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Items: 25


Integrative Multi-Kinase Approach for the Identification of Potent Antiplasmodial Hits.

Lima MNN, Cassiano GC, Tomaz KCP, Silva AC, Sousa BKP, Ferreira LT, Tavella TA, Calit J, Bargieri DY, Neves BJ, Costa FTM, Andrade CH.

Front Chem. 2019 Nov 21;7:773. doi: 10.3389/fchem.2019.00773. eCollection 2019.


Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria.

Lima MN, Neves BJ, Cassiano GC, Gomes MN, Tomaz KC, Ferreira LT, Tavella TA, Calit J, Bargieri DY, Muratov EN, Costa FT, Andrade CH.

Future Med Chem. 2019 Oct;11(20):2635-2646. doi: 10.4155/fmc-2018-0255. Epub 2019 Sep 26.


Targeting Malaria in Flight.

Bargieri DY, Williamson KC.

Cell Host Microbe. 2019 May 8;25(5):631-632. doi: 10.1016/j.chom.2019.04.007.


Screening the Pathogen Box for Molecules Active against Plasmodium Sexual Stages Using a New Nanoluciferase-Based Transgenic Line of P. berghei Identifies Transmission-Blocking Compounds.

Calit J, Dobrescu I, Gaitán XA, Borges MH, Ramos MS, Eastman RT, Bargieri DY.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01053-18. doi: 10.1128/AAC.01053-18. Print 2018 Nov.


QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities.

Lima MNN, Melo-Filho CC, Cassiano GC, Neves BJ, Alves VM, Braga RC, Cravo PVL, Muratov EN, Calit J, Bargieri DY, Costa FTM, Andrade CH.

Front Pharmacol. 2018 Mar 6;9:146. doi: 10.3389/fphar.2018.00146. eCollection 2018.


In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate.

Cravo P, Machado RB, Leite JA, Leda T, Suwanarusk R, Bittencourt N, Albrecht L, Judice C, Lopes SCP, Lacerda MVG, Ferreira MU, Soares IS, Goh YS, Bargieri DY, Nosten F, Russell B, Rénia L, Costa FTM.

Malar J. 2018 Jan 10;17(1):20. doi: 10.1186/s12936-017-2144-x.


Vaccine Containing the Three Allelic Variants of the Plasmodium vivax Circumsporozoite Antigen Induces Protection in Mice after Challenge with a Transgenic Rodent Malaria Parasite.

Gimenez AM, Lima LC, Françoso KS, Denapoli PMA, Panatieri R, Bargieri DY, Thiberge JM, Andolina C, Nosten F, Renia L, Nussenzweig RS, Nussenzweig V, Amino R, Rodrigues MM, Soares IS.

Front Immunol. 2017 Oct 11;8:1275. doi: 10.3389/fimmu.2017.01275. eCollection 2017.


Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.

Bargieri DY, Thiberge S, Tay CL, Carey AF, Rantz A, Hischen F, Lorthiois A, Straschil U, Singh P, Singh S, Triglia T, Tsuboi T, Cowman A, Chitnis C, Alano P, Baum J, Pradel G, Lavazec C, Ménard R.

Cell Host Microbe. 2016 Nov 9;20(5):618-630. doi: 10.1016/j.chom.2016.10.015.


Immunization with the MAEBL M2 Domain Protects against Lethal Plasmodium yoelii Infection.

Leite JA, Bargieri DY, Carvalho BO, Albrecht L, Lopes SC, Kayano AC, Farias AS, Chia WN, Claser C, Malleret B, Russell B, Castiñeiras C, Santos LM, Brocchi M, Wunderlich G, Soares IS, Rodrigues MM, Rénia L, Costa FT.

Infect Immun. 2015 Oct;83(10):3781-92. doi: 10.1128/IAI.00262-15. Epub 2015 Jul 13.


Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion.

Bargieri DY, Andenmatten N, Lagal V, Thiberge S, Whitelaw JA, Tardieux I, Meissner M, Ménard R.

Nat Commun. 2013;4:2552. doi: 10.1038/ncomms3552.


Immunogenicity of recombinant proteins consisting of Plasmodium vivax circumsporozoite protein allelic variant-derived epitopes fused with Salmonella enterica Serovar Typhimurium flagellin.

Leal MT, Camacho AG, Teixeira LH, Bargieri DY, Soares IS, Tararam CA, Rodrigues MM.

Clin Vaccine Immunol. 2013 Sep;20(9):1418-25. doi: 10.1128/CVI.00312-13. Epub 2013 Jul 17.


Scoring sporozoite motility.

Carey AF, Ménard R, Bargieri DY.

Methods Mol Biol. 2013;923:371-83.


TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium.

Camacho AG, Teixeira LH, Bargieri DY, Boscardin SB, Soares IS, Nussenzweig RS, Nussenzweig V, Rodrigues MM.

Mem Inst Oswaldo Cruz. 2011 Aug;106 Suppl 1:167-71.


FLP/FRT-mediated conditional mutagenesis in pre-erythrocytic stages of Plasmodium berghei.

Lacroix C, Giovannini D, Combe A, Bargieri DY, Späth S, Panchal D, Tawk L, Thiberge S, Carvalho TG, Barale JC, Bhanot P, Ménard R.

Nat Protoc. 2011 Aug 25;6(9):1412-28. doi: 10.1038/nprot.2011.363.


The novel putative transporter NPT1 plays a critical role in early stages of Plasmodium berghei sexual development.

Boisson B, Lacroix C, Bischoff E, Gueirard P, Bargieri DY, Franke-Fayard B, Janse CJ, Ménard R, Baldacci P.

Mol Microbiol. 2011 Sep;81(5):1343-57. doi: 10.1111/j.1365-2958.2011.07767.x. Epub 2011 Aug 4.


Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans?

Bargieri DY, Soares IS, Costa FT, Braga CJ, Ferreira LC, Rodrigues MM.

J Parasitol Res. 2011;2011:965369. doi: 10.1155/2011/965369. Epub 2011 Mar 14.


A recombinant vaccine based on domain II of Plasmodium vivax Apical Membrane Antigen 1 induces high antibody titres in mice.

Gentil F, Bargieri DY, Leite JA, Françoso KS, Patricio MB, Espíndola NM, Vaz AJ, Palatnik-de-Sousa CB, Rodrigues MM, Costa FT, Soares IS.

Vaccine. 2010 Aug 31;28(38):6183-90. doi: 10.1016/j.vaccine.2010.07.017. Epub 2010 Jul 21.


On the cytoadhesion of Plasmodium vivax-infected erythrocytes.

Carvalho BO, Lopes SC, Nogueira PA, Orlandi PP, Bargieri DY, Blanco YC, Mamoni R, Leite JA, Rodrigues MM, Soares IS, Oliveira TR, Wunderlich G, Lacerda MV, del Portillo HA, Araújo MO, Russell B, Suwanarusk R, Snounou G, Rénia L, Costa FT.

J Infect Dis. 2010 Aug 15;202(4):638-47. doi: 10.1086/654815.


Immunogenic properties of a recombinant fusion protein containing the C-terminal 19 kDa of Plasmodium falciparum merozoite surface protein-1 and the innate immunity agonist FliC flagellin of Salmonella typhimurium.

Bargieri DY, Leite JA, Lopes SC, Sbrogio-Almeida ME, Braga CJ, Ferreira LC, Soares IS, Costa FT, Rodrigues MM.

Vaccine. 2010 Apr 1;28(16):2818-26. doi: 10.1016/j.vaccine.2010.02.004. Epub 2010 Feb 17.


CD8+ T cell adjuvant effects of Salmonella FliCd flagellin in live vaccine vectors or as purified protein.

Braga CJ, Massis LM, Sbrogio-Almeida ME, Alencar BC, Bargieri DY, Boscardin SB, Rodrigues MM, Ferreira LC.

Vaccine. 2010 Feb 3;28(5):1373-82. doi: 10.1016/j.vaccine.2009.11.003. Epub 2009 Nov 21.


New malaria vaccine candidates based on the Plasmodium vivax Merozoite Surface Protein-1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin.

Bargieri DY, Rosa DS, Braga CJ, Carvalho BO, Costa FT, Espíndola NM, Vaz AJ, Soares IS, Ferreira LC, Rodrigues MM.

Vaccine. 2008 Nov 11;26(48):6132-42. doi: 10.1016/j.vaccine.2008.08.070. Epub 2008 Sep 18.


Plasmodium vivax apical membrane antigen-1: comparative recognition of different domains by antibodies induced during natural human infection.

Múfalo BC, Gentil F, Bargieri DY, Costa FT, Rodrigues MM, Soares IS.

Microbes Infect. 2008 Oct;10(12-13):1266-73. doi: 10.1016/j.micinf.2008.07.023. Epub 2008 Jul 22.


Role of interferon-gamma during CpG oligodeoxynucleotide-adjuvanted immunization with recombinant proteins.

Rosa DS, Bastos KR, Bargieri DY, Tzelepis F, Nomizo A, Russo M, Soares IS, Rodrigues MM.

Vaccine. 2007 Aug 10;25(32):6007-17. Epub 2007 Jun 6.


Adjuvant requirement for successful immunization with recombinant derivatives of Plasmodium vivax merozoite surface protein-1 delivered via the intranasal route.

Bargieri DY, Rosa DS, Lasaro MA, Ferreira LC, Soares IS, Rodrigues MM.

Mem Inst Oswaldo Cruz. 2007 Jun;102(3):313-7.


Immunogenicity of a recombinant protein containing the Plasmodium vivax vaccine candidate MSP1(19) and two human CD4+ T-cell epitopes administered to non-human primates (Callithrix jacchus jacchus).

Rosa DS, Iwai LK, Tzelepis F, Bargieri DY, Medeiros MA, Soares IS, Sidney J, Sette A, Kalil J, Mello LE, Cunha-Neto E, Rodrigues MM.

Microbes Infect. 2006 Jul;8(8):2130-7. Epub 2006 Jun 2.


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