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Items: 47


Lymphocyte mechanotransduction: The regulatory role of cytoskeletal dynamics in signaling cascades and effector functions.

Ben-Shmuel A, Joseph N, Sabag B, Barda-Saad M.

J Leukoc Biol. 2019 Jun;105(6):1261-1273. doi: 10.1002/JLB.MR0718-267R. Epub 2019 Feb 1. Review.


Commentary: Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse.

Ben-Shmuel A, Joseph N, Barda-Saad M.

Front Immunol. 2018 Sep 19;9:2110. doi: 10.3389/fimmu.2018.02110. eCollection 2018. No abstract available.


The Ebola-Glycoprotein Modulates the Function of Natural Killer Cells.

Edri A, Shemesh A, Iraqi M, Matalon O, Brusilovsky M, Hadad U, Radinsky O, Gershoni-Yahalom O, Dye JM, Mandelboim O, Barda-Saad M, Lobel L, Porgador A.

Front Immunol. 2018 Jul 2;9:1428. doi: 10.3389/fimmu.2018.01428. eCollection 2018.


Actin retrograde flow controls natural killer cell response by regulating the conformation state of SHP-1.

Matalon O, Ben-Shmuel A, Kivelevitz J, Sabag B, Fried S, Joseph N, Noy E, Biber G, Barda-Saad M.

EMBO J. 2018 Mar 1;37(5). pii: e96264. doi: 10.15252/embj.201696264. Epub 2018 Feb 15.


New Structural Insights into Formation of the Key Actin Regulating WIP-WASp Complex Determined by NMR and Molecular Imaging.

Halle-Bikovski A, Fried S, Rozentur-Shkop E, Biber G, Shaked H, Joseph N, Barda-Saad M, Chill JH.

ACS Chem Biol. 2018 Jan 19;13(1):100-109. doi: 10.1021/acschembio.7b00486. Epub 2017 Dec 7.


Robo Ig4 Is a Dimerization Domain.

Yom-Tov G, Barak R, Matalon O, Barda-Saad M, Guez-Haddad J, Opatowsky Y.

J Mol Biol. 2017 Nov 24;429(23):3606-3616. doi: 10.1016/j.jmb.2017.10.002. Epub 2017 Oct 7.


A conformational change within the WAVE2 complex regulates its degradation following cellular activation.

Joseph N, Biber G, Fried S, Reicher B, Levy O, Sabag B, Noy E, Barda-Saad M.

Sci Rep. 2017 Mar 23;7:44863. doi: 10.1038/srep44863.


Cbl ubiquitin ligases mediate the inhibition of natural killer cell activity.

Matalon O, Barda-Saad M.

Commun Integr Biol. 2016 Sep 8;9(6):e1216739. doi: 10.1080/19420889.2016.1216739. eCollection 2016.


Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity.

Matalon O, Fried S, Ben-Shmuel A, Pauker MH, Joseph N, Keizer D, Piterburg M, Barda-Saad M.

Sci Signal. 2016 May 24;9(429):ra54. doi: 10.1126/scisignal.aad6182.


RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK.

Ziv-Av A, Giladi ND, Lee HK, Cazacu S, Finniss S, Xiang C, Pauker MH, Barda-Saad M, Poisson L, Brodie C.

Oncotarget. 2015 Aug 14;6(23):19826-40.


New insights into the role of the disordered WIP N-terminal domain revealed by NMR structural characterization.

Elazari-Shalom H, Shaked H, Esteban-Martin S, Salvatella X, Barda-Saad M, Chill JH.

FEBS J. 2015 Feb;282(4):700-14. doi: 10.1111/febs.13174. Epub 2015 Jan 8.


WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site.

Pauker MH, Reicher B, Joseph N, Wortzel I, Jakubowicz S, Noy E, Perl O, Barda-Saad M.

J Biol Chem. 2014 Dec 12;289(50):34503-19. doi: 10.1074/jbc.M114.591685. Epub 2014 Oct 23.


Ubiquitylation-dependent downregulation of Nck regulates its functional activity.

Joseph N, Reicher B, David A, Matalon O, Barda-Saad M.

FEBS Lett. 2014 Nov 3;588(21):3808-15. doi: 10.1016/j.febslet.2014.08.033. Epub 2014 Sep 16.


WIP: more than a WASp-interacting protein.

Fried S, Matalon O, Noy E, Barda-Saad M.

J Leukoc Biol. 2014 Nov;96(5):713-27. doi: 10.1189/jlb.2RU0314-162R. Epub 2014 Sep 10. Review.


Triple-color FRET analysis reveals conformational changes in the WIP-WASp actin-regulating complex.

Fried S, Reicher B, Pauker MH, Eliyahu S, Matalon O, Noy E, Chill J, Barda-Saad M.

Sci Signal. 2014 Jun 24;7(331):ra60. doi: 10.1126/scisignal.2005198.


The nucleolar PICT-1/GLTSCR2 protein forms homo-oligomers.

Borodianskiy-Shteinberg T, Kalt I, Kipper S, Nachum N, Katz S, Pauker MH, Barda-Saad M, Gerber D, Sarid R.

J Mol Biol. 2014 Jun 12;426(12):2363-78. doi: 10.1016/j.jmb.2014.04.006. Epub 2014 Apr 13.


Unique ζ-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation.

Klieger Y, Almogi-Hazan O, Ish-Shalom E, Pato A, Pauker MH, Barda-Saad M, Wang L, Baniyash M.

Eur J Immunol. 2014 Jan;44(1):58-68. doi: 10.1002/eji.201243099. Epub 2013 Nov 4.


Wiskott-Aldrich syndrome protein--dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes.

Matalon O, Reicher B, Barda-Saad M.

Immunol Rev. 2013 Nov;256(1):10-29. doi: 10.1111/imr.12112. Review.


NMR determines transient structure and dynamics in the disordered C-terminal domain of WASp interacting protein.

Haba NY, Gross R, Novacek J, Shaked H, Zidek L, Barda-Saad M, Chill JH.

Biophys J. 2013 Jul 16;105(2):481-93. doi: 10.1016/j.bpj.2013.05.046.


The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux.

Joseph N, Reicher B, Barda-Saad M.

Biochim Biophys Acta. 2014 Feb;1838(2):557-68. doi: 10.1016/j.bbamem.2013.07.009. Epub 2013 Jul 13. Review.


Real-time live imaging of T-cell signaling complex formation.

Noy E, Pauker MH, Barda-Saad M.

J Vis Exp. 2013 Jun 23;(76). doi: 10.3791/50076.


T helper 17 polarization in familial Mediterranean fever.

Ovadia A, Livneh A, Feld O, Ben-Zvi I, Kukuy E, Kivity S, Lidar M, Barda-Saad M, Shinar Y.

Genes Immun. 2013 Jun;14(4):212-6. doi: 10.1038/gene.2013.6. Epub 2013 Mar 7.


WIP remodeling actin behind the scenes: how WIP reshapes immune and other functions.

Noy E, Fried S, Matalon O, Barda-Saad M.

Int J Mol Sci. 2012;13(6):7629-47. doi: 10.3390/ijms13067629. Epub 2012 Jun 21. Review.


Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics.

Reicher B, Joseph N, David A, Pauker MH, Perl O, Barda-Saad M.

Mol Cell Biol. 2012 Aug;32(15):3153-63. doi: 10.1128/MCB.00161-12. Epub 2012 Jun 4.


Studying the dynamics of SLP-76, Nck, and Vav1 multimolecular complex formation in live human cells with triple-color FRET.

Pauker MH, Hassan N, Noy E, Reicher B, Barda-Saad M.

Sci Signal. 2012 Apr 24;5(221):rs3. doi: 10.1126/scisignal.2002423.


Studies of novel interactions between Nck and VAV SH3 domains.

Pauker MH, Barda-Saad M.

Commun Integr Biol. 2011 Mar;4(2):175-7. doi: 10.4161/cib.4.2.14235.


Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.

Pauker MH, Reicher B, Fried S, Perl O, Barda-Saad M.

Mol Cell Biol. 2011 Jul;31(13):2653-66. doi: 10.1128/MCB.01358-10. Epub 2011 May 2.


Multiple pathways leading from the T-cell antigen receptor to the actin cytoskeleton network.

Reicher B, Barda-Saad M.

FEBS Lett. 2010 Dec 15;584(24):4858-64. doi: 10.1016/j.febslet.2010.09.002. Epub 2010 Sep 7. Review.


Cooperative interactions at the SLP-76 complex are critical for actin polymerization.

Barda-Saad M, Shirasu N, Pauker MH, Hassan N, Perl O, Balbo A, Yamaguchi H, Houtman JC, Appella E, Schuck P, Samelson LE.

EMBO J. 2010 Jul 21;29(14):2315-28. doi: 10.1038/emboj.2010.133. Epub 2010 Jun 18.


Incomplete T-cell receptor-beta peptides target the mitochondrion and induce apoptosis.

Shani N, Rubin-Lifshitz H, Peretz-Cohen Y, Shkolnik K, Shinder V, Cohen-Sfady M, Shav-Tal Y, Barda-Saad M, Zipori D.

Blood. 2009 Apr 9;113(15):3530-41. doi: 10.1182/blood-2008-07-171405. Epub 2008 Oct 17.


Bam32: a novel mediator of Erk activation in T cells.

Sommers CL, Gurson JM, Surana R, Barda-Saad M, Lee J, Kishor A, Li W, Gasser AJ, Barr VA, Miyaji M, Love PE, Samelson LE.

Int Immunol. 2008 Jul;20(7):811-8. doi: 10.1093/intimm/dxn039. Epub 2008 Apr 29.


c-Cbl-mediated regulation of LAT-nucleated signaling complexes.

Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.

Mol Cell Biol. 2007 Dec;27(24):8622-36. Epub 2007 Oct 15.


T-cell antigen receptor-induced signaling complexes: internalization via a cholesterol-dependent endocytic pathway.

Barr VA, Balagopalan L, Barda-Saad M, Polishchuk R, Boukari H, Bunnell SC, Bernot KM, Toda Y, Nossal R, Samelson LE.

Traffic. 2006 Sep;7(9):1143-62.


Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.

Houtman JC, Yamaguchi H, Barda-Saad M, Braiman A, Bowden B, Appella E, Schuck P, Samelson LE.

Nat Struct Mol Biol. 2006 Sep;13(9):798-805. Epub 2006 Aug 13.


Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains.

Braiman A, Barda-Saad M, Sommers CL, Samelson LE.

EMBO J. 2006 Feb 22;25(4):774-84. Epub 2006 Feb 9.


Examining multiprotein signaling complexes from all angles.

Houtman JC, Barda-Saad M, Samelson LE.

FEBS J. 2005 Nov;272(21):5426-35. Review.


Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways.

Houtman JC, Houghtling RA, Barda-Saad M, Toda Y, Samelson LE.

J Immunol. 2005 Aug 15;175(4):2449-58.


Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

Barda-Saad M, Braiman A, Titerence R, Bunnell SC, Barr VA, Samelson LE.

Nat Immunol. 2005 Jan;6(1):80-9. Epub 2004 Nov 21.


The mesenchymal stroma negatively regulates B cell lymphopoiesis through the expression of activin A.

Shoham T, Parameswaran R, Shav-Tal Y, Barda-Saad M, Zipori D.

Ann N Y Acad Sci. 2003 May;996:245-60.


The mesenchyme expresses T cell receptor mRNAs: relevance to cell growth control.

Barda-Saad M, Shav-Tal Y, Rozenszajn AL, Cohen M, Zauberman A, Karmazyn A, Parameswaran R, Schori H, Ashush H, Ben-Nun A, Zipori D.

Oncogene. 2002 Mar 27;21(13):2029-36.


The promotion of plasmacytoma tumor growth by mesenchymal stroma is antagonized by basic fibroblast growth factor induced activin A.

Shoham T, Sternberg D, Brosh N, Krupsky M, Barda-Saad M, Zipori D.

Leukemia. 2001 Jul;15(7):1102-10.


Role of activin A in negative regulation of normal and tumor B lymphocytes.

Zipori D, Barda-Saad M.

J Leukoc Biol. 2001 Jun;69(6):867-73. Review.


Apoptosis induction of human myeloid leukemic cells by ultrasound exposure.

Ashush H, Rozenszajn LA, Blass M, Barda-Saad M, Azimov D, Radnay J, Zipori D, Rosenschein U.

Cancer Res. 2000 Feb 15;60(4):1014-20.


Adhesion molecules involved in the interactions between early T cells and mesenchymal bone marrow stromal cells.

Barda-Saad M, Rozenszajn LA, Ashush H, Shav-Tal Y, Ben Nun A, Zipori D.

Exp Hematol. 1999 May;27(5):834-44.


Adhesion of thymocytes to bone marrow stromal cells: regulation by bFGF and IFN-gamma.

Barda-Saad M, Zhang AS, Zipori D, Rozenszajn LA.

Stem Cells. 1997;15(3):229-36.


Selective adhesion of immature thymocytes to bone marrow stromal cells: relevance to T cell lymphopoiesis.

Barda-Saad M, Rozenszajn LA, Globerson A, Zhang AS, Zipori D.

Exp Hematol. 1996 Feb;24(2):386-91.


[T-lymphocyte colony enhancing factor].

Barda-Saad M, Sredni D, Zemer R, Lenz R, Rozensajn LA.

Harefuah. 1990 Jan 15;118(2):92-5. Review. Hebrew. No abstract available.


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