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Items: 19

1.

Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis.

Boneberg FM, Brandmann T, Kobel L, van den Heuvel J, Bargsten K, Bammert L, Kutay U, Jinek M.

RNA. 2019 Jun;25(6):685-701. doi: 10.1261/rna.069609.118. Epub 2019 Mar 25.

2.

In vitro Generation of CRISPR-Cas9 Complexes with Covalently Bound Repair Templates for Genome Editing in Mammalian Cells.

Savić N, Ringnalda FC, Berk C, Bargsten K, Hall J, Jinek M, Schwank G.

Bio Protoc. 2019 Jan 5;9(1). pii: e3136. doi: 10.21769/BioProtoc.3136.

3.

Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair.

Savic N, Ringnalda FC, Lindsay H, Berk C, Bargsten K, Li Y, Neri D, Robinson MD, Ciaudo C, Hall J, Jinek M, Schwank G.

Elife. 2018 May 29;7. pii: e33761. doi: 10.7554/eLife.33761.

4.

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.

Bohnacker T, Prota AE, Beaufils F, Burke JE, Melone A, Inglis AJ, Rageot D, Sele AM, Cmiljanovic V, Cmiljanovic N, Bargsten K, Aher A, Akhmanova A, Díaz JF, Fabbro D, Zvelebil M, Williams RL, Steinmetz MO, Wymann MP.

Nat Commun. 2017 Mar 9;8:14683. doi: 10.1038/ncomms14683.

5.

Structural Basis of Microtubule Stabilization by Discodermolide.

Prota AE, Bargsten K, Redondo-Horcajo M, Smith AB 3rd, Yang CH, McDaid HM, Paterson I, Horwitz SB, Fernando Díaz J, Steinmetz MO.

Chembiochem. 2017 May 18;18(10):905-909. doi: 10.1002/cbic.201600696. Epub 2017 Mar 27.

6.

Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.

Trigili C, Barasoain I, Sánchez-Murcia PA, Bargsten K, Redondo-Horcajo M, Nogales A, Gardner NM, Meyer A, Naylor GJ, Gómez-Rubio E, Gago F, Steinmetz MO, Paterson I, Prota AE, Díaz JF.

ACS Omega. 2016 Dec 31;1(6):1192-1204. doi: 10.1021/acsomega.6b00317. Epub 2016 Dec 13.

7.

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.

Waight AB, Bargsten K, Doronina S, Steinmetz MO, Sussman D, Prota AE.

PLoS One. 2016 Aug 12;11(8):e0160890. doi: 10.1371/journal.pone.0160890. eCollection 2016.

8.

Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation.

Prota AE, Setter J, Waight AB, Bargsten K, Murga J, Diaz JF, Steinmetz MO.

J Mol Biol. 2016 Jul 31;428(15):2981-8. doi: 10.1016/j.jmb.2016.06.023. Epub 2016 Jul 6.

9.

Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes.

Doodhi H, Prota AE, Rodríguez-García R, Xiao H, Custar DW, Bargsten K, Katrukha EA, Hilbert M, Hua S, Jiang K, Grigoriev I, Yang CH, Cox D, Horwitz SB, Kapitein LC, Akhmanova A, Steinmetz MO.

Curr Biol. 2016 Jul 11;26(13):1713-1721. doi: 10.1016/j.cub.2016.04.053. Epub 2016 Jun 16.

10.

Antivascular and antitumor properties of the tubulin-binding chalcone TUB091.

Canela MD, Noppen S, Bueno O, Prota AE, Bargsten K, Sáez-Calvo G, Jimeno ML, Benkheil M, Ribatti D, Velázquez S, Camarasa MJ, Díaz JF, Steinmetz MO, Priego EM, Pérez-Pérez MJ, Liekens S.

Oncotarget. 2017 Feb 28;8(9):14325-14342. doi: 10.18632/oncotarget.9527.

11.

Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.

Anders C, Bargsten K, Jinek M.

Mol Cell. 2016 Mar 17;61(6):895-902. doi: 10.1016/j.molcel.2016.02.020.

12.

Fast native-SAD phasing for routine macromolecular structure determination.

Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota AE, Surana P, Kottur J, Nair DT, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang BC, Steinmetz MO, Caffrey M, Wang M.

Nat Methods. 2015 Feb;12(2):131-3. doi: 10.1038/nmeth.3211. Epub 2014 Dec 15. Erratum in: Nat Methods. 2015 Jul;12(7):692.

PMID:
25506719
13.

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.

Prota AE, Bargsten K, Diaz JF, Marsh M, Cuevas C, Liniger M, Neuhaus C, Andreu JM, Altmann KH, Steinmetz MO.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21. doi: 10.1073/pnas.1408124111. Epub 2014 Aug 11.

14.

The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization.

Prota AE, Danel F, Bachmann F, Bargsten K, Buey RM, Pohlmann J, Reinelt S, Lane H, Steinmetz MO.

J Mol Biol. 2014 Apr 17;426(8):1848-60. doi: 10.1016/j.jmb.2014.02.005. Epub 2014 Feb 11.

PMID:
24530796
15.

Structural basis of microtubule stabilization by laulimalide and peloruside A.

Prota AE, Bargsten K, Northcote PT, Marsh M, Altmann KH, Miller JH, Díaz JF, Steinmetz MO.

Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1621-5. doi: 10.1002/anie.201307749. Epub 2014 Jan 27.

PMID:
24470331
16.

Structural basis of tubulin tyrosination by tubulin tyrosine ligase.

Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO.

J Cell Biol. 2013 Feb 4;200(3):259-70. doi: 10.1083/jcb.201211017. Epub 2013 Jan 28.

17.

Molecular mechanism of action of microtubule-stabilizing anticancer agents.

Prota AE, Bargsten K, Zurwerra D, Field JJ, Díaz JF, Altmann KH, Steinmetz MO.

Science. 2013 Feb 1;339(6119):587-90. doi: 10.1126/science.1230582. Epub 2013 Jan 3.

18.

Interaction of mammalian end binding proteins with CAP-Gly domains of CLIP-170 and p150(glued).

Bjelić S, De Groot CO, Schärer MA, Jaussi R, Bargsten K, Salzmann M, Frey D, Capitani G, Kammerer RA, Steinmetz MO.

J Struct Biol. 2012 Jan;177(1):160-7. doi: 10.1016/j.jsb.2011.11.010. Epub 2011 Nov 17.

PMID:
22119847
19.

Insights into EB1 structure and the role of its C-terminal domain for discriminating microtubule tips from the lattice.

Buey RM, Mohan R, Leslie K, Walzthoeni T, Missimer JH, Menzel A, Bjelic S, Bargsten K, Grigoriev I, Smal I, Meijering E, Aebersold R, Akhmanova A, Steinmetz MO.

Mol Biol Cell. 2011 Aug 15;22(16):2912-23. doi: 10.1091/mbc.E11-01-0017. Epub 2011 Jul 7.

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