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Items: 1 to 50 of 137

1.

In vivo chloride concentrations surge to proteotoxic levels during acid stress.

Stull F, Hipp H, Stockbridge RB, Bardwell JCA.

Nat Chem Biol. 2018 Nov;14(11):1051-1058. doi: 10.1038/s41589-018-0143-z. Epub 2018 Oct 15.

PMID:
30323217
2.

Reply to 'Misreading chaperone-substrate complexes from random noise'.

Horowitz S, Salmon L, Koldewey P, Ahlstrom LS, Martin R, Quan S, Afonine PV, van den Bedem H, Wang L, Xu Q, Trievel RC, Brooks CL 3rd, Bardwell JCA.

Nat Struct Mol Biol. 2018 Nov;25(11):990-991. doi: 10.1038/s41594-018-0145-2. No abstract available.

PMID:
30297780
3.

Elaborating a coiled-coil-assembled octahedral protein cage with additional protein domains.

Cristie-David AS, Koldewey P, Meinen BA, Bardwell JCA, Marsh ENG.

Protein Sci. 2018 Nov;27(11):1893-1900. doi: 10.1002/pro.3497. Epub 2018 Oct 3.

PMID:
30113093
4.

Periplasmic Chaperones and Prolyl Isomerases.

Stull F, Betton JM, Bardwell JCA.

EcoSal Plus. 2018 Jul;8(1). doi: 10.1128/ecosalplus.ESP-0005-2018.

PMID:
29988001
5.

Electrostatic interactions are important for chaperone-client interaction in vivo.

Lee C, Kim H, Bardwell JCA.

Microbiology. 2018 Jul;164(7):992-997. doi: 10.1099/mic.0.000676. Epub 2018 Jun 5.

PMID:
29870331
6.

Selecting Conformational Ensembles Using Residual Electron and Anomalous Density (READ).

Salmon L, Ahlstrom LS, Bardwell JCA, Horowitz S.

Methods Mol Biol. 2018;1764:491-504. doi: 10.1007/978-1-4939-7759-8_31.

PMID:
29605935
7.

Folding against the wind.

Stull F, Bardwell JCA.

Nat Chem Biol. 2018 Apr;14(4):329-330. doi: 10.1038/s41589-018-0016-5. No abstract available.

PMID:
29507387
8.

Directed evolution to improve protein folding in vivo.

Sachsenhauser V, Bardwell JC.

Curr Opin Struct Biol. 2018 Feb;48:117-123. doi: 10.1016/j.sbi.2017.12.003. Epub 2017 Dec 23. Review.

9.

The Mechanism of HdeA Unfolding and Chaperone Activation.

Salmon L, Stull F, Sayle S, Cato C, Akgül Ş, Foit L, Ahlstrom LS, Eisenmesser EZ, Al-Hashimi HM, Bardwell JCA, Horowitz S.

J Mol Biol. 2018 Jan 5;430(1):33-40. doi: 10.1016/j.jmb.2017.11.002. Epub 2017 Nov 11.

PMID:
29138002
10.

Symmetry-Directed Self-Assembly of a Tetrahedral Protein Cage Mediated by de Novo-Designed Coiled Coils.

Badieyan S, Sciore A, Eschweiler JD, Koldewey P, Cristie-David AS, Ruotolo BT, Bardwell JCA, Su M, Marsh ENG.

Chembiochem. 2017 Oct 5;18(19):1888-1892. doi: 10.1002/cbic.201700406. Epub 2017 Aug 29.

PMID:
28763578
11.

Folding while bound to chaperones.

Horowitz S, Koldewey P, Stull F, Bardwell JC.

Curr Opin Struct Biol. 2018 Feb;48:1-5. doi: 10.1016/j.sbi.2017.06.009. Epub 2017 Jul 19. Review.

PMID:
28734135
12.

Chaperone-client interactions: Non-specificity engenders multifunctionality.

Koldewey P, Horowitz S, Bardwell JCA.

J Biol Chem. 2017 Jul 21;292(29):12010-12017. doi: 10.1074/jbc.R117.796862. Epub 2017 Jun 15. Review.

13.

Detection of the pH-dependent Activity of Escherichia coli Chaperone HdeB In Vitro and In Vivo.

Dahl JU, Koldewey P, Bardwell JC, Jakob U.

J Vis Exp. 2016 Oct 23;(116). doi: 10.3791/54527.

14.

RNAs as chaperones.

Horowitz S, Bardwell JC.

RNA Biol. 2016 Dec;13(12):1228-1231. Epub 2016 Oct 28.

15.

Corrigendum: Determining crystal structures through crowdsourcing and coursework.

Horowitz S, Koepnick B, Martin R, Tymieniecki A, Winburn AA, Cooper S, Flatten J, Rogawski DS, Koropatkin NM, Hailu TT, Jain N, Koldewey P, Ahlstrom LS, Chapman MR, Sikkema AP, Skiba MA, Maloney FP, Beinlich FR; Foldit Players; University of Michigan students, Popović Z, Baker D, Khatib F, Bardwell JC.

Nat Commun. 2016 Oct 25;7:13392. doi: 10.1038/ncomms13392. No abstract available.

16.

Computational Redesign of Thioredoxin Is Hypersensitive toward Minor Conformational Changes in the Backbone Template.

Johansson KE, Tidemand Johansen N, Christensen S, Horowitz S, Bardwell JCA, Olsen JG, Willemoës M, Lindorff-Larsen K, Ferkinghoff-Borg J, Hamelryck T, Winther JR.

J Mol Biol. 2016 Oct 23;428(21):4361-4377. doi: 10.1016/j.jmb.2016.09.013. Epub 2016 Sep 20.

17.

Determining crystal structures through crowdsourcing and coursework.

Horowitz S, Koepnick B, Martin R, Tymieniecki A, Winburn AA, Cooper S, Flatten J, Rogawski DS, Koropatkin NM, Hailu TT, Jain N, Koldewey P, Ahlstrom LS, Chapman MR, Sikkema AP, Skiba MA, Maloney FP, Beinlich FR; Foldit Players; University of Michigan students, Popović Z, Baker D, Khatib F, Bardwell JC.

Nat Commun. 2016 Sep 16;7:12549. doi: 10.1038/ncomms12549. Erratum in: Nat Commun. 2016 Oct 25;7:13392.

18.

Flexible, symmetry-directed approach to assembling protein cages.

Sciore A, Su M, Koldewey P, Eschweiler JD, Diffley KA, Linhares BM, Ruotolo BT, Bardwell JC, Skiniotis G, Marsh EN.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8681-6. doi: 10.1073/pnas.1606013113. Epub 2016 Jul 18.

19.

Capturing a Dynamic Chaperone-Substrate Interaction Using NMR-Informed Molecular Modeling.

Salmon L, Ahlstrom LS, Horowitz S, Dickson A, Brooks CL 3rd, Bardwell JC.

J Am Chem Soc. 2016 Aug 10;138(31):9826-39. doi: 10.1021/jacs.6b02382. Epub 2016 Aug 2.

20.

Forces Driving Chaperone Action.

Koldewey P, Stull F, Horowitz S, Martin R, Bardwell JCA.

Cell. 2016 Jul 14;166(2):369-379. doi: 10.1016/j.cell.2016.05.054. Epub 2016 Jun 9.

21.

Visualizing chaperone-assisted protein folding.

Horowitz S, Salmon L, Koldewey P, Ahlstrom LS, Martin R, Quan S, Afonine PV, van den Bedem H, Wang L, Xu Q, Trievel RC, Brooks CL 3rd, Bardwell JC.

Nat Struct Mol Biol. 2016 Jul;23(7):691-7. doi: 10.1038/nsmb.3237. Epub 2016 May 30.

22.

Do nucleic acids moonlight as molecular chaperones?

Docter BE, Horowitz S, Gray MJ, Jakob U, Bardwell JC.

Nucleic Acids Res. 2016 Jun 2;44(10):4835-45. doi: 10.1093/nar/gkw291. Epub 2016 Apr 21.

23.

Protein unfolding as a switch from self-recognition to high-affinity client binding.

Groitl B, Horowitz S, Makepeace KA, Petrotchenko EV, Borchers CH, Reichmann D, Bardwell JC, Jakob U.

Nat Commun. 2016 Jan 20;7:10357. doi: 10.1038/ncomms10357.

24.

Substrate protein folds while it is bound to the ATP-independent chaperone Spy.

Stull F, Koldewey P, Humes JR, Radford SE, Bardwell JCA.

Nat Struct Mol Biol. 2016 Jan;23(1):53-58. doi: 10.1038/nsmb.3133. Epub 2015 Nov 30.

25.

Converting a Sulfenic Acid Reductase into a Disulfide Bond Isomerase.

Chatelle C, Kraemer S, Ren G, Chmura H, Marechal N, Boyd D, Roggemans C, Ke N, Riggs P, Bardwell J, Berkmen M.

Antioxid Redox Signal. 2015 Oct 20;23(12):945-57. doi: 10.1089/ars.2014.6235. Epub 2015 Jul 20.

26.

Folding Optimization In Vivo Uncovers New Chaperones.

Lennon CW, Thamsen M, Friman ET, Cacciaglia A, Sachsenhauser V, Sorgenfrei FA, Wasik MA, Bardwell JC.

J Mol Biol. 2015 Sep 11;427(18):2983-94. doi: 10.1016/j.jmb.2015.05.013. Epub 2015 May 21.

27.

HdeB functions as an acid-protective chaperone in bacteria.

Dahl JU, Koldewey P, Salmon L, Horowitz S, Bardwell JC, Jakob U.

J Biol Chem. 2015 Apr 17;290(16):9950. doi: 10.1074/jbc.A114.612986. No abstract available.

28.

HdeB functions as an acid-protective chaperone in bacteria.

Dahl JU, Koldewey P, Salmon L, Horowitz S, Bardwell JC, Jakob U.

J Biol Chem. 2015 Jan 2;290(1):65-75. doi: 10.1074/jbc.M114.612986. Epub 2014 Nov 12. Erratum in: J Biol Chem. 2015 Apr 17;290(16):9950.

29.

Cytosolic selection systems to study protein stability.

Malik A, Mueller-Schickert A, Bardwell JC.

J Bacteriol. 2014 Dec;196(24):4333-43. doi: 10.1128/JB.02215-14. Epub 2014 Sep 29.

30.

Undergraduates improve upon published crystal structure in class assignment.

Horowitz S, Koldewey P, Bardwell JC.

Biochem Mol Biol Educ. 2014 Sep-Oct;42(5):398-404. doi: 10.1002/bmb.20811. Epub 2014 Jul 18.

31.

Development of Verbal HITS for intimate partner violence screening in family medicine.

Shakil A, Bardwell J, Sherin K, Sinacore JM, Zitter R, Kindratt TB.

Fam Med. 2014 Mar;46(3):180-5.

32.

Lymphocyte telomere length is long in BRCA1 and BRCA2 mutation carriers regardless of cancer-affected status.

Pooley KA, McGuffog L, Barrowdale D, Frost D, Ellis SD, Fineberg E, Platte R, Izatt L, Adlard J, Bardwell J, Brewer C, Cole T, Cook J, Davidson R, Donaldson A, Dorkins H, Douglas F, Eason J, Houghton C, Kennedy MJ, McCann E, Miedzybrodzka Z, Murray A, Porteous ME, Rogers MT, Side LE, Tischkowitz M, Walker L, Hodgson S, Eccles DM, Morrison PJ, Evans DG, Eeles RA, Antoniou AC, Easton DF, Dunning AM; EMBRACE;.

Cancer Epidemiol Biomarkers Prev. 2014 Jun;23(6):1018-24. doi: 10.1158/1055-9965.EPI-13-0635-T. Epub 2014 Mar 18.

33.

Polyphosphate is a primordial chaperone.

Gray MJ, Wholey WY, Wagner NO, Cremers CM, Mueller-Schickert A, Hock NT, Krieger AG, Smith EM, Bender RA, Bardwell JC, Jakob U.

Mol Cell. 2014 Mar 6;53(5):689-99. doi: 10.1016/j.molcel.2014.01.012. Epub 2014 Feb 20.

34.

Editorial overview: Folding and binding.

Bardwell JC, Schreiber G.

Curr Opin Struct Biol. 2014 Feb;24:viii-x. doi: 10.1016/j.sbi.2014.01.012. Epub 2014 Feb 6. No abstract available.

PMID:
24508004
35.

Super Spy variants implicate flexibility in chaperone action.

Quan S, Wang L, Petrotchenko EV, Makepeace KA, Horowitz S, Yang J, Zhang Y, Borchers CH, Bardwell JC.

Elife. 2014;3:e01584. doi: 10.7554/eLife.01584. Epub 2014 Feb 4.

36.

Chaperone activation by unfolding.

Foit L, George JS, Zhang BW, Brooks CL 3rd, Bardwell JC.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):E1254-62. doi: 10.1073/pnas.1222458110. Epub 2013 Mar 4.

37.

A tripartite fusion system for the selection of protein variants with increased stability in vivo.

Foit L, Bardwell JC.

Methods Mol Biol. 2013;978:1-20. doi: 10.1007/978-1-62703-293-3_1.

PMID:
23423885
38.

Isolation of bacteria envelope proteins.

Quan S, Hiniker A, Collet JF, Bardwell JC.

Methods Mol Biol. 2013;966:359-66. doi: 10.1007/978-1-62703-245-2_22.

PMID:
23299746
39.

In vivo detection and quantification of chemicals that enhance protein stability.

Hailu TT, Foit L, Bardwell JC.

Anal Biochem. 2013 Mar 1;434(1):181-6. doi: 10.1016/j.ab.2012.11.022. Epub 2012 Dec 5.

40.

Conditional disorder in chaperone action.

Bardwell JC, Jakob U.

Trends Biochem Sci. 2012 Dec;37(12):517-25. doi: 10.1016/j.tibs.2012.08.006. Epub 2012 Sep 24. Review.

41.

Chaperone discovery.

Quan S, Bardwell JC.

Bioessays. 2012 Nov;34(11):973-81. doi: 10.1002/bies.201200059. Epub 2012 Sep 12. Review.

42.

E. coli chaperones DnaK, Hsp33 and Spy inhibit bacterial functional amyloid assembly.

Evans ML, Schmidt JC, Ilbert M, Doyle SM, Quan S, Bardwell JC, Jakob U, Wickner S, Chapman MR.

Prion. 2011 Oct-Dec;5(4):323-34. doi: 10.4161/pri.18555. Epub 2011 Oct 1.

43.

Genetic selection designed to stabilize proteins uncovers a chaperone called Spy.

Quan S, Koldewey P, Tapley T, Kirsch N, Ruane KM, Pfizenmaier J, Shi R, Hofmann S, Foit L, Ren G, Jakob U, Xu Z, Cygler M, Bardwell JC.

Nat Struct Mol Biol. 2011 Mar;18(3):262-9. doi: 10.1038/nsmb.2016. Epub 2011 Feb 13.

44.

Engineered pathways for correct disulfide bond oxidation.

Ren G, Bardwell JC.

Antioxid Redox Signal. 2011 Jun 15;14(12):2399-412. doi: 10.1089/ars.2010.3782. Epub 2011 Mar 31.

45.

Genetic selection for enhanced folding in vivo targets the Cys14-Cys38 disulfide bond in bovine pancreatic trypsin inhibitor.

Foit L, Mueller-Schickert A, Mamathambika BS, Gleiter S, Klaska CL, Ren G, Bardwell JC.

Antioxid Redox Signal. 2011 Mar 15;14(6):973-84. doi: 10.1089/ars.2010.3712. Epub 2011 Jan 23.

46.

Protein refolding by pH-triggered chaperone binding and release.

Tapley TL, Franzmann TM, Chakraborty S, Jakob U, Bardwell JC.

Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1071-6. doi: 10.1073/pnas.0911610107. Epub 2009 Dec 31.

47.

Optimizing protein stability in vivo.

Foit L, Morgan GJ, Kern MJ, Steimer LR, von Hacht AA, Titchmarsh J, Warriner SL, Radford SE, Bardwell JC.

Mol Cell. 2009 Dec 11;36(5):861-71. doi: 10.1016/j.molcel.2009.11.022.

48.

Structural plasticity of an acid-activated chaperone allows promiscuous substrate binding.

Tapley TL, Körner JL, Barge MT, Hupfeld J, Schauerte JA, Gafni A, Jakob U, Bardwell JC.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5557-62. doi: 10.1073/pnas.0811811106. Epub 2009 Mar 24.

49.

Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue.

Ren G, Stephan D, Xu Z, Zheng Y, Tang D, Harrison RS, Kurz M, Jarrott R, Shouldice SR, Hiniker A, Martin JL, Heras B, Bardwell JC.

J Biol Chem. 2009 Apr 10;284(15):10150-9. doi: 10.1074/jbc.M809509200. Epub 2009 Jan 30.

50.

Disulfide-linked protein folding pathways.

Mamathambika BS, Bardwell JC.

Annu Rev Cell Dev Biol. 2008;24:211-35. doi: 10.1146/annurev.cellbio.24.110707.175333. Review.

PMID:
18588487

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