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Items: 43

1.

Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites.

le Roux D, Burger PB, Niemand J, Grobler A, Urbán P, Fernàndez-Busquets X, Barker RH, Serrano AE, I Louw A, Birkholtz LM.

Int J Parasitol Drugs Drug Resist. 2013 Dec 5;4(1):28-36. doi: 10.1016/j.ijpddr.2013.11.003. eCollection 2014 Apr.

2.

Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens.

Crowther GJ, Booker ML, He M, Li T, Raverdy S, Novelli JF, He P, Dale NR, Fife AM, Barker RH Jr, Kramer ML, Van Voorhis WC, Carlow CK, Wang MW.

PLoS Negl Trop Dis. 2014 Jan 9;8(1):e2628. doi: 10.1371/journal.pntd.0002628. eCollection 2014.

3.

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

Heidebrecht RW Jr, Mulrooney C, Austin CP, Barker RH Jr, Beaudoin JA, Cheng KC, Comer E, Dandapani S, Dick J, Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M, Guha R, Hinkson P, Kramer M, Lukens AK, Masi D, Marcaurelle LA, Su XZ, Thomas CJ, Weïwer M, Wiegand RC, Wirth D, Xia M, Yuan J, Zhao J, Palmer M, Munoz B, Schreiber S.

ACS Med Chem Lett. 2012 Feb 9;3(2):112-117. Epub 2011 Dec 22.

4.

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH Jr, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R.

Chem Biol. 2011 Dec 23;18(12):1602-10. doi: 10.1016/j.chembiol.2011.09.016.

5.

Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.

Skerlj RT, Bastos CM, Booker ML, Kramer ML, Barker RH Jr, Celatka CA, O'Shea TJ, Munoz B, Sidhu AB, Cortese JF, Wittlin S, Papastogiannidis P, Angulo-Barturen I, Jimenez-Diaz MB, Sybertz E.

ACS Med Chem Lett. 2011 Jul 11;2(9):708-13. doi: 10.1021/ml200143c. eCollection 2011 Sep 8.

6.

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.

Barker RH Jr, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E.

Antimicrob Agents Chemother. 2011 Jun;55(6):2612-22. doi: 10.1128/AAC.01714-10. Epub 2011 Mar 21.

7.

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity.

Urgaonkar S, Cortese JF, Barker RH, Cromwell M, Serrano AE, Wirth DF, Clardy J, Mazitschek R.

Org Lett. 2010 Sep 17;12(18):3998-4001. doi: 10.1021/ol101566h.

PMID:
20718474
8.

Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.

Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E.

J Biol Chem. 2010 Oct 22;285(43):33054-64. doi: 10.1074/jbc.M110.162081. Epub 2010 Aug 11.

9.

Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor.

Bacchi CJ, Barker RH Jr, Rodriguez A, Hirth B, Rattendi D, Yarlett N, Hendrick CL, Sybertz E.

Antimicrob Agents Chemother. 2009 Aug;53(8):3269-72. doi: 10.1128/AAC.00076-09. Epub 2009 May 18.

10.

Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT).

Hirth B, Barker RH Jr, Celatka CA, Klinger JD, Liu H, Nare B, Nijjar A, Phillips MA, Sybertz E, Willert EK, Xiang Y.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2916-9. doi: 10.1016/j.bmcl.2009.04.096. Epub 2009 Apr 24.

PMID:
19419862
11.

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.

Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J.

J Med Chem. 2009 Apr 23;52(8):2185-7. doi: 10.1021/jm801654y.

12.

Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.

Barker RH Jr, Liu H, Hirth B, Celatka CA, Fitzpatrick R, Xiang Y, Willert EK, Phillips MA, Kaiser M, Bacchi CJ, Rodriguez A, Yarlett N, Klinger JD, Sybertz E.

Antimicrob Agents Chemother. 2009 May;53(5):2052-8. doi: 10.1128/AAC.01674-08. Epub 2009 Mar 16.

13.

Tolevamer, an anionic polymer, neutralizes toxins produced by the BI/027 strains of Clostridium difficile.

Hinkson PL, Dinardo C, DeCiero D, Klinger JD, Barker RH Jr.

Antimicrob Agents Chemother. 2008 Jun;52(6):2190-5. doi: 10.1128/AAC.00041-08. Epub 2008 Apr 7.

14.

Review article: tolevamer, a novel toxin-binding polymer: overview of preclinical pharmacology and physicochemical properties.

Barker RH Jr, Dagher R, Davidson DM, Marquis JK.

Aliment Pharmacol Ther. 2006 Dec;24(11-12):1525-34. Review.

15.

GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis.

Kurtz CB, Cannon EP, Brezzani A, Pitruzzello M, Dinardo C, Rinard E, Acheson DW, Fitzpatrick R, Kelly P, Shackett K, Papoulis AT, Goddard PJ, Barker RH Jr, Palace GP, Klinger JD.

Antimicrob Agents Chemother. 2001 Aug;45(8):2340-7.

16.

Epidemiologic tools for malaria surveillance in an urban setting of low endemicity along the Colombian Pacific coast.

Carrasquilla G, Banguero M, Sanchez P, Carvajal F, Barker RH Jr, Gervais GW, Algarin E, Serrano AE.

Am J Trop Med Hyg. 2000 Jan;62(1):132-7.

PMID:
10761738
17.

Genetic characterization of an epidemic of Plasmodium falciparum malaria among Yanomami Amerindians.

Laserson KF, Petralanda I, Almera R, Barker RH Jr, Spielman A, Maguire JH, Wirth DF.

J Infect Dis. 1999 Dec;180(6):2081-5.

PMID:
10558976
18.
19.

Inhibition of Plasmodium falciparum malaria using antisense oligodeoxynucleotides.

Barker RH Jr, Metelev V, Rapaport E, Zamecnik P.

Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):514-8.

20.

Comparison of the polymerase chain reaction and serology for the detection of canine visceral leishmaniasis.

Ashford DA, Bozza M, Freire M, Miranda JC, Sherlock I, Eulalio C, Lopes U, Fernandes O, Degrave W, Barker RH Jr, et al.

Am J Trop Med Hyg. 1995 Sep;53(3):251-5.

PMID:
7573707
21.

Specificity of diagnostic PCR amplification for M. avium using the probe pMAV22.

Sritharan V, Iralu JV, Barker RH Jr.

Mol Cell Probes. 1995 Feb;9(1):71-4.

PMID:
7760864
22.

Comparison of genus- and species-specific probes for PCR detection of mycobacterial infections.

Sritharan V, Iralu JV, Barker RH Jr.

Mol Cell Probes. 1994 Oct;8(5):409-16.

PMID:
7877637
23.

Plasmodium falciparum and P. vivax: factors affecting sensitivity and specificity of PCR-based diagnosis of malaria.

Barker RH Jr, Banchongaksorn T, Courval JM, Suwonkerd W, Rimwungtragoon K, Wirth DF.

Exp Parasitol. 1994 Aug;79(1):41-9.

PMID:
8050524
24.

Atypical Plasmodium vivax infection in Peru.

Witzig RS, Barker RH Jr.

Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):198. No abstract available.

PMID:
8036671
25.

DNA probes as epidemiological tools for surveillance of Plasmodium falciparum malaria in Thailand.

Barker RH Jr, Banchongaksorn T, Courval JM, Suwonkerd W, Rimwungtragoon K, Srittong N, Wirth DF.

Int J Epidemiol. 1994 Feb;23(1):161-8.

PMID:
8194913
26.

Use of the polymerase chain reaction to directly detect malaria parasites in blood samples from the Venezuelan Amazon.

Laserson KF, Petralanda I, Hamlin DM, Almera R, Fuentes M, Carrasquel A, Barker RH Jr.

Am J Trop Med Hyg. 1994 Feb;50(2):169-80.

PMID:
8116809
27.

Use of PCR in the field.

Barker RH Jr.

Parasitol Today. 1994 Mar;10(3):117-9.

PMID:
15275495
28.

Diagnosis of Mycobacterium avium bacteremia by polymerase chain reaction.

Iralu JV, Sritharan VK, Pieciak WS, Wirth DF, Maguire JH, Barker RH Jr.

J Clin Microbiol. 1993 Jul;31(7):1811-4.

29.

A simple method to detect Plasmodium falciparum directly from blood samples using the polymerase chain reaction.

Barker RH Jr, Banchongaksorn T, Courval JM, Suwonkerd W, Rimwungtragoon K, Wirth DF.

Am J Trop Med Hyg. 1992 Apr;46(4):416-26.

PMID:
1575288
30.

A simple method for diagnosing M. tuberculosis infection in clinical samples using PCR.

Sritharan V, Barker RH Jr.

Mol Cell Probes. 1991 Oct;5(5):385-95.

PMID:
1791860
31.

DNA probe diagnosis of parasitic infections.

Barker RH Jr.

Exp Parasitol. 1990 May;70(4):494-9. Review. No abstract available.

PMID:
2108876
32.

Plasmodium falciparum: DNA probe diagnosis of malaria in Kenya.

Barker RH Jr, Brandling-Bennett AD, Koech DK, Mugambi M, Khan B, David R, David JR, Wirth DF.

Exp Parasitol. 1989 Oct;69(3):226-33.

PMID:
2676577
33.

Detection of Plasmodium falciparum infection in human patients: a comparison of the DNA probe method to microscopic diagnosis.

Barker RH Jr, Suebsaeng L, Rooney W, Wirth DF.

Am J Trop Med Hyg. 1989 Sep;41(3):266-72.

PMID:
2679157
34.

Response: malaria diagnosis.

Wirth DF, Barker RH Jr.

Science. 1987 Apr 3;236(4797):12. No abstract available.

PMID:
17759192
35.

Specific DNA probe for the diagnosis of Plasmodium falciparum malaria.

Barker RH Jr, Suebsaeng L, Rooney W, Alecrim GC, Dourado HV, Wirth DF.

Science. 1986 Mar 21;231(4744):1434-6.

PMID:
3513309
36.
37.

Application of cloning techniques to development of a synthetic vaccine against schistosomiasis.

Knopf PM, Srivastava BS, Barker RH Jr.

Vet Parasitol. 1982 Jun;10(2-3):255-9. No abstract available.

PMID:
6182680
38.

Adherence of murine T cells to solid substrata in the absence of serum.

Barker RH Jr, O'Shea PF, Strauss PR.

J Cell Physiol. 1981 Nov;109(2):243-51.

PMID:
6975279
39.

Additives in fibers and fabrics.

Barker RH.

Environ Health Perspect. 1975 Jun;11:41-5.

40.

Conformations of oilseed storage proteins (globulins) determined by circular dichroism.

Jacks TJ, Barker RH, Weigang OE Jr.

Int J Pept Protein Res. 1973;5(4):289-91. No abstract available.

PMID:
4796700
41.

Expulsion of methionine residue from peptide model on alkylation.

Jendrek JP, Barker RH, Altschul AM.

Biochim Biophys Acta. 1967 Mar 22;136(2):409-11. No abstract available.

PMID:
6049508
42.

NATURE OF THE COFACTOR FOR THE ACID LIPASE OF RICINUS COMMUNIS.

ORY RL, BARKER RH, BOUDREAUX GJ.

Biochemistry. 1964 Dec;3:2013-6. No abstract available.

PMID:
14269328
43.

Vaginal Absorption of Penicillin.

Rock J, Barker RH, Bacon WB.

Science. 1947 Jan 3;105(2714):13.

PMID:
17796160

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