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Items: 38


Liquid Biopsy Assay for Lung Carcinoma Using Centrifuged Supernatants from Fine Needle Aspiration Specimens.

Hannigan B, Ye W, Mehrotra M, Lam V, Bolivar A, Zalles S, Barkoh BA, Duose D, Hu PC, Broaddus R, Stewart J, Heymach J, Medeiros LJ, Wistuba I, Luthra R, Roy-Chowdhuri S.

Ann Oncol. 2019 Mar 18. pii: mdz102. doi: 10.1093/annonc/mdz102. [Epub ahead of print]


Centrifuged supernatants from FNA provide a liquid biopsy option for clinical next-generation sequencing of thyroid nodules.

Ye W, Hannigan B, Zalles S, Mehrotra M, Barkoh BA, Williams MD, Cabanillas ME, Edeiken-Monroe B, Hu P, Duose D, Wistuba II, Medeiros LJ, Stewart J, Luthra R, Roy-Chowdhuri S.

Cancer Cytopathol. 2019 Mar;127(3):146-160. doi: 10.1002/cncy.22098. Epub 2019 Jan 8.


Ultra-Rapid Reporting of GENomic Targets (URGENTseq): Clinical Next-Generation Sequencing Results within 48 Hours of Sample Collection.

Patel KP, Ruiz-Cordero R, Chen W, Routbort MJ, Floyd K, Rodriguez S, Galbincea J, Barkoh BA, Hatfield D, Khogeer H, Kanagal-Shamanna R, Yin CC, Zuo Z, Loghavi S, Ok CY, DiNardo CD, Luthra R, Medeiros LJ.

J Mol Diagn. 2019 Jan;21(1):89-98. doi: 10.1016/j.jmoldx.2018.08.002.


Targeted next-generation sequencing of endometrial cancer and matched circulating tumor DNA: identification of plasma-based, tumor-associated mutations in early stage patients.

Bolivar AM, Luthra R, Mehrotra M, Chen W, Barkoh BA, Hu P, Zhang W, Broaddus RR.

Mod Pathol. 2019 Mar;32(3):405-414. doi: 10.1038/s41379-018-0158-8. Epub 2018 Oct 12.


Clinical molecular testing for ASXL1 c.1934dupG p.Gly646fs mutation in hematologic neoplasms in the NGS era.

Montes-Moreno S, Routbort MJ, Lohman EJ, Barkoh BA, Kanagal-Shamanna R, Bueso-Ramos CE, Singh RR, Medeiros LJ, Luthra R, Patel KP.

PLoS One. 2018 Sep 17;13(9):e0204218. doi: 10.1371/journal.pone.0204218. eCollection 2018.


Detection of somatic mutations in cell-free DNA in plasma and correlation with overall survival in patients with solid tumors.

Mehrotra M, Singh RR, Loghavi S, Duose DY, Barkoh BA, Behrens C, Patel KP, Routbort MJ, Kopetz S, Broaddus RR, Medeiros LJ, Wistuba II, Luthra R.

Oncotarget. 2017 Oct 24;9(12):10259-10271. doi: 10.18632/oncotarget.21982. eCollection 2018 Feb 13.


Salvaging the supernatant: next generation cytopathology for solid tumor mutation profiling.

Roy-Chowdhuri S, Mehrotra M, Bolivar AM, Kanagal-Shamanna R, Barkoh BA, Hannigan B, Zalles S, Ye W, Duose D, Broaddus R, Staerkel G, Wistuba I, Medeiros LJ, Luthra R.

Mod Pathol. 2018 Jul;31(7):1036-1045. doi: 10.1038/s41379-018-0006-x. Epub 2018 Feb 20.


Versatile ion S5XL sequencer for targeted next generation sequencing of solid tumors in a clinical laboratory.

Mehrotra M, Duose DY, Singh RR, Barkoh BA, Manekia J, Harmon MA, Patel KP, Routbort MJ, Medeiros LJ, Wistuba II, Luthra R.

PLoS One. 2017 Aug 2;12(8):e0181968. doi: 10.1371/journal.pone.0181968. eCollection 2017.


Study of Preanalytic and Analytic Variables for Clinical Next-Generation Sequencing of Circulating Cell-Free Nucleic Acid.

Mehrotra M, Singh RR, Chen W, Huang RSP, Almohammedsalim AA, Barkoh BA, Simien CM, Hernandez M, Behrens C, Patel KP, Routbort MJ, Broaddus RR, Medeiros LJ, Wistuba II, Kopetz S, Luthra R.

J Mol Diagn. 2017 Jul;19(4):514-524. doi: 10.1016/j.jmoldx.2017.03.003. Epub 2017 May 12.


Concurrent fine needle aspirations and core needle biopsies: a comparative study of substrates for next-generation sequencing in solid organ malignancies.

Roy-Chowdhuri S, Chen H, Singh RR, Krishnamurthy S, Patel KP, Routbort MJ, Manekia J, Barkoh BA, Yao H, Sabir S, Broaddus RR, Medeiros LJ, Staerkel G, Stewart J, Luthra R.

Mod Pathol. 2017 Apr;30(4):499-508. doi: 10.1038/modpathol.2016.228. Epub 2017 Jan 13.


Clinical Validation of a CXCR4 Mutation Screening Assay for Waldenstrom Macroglobulinemia.

Ballester LY, Loghavi S, Kanagal-Shamanna R, Barkoh BA, Lin P, Medeiros LJ, Luthra R, Patel KP.

Clin Lymphoma Myeloma Leuk. 2016 Jul;16(7):395-403.e1. doi: 10.1016/j.clml.2016.04.014. Epub 2016 May 5.


Identification of Factors Affecting the Success of Next-Generation Sequencing Testing in Solid Tumors.

Goswami RS, Luthra R, Singh RR, Patel KP, Routbort MJ, Aldape KD, Yao H, Dang HD, Barkoh BA, Manekia J, Medeiros LJ, Roy-Chowdhuri S, Stewart J, Broaddus RR, Chen H.

Am J Clin Pathol. 2016 Feb;145(2):222-37. doi: 10.1093/ajcp/aqv023. Epub 2016 Feb 12.


Clinical validation of a multipurpose assay for detection and genotyping of CALR mutations in myeloproliferative neoplasms.

Mehrotra M, Luthra R, Singh RR, Barkoh BA, Galbincea J, Mehta P, Goswami RS, Jabbar KJ, Loghavi S, Medeiros LJ, Verstovsek S, Patel KP.

Am J Clin Pathol. 2015 Nov;144(5):746-55. doi: 10.1309/AJCP5LA2LDDNQNNC.


Factors affecting the success of next-generation sequencing in cytology specimens.

Roy-Chowdhuri S, Goswami RS, Chen H, Patel KP, Routbort MJ, Singh RR, Broaddus RR, Barkoh BA, Manekia J, Yao H, Medeiros LJ, Staerkel G, Luthra R, Stewart J.

Cancer Cytopathol. 2015 Nov;123(11):659-68. doi: 10.1002/cncy.21597. Epub 2015 Jul 31.


Cutaneous carcinosarcoma and the EMT: to transition, or not to transition? That is the question.

Paniz-Mondolfi A, Singh R, Jour G, Mahmoodi M, Diwan AH, Barkoh BA, Cason R, Huttenbach Y, Benaim G, Galbincea J, Luthra R.

Virchows Arch. 2015 Mar;466(3):359-60. doi: 10.1007/s00428-015-1718-7. Epub 2015 Jan 27. No abstract available.


Clinical massively parallel next-generation sequencing analysis of 409 cancer-related genes for mutations and copy number variations in solid tumours.

Singh RR, Patel KP, Routbort MJ, Aldape K, Lu X, Manekia J, Abraham R, Reddy NG, Barkoh BA, Veliyathu J, Medeiros LJ, Luthra R.

Br J Cancer. 2014 Nov 11;111(10):2014-23. doi: 10.1038/bjc.2014.518. Epub 2014 Oct 14.


Identification of putative pathogenic microRNA and its downstream targets in anaplastic lymphoma kinase-negative anaplastic large cell lymphoma.

Mehrotra M, Medeiros LJ, Luthra R, Sargent RL, Yao H, Barkoh BA, Singh R, Patel KP.

Hum Pathol. 2014 Oct;45(10):1995-2005. doi: 10.1016/j.humpath.2014.06.012. Epub 2014 Jun 30.


Cutaneous carcinosarcoma: further insights into its mutational landscape through massive parallel genome sequencing.

Paniz-Mondolfi A, Singh R, Jour G, Mahmoodi M, Diwan AH, Barkoh BA, Cason R, Huttenbach Y, Benaim G, Galbincea J, Luthra R.

Virchows Arch. 2014 Sep;465(3):339-50. doi: 10.1007/s00428-014-1628-0. Epub 2014 Jul 17.


Quantitative assessment of mutant allele burden in solid tumors by semiconductor-based next-generation sequencing.

Portier BP, Kanagal-Shamanna R, Luthra R, Singh R, Routbort MJ, Handal B, Reddy N, Barkoh BA, Zuo Z, Medeiros LJ, Aldape K, Patel KP.

Am J Clin Pathol. 2014 Apr;141(4):559-72. doi: 10.1309/AJCP1JUGQMW7ZNTL.


Identification of clinically important chromosomal aberrations in acute myeloid leukemia by array-based comparative genomic hybridization.

Mehrotra M, Luthra R, Ravandi F, Sargent RL, Barkoh BA, Abraham R, Mishra BM, Medeiros LJ, Patel KP.

Leuk Lymphoma. 2014 Nov;55(11):2538-48. doi: 10.3109/10428194.2014.883073.


Next-generation sequencing-based multigene mutational screening for acute myeloid leukemia using MiSeq: applicability for diagnostics and disease monitoring.

Luthra R, Patel KP, Reddy NG, Haghshenas V, Routbort MJ, Harmon MA, Barkoh BA, Kanagal-Shamanna R, Ravandi F, Cortes JE, Kantarjian HM, Medeiros LJ, Singh RR.

Haematologica. 2014 Mar;99(3):465-73. doi: 10.3324/haematol.2013.093765. Epub 2013 Oct 18.


Primary cutaneous carcinosarcoma: insights into its clonal origin and mutational pattern expression analysis through next-generation sequencing.

Paniz Mondolfi AE, Jour G, Johnson M, Reidy J, Cason RC, Barkoh BA, Benaim G, Singh R, Luthra R.

Hum Pathol. 2013 Dec;44(12):2853-60. doi: 10.1016/j.humpath.2013.07.014. Epub 2013 Sep 24.


Next-generation sequencing-based multi-gene mutation profiling of solid tumors using fine needle aspiration samples: promises and challenges for routine clinical diagnostics.

Kanagal-Shamanna R, Portier BP, Singh RR, Routbort MJ, Aldape KD, Handal BA, Rahimi H, Reddy NG, Barkoh BA, Mishra BM, Paladugu AV, Manekia JH, Kalhor N, Chowdhuri SR, Staerkel GA, Medeiros LJ, Luthra R, Patel KP.

Mod Pathol. 2014 Feb;27(2):314-27. doi: 10.1038/modpathol.2013.122. Epub 2013 Aug 2.


Clinical validation of a next-generation sequencing screen for mutational hotspots in 46 cancer-related genes.

Singh RR, Patel KP, Routbort MJ, Reddy NG, Barkoh BA, Handal B, Kanagal-Shamanna R, Greaves WO, Medeiros LJ, Aldape KD, Luthra R.

J Mol Diagn. 2013 Sep;15(5):607-22. doi: 10.1016/j.jmoldx.2013.05.003. Epub 2013 Jun 26.


Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma.

Greaves WO, Verma S, Patel KP, Davies MA, Barkoh BA, Galbincea JM, Yao H, Lazar AJ, Aldape KD, Medeiros LJ, Luthra R.

J Mol Diagn. 2013 Mar;15(2):220-6. doi: 10.1016/j.jmoldx.2012.10.002. Epub 2012 Dec 27.


Detection of high-frequency and novel DNMT3A mutations in acute myeloid leukemia by high-resolution melting curve analysis.

Singh RR, Bains A, Patel KP, Rahimi H, Barkoh BA, Paladugu A, Bisrat T, Ravandi-Kashani F, Cortes JE, Kantarjian HM, Medeiros LJ, Luthra R.

J Mol Diagn. 2012 Jul;14(4):336-45. doi: 10.1016/j.jmoldx.2012.02.009. Epub 2012 May 27.


Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing.

Djordjevic B, Hennessy BT, Li J, Barkoh BA, Luthra R, Mills GB, Broaddus RR.

Mod Pathol. 2012 May;25(5):699-708. doi: 10.1038/modpathol.2011.208. Epub 2012 Feb 3.


Complex patterns of altered MicroRNA expression during the adenoma-adenocarcinoma sequence for microsatellite-stable colorectal cancer.

Bartley AN, Yao H, Barkoh BA, Ivan C, Mishra BM, Rashid A, Calin GA, Luthra R, Hamilton SR.

Clin Cancer Res. 2011 Dec 1;17(23):7283-93. doi: 10.1158/1078-0432.CCR-11-1452. Epub 2011 Sep 23.


Diagnostic testing for IDH1 and IDH2 variants in acute myeloid leukemia an algorithmic approach using high-resolution melting curve analysis.

Patel KP, Barkoh BA, Chen Z, Ma D, Reddy N, Medeiros LJ, Luthra R.

J Mol Diagn. 2011 Nov;13(6):678-86. doi: 10.1016/j.jmoldx.2011.06.004. Epub 2011 Sep 1.


Detection of nucleophosmin 1 mutations by quantitative real-time polymerase chain reaction versus capillary electrophoresis: a comparative study.

Barakat FH, Luthra R, Yin CC, Barkoh BA, Hai S, Jamil W, Bhakta YI, Chen S, Medeiros LJ, Zuo Z.

Arch Pathol Lab Med. 2011 Aug;135(8):994-1000. doi: 10.5858/2010-0490-OAR1.


Acute myeloid leukemia with IDH1 or IDH2 mutation: frequency and clinicopathologic features.

Patel KP, Ravandi F, Ma D, Paladugu A, Barkoh BA, Medeiros LJ, Luthra R.

Am J Clin Pathol. 2011 Jan;135(1):35-45. doi: 10.1309/AJCPD7NR2RMNQDVF.


Application of COLD-PCR for improved detection of KRAS mutations in clinical samples.

Zuo Z, Chen SS, Chandra PK, Galbincea JM, Soape M, Doan S, Barkoh BA, Koeppen H, Medeiros LJ, Luthra R.

Mod Pathol. 2009 Aug;22(8):1023-31. doi: 10.1038/modpathol.2009.59. Epub 2009 May 8.


MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers.

Luthra R, Singh RR, Luthra MG, Li YX, Hannah C, Romans AM, Barkoh BA, Chen SS, Ensor J, Maru DM, Broaddus RR, Rashid A, Albarracin CT.

Oncogene. 2008 Nov 6;27(52):6667-78. doi: 10.1038/onc.2008.256. Epub 2008 Jul 28.


Quantitative profiling of codon 816 KIT mutations can aid in the classification of systemic mast cell disease.

Zhao W, Bueso-Ramos CE, Verstovsek S, Barkoh BA, Khitamy AA, Jones D.

Leukemia. 2007 Jul;21(7):1574-6. Epub 2007 Apr 5. No abstract available.


Establishment and characterization of a new mantle cell lymphoma cell line M-1.

Goy A, Remache YK, Gu J, Stewart J, Hayes KJ, Gold D, Jiang Y, Barkoh BA, Katz R, Cabanillas F, Gilles F.

Leuk Lymphoma. 2004 Jun;45(6):1255-60.


Establishment and characterization by gene expression profiling of a new diffuse large B-cell lymphoma cell line, EJ-1, carrying t(14;18) and t(8;14) translocations.

Goy A, Ramdas L, Remache YK, Gu J, Fayad L, Hayes KJ, Coombes KR, Barkoh BA, Katz R, Ford R, Cabanillas F, Gilles F.

Lab Invest. 2003 Jun;83(6):913-6. No abstract available.


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