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Items: 22

1.

Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.

Wagner T, André-Leroux G, Hindie V, Barilone N, Lisa MN, Hoos S, Raynal B, Vulliez-Le Normand B, O'Hare HM, Bellinzoni M, Alzari PM.

Sci Signal. 2019 May 7;12(580). pii: eaav9504. doi: 10.1126/scisignal.aav9504.

PMID:
31064884
2.

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.

Lisa MN, Wagner T, Alexandre M, Barilone N, Raynal B, Alzari PM, Bellinzoni M.

FEBS J. 2017 Feb;284(4):602-614. doi: 10.1111/febs.14003. Epub 2017 Jan 29.

3.

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.

Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR.

Chem Biol. 2015 Jul 23;22(7):917-27. doi: 10.1016/j.chembiol.2015.05.016. Epub 2015 Jun 18.

4.

Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis.

Lisa MN, Gil M, André-Leroux G, Barilone N, Durán R, Biondi RM, Alzari PM.

Structure. 2015 Jun 2;23(6):1039-48. doi: 10.1016/j.str.2015.04.001. Epub 2015 May 7.

5.

The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.

Wagner T, Alexandre M, Duran R, Barilone N, Wehenkel A, Alzari PM, Bellinzoni M.

Proteins. 2015 May;83(5):982-8. doi: 10.1002/prot.24754. Epub 2015 Mar 25.

6.

Secondary structure reshuffling modulates glycosyltransferase function at the membrane.

Giganti D, Albesa-Jové D, Urresti S, Rodrigo-Unzueta A, Martínez MA, Comino N, Barilone N, Bellinzoni M, Chenal A, Guerin ME, Alzari PM.

Nat Chem Biol. 2015 Jan;11(1):16-8. doi: 10.1038/nchembio.1694. Epub 2014 Nov 17.

PMID:
25402770
7.

A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase).

Wagner T, Barilone N, Alzari PM, Bellinzoni M.

Biochem J. 2014 Feb 1;457(3):425-34. doi: 10.1042/BJ20131142. Erratum in: Biochem J. 2014 Mar 1;458(2):419.

PMID:
24171907
8.

GarA is an essential regulator of metabolism in Mycobacterium tuberculosis.

Ventura M, Rieck B, Boldrin F, Degiacomi G, Bellinzoni M, Barilone N, Alzaidi F, Alzari PM, Manganelli R, O'Hare HM.

Mol Microbiol. 2013 Oct;90(2):356-66. doi: 10.1111/mmi.12368. Epub 2013 Sep 8.

9.

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

Mechaly AE, Haouz A, Miras I, Barilone N, Weber P, Shepard W, Alzari PM, Bellinzoni M.

FEBS Lett. 2012 Jun 4;586(11):1606-11. doi: 10.1016/j.febslet.2012.04.034. Epub 2012 May 3.

10.

Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis.

Skovierová H, Larrouy-Maumus G, Pham H, Belanová M, Barilone N, Dasgupta A, Mikusová K, Gicquel B, Gilleron M, Brennan PJ, Puzo G, Nigou J, Jackson M.

J Biol Chem. 2010 Dec 31;285(53):41348-55. doi: 10.1074/jbc.M110.188110. Epub 2010 Oct 28.

11.

Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic.

Minime-Lingoupou F, Pierre-Audigier C, Kassa-Kélémbho E, Barilone N, Zandanga G, Rauzier J, Cadet-Daniel V, Le Faou A, Gicquel B.

Int J Tuberc Lung Dis. 2010 Jun;14(6):782-5.

PMID:
20487620
12.

AftD, a novel essential arabinofuranosyltransferase from mycobacteria.

Skovierová H, Larrouy-Maumus G, Zhang J, Kaur D, Barilone N, Korduláková J, Gilleron M, Guadagnini S, Belanová M, Prevost MC, Gicquel B, Puzo G, Chatterjee D, Brennan PJ, Nigou J, Jackson M.

Glycobiology. 2009 Nov;19(11):1235-47. doi: 10.1093/glycob/cwp116. Epub 2009 Aug 4.

13.

Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice.

Sambou T, Dinadayala P, Stadthagen G, Barilone N, Bordat Y, Constant P, Levillain F, Neyrolles O, Gicquel B, Lemassu A, Daffé M, Jackson M.

Mol Microbiol. 2008 Nov;70(3):762-74. doi: 10.1111/j.1365-2958.2008.06445.x. Epub 2008 Sep 18.

14.

Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics.

Fonvielle M, Coinçon M, Daher R, Desbenoit N, Kosieradzka K, Barilone N, Gicquel B, Sygusch J, Jackson M, Therisod M.

Chemistry. 2008;14(28):8521-9. doi: 10.1002/chem.200800857.

PMID:
18688832
15.

A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra.

Chesne-Seck ML, Barilone N, Boudou F, Gonzalo Asensio J, Kolattukudy PE, Martín C, Cole ST, Gicquel B, Gopaul DN, Jackson M.

J Bacteriol. 2008 Feb;190(4):1329-34. Epub 2007 Dec 7.

16.

Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis.

Korduláková J, Janin YL, Liav A, Barilone N, Dos Vultos T, Rauzier J, Brennan PJ, Gicquel B, Jackson M.

Antimicrob Agents Chemother. 2007 Nov;51(11):3824-9. Epub 2007 Sep 4.

17.

Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis.

Stadthagen G, Sambou T, Guerin M, Barilone N, Boudou F, Korduláková J, Charles P, Alzari PM, Lemassu A, Daffé M, Puzo G, Gicquel B, Rivière M, Jackson M.

J Biol Chem. 2007 Sep 14;282(37):27270-6. Epub 2007 Jul 19.

18.

The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth.

Fernandez P, Saint-Joanis B, Barilone N, Jackson M, Gicquel B, Cole ST, Alzari PM.

J Bacteriol. 2006 Nov;188(22):7778-84. Epub 2006 Sep 15.

19.

Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives.

Stadthagen G, Jackson M, Charles P, Boudou F, Barilone N, Huerre M, Constant P, Liav A, Bottova I, Nigou J, Brando T, Puzo G, Daffé M, Benjamin P, Coade S, Buxton RS, Tascon RE, Rae A, Robertson BD, Lowrie DB, Young DB, Gicquel B, Griffin R.

Microbes Infect. 2006 Jul;8(8):2245-53. Epub 2006 May 30.

20.

The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria.

Wehenkel A, Fernandez P, Bellinzoni M, Catherinot V, Barilone N, Labesse G, Jackson M, Alzari PM.

FEBS Lett. 2006 May 29;580(13):3018-22. Epub 2006 Apr 27.

21.

The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis.

Gonzalo Asensio J, Maia C, Ferrer NL, Barilone N, Laval F, Soto CY, Winter N, Daffé M, Gicquel B, Martín C, Jackson M.

J Biol Chem. 2006 Jan 20;281(3):1313-6. Epub 2005 Dec 2.

22.

p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis.

Stadthagen G, Korduláková J, Griffin R, Constant P, Bottová I, Barilone N, Gicquel B, Daffé M, Jackson M.

J Biol Chem. 2005 Dec 9;280(49):40699-706. Epub 2005 Oct 6.

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