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Items: 1 to 50 of 430

1.

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series.

Aspatwar A, Parvathaneni NK, Barker H, Anduran E, Supuran CT, Dubois L, Lambin P, Parkkila S, Winum JY.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):109-117. doi: 10.1080/14756366.2019.1685510.

2.

Genotyping determination of Acanthamoeba strains: an original study and a systematic review in Iran.

Mirahmadi H, Nia MM, Ebrahimzadeh A, Mehravaran A, Shafiei R, Rahimi MT, Emameh RZ, Barker HR.

J Water Health. 2019 Oct;17(5):717-727. doi: 10.2166/wh.2019.048.

PMID:
31638023
3.

Genomics of gynaecological carcinosarcomas and future treatment options.

Barker HE, Scott CL.

Semin Cancer Biol. 2019 Oct 14. pii: S1044-579X(19)30295-0. doi: 10.1016/j.semcancer.2019.10.006. [Epub ahead of print] Review.

PMID:
31622660
4.

Editor's Note: LOX-Mediated Collagen Cross-linking Is Responsible for Fibrosis-Enhanced Metastasis.

Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G, Erler JT.

Cancer Res. 2019 Oct 1;79(19):5124. doi: 10.1158/0008-5472.CAN-19-2419. No abstract available.

PMID:
31575632
5.

Correction: LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution.

Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A, Erler JT.

Cancer Res. 2019 Oct 1;79(19):5123. doi: 10.1158/0008-5472.CAN-19-2420. No abstract available.

PMID:
31575631
6.

Molecular Mechanisms Associated with ROR1-Mediated Drug Resistance: Crosstalk with Hippo-YAP/TAZ and BMI-1 Pathways.

Karvonen H, Barker H, Kaleva L, Niininen W, Ungureanu D.

Cells. 2019 Aug 2;8(8). pii: E812. doi: 10.3390/cells8080812. Review.

7.

Preclinical rare cancer research to inform clinical trial design.

Barker HE, Scott CL.

Nat Rev Cancer. 2019 Sep;19(9):481-482. doi: 10.1038/s41568-019-0172-2. No abstract available.

PMID:
31263218
8.

Linking plant genes to insect communities: Identifying the genetic bases of plant traits and community composition.

Barker HL, Riehl JF, Bernhardsson C, Rubert-Nason KF, Holeski LM, Ingvarsson PK, Lindroth RL.

Mol Ecol. 2019 Oct;28(19):4404-4421. doi: 10.1111/mec.15158. Epub 2019 Jul 15.

PMID:
31233634
9.

Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer.

Krook MA, Barker H, Chen HZ, Reeser JW, Wing MR, Martin D, Smith AM, Dao T, Bonneville R, Samorodnitsky E, Miya J, Freud AG, Monk JP, Clinton SK, Roychowdhury S.

Prostate Cancer Prostatic Dis. 2019 Dec;22(4):624-632. doi: 10.1038/s41391-019-0145-2. Epub 2019 May 1.

10.

Altered relationship between prefrontal glutamate and activation during cognitive control in people with high trait anxiety.

Morgenroth E, Orlov N, Lythgoe DJ, Stone JM, Barker H, Munro J, Eysenck M, Allen P.

Cortex. 2019 Aug;117:53-63. doi: 10.1016/j.cortex.2019.02.021. Epub 2019 Mar 7.

PMID:
30928721
11.

Primary cutaneous Hodgkin-like polymorphic post-transplant lymphoproliferative disorder.

Dunn C, Nguyen HP, Patel V, Barker HS, Diwan AH, Yared M, Elghetany T, Restrepo A, Dao H.

J Cutan Pathol. 2019 May;46(5):358-362. doi: 10.1111/cup.13427. Epub 2019 Feb 27.

PMID:
30672006
12.

Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting.

Karvonen H, Perttilä R, Niininen W, Hautanen V, Barker H, Murumägi A, Heckman CA, Ungureanu D.

Oncogene. 2019 Apr;38(17):3288-3300. doi: 10.1038/s41388-018-0670-9. Epub 2019 Jan 10.

PMID:
30631148
13.

R-Ras regulates vascular permeability, but not overall healing in skin wounds.

Ketomäki T, Vähätupa M, May U, Pemmari T, Ruikka E, Hietamo J, Kaipiainen P, Barker H, Parkkila S, Uusitalo-Järvinen H, Järvinen TAH.

Exp Dermatol. 2019 Feb;28(2):202-206. doi: 10.1111/exd.13851. Epub 2018 Dec 21.

PMID:
30489650
14.

Worry is associated with inefficient functional activity and connectivity in prefrontal and cingulate cortices during emotional interference.

Barker H, Munro J, Orlov N, Morgenroth E, Moser J, Eysenck MW, Allen P.

Brain Behav. 2018 Dec;8(12):e01137. doi: 10.1002/brb3.1137. Epub 2018 Oct 30.

15.

Implementing the Creating Learning Environments for Compassionate Care (CLECC) programme in acute hospital settings: a pilot RCT and feasibility study.

Bridges J, Pickering RM, Barker H, Chable R, Fuller A, Gould L, Libberton P, Mesa-Eguiagaray I, Raftery J, Sayer AA, Westwood G, Wigley W, Yao G, Zhu S, Griffiths P.

Southampton (UK): NIHR Journals Library; 2018 Sep.

16.

Genotypic variation in plant traits shapes herbivorous insect and ant communities on a foundation tree species.

Barker HL, Holeski LM, Lindroth RL.

PLoS One. 2018 Jul 31;13(7):e0200954. doi: 10.1371/journal.pone.0200954. eCollection 2018.

17.

Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status.

Hafsi H, Dillon MT, Barker HE, Kyula JN, Schick U, Paget JT, Smith HG, Pedersen M, McLaughlin M, Harrington KJ.

Front Oncol. 2018 Jul 13;8:245. doi: 10.3389/fonc.2018.00245. eCollection 2018.

18.

Targeting Wnt signaling pseudokinases in hematological cancers.

Karvonen H, Perttilä R, Niininen W, Barker H, Ungureanu D.

Eur J Haematol. 2018 Oct;101(4):457-465. doi: 10.1111/ejh.13137. Epub 2018 Sep 5. Review.

PMID:
29989208
19.

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes.

Aspatwar A, Becker HM, Parvathaneni NK, Hammaren M, Svorjova A, Barker H, Supuran CT, Dubois L, Lambin P, Parikka M, Parkkila S, Winum JY.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1064-1073. doi: 10.1080/14756366.2018.1482285.

20.

Involvement of β-Carbonic Anhydrase Genes in Bacterial Genomic Islands and Their Horizontal Transfer to Protists.

Zolfaghari Emameh R, Barker HR, Hytönen VP, Parkkila S.

Appl Environ Microbiol. 2018 Jul 17;84(15). pii: e00771-18. doi: 10.1128/AEM.00771-18. Print 2018 Aug 1.

21.

Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors.

Karjalainen SL, Haapasalo HK, Aspatwar A, Barker H, Parkkila S, Haapasalo JA.

BMC Cancer. 2018 May 23;18(1):584. doi: 10.1186/s12885-018-4493-4.

22.

Chromatin accessibility is associated with CRISPR-Cas9 efficiency in the zebrafish (Danio rerio).

Uusi-Mäkelä MIE, Barker HR, Bäuerlein CA, Häkkinen T, Nykter M, Rämet M.

PLoS One. 2018 Apr 23;13(4):e0196238. doi: 10.1371/journal.pone.0196238. eCollection 2018.

23.

Compassionate care intervention for hospital nursing teams caring for older people: a pilot cluster randomised controlled trial.

Gould LJ, Griffiths P, Barker HR, Libberton P, Mesa-Eguiagaray I, Pickering RM, Shipway LJ, Bridges J.

BMJ Open. 2018 Feb 22;8(2):e018563. doi: 10.1136/bmjopen-2017-018563.

24.

Interaction between ROR1 and MuSK activation complex in myogenic cells.

Karvonen H, Summala K, Niininen W, Barker HR, Ungureanu D.

FEBS Lett. 2018 Feb;592(3):434-445. doi: 10.1002/1873-3468.12966. Epub 2018 Jan 14.

25.

Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase.

Patrikainen MS, Tolvanen MEE, Aspatwar A, Barker HR, Ortutay C, Jänis J, Laitaoja M, Hytönen VP, Azizi L, Manandhar P, Jáger E, Vullo D, Kukkurainen S, Hilvo M, Supuran CT, Parkkila S.

PeerJ. 2017 Dec 7;5:e4128. doi: 10.7717/peerj.4128. eCollection 2017.

26.

Enablers and barriers to secondary prophylaxis for rheumatic fever among Māori aged 14-21 in New Zealand: a framework method study.

Barker H, Oetzel JG, Scott N, Morley M, Carr PEA, Oetzel KB.

Int J Equity Health. 2017 Nov 17;16(1):201. doi: 10.1186/s12939-017-0700-1.

27.

Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy.

Vähätupa M, Cordova ZM, Barker H, Aittomäki S, Uusitalo H, Järvinen TAH, Pesu M, Uusitalo-Järvinen H.

Exp Eye Res. 2018 Jan;166:160-167. doi: 10.1016/j.exer.2017.10.013. Epub 2017 Oct 13.

28.

Optimising impact and sustainability: a qualitative process evaluation of a complex intervention targeted at compassionate care.

Bridges J, May C, Fuller A, Griffiths P, Wigley W, Gould L, Barker H, Libberton P.

BMJ Qual Saf. 2017 Dec;26(12):970-977. doi: 10.1136/bmjqs-2017-006702. Epub 2017 Sep 15.

29.

RNA Misprocessing in C9orf72-Linked Neurodegeneration.

Barker HV, Niblock M, Lee YB, Shaw CE, Gallo JM.

Front Cell Neurosci. 2017 Jul 11;11:195. doi: 10.3389/fncel.2017.00195. eCollection 2017. Review.

30.

Zebrafish as a Model Organism for the Development of Drugs for Skin Cancer.

Bootorabi F, Manouchehri H, Changizi R, Barker H, Palazzo E, Saltari A, Parikka M, Pincelli C, Aspatwar A.

Int J Mol Sci. 2017 Jul 18;18(7). pii: E1550. doi: 10.3390/ijms18071550. Review.

31.

β-CA-specific inhibitor dithiocarbamate Fc14-584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis.

Aspatwar A, Hammarén M, Koskinen S, Luukinen B, Barker H, Carta F, Supuran CT, Parikka M, Parkkila S.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):832-840. doi: 10.1080/14756366.2017.1332056.

32.

Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.

Kondrashova O, Nguyen M, Shield-Artin K, Tinker AV, Teng NNH, Harrell MI, Kuiper MJ, Ho GY, Barker H, Jasin M, Prakash R, Kass EM, Sullivan MR, Brunette GJ, Bernstein KA, Coleman RL, Floquet A, Friedlander M, Kichenadasse G, O'Malley DM, Oza A, Sun J, Robillard L, Maloney L, Bowtell D, Giordano H, Wakefield MJ, Kaufmann SH, Simmons AD, Harding TC, Raponi M, McNeish IA, Swisher EM, Lin KK, Scott CL; AOCS Study Group.

Cancer Discov. 2017 Sep;7(9):984-998. doi: 10.1158/2159-8290.CD-17-0419. Epub 2017 Jun 6.

33.

Role of carbonic anhydrases in skin wound healing.

Barker H, Aaltonen M, Pan P, Vähätupa M, Kaipiainen P, May U, Prince S, Uusitalo-Järvinen H, Waheed A, Pastoreková S, Sly WS, Parkkila S, Järvinen TA.

Exp Mol Med. 2017 May 19;49(5):e334. doi: 10.1038/emm.2017.60.

34.

Global-Service Learning and Student-Athletes: A Model for Enhanced Academic Inclusion at the University of Washington.

Barker HM.

Ann Glob Health. 2016 Nov - Dec;82(6):1070-1077. doi: 10.1016/j.aogh.2016.11.001.

35.

HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation.

McLaughlin M, Barker HE, Khan AA, Pedersen M, Dillon M, Mansfield DC, Patel R, Kyula JN, Bhide SA, Newbold KL, Nutting CM, Harrington KJ.

BMC Cancer. 2017 Jan 31;17(1):86. doi: 10.1186/s12885-017-3084-0.

36.

An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation.

Patel R, Barker HE, Kyula J, McLaughlin M, Dillon MT, Schick U, Hafsi H, Thompson A, Khoo V, Harrington K, Zaidi S.

Radiother Oncol. 2017 Mar;122(3):470-475. doi: 10.1016/j.radonc.2016.12.026. Epub 2017 Jan 25.

37.

Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei.

Dillon MT, Barker HE, Pedersen M, Hafsi H, Bhide SA, Newbold KL, Nutting CM, McLaughlin M, Harrington KJ.

Mol Cancer Ther. 2017 Jan;16(1):25-34. doi: 10.1158/1535-7163.MCT-16-0239. Epub 2016 Nov 9.

38.

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).

Dong Y, Wang X, Kamaraj S, Bulbule VJ, Chiu FC, Chollet J, Dhanasekaran M, Hein CD, Papastogiannidis P, Morizzi J, Shackleford DM, Barker H, Ryan E, Scheurer C, Tang Y, Zhao Q, Zhou L, White KL, Urwyler H, Charman WN, Matile H, Wittlin S, Charman SA, Vennerstrom JL.

J Med Chem. 2017 Apr 13;60(7):2654-2668. doi: 10.1021/acs.jmedchem.6b01586. Epub 2017 Jan 18.

PMID:
28052200
39.

Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model.

Maguire SL, Peck B, Wai PT, Campbell J, Barker H, Gulati A, Daley F, Vyse S, Huang P, Lord CJ, Farnie G, Brennan K, Natrajan R.

J Pathol. 2016 Nov;240(3):315-328. doi: 10.1002/path.4778.

40.

'I've got to prioritise': being a parent with cystic fibrosis.

Barker H, Moses J, O'Leary C.

Psychol Health Med. 2017 Jul;22(6):744-752. doi: 10.1080/13548506.2016.1233345. Epub 2016 Sep 21.

PMID:
27654805
41.

Identification and inhibition of carbonic anhydrases from nematodes.

Zolfaghari Emameh R, Barker HR, Syrjänen L, Urbański L, Supuran CT, Parkkila S.

J Enzyme Inhib Med Chem. 2016;31(sup4):176-184. Epub 2016 Aug 25. Review.

PMID:
27557594
42.

Maternal Therapy with Ad.VEGF-A165 Increases Fetal Weight at Term in a Guinea-Pig Model of Fetal Growth Restriction.

Swanson AM, Rossi CA, Ofir K, Mehta V, Boyd M, Barker H, Ledwozyw A, Vaughan O, Martin J, Zachary I, Sebire N, Peebles DM, David AL.

Hum Gene Ther. 2016 Dec;27(12):997-1007. doi: 10.1089/hum.2016.046. Epub 2016 Aug 16.

PMID:
27530140
43.

Quantity and quality of interaction between staff and older patients in UK hospital wards: A descriptive study.

Barker HR, Griffiths P, Mesa-Eguiagaray I, Pickering R, Gould L, Bridges J.

Int J Nurs Stud. 2016 Oct;62:100-7. doi: 10.1016/j.ijnurstu.2016.07.018. Epub 2016 Jul 19.

44.

CHK1 Inhibition Radiosensitizes Head and Neck Cancers to Paclitaxel-Based Chemoradiotherapy.

Barker HE, Patel R, McLaughlin M, Schick U, Zaidi S, Nutting CM, Newbold KL, Bhide S, Harrington KJ.

Mol Cancer Ther. 2016 Sep;15(9):2042-54. doi: 10.1158/1535-7163.MCT-15-0998. Epub 2016 Jul 15.

45.

Altered gene expression in the lower respiratory tract of Car6 (-/-) mice.

Patrikainen MS, Pan P, Barker HR, Parkkila S.

Transgenic Res. 2016 Oct;25(5):649-64. doi: 10.1007/s11248-016-9961-5. Epub 2016 May 21.

PMID:
27209317
46.

The use of ultrasound to assess fetal growth in a guinea pig model of fetal growth restriction.

Swanson AM, Mehta V, Ofir K, Rowe M, Rossi C, Ginsberg Y, Griffin H, Barker H, White T, Boyd M, David AL.

Lab Anim. 2017 Apr;51(2):181-190. doi: 10.1177/0023677216637506. Epub 2016 Jul 9.

PMID:
27118731
47.

Horizontal transfer of β-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes.

Zolfaghari Emameh R, Barker HR, Tolvanen ME, Parkkila S, Hytönen VP.

Parasit Vectors. 2016 Mar 16;9:152. doi: 10.1186/s13071-016-1415-7.

48.

Gene Targeting to the Uteroplacental Circulation of Pregnant Guinea Pigs.

Mehta V, Ofir K, Swanson A, Kloczko E, Boyd M, Barker H, Avdic-Belltheus A, Martin J, Zachary I, Peebles D, David AL.

Reprod Sci. 2016 Aug;23(8):1087-95. doi: 10.1177/1933719116630411. Epub 2016 Feb 10.

PMID:
26865541
49.

Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis.

Zolfaghari Emameh R, Kuuslahti M, Vullo D, Barker HR, Supuran CT, Parkkila S.

Parasit Vectors. 2015 Sep 18;8:479. doi: 10.1186/s13071-015-1098-5.

50.

Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish.

Aspatwar A, Tolvanen ME, Ojanen MJ, Barker HR, Saralahti AK, Bäuerlein CA, Ortutay C, Pan P, Kuuslahti M, Parikka M, Rämet M, Parkkila S.

PLoS One. 2015 Jul 28;10(7):e0134263. doi: 10.1371/journal.pone.0134263. eCollection 2015.

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