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Mouse Models of Type 2 Diabetes Mellitus in Drug Discovery.

Baribault H.

Methods Mol Biol. 2016;1438:153-75. doi: 10.1007/978-1-4939-3661-8_10. Review.


GPR21 KO mice demonstrate no resistance to high fat diet induced obesity or improved glucose tolerance.

Wang J, Pan Z, Baribault H, Chui D, Gundel C, Véniant M.

Version 2. F1000Res. 2016 Feb 4 [revised 2016 Jan 1];5:136. doi: 10.12688/f1000research.7822.2. eCollection 2016.


Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate.

Rulifson IC, Cao P, Miao L, Kopecky D, Huang L, White RD, Samayoa K, Gardner J, Wu X, Chen K, Tsuruda T, Homann O, Baribault H, Yamane H, Carlson T, Wiltzius J, Li Y.

PLoS One. 2016 Feb 3;11(2):e0147254. doi: 10.1371/journal.pone.0147254. eCollection 2016.


Soluble CLEC2 Extracellular Domain Improves Glucose and Lipid Homeostasis by Regulating Liver Kupffer Cell Polarization.

Wu X, Zhang J, Ge H, Gupte J, Baribault H, Lee KJ, Lemon B, Coberly S, Gong Y, Pan Z, Rulifson IC, Gardner J, Richards WG, Li Y.

EBioMedicine. 2015 Feb 25;2(3):214-24. doi: 10.1016/j.ebiom.2015.02.013. eCollection 2015 Mar.


Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia.

Ge H, Gardner J, Wu X, Rulifson I, Wang J, Xiong Y, Ye J, Belouski E, Cao P, Tang J, Lee KJ, Coberly S, Wu X, Gupte J, Miao L, Yang L, Nguyen N, Shan B, Yeh WC, Véniant MM, Li Y, Baribault H.

PLoS One. 2015 Jun 17;10(6):e0126924. doi: 10.1371/journal.pone.0126924. eCollection 2015.


Inhibition of secreted frizzled-related protein 5 improves glucose metabolism.

Rulifson IC, Majeti JZ, Xiong Y, Hamburger A, Lee KJ, Miao L, Lu M, Gardner J, Gong Y, Wu H, Case R, Yeh WC, Richards WG, Baribault H, Li Y.

Am J Physiol Endocrinol Metab. 2014 Dec 15;307(12):E1144-52. doi: 10.1152/ajpendo.00283.2014. Epub 2014 Nov 4.


Advancing therapeutic discovery through phenotypic screening of the extracellular proteome using hydrodynamic intravascular injection.

Baribault H, Majeti JZ, Ge H, Wang J, Xiong Y, Gardner J, Yang L, Gupte J, Gong Y, Pan Z, Cutler G, Kassner P, Tu H, Shan B, Wu X, Li Y.

Expert Opin Ther Targets. 2014 Nov;18(11):1253-64. doi: 10.1517/14728222.2014.968128. Epub 2014 Oct 7.


Fibroblast growth factor receptor 4 (FGFR4) deficiency improves insulin resistance and glucose metabolism under diet-induced obesity conditions.

Ge H, Zhang J, Gong Y, Gupte J, Ye J, Weiszmann J, Samayoa K, Coberly S, Gardner J, Wang H, Corbin T, Chui D, Baribault H, Li Y.

J Biol Chem. 2014 Oct 31;289(44):30470-80. doi: 10.1074/jbc.M114.592022. Epub 2014 Sep 9.


Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1.

Xiong Y, Swaminath G, Cao Q, Yang L, Guo Q, Salomonis H, Lu J, Houze JB, Dransfield PJ, Wang Y, Liu JJ, Wong S, Schwandner R, Steger F, Baribault H, Liu L, Coberly S, Miao L, Zhang J, Lin DC, Schwarz M.

Mol Cell Endocrinol. 2013 Apr 30;369(1-2):119-29. doi: 10.1016/j.mce.2013.01.009. Epub 2013 Feb 9.


Dual actions of fibroblast growth factor 19 on lipid metabolism.

Wu X, Ge H, Baribault H, Gupte J, Weiszmann J, Lemon B, Gardner J, Fordstrom P, Tang J, Zhou M, Wang M, Li Y.

J Lipid Res. 2013 Feb;54(2):325-32. doi: 10.1194/jlr.M027094. Epub 2012 Dec 2.


Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.

Foltz IN, Hu S, King C, Wu X, Yang C, Wang W, Weiszmann J, Stevens J, Chen JS, Nuanmanee N, Gupte J, Komorowski R, Sekirov L, Hager T, Arora T, Ge H, Baribault H, Wang F, Sheng J, Karow M, Wang M, Luo Y, McKeehan W, Wang Z, Véniant MM, Li Y.

Sci Transl Med. 2012 Nov 28;4(162):162ra153. doi: 10.1126/scitranslmed.3004690.


Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism.

Ge H, Baribault H, Vonderfecht S, Lemon B, Weiszmann J, Gardner J, Lee KJ, Gupte J, Mookherjee P, Wang M, Sheng J, Wu X, Li Y.

PLoS One. 2012;7(3):e33603. doi: 10.1371/journal.pone.0033603. Epub 2012 Mar 23.


A unique FGF23 with the ability to activate FGFR signaling through both αKlotho and βKlotho.

Wu X, Weiszmann J, Ge H, Baribault H, Stevens J, Hawkins N, Vonderfecht S, Gardner J, Gupte J, Sheng J, Wang M, Li Y.

J Mol Biol. 2012 Apr 20;418(1-2):82-9. doi: 10.1016/j.jmb.2012.02.027. Epub 2012 Feb 24.


G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response.

Gardner J, Wu S, Ling L, Danao J, Li Y, Yeh WC, Tian H, Baribault H.

Biochem Biophys Res Commun. 2012 Feb 3;418(1):1-5. doi: 10.1016/j.bbrc.2011.11.117. Epub 2011 Dec 1.


Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19).

Wu X, Ge H, Lemon B, Vonderfecht S, Baribault H, Weiszmann J, Gupte J, Gardner J, Lindberg R, Wang Z, Li Y.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14158-63. doi: 10.1073/pnas.1009427107. Epub 2010 Jul 26.


Mouse models of type II diabetes mellitus in drug discovery.

Baribault H.

Methods Mol Biol. 2010;602:135-55. doi: 10.1007/978-1-60761-058-8_9.


Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids.

Ge H, Li X, Weiszmann J, Wang P, Baribault H, Chen JL, Tian H, Li Y.

Endocrinology. 2008 Sep;149(9):4519-26. doi: 10.1210/en.2008-0059. Epub 2008 May 22.


Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury.

Toivola DM, Nakamichi I, Strnad P, Michie SA, Ghori N, Harada M, Zeh K, Oshima RG, Baribault H, Omary MB.

Am J Pathol. 2008 Apr;172(4):882-92. doi: 10.2353/ajpath.2008.070830. Epub 2008 Mar 18.


Elucidation of signaling and functional activities of an orphan GPCR, GPR81.

Ge H, Weiszmann J, Reagan JD, Gupte J, Baribault H, Gyuris T, Chen JL, Tian H, Li Y.

J Lipid Res. 2008 Apr;49(4):797-803. doi: 10.1194/jlr.M700513-JLR200. Epub 2008 Jan 3.


Significant gene content variation characterizes the genomes of inbred mouse strains.

Cutler G, Marshall LA, Chin N, Baribault H, Kassner PD.

Genome Res. 2007 Dec;17(12):1743-54. Epub 2007 Nov 7.


C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a.

Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, McKerlie C, Lee T, Baribault H, Tian H, Yeh WC.

Nature. 2007 Mar 8;446(7132):203-7. Epub 2007 Feb 25.


The G-protein-coupled receptor GPR103 regulates bone formation.

Baribault H, Danao J, Gupte J, Yang L, Sun B, Richards W, Tian H.

Mol Cell Biol. 2006 Jan;26(2):709-17.


Keratin 8 overexpression promotes mouse Mallory body formation.

Nakamichi I, Toivola DM, Strnad P, Michie SA, Oshima RG, Baribault H, Omary MB.

J Cell Biol. 2005 Dec 19;171(6):931-7.


Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects.

Roy M, David NK, Danao JV, Baribault H, Tian H, Giorgetti M.

Neuropsychopharmacology. 2006 Jan;31(1):112-20.


Novel pan-neuronal Cre-transgenic line for conditional ablation of genes in the nervous system.

Banares S, Zeh K, Krajewska M, Kermer P, Baribault H, Reed JC, Krajewski S.

Genesis. 2005 May;42(1):6-16.


Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension.

Morita H, Mazerbourg S, Bouley DM, Luo CW, Kawamura K, Kuwabara Y, Baribault H, Tian H, Hsueh AJ.

Mol Cell Biol. 2004 Nov;24(22):9736-43.


Keratin 8 protection of placental barrier function.

Jaquemar D, Kupriyanov S, Wankell M, Avis J, Benirschke K, Baribault H, Oshima RG.

J Cell Biol. 2003 May 26;161(4):749-56.


Disturbances in hepatic cell-cycle regulation in mice with assembly-deficient keratins 8/18.

Toivola DM, Nieminen MI, Hesse M, He T, Baribault H, Magin TM, Omary MB, Eriksson JE.

Hepatology. 2001 Dec;34(6):1174-83.


Simple epithelial keratins are dispensable for cytoprotection in two pancreatitis models.

Toivola DM, Baribault H, Magin T, Michie SA, Omary MB.

Am J Physiol Gastrointest Liver Physiol. 2000 Dec;279(6):G1343-54.


Cytokeratins 8 and 19 in the mouse placental development.

Tamai Y, Ishikawa T, Bösl MR, Mori M, Nozaki M, Baribault H, Oshima RG, Taketo MM.

J Cell Biol. 2000 Oct 30;151(3):563-72.


Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies.

Zatloukal K, Stumptner C, Lehner M, Denk H, Baribault H, Eshkind LG, Franke WW.

Am J Pathol. 2000 Apr;156(4):1263-74.


Double pronuclei injection of DNA into zygotes increases yields of transgenic mouse lines.

Kupriyanov S, Zeh K, Baribault H.

Transgenic Res. 1998 May;7(3):223-6.


Genetic control of extraembryonic cell lineages studied with tetraploid<-->diploid chimeric concepti.

Kupriyanov S, Baribault H.

Biochem Cell Biol. 1998;76(6):1017-27. Review.


Selection of primary cell cultures with cre recombinase induced somatic mutations from transgenic mice.

Zeh K, Andahazy M, O'Gorman S, Baribault H.

Nucleic Acids Res. 1998 Sep 15;26(18):4301-3.


Vinculin knockout results in heart and brain defects during embryonic development.

Xu W, Baribault H, Adamson ED.

Development. 1998 Jan;125(2):327-37.


Functional analysis of mouse keratin 8 in polyoma middle T-induced mammary gland tumours.

Baribault H, Wilson-Heiner M, Muller W, Penner J, Bakhiet N.

Transgenic Res. 1997 Nov;6(6):359-67.


Simple epithelium keratins are required for maintenance of hepatocyte integrity.

Loranger A, Duclos S, Grenier A, Price J, Wilson-Heiner M, Baribault H, Marceau N.

Am J Pathol. 1997 Dec;151(6):1673-83.


Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility.

Danielson KG, Baribault H, Holmes DF, Graham H, Kadler KE, Iozzo RV.

J Cell Biol. 1997 Feb 10;136(3):729-43.


Oncogenic regulation and function of keratins 8 and 18.

Oshima RG, Baribault H, Caulín C.

Cancer Metastasis Rev. 1996 Dec;15(4):445-71. Review.


Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

McKercher SR, Torbett BE, Anderson KL, Henkel GW, Vestal DJ, Baribault H, Klemsz M, Feeney AJ, Wu GE, Paige CJ, Maki RA.

EMBO J. 1996 Oct 15;15(20):5647-58.


Perfect wound healing in the keratin 8 deficient mouse embryo.

Brock J, McCluskey J, Baribault H, Martin P.

Cell Motil Cytoskeleton. 1996;35(4):358-66.


Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion.

Coll JL, Ben-Ze'ev A, Ezzell RM, Rodríguez Fernández JL, Baribault H, Oshima RG, Adamson ED.

Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9161-5.


Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice.

Baribault H, Penner J, Iozzo RV, Wilson-Heiner M.

Genes Dev. 1994 Dec 15;8(24):2964-73.


Mid-gestational lethality in mice lacking keratin 8.

Baribault H, Price J, Miyai K, Oshima RG.

Genes Dev. 1993 Jul;7(7A):1191-202.


Inactivation of keratin genes by gene targeting: a perspective.

Oshima RG, Baribault H.

J Dermatol. 1992 Nov;19(11):786-9.


The structure of the gene coding for the mouse cell adhesion molecule uvomorulin.

Ringwald M, Baribault H, Schmidt C, Kemler R.

Nucleic Acids Res. 1991 Dec 11;19(23):6533-9.


Altered uvomorulin expression in a noncompacting mutant cell line of F9 embryonal carcinoma cells.

Adamson ED, Baribault H, Kemler R.

Dev Biol. 1990 Apr;138(2):338-47.


Embryonic stem cell culture and gene targeting in transgenic mice.

Baribault H, Kemler R.

Mol Biol Med. 1989 Dec;6(6):481-92. Review.


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