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Production and Clinical Evaluation of Norwalk GI.1 Virus Lot 001-09NV in Norovirus Vaccine Development.

Mateo R, Lindesmith LC, Garg SJ, Gottlieb K, Lin K, Said S, Leon JS, Sims AC, Weber DJ, Baric RS, Tucker SN, Taylor DN.

J Infect Dis. 2019 Oct 20. pii: jiz540. doi: 10.1093/infdis/jiz540. [Epub ahead of print]


Immune predictors of mortality following RNA virus infection.

Graham JB, Swarts JL, Menachery VD, Gralinski LE, Schäfer A, Plante KS, Morrison CR, Voss KM, Green R, Choonoo G, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Gale M, Heise MT, Baric RS, Lund JM.

J Infect Dis. 2019 Oct 17. pii: jiz531. doi: 10.1093/infdis/jiz531. [Epub ahead of print]


The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections.

Mitchell HD, Eisfeld AJ, Stratton KG, Heller NC, Bramer LM, Wen J, McDermott JE, Gralinski LE, Sims AC, Le MQ, Baric RS, Kawaoka Y, Waters KM.

Front Cell Dev Biol. 2019 Sep 20;7:200. doi: 10.3389/fcell.2019.00200. eCollection 2019.


Small molecule antiviral β-D-N 4-hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance.

Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, Denison MR.

J Virol. 2019 Oct 2. pii: JVI.01348-19. doi: 10.1128/JVI.01348-19. [Epub ahead of print]


STAT5: A Target of Antagonism by Neurotropic Flaviviruses.

Zimmerman MG, Bowen JR, McDonald CE, Young E, Baric RS, Pulendran B, Suthar MS.

J Virol. 2019 Sep 18. pii: JVI.00665-19. doi: 10.1128/JVI.00665-19. [Epub ahead of print]


Role of Zika Virus Envelope Protein Domain III as a Target of Human Neutralizing Antibodies.

Gallichotte EN, Young EF, Baric TJ, Yount BL, Metz SW, Begley MC, de Silva AM, Baric RS.

MBio. 2019 Sep 17;10(5). pii: e01485-19. doi: 10.1128/mBio.01485-19.


Human Norovirus Histo-Blood Group Antigen (HBGA) Binding Sites Mediate the Virus Specific Interactions with Lettuce Carbohydrates.

Esseili MA, Gao X, Boley P, Hou Y, Saif LJ, Brewer-Jensen P, Lindesmith LC, Baric RS, Atmar RL, Wang Q.

Viruses. 2019 Sep 8;11(9). pii: E833. doi: 10.3390/v11090833.


Precision mouse models with expanded tropism for human pathogens.

Wahl A, De C, Abad Fernandez M, Lenarcic EM, Xu Y, Cockrell AS, Cleary RA, Johnson CE, Schramm NJ, Rank LM, Newsome IG, Vincent HA, Sanders W, Aguilera-Sandoval CR, Boone A, Hildebrand WH, Dayton PA, Baric RS, Pickles RJ, Braunstein M, Moorman NJ, Goonetilleke N, Victor Garcia J.

Nat Biotechnol. 2019 Oct;37(10):1163-1173. doi: 10.1038/s41587-019-0225-9. Epub 2019 Aug 26.


Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis.

Leist SR, Jensen KL, Baric RS, Sheahan TP.

PLoS One. 2019 Jul 24;14(7):e0220126. doi: 10.1371/journal.pone.0220126. eCollection 2019.


Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.

Brown AJ, Won JJ, Graham RL, Dinnon KH 3rd, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP.

Antiviral Res. 2019 Sep;169:104541. doi: 10.1016/j.antiviral.2019.104541. Epub 2019 Jun 21.


Sera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination.

Lindesmith LC, McDaniel JR, Changela A, Verardi R, Kerr SA, Costantini V, Brewer-Jensen PD, Mallory ML, Voss WN, Boutz DR, Blazeck JJ, Ippolito GC, Vinje J, Kwong PD, Georgiou G, Baric RS.

Immunity. 2019 Jun 18;50(6):1530-1541.e8. doi: 10.1016/j.immuni.2019.05.007.


Envelope Protein Glycosylation Mediates Zika Virus Pathogenesis.

Carbaugh DL, Baric RS, Lazear HM.

J Virol. 2019 May 29;93(12). pii: e00113-19. doi: 10.1128/JVI.00113-19. Print 2019 Jun 15.


Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection.

Comar CE, Goldstein SA, Li Y, Yount B, Baric RS, Weiss SR.

MBio. 2019 Mar 26;10(2). pii: e00319-19. doi: 10.1128/mBio.00319-19.


Beyond Neutralizing Antibody Levels: The Epitope Specificity of Antibodies Induced by National Institutes of Health Monovalent Dengue Virus Vaccines.

Swanstrom JA, Nivarthi UK, Patel B, Delacruz MJ, Yount B, Widman DG, Durbin AP, Whitehead SS, De Silva AM, Baric RS.

J Infect Dis. 2019 Jun 19;220(2):219-227. doi: 10.1093/infdis/jiz109.


Longitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection model.

Nivarthi UK, Tu HA, Delacruz MJ, Swanstrom J, Patel B, Durbin AP, Whitehead SS, Pierce KK, Kirkpatrick BD, Baric RS, Nguyen N, Emerling DE, de Silva AM, Diehl SA.

EBioMedicine. 2019 Mar;41:465-478. doi: 10.1016/j.ebiom.2019.02.060. Epub 2019 Mar 8.


Shortening of Zika virus CD-loop reduces neurovirulence while preserving antigenicity.

Dinnon Iii KH, Gallichotte EN, Fritch EJ, Menachery VD, Baric RS.

PLoS Negl Trop Dis. 2019 Mar 7;13(3):e0007212. doi: 10.1371/journal.pntd.0007212. eCollection 2019 Mar.


GII.4 Human Norovirus: Surveying the Antigenic Landscape.

Mallory ML, Lindesmith LC, Graham RL, Baric RS.

Viruses. 2019 Feb 20;11(2). pii: E177. doi: 10.3390/v11020177. Review.


SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus).

van Doremalen N, Schäfer A, Menachery VD, Letko M, Bushmaker T, Fischer RJ, Figueroa DM, Hanley PW, Saturday G, Baric RS, Munster VJ.

Viruses. 2018 Dec 19;10(12). pii: E727. doi: 10.3390/v10120727.


Is regulation preventing the development of therapeutics that may prevent future coronavirus pandemics?

Sheahan TP, Baric RS.

Future Virol. 2018 Mar;13(3):143-146. doi: 10.2217/fvl-2017-0143. Epub 2018 Feb 21. No abstract available.


The Human Sodium Iodide Symporter as a Reporter Gene for Studying Middle East Respiratory Syndrome Coronavirus Pathogenesis.

Chefer S, Seidel J, Cockrell AS, Yount B, Solomon J, Hagen KR, Liu DX, Huzella LM, Kumar MR, Postnikova E, Bohannon JK, Lackemeyer MG, Cooper K, Endlich-Frazier A, Sharma H, Thomasson D, Bartos C, Sayre PJ, Sims A, Dyall J, Holbrook MR, Jahrling PB, Baric RS, Johnson RF.

mSphere. 2018 Dec 12;3(6). pii: e00540-18. doi: 10.1128/mSphere.00540-18.


Maternally Acquired Zika Antibodies Enhance Dengue Disease Severity in Mice.

Fowler AM, Tang WW, Young MP, Mamidi A, Viramontes KM, McCauley MD, Carlin AF, Schooley RT, Swanstrom J, Baric RS, Govero J, Diamond MS, Shresta S.

Cell Host Microbe. 2018 Nov 14;24(5):743-750.e5. doi: 10.1016/j.chom.2018.09.015.


Evaluation of a recombination-resistant coronavirus as a broadly applicable, rapidly implementable vaccine platform.

Graham RL, Deming DJ, Deming ME, Yount BL, Baric RS.

Commun Biol. 2018 Oct 29;1:179. doi: 10.1038/s42003-018-0175-7. eCollection 2018.


Genetic Variation between Dengue Virus Type 4 Strains Impacts Human Antibody Binding and Neutralization.

Gallichotte EN, Baric TJ, Nivarthi U, Delacruz MJ, Graham R, Widman DG, Yount BL, Durbin AP, Whitehead SS, de Silva AM, Baric RS.

Cell Rep. 2018 Oct 30;25(5):1214-1224. doi: 10.1016/j.celrep.2018.10.006.


Human Norovirus Epitope D Plasticity Allows Escape from Antibody Immunity without Loss of Capacity for Binding Cellular Ligands.

Lindesmith LC, Brewer-Jensen PD, Mallory ML, Yount B, Collins MH, Debbink K, Graham RL, Baric RS.

J Virol. 2019 Jan 4;93(2). pii: e01813-18. doi: 10.1128/JVI.01813-18. Print 2019 Jan 15.


Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.

Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT, Baric RS.

MBio. 2018 Oct 9;9(5). pii: e01753-18. doi: 10.1128/mBio.01753-18.


Giving the Genes a Shuffle: Using Natural Variation to Understand Host Genetic Contributions to Viral Infections.

Leist SR, Baric RS.

Trends Genet. 2018 Oct;34(10):777-789. doi: 10.1016/j.tig.2018.07.005. Epub 2018 Aug 18. Review.


The Endonucleolytic RNA Cleavage Function of nsp1 of Middle East Respiratory Syndrome Coronavirus Promotes the Production of Infectious Virus Particles in Specific Human Cell Lines.

Nakagawa K, Narayanan K, Wada M, Popov VL, Cajimat M, Baric RS, Makino S.

J Virol. 2018 Oct 12;92(21). pii: e01157-18. doi: 10.1128/JVI.01157-18. Print 2018 Nov 1.


Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice.

Cockrell AS, Leist SR, Douglas MG, Baric RS.

Mamm Genome. 2018 Aug;29(7-8):367-383. doi: 10.1007/s00335-018-9760-9. Epub 2018 Jul 24. Review.


A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques.

Cockrell AS, Johnson JC, Moore IN, Liu DX, Bock KW, Douglas MG, Graham RL, Solomon J, Torzewski L, Bartos C, Hart R, Baric RS, Johnson RF.

Sci Rep. 2018 Jul 16;8(1):10727. doi: 10.1038/s41598-018-28900-1.


Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, McAnarney ET, Graham RL, Waters KM, Baric RS.

J Virol. 2018 Aug 16;92(17). pii: e00710-18. doi: 10.1128/JVI.00710-18. Print 2018 Sep 1.


CC002/Unc females are mouse models of exercise-induced paradoxical fat response.

McMullan RC, Ferris MT, Bell TA, Menachery VD, Baric RS, Hua K, Pomp D, Smith-Ryan AE, de Villena FP.

Physiol Rep. 2018 Jun;6(12):e13716. doi: 10.14814/phy2.13716.


The Molecular Specificity of the Human Antibody Response to Dengue Virus Infections.

Gallichotte EN, Baric RS, de Silva AM.

Adv Exp Med Biol. 2018;1062:63-76. doi: 10.1007/978-981-10-8727-1_5. Review.


Vaccination-induced herd immunity: Successes and challenges.

Mallory ML, Lindesmith LC, Baric RS.

J Allergy Clin Immunol. 2018 Jul;142(1):64-66. doi: 10.1016/j.jaci.2018.05.007. Epub 2018 May 24. No abstract available.


Analyzing the Human Serum Antibody Responses to a Live Attenuated Tetravalent Dengue Vaccine Candidate.

Swanstrom JA, Henein S, Plante JA, Yount BL, Widman DG, Gallichotte EN, Dean HJ, Osorio JE, Partidos CD, de Silva AM, Baric RS.

J Infect Dis. 2018 May 25;217(12):1932-1941. doi: 10.1093/infdis/jiy063.


Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro.

Shin JS, Jung E, Kim M, Baric RS, Go YY.

Viruses. 2018 May 24;10(6). pii: E283. doi: 10.3390/v10060283.


Bat Caliciviruses and Human Noroviruses Are Antigenically Similar and Have Overlapping Histo-Blood Group Antigen Binding Profiles.

Kocher JF, Lindesmith LC, Debbink K, Beall A, Mallory ML, Yount BL, Graham RL, Huynh J, Gates JE, Donaldson EF, Baric RS.

MBio. 2018 May 22;9(3). pii: e00869-18. doi: 10.1128/mBio.00869-18.


An Immunocompetent Mouse Model of Zika Virus Infection.

Gorman MJ, Caine EA, Zaitsev K, Begley MC, Weger-Lucarelli J, Uccellini MB, Tripathi S, Morrison J, Yount BL, Dinnon KH 3rd, Rückert C, Young MC, Zhu Z, Robertson SJ, McNally KL, Ye J, Cao B, Mysorekar IU, Ebel GD, Baric RS, Best SM, Artyomov MN, Garcia-Sastre A, Diamond MS.

Cell Host Microbe. 2018 May 9;23(5):672-685.e6. doi: 10.1016/j.chom.2018.04.003.


Human coronaviruses and other respiratory infections in young adults on a university campus: Prevalence, symptoms, and shedding.

Davis BM, Foxman B, Monto AS, Baric RS, Martin ET, Uzicanin A, Rainey JJ, Aiello AE.

Influenza Other Respir Viruses. 2018 Apr 16. doi: 10.1111/irv.12563. [Epub ahead of print]


Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform.

Agnihothram S, Menachery VD, Yount BL Jr.,, Lindesmith LC, Scobey T, Whitmore A, Schäfer A, Heise MT, Baric RS.

J Virol. 2018 May 14;92(11). pii: e00027-18. doi: 10.1128/JVI.00027-18. Print 2018 Jun 1.


Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR.

MBio. 2018 Mar 6;9(2). pii: e00221-18. doi: 10.1128/mBio.00221-18.


Human dengue virus serotype 2 neutralizing antibodies target two distinct quaternary epitopes.

Gallichotte EN, Baric TJ, Yount BL Jr, Widman DG, Durbin A, Whitehead S, Baric RS, de Silva AM.

PLoS Pathog. 2018 Feb 26;14(2):e1006934. doi: 10.1371/journal.ppat.1006934. eCollection 2018 Feb.


Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion.

Lindesmith LC, Mallory ML, Debbink K, Donaldson EF, Brewer-Jensen PD, Swann EW, Sheahan TP, Graham RL, Beltramello M, Corti D, Lanzavecchia A, Baric RS.

mSphere. 2018 Feb 7;3(1). pii: e00518-17. doi: 10.1128/mSphere.00518-17. eCollection 2018 Jan-Feb.


Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain.

Adams Waldorf KM, Nelson BR, Stencel-Baerenwald JE, Studholme C, Kapur RP, Armistead B, Walker CL, Merillat S, Vornhagen J, Tisoncik-Go J, Baldessari A, Coleman M, Dighe MK, Shaw DWW, Roby JA, Santana-Ufret V, Boldenow E, Li J, Gao X, Davis MA, Swanstrom JA, Jensen K, Widman DG, Baric RS, Medwid JT, Hanley KA, Ogle J, Gough GM, Lee W, English C, Durning WM, Thiel J, Gatenby C, Dewey EC, Fairgrieve MR, Hodge RD, Grant RF, Kuller L, Dobyns WB, Hevner RF, Gale M Jr, Rajagopal L.

Nat Med. 2018 Mar;24(3):368-374. doi: 10.1038/nm.4485. Epub 2018 Feb 5.


MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.

Menachery VD, Schäfer A, Burnum-Johnson KE, Mitchell HD, Eisfeld AJ, Walters KB, Nicora CD, Purvine SO, Casey CP, Monroe ME, Weitz KK, Stratton KG, Webb-Robertson BM, Gralinski LE, Metz TO, Smith RD, Waters KM, Sims AC, Kawaoka Y, Baric RS.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E1012-E1021. doi: 10.1073/pnas.1706928115. Epub 2018 Jan 16.


Antigenic Characterization of a Novel Recombinant GII.P16-GII.4 Sydney Norovirus Strain With Minor Sequence Variation Leading to Antibody Escape.

Lindesmith LC, Brewer-Jensen PD, Mallory ML, Debbink K, Swann EW, Vinjé J, Baric RS.

J Infect Dis. 2018 Mar 13;217(7):1145-1152. doi: 10.1093/infdis/jix651.


Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease.

Douglas MG, Kocher JF, Scobey T, Baric RS, Cockrell AS.

Virology. 2018 Apr;517:98-107. doi: 10.1016/j.virol.2017.12.006. Epub 2017 Dec 23.


Transplantation of a quaternary structure neutralizing antibody epitope from dengue virus serotype 3 into serotype 4.

Widman DG, Young E, Nivarthi U, Swanstrom JA, Royal SR, Yount BL, Debbink K, Begley M, Marcet S, Durbin A, de Silva AM, Messer WB, Baric RS.

Sci Rep. 2017 Dec 7;7(1):17169. doi: 10.1038/s41598-017-17355-5.


Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice.

Maurizio PL, Ferris MT, Keele GR, Miller DR, Shaw GD, Whitmore AC, West A, Morrison CR, Noll KE, Plante KS, Cockrell AS, Threadgill DW, Pardo-Manuel de Villena F, Baric RS, Heise MT, Valdar W.

G3 (Bethesda). 2018 Feb 2;8(2):427-445. doi: 10.1534/g3.117.300438.


Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, Graham RL, McAnarney ET, Stratton KG, Cockrell AS, Debbink K, Sims AC, Waters KM, Baric RS.

mSphere. 2017 Nov 15;2(6). pii: e00346-17. doi: 10.1128/mSphere.00346-17. eCollection 2017 Nov-Dec.


Expanded subgenomic mRNA transcriptome and coding capacity of a nidovirus.

Di H, Madden JC Jr, Morantz EK, Tang HY, Graham RL, Baric RS, Brinton MA.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):E8895-E8904. doi: 10.1073/pnas.1706696114. Epub 2017 Oct 4.

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