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A MAD way to regulate mitosis.

Barford D.

Nat Rev Mol Cell Biol. 2019 Mar;20(3):135. doi: 10.1038/s41580-018-0084-0. No abstract available.


Architecture of the CBF3-centromere complex of the budding yeast kinetochore.

Yan K, Zhang Z, Yang J, McLaughlin SH, Barford D.

Nat Struct Mol Biol. 2018 Dec;25(12):1103-1110. doi: 10.1038/s41594-018-0154-1. Epub 2018 Nov 26.


Methods for Preparing Cryo-EM Grids of Large Macromolecular Complexes.

Chang L, Barford D.

Methods Mol Biol. 2018;1844:209-215. doi: 10.1007/978-1-4939-8706-1_14.


Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13.

Alfieri C, Chang L, Barford D.

Nature. 2018 Jul;559(7713):274-278. doi: 10.1038/s41586-018-0281-1. Epub 2018 Jul 4.


Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).

Alfieri C, Zhang S, Barford D.

Open Biol. 2017 Nov;7(11). pii: 170204. doi: 10.1098/rsob.170204. Review.


The potential of cryo-electron microscopy for structure-based drug design.

Boland A, Chang L, Barford D.

Essays Biochem. 2017 Nov 8;61(5):543-560. doi: 10.1042/EBC20170032. Print 2017 Nov 8. Review.


Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.

Boland A, Martin TG, Zhang Z, Yang J, Bai XC, Chang L, Scheres SH, Barford D.

Nat Struct Mol Biol. 2017 Apr;24(4):414-418. doi: 10.1038/nsmb.3386. Epub 2017 Mar 6.


WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.

Li Q, Chang L, Aibara S, Yang J, Zhang Z, Barford D.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10547-52. doi: 10.1073/pnas.1607147113. Epub 2016 Sep 6.


Molecular basis of APC/C regulation by the spindle assembly checkpoint.

Alfieri C, Chang L, Zhang Z, Yang J, Maslen S, Skehel M, Barford D.

Nature. 2016 Aug 25;536(7617):431-436. doi: 10.1038/nature19083. Epub 2016 Aug 10.


Molecular mechanism of APC/C activation by mitotic phosphorylation.

Zhang S, Chang L, Alfieri C, Zhang Z, Yang J, Maslen S, Skehel M, Barford D.

Nature. 2016 May 12;533(7602):260-264. doi: 10.1038/nature17973. Epub 2016 Apr 27.


Editorial overview: Macromolecular machines and assemblies.

Barford D, Hopfner KP.

Curr Opin Struct Biol. 2016 Apr;37:vi-viii. doi: 10.1016/ Epub 2016 Mar 16. No abstract available.


Data collection with a tailored X-ray beam size at 2.69 Å wavelength (4.6 keV): sulfur SAD phasing of Cdc23(Nterm).

Cianci M, Groves MR, Barford D, Schneider TR.

Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):403-12. doi: 10.1107/S2059798315010268. Epub 2016 Mar 1.


Recombinant expression and reconstitution of multiprotein complexes by the USER cloning method in the insect cell-baculovirus expression system.

Zhang Z, Yang J, Barford D.

Methods. 2016 Feb 15;95:13-25. doi: 10.1016/j.ymeth.2015.10.003. Epub 2015 Oct 9. Review.


Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.

Cronin NB, Yang J, Zhang Z, Kulkarni K, Chang L, Yamano H, Barford D.

J Mol Biol. 2015 Oct 9;427(20):3300-3315. doi: 10.1016/j.jmb.2015.08.023. Epub 2015 Sep 4.


Atomic structure of the APC/C and its mechanism of protein ubiquitination.

Chang L, Zhang Z, Yang J, McLaughlin SH, Barford D.

Nature. 2015 Jun 25;522(7557):450-454. doi: 10.1038/nature14471. Epub 2015 Jun 15.


Understanding the structural basis for controlling chromosome division.

Barford D.

Philos Trans A Math Phys Eng Sci. 2015 Mar 6;373(2036). pii: 20130392. doi: 10.1098/rsta.2013.0392. Review.


Insights into the anaphase-promoting complex: a molecular machine that regulates mitosis.

Chang L, Barford D.

Curr Opin Struct Biol. 2014 Dec;29:1-9. doi: 10.1016/ Epub 2014 Aug 24. Review.


Molecular architecture and mechanism of the anaphase-promoting complex.

Chang LF, Zhang Z, Yang J, McLaughlin SH, Barford D.

Nature. 2014 Sep 18;513(7518):388-393. doi: 10.1038/nature13543. Epub 2014 Jul 20.


Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1.

Manolaridis I, Kulkarni K, Dodd RB, Ogasawara S, Zhang Z, Bineva G, Reilly NO, Hanrahan SJ, Thompson AJ, Cronin N, Iwata S, Barford D.

Nature. 2013 Dec 12;504(7479):301-5. doi: 10.1038/nature12754. Epub 2013 Dec 1.


KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.

Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, Hendricks A, Keogh JM, Henning E, Doree D, Jeter-Jones S, Garg S, Bochukova EG, Bounds R, Ashford S, Gayton E, Hindmarsh PC, Shield JP, Crowne E, Barford D, Wareham NJ; UK10K consortium, O'Rahilly S, Murphy MP, Powell DR, Barroso I, Farooqi IS.

Cell. 2013 Nov 7;155(4):765-77.


Building a pseudo-atomic model of the anaphase-promoting complex.

Kulkarni K, Zhang Z, Chang L, Yang J, da Fonseca PC, Barford D.

Acta Crystallogr D Biol Crystallogr. 2013 Nov;69(Pt 11):2236-43. doi: 10.1107/S0907444913018593. Epub 2013 Oct 12.


Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex.

He J, Chao WC, Zhang Z, Yang J, Cronin N, Barford D.

Mol Cell. 2013 Jun 6;50(5):649-60. doi: 10.1016/j.molcel.2013.04.024. Epub 2013 May 23.


Baculovirus expression: tackling the complexity challenge.

Barford D, Takagi Y, Schultz P, Berger I.

Curr Opin Struct Biol. 2013 Jun;23(3):357-64. doi: 10.1016/ Epub 2013 Apr 27. Review.


The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix.

Zhang Z, Chang L, Yang J, Conin N, Kulkarni K, Barford D.

J Mol Biol. 2013 Nov 15;425(22):4236-48. doi: 10.1016/j.jmb.2013.04.004. Epub 2013 Apr 11.


Regulation of A20 and other OTU deubiquitinases by reversible oxidation.

Kulathu Y, Garcia FJ, Mevissen TE, Busch M, Arnaudo N, Carroll KS, Barford D, Komander D.

Nat Commun. 2013;4:1569. doi: 10.1038/ncomms2567.


Louise N. Johnson 1940-2012.

Barford D, Stuart DI.

Nat Struct Mol Biol. 2012 Dec;19(12):1216-7. doi: 10.1038/nsmb.2464. No abstract available.


Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C).

Zhang Z, Yang J, Kong EH, Chao WC, Morris EP, da Fonseca PC, Barford D.

Biochem J. 2013 Jan 15;449(2):365-71. doi: 10.1042/BJ20121374.


Pellino1 is required for interferon production by viral double-stranded RNA.

Enesa K, Ordureau A, Smith H, Barford D, Cheung PC, Patterson-Kane J, Arthur JS, Cohen P.

J Biol Chem. 2012 Oct 5;287(41):34825-35. doi: 10.1074/jbc.M112.367557. Epub 2012 Aug 17.


Structure of the mitotic checkpoint complex.

Chao WC, Kulkarni K, Zhang Z, Kong EH, Barford D.

Nature. 2012 Mar 21;484(7393):208-13. doi: 10.1038/nature10896.


The structure of the 26S proteasome subunit Rpn2 reveals its PC repeat domain as a closed toroid of two concentric α-helical rings.

He J, Kulkarni K, da Fonseca PC, Krutauz D, Glickman MH, Barford D, Morris EP.

Structure. 2012 Mar 7;20(3):513-21. doi: 10.1016/j.str.2011.12.015.


Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT.

Yang J, Kulkarni K, Manolaridis I, Zhang Z, Dodd RB, Mas-Droux C, Barford D.

Mol Cell. 2011 Dec 23;44(6):997-1004. doi: 10.1016/j.molcel.2011.10.020.


Structural insights into anaphase-promoting complex function and mechanism.

Barford D.

Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27;366(1584):3605-24. doi: 10.1098/rstb.2011.0069. Review.


Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity.

Haque A, Andersen JN, Salmeen A, Barford D, Tonks NK.

Cell. 2011 Sep 30;147(1):185-98. doi: 10.1016/j.cell.2011.08.036.


Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.

Kulkarni K, Yang J, Zhang Z, Barford D.

J Biol Chem. 2011 Jul 15;286(28):25341-51. doi: 10.1074/jbc.M111.236455. Epub 2011 May 24.


Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex.

Gold MG, Stengel F, Nygren PJ, Weisbrod CR, Bruce JE, Robinson CV, Barford D, Scott JD.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6426-31. doi: 10.1073/pnas.1014400108. Epub 2011 Apr 4.


A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.

Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D.

Nature. 2011 Apr 21;472(7343):366-9. doi: 10.1038/nature09860. Epub 2011 Mar 27.


Structural basis for the subunit assembly of the anaphase-promoting complex.

Schreiber A, Stengel F, Zhang Z, Enchev RI, Kong EH, Morris EP, Robinson CV, da Fonseca PC, Barford D.

Nature. 2011 Feb 10;470(7333):227-32. doi: 10.1038/nature09756.


Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor.

da Fonseca PC, Kong EH, Zhang Z, Schreiber A, Williams MA, Morris EP, Barford D.

Nature. 2011 Feb 10;470(7333):274-8. doi: 10.1038/nature09625. Epub 2010 Nov 24.


Structure, function and mechanism of the anaphase promoting complex (APC/C).

Barford D.

Q Rev Biophys. 2011 May;44(2):153-90. doi: 10.1017/S0033583510000259. Epub 2010 Nov 22. Review.


The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27.

Zhang Z, Kulkarni K, Hanrahan SJ, Thompson AJ, Barford D.

EMBO J. 2010 Nov 3;29(21):3733-44. doi: 10.1038/emboj.2010.247. Epub 2010 Oct 5.


Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture.

Zhang Z, Roe SM, Diogon M, Kong E, El Alaoui H, Barford D.

J Mol Biol. 2010 Apr 16;397(5):1316-28. doi: 10.1016/j.jmb.2010.02.045. Epub 2010 Mar 3.


Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.

Yang J, Zhang Z, Roe SM, Marshall CJ, Barford D.

Science. 2009 Sep 11;325(5946):1398-402. doi: 10.1126/science.1174468.


Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains.

Komander D, Reyes-Turcu F, Licchesi JD, Odenwaelder P, Wilkinson KD, Barford D.

EMBO Rep. 2009 May;10(5):466-73. doi: 10.1038/embor.2009.55. Epub 2009 Apr 17.


Eliminylation: a post-translational modification catalyzed by phosphothreonine lyases.

Brennan DF, Barford D.

Trends Biochem Sci. 2009 Mar;34(3):108-14. doi: 10.1016/j.tibs.2008.11.005. Epub 2009 Feb 21.


Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein.

Parker JS, Parizotto EA, Wang M, Roe SM, Barford D.

Mol Cell. 2009 Jan 30;33(2):204-14. doi: 10.1016/j.molcel.2008.12.012.


Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure.

Komander D, Garg R, Wan PT, Ridley AJ, Barford D.

EMBO J. 2008 Dec 3;27(23):3175-85. doi: 10.1038/emboj.2008.226. Epub 2008 Oct 23.


An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling.

Komander D, Patel M, Laurin M, Fradet N, Pelletier A, Barford D, Côté JF.

Mol Biol Cell. 2008 Nov;19(11):4837-51. doi: 10.1091/mbc.E08-04-0345. Epub 2008 Sep 3.


The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module.

Komander D, Lord CJ, Scheel H, Swift S, Hofmann K, Ashworth A, Barford D.

Mol Cell. 2008 Feb 29;29(4):451-64. doi: 10.1016/j.molcel.2007.12.018.


AKAP18 contains a phosphoesterase domain that binds AMP.

Gold MG, Smith FD, Scott JD, Barford D.

J Mol Biol. 2008 Feb 1;375(5):1329-43. Epub 2007 Nov 22.

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