pitt SJ, Martinez-Pinna J, Barnard EA, Mahaut-Smith MP.

Mol Pharmacol. 2005 May;67(5):1705-13. Epub 2005 Feb 14.

PMID:
15710744
10.

The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor.

Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Miras-Portugal MT, King BF, Gachet C, Jacobson KA, Weisman GA.

Trends Pharmacol Sci. 2005 Jan;26(1):8-9. No abstract available.

PMID:
15629198
11.

Activation and inhibition of neuronal G protein-gated inwardly rectifying K(+) channels by P2Y nucleotide receptors.

Filippov AK, Fernández-Fernández JM, Marsh SJ, Simon J, Barnard EA, Brown DA.

Mol Pharmacol. 2004 Sep;66(3):468-77.

PMID:
15322238
12.

P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions.

Tung EK, Choi RC, Siow NL, Jiang JX, Ling KK, Simon J, Barnard EA, Tsim KW.

Mol Pharmacol. 2004 Oct;66(4):794-806. Epub 2004 Jul 16.

PMID:
15258260
13.

Analysis of the set of GABA(A) receptor genes in the human genome.

Simon J, Wakimoto H, Fujita N, Lalande M, Barnard EA.

J Biol Chem. 2004 Oct 1;279(40):41422-35. Epub 2004 Jul 16.

14.

ATP induces post-synaptic gene expressions in vertebrate skeletal neuromuscular junctions.

Tsim KW, Choi RC, Siow NL, Cheng AW, Ling KK, Jiang JX, Tung EK, Lee HH, Xie QH, Simon J, Barnard EA.

J Neurocytol. 2003 Jun-Sep;32(5-8):603-17. Review.

PMID:
15034256
15.

The P2Y nucleotide receptors in the human genome.

Simon J, Barnard EA.

Acta Biol Hung. 2003;54(2):191-201.

PMID:
14535625
16.

ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: transduction and transcription control.

Choi RC, Siow NL, Cheng AW, Ling KK, Tung EK, Simon J, Barnard EA, Tsim KW.

J Neurosci. 2003 Jun 1;23(11):4445-56.

17.

Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.

Abbracchio MP, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Miras-Portugal MT, King BF, Gachet C, Jacobson KA, Weisman GA, Burnstock G.

Trends Pharmacol Sci. 2003 Feb;24(2):52-5. Review.

PMID:
12559763
18.

Coupling of the nucleotide P2Y4 receptor to neuronal ion channels.

Filippov AK, Simon J, Barnard EA, Brown DA.

Br J Pharmacol. 2003 Jan;138(2):400-6. Erratum in: Br J Pharmacol. 2003 Feb;138(4):716.

19.

Characterization and channel coupling of the P2Y(12) nucleotide receptor of brain capillary endothelial cells.

Simon J, Filippov AK, Göransson S, Wong YH, Frelin C, Michel AD, Brown DA, Barnard EA.

J Biol Chem. 2002 Aug 30;277(35):31390-400. Epub 2002 Jun 21.

20.

Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement.

Greenfield LJ Jr, Zaman SH, Sutherland ML, Lummis SC, Niemeyer MI, Barnard EA, Macdonald RL.

Neuropharmacology. 2002 Mar;42(4):502-21.

PMID:
11955521
21.
22.

Kinetic analysis of [35S]dATP alpha S interaction with P2y(1) nucleotide receptor.

Oras A, Kilk K, Kunapuli S, Barnard EA, Järv J.

Neurochem Int. 2002 Apr;40(5):381-6.

PMID:
11821144
23.
24.

An elusive receptor is finally caught: P2Y(12'), an important drug target in platelets.

Barnard EA, Simon J.

Trends Pharmacol Sci. 2001 Aug;22(8):388-91. Review.

PMID:
11478981
25.

Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis.

Sellers LA, Simon J, Lundahl TS, Cousens DJ, Humphrey PP, Barnard EA.

J Biol Chem. 2001 May 11;276(19):16379-90. Epub 2001 Jan 25.

26.

Structural diversity despite strong evolutionary conservation in the 5'-untranslated region of the P-type dystrophin transcript.

Abdulrazzak H, Noro N, Simons JP, Goldspink G, Barnard EA, Górecki DC.

Mol Cell Neurosci. 2001 Mar;17(3):500-13.

PMID:
11273645
27.

Dual effect of nucleotides on P2Y receptors.

Sak K, Barnard EA, Järv J.

IUBMB Life. 2000 Aug;50(2):99-103.

28.

alpha(1B) adrenergic receptors in gonadotrophin-releasing hormone neurones: relation to Transport-P.

Al-Damluji S, Shen WB, White S, Barnard EA.

Br J Pharmacol. 2001 Jan;132(1):336-44.

29.

Activity of adenosine diphosphates and triphosphates on a P2Y(T) -type receptor in brain capillary endothelial cells.

Simon J, Vigne P, Eklund KM, Michel AD, Carruthers AM, Humphrey PP, Frelin C, Barnard EA.

Br J Pharmacol. 2001 Jan;132(1):173-82.

30.

Inhibition of potassium and calcium currents in neurones by molecularly-defined P2Y receptors.

Brown DA, Filippov AK, Barnard EA.

J Auton Nerv Syst. 2000 Jul 3;81(1-3):31-6. Review.

PMID:
10869697
31.

Imagination and reality in the search for the P2Y receptors.

Barnard EA.

J Auton Nerv Syst. 2000 Jul 3;81(1-3):10-5. Review.

PMID:
10869694
32.
33.

Functional characterization of the P2X(4) receptor orthologues.

Jones CA, Chessell IP, Simon J, Barnard EA, Miller KJ, Michel AD, Humphrey PP.

Br J Pharmacol. 2000 Jan;129(2):388-94.

34.

Molecular biology of P2Y receptors expressed in the nervous system.

Webb TE, Barnard EA.

Prog Brain Res. 1999;120:23-31. Review. No abstract available.

PMID:
10550985
35.
36.

Impact of the human genome project on the principles for classification and nomenclature of 5-HT receptors.

Hoyer D, Humphrey PA, Barnard EA.

Ann N Y Acad Sci. 1998 Dec 15;861:230-1. No abstract available.

PMID:
9928260
37.

Cloning and functional characterisation of the mouse P2X7 receptor.

Chessell IP, Simon J, Hibell AD, Michel AD, Barnard EA, Humphrey PP.

FEBS Lett. 1998 Nov 13;439(1-2):26-30.

38.

Molecular cloning and characterization of the rat P2Y4 receptor.

Webb TE, Henderson DJ, Roberts JA, Barnard EA.

J Neurochem. 1998 Oct;71(4):1348-57.

39.

Plasticity of agonist binding sites in hetero-oligomers of the unitary glutamate receptor subunit XenU1.

Soloviev MM, Abutidze K, Mellor I, Streit P, Grishin EV, Usherwood PN, Barnard EA.

J Neurochem. 1998 Sep;71(3):991-1001.

40.

Phenotype changes of the vascular smooth muscle cell regulate P2 receptor expression as measured by quantitative RT-PCR.

Erlinge D, Hou M, Webb TE, Barnard EA, Möller S.

Biochem Biophys Res Commun. 1998 Jul 30;248(3):864-70.

PMID:
9704019
41.

Stimulation of P2Y receptors activates c-fos gene expression and inhibits DNA synthesis in cultured cardiac fibroblasts.

Zheng JS, O'Neill L, Long X, Webb TE, Barnard EA, Lakatta EG, Boluyt MO.

Cardiovasc Res. 1998 Mar;37(3):718-28.

PMID:
9659456
42.
43.

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ.

Pharmacol Rev. 1998 Jun;50(2):291-313. Review. No abstract available.

PMID:
9647870
44.

International Union of Pharmacology. XIX. The IUPHAR receptor code: a proposal for an alphanumeric classification system.

Humphrey PP, Barnard EA.

Pharmacol Rev. 1998 Jun;50(2):271-7. Review. No abstract available.

PMID:
9647868
45.
47.

Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms.

Barnard EA, Simon J, Webb TE.

Mol Neurobiol. 1997 Oct;15(2):103-29. Review.

PMID:
9396007
48.

Xenopus oocytes express a unitary glutamate receptor endogenously.

Soloviev MM, Barnard EA.

J Mol Biol. 1997 Oct 17;273(1):14-8.

PMID:
9367741
49.

Distribution of [35S]dATP alpha S binding sites in the adult rat neuraxis.

Simon J, Webb TE, Barnard EA.

Neuropharmacology. 1997 Sep;36(9):1243-51.

PMID:
9364479
50.

Localization and functional expression of splice variants of the P2X2 receptor.

Simon J, Kidd EJ, Smith FM, Chessell IP, Murrell-Lagnado R, Humphrey PP, Barnard EA.

Mol Pharmacol. 1997 Aug;52(2):237-48.

PMID:
9271346

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