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Pseudokinases: Flipping the ATP for AMPylation.

Bardwell L.

Curr Biol. 2019 Jan 7;29(1):R23-R25. doi: 10.1016/j.cub.2018.11.018.


Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila.

Syed A, Lukacsovich T, Pomeroy M, Bardwell AJ, Decker GT, Waymire KG, Purcell J, Huang W, Gui J, Padilla EM, Park C, Paul A, Pham TBT, Rodriguez Y, Wei S, Worthge S, Zebarjedi R, Zhang B, Bardwell L, Marsh JL, MacGregor GR.

Dev Biol. 2019 Jan 1;445(1):37-53. doi: 10.1016/j.ydbio.2018.10.016. Epub 2018 Oct 25.


The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2.

Bardwell AJ, Lagunes L, Zebarjedi R, Bardwell L.

J Biol Chem. 2017 May 26;292(21):8750-8761. doi: 10.1074/jbc.M116.767087. Epub 2017 Apr 10.


Two hydrophobic residues can determine the specificity of mitogen-activated protein kinase docking interactions.

Bardwell AJ, Bardwell L.

J Biol Chem. 2015 Oct 30;290(44):26661-74. doi: 10.1074/jbc.M115.691436. Epub 2015 Sep 14.


CK2 activates kinesin via induction of a conformational change.

Mattson-Hoss MK, Niitani Y, Gordon EA, Jun Y, Bardwell L, Tomishige M, Gross SP.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7000-5. doi: 10.1073/pnas.1321419111. Epub 2014 Apr 29.


Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate.

Gordon EA, Whisenant TC, Zeller M, Kaake RM, Gordon WM, Krotee P, Patel V, Huang L, Baldi P, Bardwell L.

Cell Signal. 2013 Dec;25(12):2518-29. doi: 10.1016/j.cellsig.2013.08.004. Epub 2013 Aug 24.


Correcting for rater bias in scores on a continuous scale, with application to breast density.

Sperrin M, Bardwell L, Sergeant JC, Astley S, Buchan I.

Stat Med. 2013 Nov 20;32(26):4666-78. doi: 10.1002/sim.5848. Epub 2013 May 15.


Protein scaffolds can enhance the bistability of multisite phosphorylation systems.

Chan C, Liu X, Wang L, Bardwell L, Nie Q, Enciso G.

PLoS Comput Biol. 2012;8(6):e1002551. doi: 10.1371/journal.pcbi.1002551. Epub 2012 Jun 21.


Casein kinase 2 reverses tail-independent inactivation of kinesin-1.

Xu J, Reddy BJ, Anand P, Shu Z, Cermelli S, Mattson MK, Tripathy SK, Hoss MT, James NS, King SJ, Huang L, Bardwell L, Gross SP.

Nat Commun. 2012 Mar 27;3:754. doi: 10.1038/ncomms1760.


Noise filtering tradeoffs in spatial gradient sensing and cell polarization response.

Chou CS, Bardwell L, Nie Q, Yi TM.

BMC Syst Biol. 2011 Dec 13;5:196. doi: 10.1186/1752-0509-5-196.


BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.

Bernardo AS, Faial T, Gardner L, Niakan KK, Ortmann D, Senner CE, Callery EM, Trotter MW, Hemberger M, Smith JC, Bardwell L, Moffett A, Pedersen RA.

Cell Stem Cell. 2011 Aug 5;9(2):144-55. doi: 10.1016/j.stem.2011.06.015.


Connecting food environments and health through the relational nature of aesthetics: gaining insight through the community gardening experience.

Hale J, Knapp C, Bardwell L, Buchenau M, Marshall J, Sancar F, Litt JS.

Soc Sci Med. 2011 Jun;72(11):1853-63. doi: 10.1016/j.socscimed.2011.03.044. Epub 2011 May 1.


Plant signalling pathways: a comparative evolutionary overview.

Hetherington AM, Bardwell L.

Curr Biol. 2011 May 10;21(9):R317-9. doi: 10.1016/j.cub.2011.04.013. No abstract available.


Synthetic biology: modulating the MAP kinase module.

Bardwell L.

Curr Biol. 2011 Apr 12;21(7):R249-51. doi: 10.1016/j.cub.2011.02.042.


A scalable and integrative system for pathway bioinformatics and systems biology.

Compani B, Su T, Chang I, Cheng J, Shah KH, Whisenant T, Dou Y, Bergmann A, Cheong R, Wold B, Bardwell L, Levchenko A, Baldi P, Mjolsness E.

Adv Exp Med Biol. 2010;680:523-34. doi: 10.1007/978-1-4419-5913-3_58.


Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors.

Whisenant TC, Ho DT, Benz RW, Rogers JS, Kaake RM, Gordon EA, Huang L, Baldi P, Bardwell L.

PLoS Comput Biol. 2010 Aug 26;6(8). pii: e1000908. doi: 10.1371/journal.pcbi.1000908.


Ultrasensitive responses and specificity in cell signaling.

Haney S, Bardwell L, Nie Q.

BMC Syst Biol. 2010 Aug 25;4:119. doi: 10.1186/1752-0509-4-119.


A combination of multisite phosphorylation and substrate sequestration produces switchlike responses.

Liu X, Bardwell L, Nie Q.

Biophys J. 2010 Apr 21;98(8):1396-407. doi: 10.1016/j.bpj.2009.12.4307.


Collective efficacy in Denver, Colorado: Strengthening neighborhoods and health through community gardens.

Teig E, Amulya J, Bardwell L, Buchenau M, Marshall JA, Litt JS.

Health Place. 2009 Dec;15(4):1115-22. doi: 10.1016/j.healthplace.2009.06.003. Epub 2009 Jun 21.


Selectivity of docking sites in MAPK kinases.

Bardwell AJ, Frankson E, Bardwell L.

J Biol Chem. 2009 May 8;284(19):13165-73. doi: 10.1074/jbc.M900080200. Epub 2009 Feb 5.


Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis.

Hilioti Z, Sabbagh W Jr, Paliwal S, Bergmann A, Goncalves MD, Bardwell L, Levchenko A.

Curr Biol. 2008 Nov 11;18(21):1700-6. doi: 10.1016/j.cub.2008.09.027. Epub 2008 Oct 30. Erratum in: Curr Biol. 2008 Dec 9;18(23):1897.


Signal transduction: turning a switch into a rheostat.

Bardwell L.

Curr Biol. 2008 Oct 14;18(19):R910-2. doi: 10.1016/j.cub.2008.07.082.


Mathematical models of specificity in cell signaling.

Bardwell L, Zou X, Nie Q, Komarova NL.

Biophys J. 2007 May 15;92(10):3425-41. Epub 2007 Feb 26.


Mechanisms of MAPK signalling specificity.

Bardwell L.

Biochem Soc Trans. 2006 Nov;34(Pt 5):837-41.


G-protein signaling: a new branch in an old pathway.

Bardwell L.

Curr Biol. 2006 Oct 10;16(19):R853-5.


A theoretical framework for specificity in cell signaling.

Komarova NL, Zou X, Nie Q, Bardwell L.

Mol Syst Biol. 2005;1:2005.0023. Epub 2005 Oct 18.


Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases.

Ho DT, Bardwell AJ, Grewal S, Iverson C, Bardwell L.

J Biol Chem. 2006 May 12;281(19):13169-79. Epub 2006 Mar 13.


A walk-through of the yeast mating pheromone response pathway.

Bardwell L.

Peptides. 2005 Feb;26(2):339-50. Review.


A walk-through of the yeast mating pheromone response pathway.

Bardwell L.

Peptides. 2004 Sep;25(9):1465-76. Review. Erratum in: Peptides. 2005 Feb;26(2):337. Corrected and republished in: Peptides. 2005 Feb;26(2):339-50.


A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast.

Cullen PJ, Sabbagh W Jr, Graham E, Irick MM, van Olden EK, Neal C, Delrow J, Bardwell L, Sprague GF Jr.

Genes Dev. 2004 Jul 15;18(14):1695-708.


A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1.

Kusari AB, Molina DM, Sabbagh W Jr, Lau CS, Bardwell L.

J Cell Biol. 2004 Jan 19;164(2):267-77.


A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.

Ho DT, Bardwell AJ, Abdollahi M, Bardwell L.

J Biol Chem. 2003 Aug 29;278(35):32662-72. Epub 2003 Jun 3.


Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation.

Sabbagh W Jr, Flatauer LJ, Bardwell AJ, Bardwell L.

Mol Cell. 2001 Sep;8(3):683-91.


A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission.

Bardwell AJ, Flatauer LJ, Matsukuma K, Thorner J, Bardwell L.

J Biol Chem. 2001 Mar 30;276(13):10374-86. Epub 2000 Dec 28.


Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins.

Bardwell L, Cook JG, Zhu-Shimoni JX, Voora D, Thorner J.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15400-5.


Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.

Bardwell L, Cook JG, Voora D, Baggott DM, Martinez AR, Thorner J.

Genes Dev. 1998 Sep 15;12(18):2887-98.


A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs.

Bardwell L, Thorner J.

Trends Biochem Sci. 1996 Oct;21(10):373-4. No abstract available.


Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription.

Friedberg EC, Bardwell AJ, Bardwell L, Feaver WJ, Kornberg RD, Svejstrup JQ, Tomkinson AE, Wang Z.

Philos Trans R Soc Lond B Biol Sci. 1995 Jan 30;347(1319):63-8. Review.


Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae.

Bardwell L, Cook JG, Inouye CJ, Thorner J.

Dev Biol. 1994 Dec;166(2):363-79. Review.


Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease.

Bardwell AJ, Bardwell L, Tomkinson AE, Friedberg EC.

Science. 1994 Sep 30;265(5181):2082-5.


Recent insights on DNA repair. The mechanism of damaged nucleotide excision in eukaryotes and its relationship to other cellular processes.

Bardwell AJ, Bardwell L, Wang Z, Siede W, Reagan MS, Tomkinson AE, Friedberg AS, Pittenger C, Feaver WJ, Svejstrup J, et al.

Ann N Y Acad Sci. 1994 Jul 29;726:281-91. Review. No abstract available.


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