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Peptide Deformylase (def) is essential in Mycobacterium smegmatis, but the essentiality is compensated by inactivation of methionine formylation.

Naor N, Gadot O, Meir M, Barkan D.

BMC Microbiol. 2019 Oct 26;19(1):232. doi: 10.1186/s12866-019-1611-7.


Dormant disseminated tumor cells and cancer stem/progenitor-like cells: Similarities and opportunities.

Hen O, Barkan D.

Semin Cancer Biol. 2019 Sep 3. pii: S1044-579X(19)30185-3. doi: 10.1016/j.semcancer.2019.09.002. [Epub ahead of print] Review.


IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation.

Kumaran Satyanarayanan S, El Kebir D, Soboh S, Butenko S, Sekheri M, Saadi J, Peled N, Assi S, Othman A, Schif-Zuck S, Feuermann Y, Barkan D, Sher N, Filep JG, Ariel A.

Nat Commun. 2019 Aug 2;10(1):3471. doi: 10.1038/s41467-019-10903-9.


MapB Protein is the Essential Methionine Aminopeptidase in Mycobacterium tuberculosis.

Vanunu M, Schall P, Reingewertz TH, Chakraborti PK, Grimm B, Barkan D.

Cells. 2019 Apr 28;8(5). pii: E393. doi: 10.3390/cells8050393.


Mapping the Heterogeneity of Histone Modifications on Hepatitis B Virus DNA Using Liver Needle Biopsies Obtained from Chronically Infected Patients.

Flecken T, Meier MA, Skewes-Cox P, Barkan DT, Heim MH, Wieland SF, Holdorf MM.

J Virol. 2019 Apr 17;93(9). pii: e02036-18. doi: 10.1128/JVI.02036-18. Print 2019 May 1.


The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model.

Meir M, Bifani P, Barkan D.

Antimicrob Resist Infect Control. 2018 Dec 13;7:151. doi: 10.1186/s13756-018-0448-4. eCollection 2018.


The Unexpected Essentiality of glnA2 in Mycobacterium smegmatis Is Salvaged by Overexpression of the Global Nitrogen Regulator glnR, but Not by L-, D- or Iso-Glutamine.

Rakovitsky N, Bar Oz M, Goldberg K, Gibbons S, Zimhony O, Barkan D.

Front Microbiol. 2018 Sep 11;9:2143. doi: 10.3389/fmicb.2018.02143. eCollection 2018.


EMT and Stemness in Tumor Dormancy and Outgrowth: Are They Intertwined Processes?

Weidenfeld K, Barkan D.

Front Oncol. 2018 Sep 12;8:381. doi: 10.3389/fonc.2018.00381. eCollection 2018. Review.


The Safety and Antiviral Activity of BZF961 with or without Ritonavir in Patients Infected with Hepatitis C Virus: A Randomized, Multicenter Trial.

Lawitz E, Bidair M, Marbury T, Jones CT, Barve A, Magnusson B, Barkan DT, Bodendorf U, Bracken K, Canino E, Chen D, Dabovic K, Heimbach T, Ison M, Jones CL, Kovacs SJ, Lakshman JP, Li B, Raman P, Steiner-Swiat R, Thohan S, Wong KA, Zhong W, Colvin RA.

Clin Ther. 2018 Sep;40(9):1567-1581.e4. doi: 10.1016/j.clinthera.2018.07.019. Epub 2018 Sep 2.


Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae.

Dean CR, Barkan DT, Bermingham A, Blais J, Casey F, Casarez A, Colvin R, Fuller J, Jones AK, Li C, Lopez S, Metzger LE 4th, Mostafavi M, Prathapam R, Rasper D, Reck F, Ruzin A, Shaul J, Shen X, Simmons RL, Skewes-Cox P, Takeoka KT, Tamrakar P, Uehara T, Wei JR.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01200-18. doi: 10.1128/AAC.01200-18. Print 2018 Oct.


Soluble Mediators Produced by Pro-Resolving Macrophages Inhibit Angiogenesis.

Michaeli S, Dakwar V, Weidenfeld K, Granski O, Gilon O, Schif-Zuck S, Mamchur A, Shams I, Barkan D.

Front Immunol. 2018 Apr 25;9:768. doi: 10.3389/fimmu.2018.00768. eCollection 2018.


Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses.

Velasquez LN, Stüve P, Gentilini MV, Swallow M, Bartel J, Lycke NY, Barkan D, Martina M, Lujan HD, Kalay H, van Kooyk Y, Sparwasser TD, Berod L.

Front Immunol. 2018 Mar 9;9:471. doi: 10.3389/fimmu.2018.00471. eCollection 2018.


Establishment and Validation of Galleria mellonella as a Novel Model Organism To Study Mycobacterium abscessus Infection, Pathogenesis, and Treatment.

Meir M, Grosfeld T, Barkan D.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02539-17. doi: 10.1128/AAC.02539-17. Print 2018 Apr.


The Role of KLRG1 in Human CD4+ T-Cell Immunity Against Tuberculosis.

Hu Z, Zhao HM, Li CL, Liu XH, Barkan D, Lowrie DB, Lu SH, Fan XY.

J Infect Dis. 2018 Apr 11;217(9):1491-1503. doi: 10.1093/infdis/jiy046.


The gene fmt, encoding tRNAfMet-formyl transferase, is essential for normal growth of M. bovis, but not for viability.

Vanunu M, Lang Z, Barkan D.

Sci Rep. 2017 Nov 9;7(1):15161. doi: 10.1038/s41598-017-15618-9.


'Normalizing' the malignant phenotype of luminal breast cancer cells via alpha(v)beta(3)-integrin.

Abu-Tayeh H, Weidenfeld K, Zhilin-Roth A, Schif-Zuck S, Thaler S, Cotarelo C, Tan TZ, Thiery JP, Green JE, Klorin G, Sabo E, Sleeman JP, Tzukerman M, Barkan D.

Cell Death Dis. 2016 Dec 1;7(12):e2491. doi: 10.1038/cddis.2016.387.


Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23.

Barkan DT, Cheng XL, Celino H, Tran TT, Bhandari A, Craik CS, Sali A, Smythe ML.

BMC Bioinformatics. 2016 Nov 23;17(1):481.


Dormant tumor cells expressing LOXL2 acquire a stem-like phenotype mediating their transition to proliferative growth.

Weidenfeld K, Schif-Zuck S, Abu-Tayeh H, Kang K, Kessler O, Weissmann M, Neufeld G, Barkan D.

Oncotarget. 2016 Nov 1;7(44):71362-71377. doi: 10.18632/oncotarget.12109.


In Vitro Characterization of Human Cytomegalovirus-Targeting Therapeutic Monoclonal Antibodies LJP538 and LJP539.

Patel HD, Nikitin P, Gesner T, Lin JJ, Barkan DT, Ciferri C, Carfi A, Akbarnejad Yazdi T, Skewes-Cox P, Wiedmann B, Jarousse N, Zhong W, Feire A, Hebner CM.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4961-71. doi: 10.1128/AAC.00382-16. Print 2016 Aug.


Real-time PCR for Strongyloides stercoralis-associated meningitis.

Nadir E, Grossman T, Ciobotaro P, Attali M, Barkan D, Bardenstein R, Zimhony O.

Diagn Microbiol Infect Dis. 2016 Mar;84(3):197-9. doi: 10.1016/j.diagmicrobio.2015.11.015. Epub 2015 Nov 17.


Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection.

Heaton BE, Barkan D, Bongiorno P, Karakousis PC, Glickman MS.

Infect Immun. 2014 Aug;82(8):3177-85. doi: 10.1128/IAI.01540-14. Epub 2014 May 19.


M.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model.

Hedhli D, Denis O, Barkan D, Daffé M, Glickman MS, Huygen K.

PLoS One. 2013 Oct 17;8(10):e76442. doi: 10.1371/journal.pone.0076442. eCollection 2013.


Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.

Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL.

Mol Cell Proteomics. 2012 Aug;11(8):215-29. doi: 10.1074/mcp.O112.018366. Epub 2012 May 29.


Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice.

Barkan D, Hedhli D, Yan HG, Huygen K, Glickman MS.

Infect Immun. 2012 Jun;80(6):1958-68. doi: 10.1128/IAI.00021-12. Epub 2012 Mar 19.


Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland.

O'Brien J, Hansen K, Barkan D, Green J, Schedin P, O'Brien J, Hansen K, Barkan D, Green J, Schedin P.

Int J Dev Biol. 2011;55(7-9):745-55. doi: 10.1387/ijdb.113379jo.


β1-integrin: a potential therapeutic target in the battle against cancer recurrence.

Barkan D, Chambers AF.

Clin Cancer Res. 2011 Dec 1;17(23):7219-23. doi: 10.1158/1078-0432.CCR-11-0642. Epub 2011 Sep 7. Review.


An in vitro system to study tumor dormancy and the switch to metastatic growth.

Barkan D, Green JE.

J Vis Exp. 2011 Aug 11;(54). pii: 2914. doi: 10.3791/2914.


Mycobacteria exploit three genetically distinct DNA double-strand break repair pathways.

Gupta R, Barkan D, Redelman-Sidi G, Shuman S, Glickman MS.

Mol Microbiol. 2011 Jan;79(2):316-30. doi: 10.1111/j.1365-2958.2010.07463.x. Epub 2010 Nov 24.


ModBase, a database of annotated comparative protein structure models, and associated resources.

Pieper U, Webb BM, Barkan DT, Schneidman-Duhovny D, Schlessinger A, Braberg H, Yang Z, Meng EC, Pettersen EF, Huang CC, Datta RS, Sampathkumar P, Madhusudhan MS, Sjölander K, Ferrin TE, Burley SK, Sali A.

Nucleic Acids Res. 2011 Jan;39(Database issue):D465-74. doi: 10.1093/nar/gkq1091. Epub 2010 Nov 19.


An improved counterselectable marker system for mycobacterial recombination using galK and 2-deoxy-galactose.

Barkan D, Stallings CL, Glickman MS.

Gene. 2011 Jan 1;470(1-2):31-6. doi: 10.1016/j.gene.2010.09.005. Epub 2010 Sep 17.


Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment.

Barkan D, El Touny LH, Michalowski AM, Smith JA, Chu I, Davis AS, Webster JD, Hoover S, Simpson RM, Gauldie J, Green JE.

Cancer Res. 2010 Jul 15;70(14):5706-16. doi: 10.1158/0008-5472.CAN-09-2356. Epub 2010 Jun 22.


Prediction of protease substrates using sequence and structure features.

Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A.

Bioinformatics. 2010 Jul 15;26(14):1714-22. doi: 10.1093/bioinformatics/btq267. Epub 2010 May 26.


Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolates.

Barkan D, Rao V, Sukenick GD, Glickman MS.

J Bacteriol. 2010 Jul;192(14):3661-8. doi: 10.1128/JB.00312-10. Epub 2010 May 14.


Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth.

Barkan D, Green JE, Chambers AF.

Eur J Cancer. 2010 May;46(7):1181-8. doi: 10.1016/j.ejca.2010.02.027. Epub 2010 Mar 19. Review.


BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.

Hoenerhoff MJ, Chu I, Barkan D, Liu ZY, Datta S, Dimri GP, Green JE.

Oncogene. 2009 Aug 27;28(34):3022-32. doi: 10.1038/onc.2009.165. Epub 2009 Jun 22.


Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum.

Pandey KC, Barkan DT, Sali A, Rosenthal PJ.

PLoS One. 2009 May 27;4(5):e5694. doi: 10.1371/journal.pone.0005694.


Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.

Barkan D, Liu Z, Sacchettini JC, Glickman MS.

Chem Biol. 2009 May 29;16(5):499-509. doi: 10.1016/j.chembiol.2009.04.001.


MODBASE, a database of annotated comparative protein structure models and associated resources.

Pieper U, Eswar N, Webb BM, Eramian D, Kelly L, Barkan DT, Carter H, Mankoo P, Karchin R, Marti-Renom MA, Davis FP, Sali A.

Nucleic Acids Res. 2009 Jan;37(Database issue):D347-54. doi: 10.1093/nar/gkn791. Epub 2008 Oct 23.


Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini.

Mahrus S, Trinidad JC, Barkan DT, Sali A, Burlingame AL, Wells JA.

Cell. 2008 Sep 5;134(5):866-76. doi: 10.1016/j.cell.2008.08.012. Epub 2008 Aug 21.


Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.

Barkan D, Kleinman H, Simmons JL, Asmussen H, Kamaraju AK, Hoenorhoff MJ, Liu ZY, Costes SV, Cho EH, Lockett S, Khanna C, Chambers AF, Green JE.

Cancer Res. 2008 Aug 1;68(15):6241-50. doi: 10.1158/0008-5472.CAN-07-6849.


IL-6/IL-6R axis plays a critical role in acute kidney injury.

Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, Axelrod JH.

J Am Soc Nephrol. 2008 Jun;19(6):1106-15. doi: 10.1681/ASN.2007070744. Epub 2008 Mar 12.


Host pathogen protein interactions predicted by comparative modeling.

Davis FP, Barkan DT, Eswar N, McKerrow JH, Sali A.

Protein Sci. 2007 Dec;16(12):2585-96. Epub 2007 Oct 26.


Navel piercing as a cause for Streptococcus viridans endocarditis: case report, review of the literature and implications for antibiotic prophylaxis.

Barkan D, Abu Fanne R, Elazari-Scheiman A, Maayan S, Beeri R.

Cardiology. 2007;108(3):159-60. Epub 2006 Oct 30. Review.


Clozapine-induced systemic lupus erythematosus.

Rami AF, Barkan D, Mevorach D, Leitersdorf E, Caraco Y.

Ann Pharmacother. 2006 May;40(5):983-5. Epub 2006 May 2.


Leptin induces ovulation in GnRH-deficient mice.

Barkan D, Hurgin V, Dekel N, Amsterdam A, Rubinstein M.

FASEB J. 2005 Jan;19(1):133-5. Epub 2004 Oct 25.


[Splenic infarction as an unusual cause of left pleural effusion].

Mazal B, Amital H, Barkan D, Shaham D, Leitersdorf E.

Harefuah. 2004 Aug;143(8):563-5, 623. Hebrew.


Tube thoracostomy during allogeneic stem cell transplantation does not carry an increased risk for infections or bleeding.

Barkan D, Nusair S, Resnick IB, Bitan M, Segel MJ, Or R, Ackerstein A, Samuel S, Breuer R, Shapira MY.

Clin Transplant. 2004 Feb;18(1):85-8.


Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.

Deharo E, Barkan D, Krugliak M, Golenser J, Ginsburg H.

Biochem Pharmacol. 2003 Sep 1;66(5):809-17.


Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats.

Almog B, Gold R, Tajima K, Dantes A, Salim K, Rubinstein M, Barkan D, Homburg R, Lessing JB, Nevo N, Gertler A, Amsterdam A.

Mol Cell Endocrinol. 2001 Oct 25;183(1-2):179-91.


Leptin induces angiopoietin-2 expression in adipose tissues.

Cohen B, Barkan D, Levy Y, Goldberg I, Fridman E, Kopolovic J, Rubinstein M.

J Biol Chem. 2001 Mar 16;276(11):7697-700. Epub 2001 Jan 4.

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