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Developmental Axon Degeneration Requires TRPV1-Dependent Ca2+ Influx.

Johnstone AD, de Léon A, Unsain N, Gibon J, Barker PA.

eNeuro. 2019 Feb 27;6(1). pii: ENEURO.0019-19.2019. doi: 10.1523/ENEURO.0019-19.2019. eCollection 2019 Jan-Feb.


Strong and recurring seasonality revealed within stream diatom assemblages.

Snell MA, Barker PA, Surridge BWJ, Benskin CMH, Barber N, Reaney SM, Tych W, Mindham D, Large ARG, Burke S, Haygarth PM.

Sci Rep. 2019 Mar 1;9(1):3313. doi: 10.1038/s41598-018-37831-w.


The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic Activity in Hippocampal and Cortical Neurons.

Thomas RA, Gibon J, Chen CXQ, Chierzi S, Soubannier VG, Baulac S, Séguéla P, Murai K, Barker PA.

eNeuro. 2018 Sep 7;5(4). pii: ENEURO.0185-18.2018. doi: 10.1523/ENEURO.0185-18.2018. eCollection 2018 Jul-Aug.


A novel method for quantifying axon degeneration.

Johnstone AD, Hallett RM, de Léon A, Carturan B, Gibon J, Barker PA.

PLoS One. 2018 Jul 18;13(7):e0199570. doi: 10.1371/journal.pone.0199570. eCollection 2018.


Author Correction: Remodeling of the Actin/Spectrin Membrane-associated Periodic Skeleton, Growth Cone Collapse and F-Actin Decrease during Axonal Degeneration.

Unsain N, Bordenave MD, Martinez GF, Jalil S, von Bilderling C, Barabas FM, Masullo LA, Johnstone AD, Barker PA, Bisbal M, Stefani FD, Cáceres AO.

Sci Rep. 2018 Apr 12;8(1):6002. doi: 10.1038/s41598-018-23781-w.


Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat.

Décarie-Spain L, Sharma S, Hryhorczuk C, Issa-Garcia V, Barker PA, Arbour N, Alquier T, Fulton S.

Mol Metab. 2018 Apr;10:1-13. doi: 10.1016/j.molmet.2018.01.018. Epub 2018 Jan 31.


Remodeling of the Actin/Spectrin Membrane-associated Periodic Skeleton, Growth Cone Collapse and F-Actin Decrease during Axonal Degeneration.

Unsain N, Bordenave MD, Martinez GF, Jalil S, von Bilderling C, Barabas FM, Masullo LA, Johnstone AD, Barker PA, Bisbal M, Stefani FD, Cáceres AO.

Sci Rep. 2018 Feb 14;8(1):3007. doi: 10.1038/s41598-018-21232-0. Erratum in: Sci Rep. 2018 Apr 12;8(1):6002.


Major agricultural changes required to mitigate phosphorus losses under climate change.

Ockenden MC, Hollaway MJ, Beven KJ, Collins AL, Evans R, Falloon PD, Forber KJ, Hiscock KM, Kahana R, Macleod CJA, Tych W, Villamizar ML, Wearing C, Withers PJA, Zhou JG, Barker PA, Burke S, Freer JE, Johnes PJ, Snell MA, Surridge BWJ, Haygarth PM.

Nat Commun. 2017 Jul 31;8(1):161. doi: 10.1038/s41467-017-00232-0.


Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain.

Gibon J, Barker PA.

Neuroscientist. 2017 Dec;23(6):587-604. doi: 10.1177/1073858417697037. Epub 2017 Mar 17. Review.


Generation and characterization of mice bearing null alleles of nradd/Nrh2.

Unsain N, Dorval G, Sheen JH, Barker PA.

Genesis. 2016 Dec;54(12):605-612. doi: 10.1002/dvg.22989. Epub 2016 Nov 12.


Interpretation and application of carbon isotope ratios in freshwater diatom silica.

Webb M, Barker PA, Wynn PM, Heiri O, van Hardenbroek M, Pick F, Russell JM, Stott AW, Leng MJ.

J Quat Sci. 2016 May;31(4):300-309. Epub 2016 Jun 17.


Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile.

Gibon J, Kang MS, Aliaga A, Sharif B, Rosa-Neto P, Séguéla P, Barker PA, Kostikov A.

Bioorg Med Chem. 2016 Oct 1;24(19):4759-4765. doi: 10.1016/j.bmc.2016.08.020. Epub 2016 Aug 13.


Identification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1-LGI1 signaling.

Thomas RA, Ambalavanan A, Rouleau GA, Barker PA.

Mol Genet Genomic Med. 2016 Mar 11;4(4):447-56. doi: 10.1002/mgg3.215. eCollection 2016 Jul.


Calpain-dependent truncated form of TrkB-FL increases in neurodegenerative processes.

Danelon V, Montroull LE, Unsain N, Barker PA, Mascó DH.

Mol Cell Neurosci. 2016 Sep;75:81-92. doi: 10.1016/j.mcn.2016.07.002. Epub 2016 Jul 20.


The X-linked inhibitor of apoptosis regulates long-term depression and learning rate.

Gibon J, Unsain N, Gamache K, Thomas RA, De Leon A, Johnstone A, Nader K, Séguéla P, Barker PA.

FASEB J. 2016 Sep;30(9):3083-90. doi: 10.1096/fj.201600384R. Epub 2016 May 17.


North Atlantic forcing of moisture delivery to Europe throughout the Holocene.

Smith AC, Wynn PM, Barker PA, Leng MJ, Noble SR, Tych W.

Sci Rep. 2016 Apr 25;6:24745. doi: 10.1038/srep24745.


Eiger-induced cell death relies on Rac1-dependent endocytosis.

Ruan W, Srinivasan A, Lin S, Kara kI, Barker PA.

Cell Death Dis. 2016 Apr 7;7:e2181. doi: 10.1038/cddis.2016.80.


HBpF-proBDNF: A New Tool for the Analysis of Pro-Brain Derived Neurotrophic Factor Receptor Signaling and Cell Biology.

Gaub P, de Léon A, Gibon J, Soubannier V, Dorval G, Séguéla P, Barker PA.

PLoS One. 2016 Mar 7;11(3):e0150601. doi: 10.1371/journal.pone.0150601. eCollection 2016.


Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex.

Gibon J, Barker PA, Séguéla P.

Mol Brain. 2016 Mar 1;9:23. doi: 10.1186/s13041-016-0203-9.


An experiment to assess the effects of diatom dissolution on oxygen isotope ratios.

Smith AC, Leng MJ, Swann GE, Barker PA, Mackay AW, Ryves DB, Sloane HJ, Chenery SR, Hems M.

Rapid Commun Mass Spectrom. 2016 Jan 30;30(2):293-300. doi: 10.1002/rcm.7446.


New Views on the Misconstrued: Executioner Caspases and Their Diverse Non-apoptotic Roles.

Unsain N, Barker PA.

Neuron. 2015 Nov 4;88(3):461-74. doi: 10.1016/j.neuron.2015.08.029. Review.


cIAP2 supports viability of mice lacking cIAP1 and XIAP.

Heard KN, Bertrand MJ, Barker PA.

EMBO J. 2015 Oct 1;34(19):2393-5. doi: 10.15252/embj.201592060. No abstract available.


Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation.

Cueva Vargas JL, Osswald IK, Unsain N, Aurousseau MR, Barker PA, Bowie D, Di Polo A.

J Neurosci. 2015 Sep 2;35(35):12088-102. doi: 10.1523/JNEUROSCI.1273-15.2015.


Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation.

Anastasia A, Barker PA, Chao MV, Hempstead BL.

J Neurosci. 2015 Aug 26;35(34):11911-20. doi: 10.1523/JNEUROSCI.0591-15.2015.


proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons.

Gibon J, Buckley SM, Unsain N, Kaartinen V, Séguéla P, Barker PA.

J Neurosci. 2015 Jul 1;35(26):9741-53. doi: 10.1523/JNEUROSCI.4655-14.2015.


Drip water electrical conductivity as an indicator of cave ventilation at the event scale.

Smith AC, Wynn PM, Barker PA, Leng MJ.

Sci Total Environ. 2015 Nov 1;532:517-27. doi: 10.1016/j.scitotenv.2015.06.037. Epub 2015 Jun 19.


High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.

Choe KY, Han SY, Gaub P, Shell B, Voisin DL, Knapp BA, Barker PA, Brown CH, Cunningham JT, Bourque CW.

Neuron. 2015 Feb 4;85(3):549-60. doi: 10.1016/j.neuron.2014.12.048. Epub 2015 Jan 22.


p75NTR-dependent Rac1 activation requires receptor cleavage and activation of an NRAGE and NEDD9 signaling cascade.

Zeinieh M, Salehi A, Rajkumar V, Barker PA.

J Cell Sci. 2015 Feb 1;128(3):447-59.


LRRK2 localizes to endosomes and interacts with clathrin-light chains to limit Rac1 activation.

Schreij AM, Chaineau M, Ruan W, Lin S, Barker PA, Fon EA, McPherson PS.

EMBO Rep. 2015 Jan;16(1):79-86. doi: 10.15252/embr.201438714. Epub 2014 Nov 26.


Production and isolation of axons from sensory neurons for biochemical analysis using porous filters.

Unsain N, Heard KN, Higgins JM, Barker PA.

J Vis Exp. 2014 Jul 8;(89). doi: 10.3791/51795.


S100B protein activates a RAGE-dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis.

Villarreal A, Seoane R, González Torres A, Rosciszewski G, Angelo MF, Rossi A, Barker PA, Ramos AJ.

J Neurochem. 2014 Oct;131(2):190-205. doi: 10.1111/jnc.12790. Epub 2014 Jul 5.


Neurotrophins in the regulation of cellular survival and death.

Ceni C, Unsain N, Zeinieh MP, Barker PA.

Handb Exp Pharmacol. 2014;220:193-221. doi: 10.1007/978-3-642-45106-5_8. Review.


High frequency variability of environmental drivers determining benthic community dynamics in headwater streams.

Snell MA, Barker PA, Surridge BW, Large AR, Jonczyk J, Benskin CM, Reaney S, Perks MT, Owen GJ, Cleasby W, Deasy C, Burke S, Haygarth PM.

Environ Sci Process Impacts. 2014 Jul;16(7):1629-36. doi: 10.1039/c3em00680h.


p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.

Forsyth PA, Krishna N, Lawn S, Valadez JG, Qu X, Fenstermacher DA, Fournier M, Potthast L, Chinnaiyan P, Gibney GT, Zeinieh M, Barker PA, Carter BD, Cooper MK, Kenchappa RS.

J Biol Chem. 2014 Mar 21;289(12):8067-85. doi: 10.1074/jbc.M113.513762. Epub 2014 Feb 11.


XIAP regulates caspase activity in degenerating axons.

Unsain N, Higgins JM, Parker KN, Johnstone AD, Barker PA.

Cell Rep. 2013 Aug 29;4(4):751-63. doi: 10.1016/j.celrep.2013.07.015. Epub 2013 Aug 15.


Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.

Methot L, Hermann R, Tang Y, Lo R, Al-Jehani H, Jhas S, Svoboda D, Slack RS, Barker PA, Stifani S.

Mol Cell Biol. 2013 Jul;33(14):2797-808. doi: 10.1128/MCB.01610-12. Epub 2013 May 20.


Wengen, the sole tumour necrosis factor receptor in Drosophila, collaborates with moesin to control photoreceptor axon targeting during development.

Ruan W, Unsain N, Desbarats J, Fon EA, Barker PA.

PLoS One. 2013;8(3):e60091. doi: 10.1371/journal.pone.0060091. Epub 2013 Mar 27.


ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo.

Wilson AM, Morquette B, Abdouh M, Unsain N, Barker PA, Feinstein E, Bernier G, Di Polo A.

J Neurosci. 2013 Jan 30;33(5):2205-16. doi: 10.1523/JNEUROSCI.2635-12.2013.


An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.

Kenneth NS, Younger JM, Hughes ED, Marcotte D, Barker PA, Saunders TL, Duckett CS.

Biochem J. 2012 Apr 15;443(2):355-9. doi: 10.1042/BJ20120249.


Developing a methodology for carbon isotope analysis of lacustrine diatoms.

Hurrell ER, Barker PA, Leng MJ, Vane CH, Wynn P, Kendrick CP, Verschuren D, Street-Perrott FA.

Rapid Commun Mass Spectrom. 2011 Jun 15;25(11):1567-74. doi: 10.1002/rcm.5020.


Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling.

Kommaddi RP, Thomas R, Ceni C, Daigneault K, Barker PA.

FASEB J. 2011 Jun;25(6):2061-70. doi: 10.1096/fj.10-173740. Epub 2011 Mar 16.


Stress-induced expression of the p75 neurotrophin receptor is regulated by O-GlcNAcylation of the Sp1 transcription factor.

Kommaddi RP, Dickson KM, Barker PA.

J Neurochem. 2011 Feb;116(3):396-405. doi: 10.1111/j.1471-4159.2010.07120.x. Epub 2010 Dec 13.


The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling.

Ceni C, Kommaddi RP, Thomas R, Vereker E, Liu X, McPherson PS, Ritter B, Barker PA.

J Cell Sci. 2010 Jul 1;123(Pt 13):2299-307. doi: 10.1242/jcs.062612. Epub 2010 Jun 8.


Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborization.

Xu B, Goldman JS, Rymar VV, Forget C, Lo PS, Bull SJ, Vereker E, Barker PA, Trudeau LE, Sadikot AF, Kennedy TE.

Neuroscience. 2010 Aug 25;169(2):932-49. doi: 10.1016/j.neuroscience.2010.05.025. Epub 2010 May 21.


LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition.

Thomas R, Favell K, Morante-Redolat J, Pool M, Kent C, Wright M, Daignault K, Ferraro GB, Montcalm S, Durocher Y, Fournier A, Perez-Tur J, Barker PA.

J Neurosci. 2010 May 12;30(19):6607-12. doi: 10.1523/JNEUROSCI.5147-09.2010.


De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia.

Gauthier J, Champagne N, Lafrenière RG, Xiong L, Spiegelman D, Brustein E, Lapointe M, Peng H, Côté M, Noreau A, Hamdan FF, Addington AM, Rapoport JL, Delisi LE, Krebs MO, Joober R, Fathalli F, Mouaffak F, Haghighi AP, Néri C, Dubé MP, Samuels ME, Marineau C, Stone EA, Awadalla P, Barker PA, Carbonetto S, Drapeau P, Rouleau GA; S2D Team.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7863-8. doi: 10.1073/pnas.0906232107. Epub 2010 Apr 12.


ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway.

Lebrun-Julien F, Bertrand MJ, De Backer O, Stellwagen D, Morales CR, Di Polo A, Barker PA.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3817-22. doi: 10.1073/pnas.0909276107. Epub 2010 Feb 3.


TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex.

Zhang Z, Reboreda A, Alonso A, Barker PA, Séguéla P.

Hippocampus. 2011 Apr;21(4):386-97. doi: 10.1002/hipo.20755.


Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

Bertrand MJ, Doiron K, Labbé K, Korneluk RG, Barker PA, Saleh M.

Immunity. 2009 Jun 19;30(6):789-801. doi: 10.1016/j.immuni.2009.04.011. Epub 2009 May 21.


Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism.

Lebrun-Julien F, Duplan L, Pernet V, Osswald I, Sapieha P, Bourgeois P, Dickson K, Bowie D, Barker PA, Di Polo A.

J Neurosci. 2009 Apr 29;29(17):5536-45. doi: 10.1523/JNEUROSCI.0831-09.2009.

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