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Fragile X Mental Retardation Protein: To Be or Not to Be a Translational Enhancer.

Maurin T, Bardoni B.

Front Mol Biosci. 2018 Dec 11;5:113. doi: 10.3389/fmolb.2018.00113. eCollection 2018. No abstract available.


New Insights Into the Role of Cav2 Protein Family in Calcium Flux Deregulation in Fmr1-KO Neurons.

Castagnola S, Delhaye S, Folci A, Paquet A, Brau F, Duprat F, Jarjat M, Grossi M, Béal M, Martin S, Mantegazza M, Bardoni B, Maurin T.

Front Mol Neurosci. 2018 Sep 27;11:342. doi: 10.3389/fnmol.2018.00342. eCollection 2018.


Involvement of Phosphodiesterase 2A Activity in the Pathophysiology of Fragile X Syndrome.

Maurin T, Melancia F, Jarjat M, Castro L, Costa L, Delhaye S, Khayachi A, Castagnola S, Mota E, Di Giorgio A, Servadio M, Drozd M, Poupon G, Schiavi S, Sardone L, Azoulay S, Ciranna L, Martin S, Vincent P, Trezza V, Bardoni B.

Cereb Cortex. 2018 Aug 23. doi: 10.1093/cercor/bhy192. [Epub ahead of print]


Exploration and characterisation of the phenotypic and genetic profiles of patients with early onset schizophrenia associated with autism spectrum disorder and their first-degree relatives: a French multicentre case series study protocol (GenAuDiss).

Fernandez A, Dor E, Maurin T, Laure G, Menard ML, Drozd M, Poinso F, Bardoni B, Askenazy F, Thümmler S.

BMJ Open. 2018 Jul 5;8(7):e023330. doi: 10.1136/bmjopen-2018-023330.


Translating molecular advances in Down syndrome and Fragile X syndrome into therapies.

Faundez V, De Toma I, Bardoni B, Bartesaghi R, Nizetic D, de la Torre R, Cohen Kadosh R, Herault Y, Dierssen M, Potier MC; Down Syndrome and Other Genetic Developmental Disorders ECNP Network.

Eur Neuropsychopharmacol. 2018 Jun;28(6):675-690. doi: 10.1016/j.euroneuro.2018.03.006. Epub 2018 Jun 7. Review.


Modeling Fragile X Syndrome in Drosophila.

Drozd M, Bardoni B, Capovilla M.

Front Mol Neurosci. 2018 Apr 16;11:124. doi: 10.3389/fnmol.2018.00124. eCollection 2018. Review.


HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein.

Maurin T, Lebrigand K, Castagnola S, Paquet A, Jarjat M, Popa A, Grossi M, Rage F, Bardoni B.

Nucleic Acids Res. 2018 Jul 6;46(12):6344-6355. doi: 10.1093/nar/gky267.


Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation.

Khayachi A, Gwizdek C, Poupon G, Alcor D, Chafai M, Cassé F, Maurin T, Prieto M, Folci A, De Graeve F, Castagnola S, Gautier R, Schorova L, Loriol C, Pronot M, Besse F, Brau F, Deval E, Bardoni B, Martin S.

Nat Commun. 2018 Feb 22;9(1):757. doi: 10.1038/s41467-018-03222-y.


The Search for an Effective Therapy to Treat Fragile X Syndrome: Dream or Reality?

Castagnola S, Bardoni B, Maurin T.

Front Synaptic Neurosci. 2017 Nov 6;9:15. doi: 10.3389/fnsyn.2017.00015. eCollection 2017. Review.


A new cis-acting motif is required for the axonal SMN-dependent Anxa2 mRNA localization.

Rihan K, Antoine E, Maurin T, Bardoni B, Bordonné R, Soret J, Rage F.

RNA. 2017 Jun;23(6):899-909. doi: 10.1261/rna.056788.116. Epub 2017 Mar 3.


Modeling Fragile X syndrome in neurogenesis: An unexpected phenotype and a novel tool for future therapies.

Bardoni B, Capovilla M, Lalli E.

Neurogenesis (Austin). 2017 Jan 31;4(1):e1270384. doi: 10.1080/23262133.2016.1270384. eCollection 2017.


New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes.

Abekhoukh S, Sahin HB, Grossi M, Zongaro S, Maurin T, Madrigal I, Kazue-Sugioka D, Raas-Rothschild A, Doulazmi M, Carrera P, Stachon A, Scherer S, Drula Do Nascimento MR, Trembleau A, Arroyo I, Szatmari P, Smith IM, Milà M, Smith AC, Giangrande A, Caillé I, Bardoni B.

Dis Model Mech. 2017 Apr 1;10(4):463-474. doi: 10.1242/dmm.025809. Epub 2017 Feb 9.


Depletion of the Fragile X Mental Retardation Protein in Embryonic Stem Cells Alters the Kinetics of Neurogenesis.

Khalfallah O, Jarjat M, Davidovic L, Nottet N, Cestèle S, Mantegazza M, Bardoni B.

Stem Cells. 2017 Feb;35(2):374-385. doi: 10.1002/stem.2505. Epub 2016 Oct 26.


Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons.

Tabet R, Moutin E, Becker JA, Heintz D, Fouillen L, Flatter E, Krężel W, Alunni V, Koebel P, Dembélé D, Tassone F, Bardoni B, Mandel JL, Vitale N, Muller D, Le Merrer J, Moine H.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3619-28. doi: 10.1073/pnas.1522631113. Epub 2016 May 27.


Dendritic targeting of short and long 3' UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins.

Vicario A, Colliva A, Ratti A, Davidovic L, Baj G, Gricman Ł, Colombrita C, Pallavicini A, Jones KR, Bardoni B, Tongiorgi E.

Front Mol Neurosci. 2015 Oct 29;8:62. doi: 10.3389/fnmol.2015.00062. eCollection 2015.


The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum.

Maurin T, Melko M, Abekhoukh S, Khalfallah O, Davidovic L, Jarjat M, D'Antoni S, Catania MV, Moine H, Bechara E, Bardoni B.

Nucleic Acids Res. 2015 Sep 30;43(17):8540-50. doi: 10.1093/nar/gkv801. Epub 2015 Aug 6.


Fragile X mental retardation protein (FMRP) interacting proteins exhibit different expression patterns during development.

Bonaccorso CM, Spatuzza M, Di Marco B, Gloria A, Barrancotto G, Cupo A, Musumeci SA, D'Antoni S, Bardoni B, Catania MV.

Int J Dev Neurosci. 2015 May;42:15-23. doi: 10.1016/j.ijdevneu.2015.02.004. Epub 2015 Feb 11.


Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA.

Schertzer M, Jouravleva K, Perderiset M, Dingli F, Loew D, Le Guen T, Bardoni B, de Villartay JP, Revy P, Londoño-Vallejo A.

Nucleic Acids Res. 2015 Feb 18;43(3):1834-47. doi: 10.1093/nar/gku1402. Epub 2015 Jan 27.


Editorial: neural and behavioral biology of intellectual disability (ID).

Ricceri L, Catania MV, Bardoni B.

Neurosci Biobehav Rev. 2014 Oct;46 Pt 2:159-60. doi: 10.1016/j.neubiorev.2014.10.015. Epub 2014 Nov 8. No abstract available.


Quantitative phosphoproteomics of murine Fmr1-KO cell lines provides new insights into FMRP-dependent signal transduction mechanisms.

Matic K, Eninger T, Bardoni B, Davidovic L, Macek B.

J Proteome Res. 2014 Oct 3;13(10):4388-97. doi: 10.1021/pr5006372. Epub 2014 Sep 15.


CYFIP family proteins between autism and intellectual disability: links with Fragile X syndrome.

Abekhoukh S, Bardoni B.

Front Cell Neurosci. 2014 Mar 27;8:81. doi: 10.3389/fncel.2014.00081. eCollection 2014. Review.


Fragile X Syndrome: from molecular pathology to therapy.

Maurin T, Zongaro S, Bardoni B.

Neurosci Biobehav Rev. 2014 Oct;46 Pt 2:242-55. doi: 10.1016/j.neubiorev.2014.01.006. Epub 2014 Jan 22. Review.


Visual search of neuropil-enriched RNAs from brain in situ hybridization data through the image analysis pipeline hippo-ATESC.

Ugolotti R, Mesejo P, Zongaro S, Bardoni B, Berto G, Bianchi F, Molineris I, Giacobini M, Cagnoni S, Di Cunto F.

PLoS One. 2013 Sep 9;8(9):e74481. doi: 10.1371/journal.pone.0074481. eCollection 2013.


Loss of FMR2 further emphasizes the link between deregulation of immediate early response genes FOS and JUN and intellectual disability.

Melko M, Nguyen LS, Shaw M, Jolly L, Bardoni B, Gecz J.

Hum Mol Genet. 2013 Aug 1;22(15):2984-91. doi: 10.1093/hmg/ddt155. Epub 2013 Apr 5.


A novel role for the RNA-binding protein FXR1P in myoblasts cell-cycle progression by modulating p21/Cdkn1a/Cip1/Waf1 mRNA stability.

Davidovic L, Durand N, Khalfallah O, Tabet R, Barbry P, Mari B, Sacconi S, Moine H, Bardoni B.

PLoS Genet. 2013 Mar;9(3):e1003367. doi: 10.1371/journal.pgen.1003367. Epub 2013 Mar 21.


The 3' UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse.

Zongaro S, Hukema R, D'Antoni S, Davidovic L, Barbry P, Catania MV, Willemsen R, Mari B, Bardoni B.

Hum Mol Genet. 2013 May 15;22(10):1971-82. doi: 10.1093/hmg/ddt044. Epub 2013 Feb 5.


Intellectual disabilities, neuronal posttranscriptional RNA metabolism, and RNA-binding proteins: three actors for a complex scenario.

Bardoni B, Abekhoukh S, Zongaro S, Melko M.

Prog Brain Res. 2012;197:29-51. doi: 10.1016/B978-0-444-54299-1.00003-0. Review.


A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model.

Davidovic L, Navratil V, Bonaccorso CM, Catania MV, Bardoni B, Dumas ME.

Genome Res. 2011 Dec;21(12):2190-202. doi: 10.1101/gr.116764.110. Epub 2011 Sep 7.


Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability.

Melko M, Douguet D, Bensaid M, Zongaro S, Verheggen C, Gecz J, Bardoni B.

Hum Mol Genet. 2011 May 15;20(10):1873-85. doi: 10.1093/hmg/ddr069. Epub 2011 Feb 17.


The role of G-quadruplex in RNA metabolism: involvement of FMRP and FMR2P.

Melko M, Bardoni B.

Biochimie. 2010 Aug;92(8):919-26. doi: 10.1016/j.biochi.2010.05.018. Epub 2010 Jun 4. Review.


Dax-1 knockdown in mouse embryonic stem cells induces loss of pluripotency and multilineage differentiation.

Khalfallah O, Rouleau M, Barbry P, Bardoni B, Lalli E.

Stem Cells. 2009 Jul;27(7):1529-37. doi: 10.1002/stem.78.


A novel function for fragile X mental retardation protein in translational activation.

Bechara EG, Didiot MC, Melko M, Davidovic L, Bensaid M, Martin P, Castets M, Pognonec P, Khandjian EW, Moine H, Bardoni B.

PLoS Biol. 2009 Jan 20;7(1):e16. doi: 10.1371/journal.pbio.1000016.


FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure.

Bensaid M, Melko M, Bechara EG, Davidovic L, Berretta A, Catania MV, Gecz J, Lalli E, Bardoni B.

Nucleic Acids Res. 2009 Mar;37(4):1269-79. doi: 10.1093/nar/gkn1058. Epub 2009 Jan 9.


Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients.

Davidovic L, Sacconi S, Bechara EG, Delplace S, Allegra M, Desnuelle C, Bardoni B.

J Med Genet. 2008 Oct;45(10):679-85. doi: 10.1136/jmg.2008.060541. Epub 2008 Jul 15.


The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery.

Boulon S, Marmier-Gourrier N, Pradet-Balade B, Wurth L, Verheggen C, Jády BE, Rothé B, Pescia C, Robert MC, Kiss T, Bardoni B, Krol A, Branlant C, Allmang C, Bertrand E, Charpentier B.

J Cell Biol. 2008 Feb 11;180(3):579-95. doi: 10.1083/jcb.200708110.


The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules.

Davidovic L, Jaglin XH, Lepagnol-Bestel AM, Tremblay S, Simonneau M, Bardoni B, Khandjian EW.

Hum Mol Genet. 2007 Dec 15;16(24):3047-58. Epub 2007 Sep 19.


Fragile X related protein 1 isoforms differentially modulate the affinity of fragile X mental retardation protein for G-quartet RNA structure.

Bechara E, Davidovic L, Melko M, Bensaid M, Tremblay S, Grosgeorge J, Khandjian EW, Lalli E, Bardoni B.

Nucleic Acids Res. 2007;35(1):299-306. Epub 2006 Dec 14.


Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.

Kim Y, Sung JY, Ceglia I, Lee KW, Ahn JH, Halford JM, Kim AM, Kwak SP, Park JB, Ho Ryu S, Schenck A, Bardoni B, Scott JD, Nairn AC, Greengard P.

Nature. 2006 Aug 17;442(7104):814-7. Epub 2006 Jul 16.


The fragile X syndrome: exploring its molecular basis and seeking a treatment.

Bardoni B, Davidovic L, Bensaid M, Khandjian EW.

Expert Rev Mol Med. 2006 Apr 21;8(8):1-16. Review.


The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons.

Davidovic L, Bechara E, Gravel M, Jaglin XH, Tremblay S, Sik A, Bardoni B, Khandjian EW.

Hum Mol Genet. 2006 May 1;15(9):1525-38. Epub 2006 Mar 28.


The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction.

Ramos A, Hollingworth D, Adinolfi S, Castets M, Kelly G, Frenkiel TA, Bardoni B, Pastore A.

Structure. 2006 Jan;14(1):21-31.


FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts.

Castets M, Schaeffer C, Bechara E, Schenck A, Khandjian EW, Luche S, Moine H, Rabilloud T, Mandel JL, Bardoni B.

Hum Mol Genet. 2005 Mar 15;14(6):835-44. Epub 2005 Feb 9.


WAVE/SCAR, a multifunctional complex coordinating different aspects of neuronal connectivity.

Schenck A, Qurashi A, Carrera P, Bardoni B, Diebold C, Schejter E, Mandel JL, Giangrande A.

Dev Biol. 2004 Oct 15;274(2):260-70.


Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles.

Khandjian EW, Huot ME, Tremblay S, Davidovic L, Mazroui R, Bardoni B.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13357-62. Epub 2004 Aug 25.


Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo.

Mientjes EJ, Willemsen R, Kirkpatrick LL, Nieuwenhuizen IM, Hoogeveen-Westerveld M, Verweij M, Reis S, Bardoni B, Hoogeveen AT, Oostra BA, Nelson DL.

Hum Mol Genet. 2004 Jul 1;13(13):1291-302. Epub 2004 May 5.


CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion.

Mayne M, Moffatt T, Kong H, McLaren PJ, Fowke KR, Becker KG, Namaka M, Schenck A, Bardoni B, Bernstein CN, Melanson M.

Eur J Immunol. 2004 Apr;34(4):1217-27.


The N-terminus of the fragile X mental retardation protein contains a novel domain involved in dimerization and RNA binding.

Adinolfi S, Ramos A, Martin SR, Dal Piaz F, Pucci P, Bardoni B, Mandel JL, Pastore A.

Biochemistry. 2003 Sep 9;42(35):10437-44.


NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes.

Bardoni B, Willemsen R, Weiler IJ, Schenck A, Severijnen LA, Hindelang C, Lalli E, Mandel JL.

Exp Cell Res. 2003 Sep 10;289(1):95-107.


82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization.

Bardoni B, Castets M, Huot ME, Schenck A, Adinolfi S, Corbin F, Pastore A, Khandjian EW, Mandel JL.

Hum Mol Genet. 2003 Jul 15;12(14):1689-98.


CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.

Schenck A, Bardoni B, Langmann C, Harden N, Mandel JL, Giangrande A.

Neuron. 2003 Jun 19;38(6):887-98.

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