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Pregnancy-related immune suppression leads to altered influenza vaccine recall responses.

Shah NM, Imami N, Kelleher P, Barclay WS, Johnson MR.

Clin Immunol. 2019 Aug 27;208:108254. doi: 10.1016/j.clim.2019.108254. [Epub ahead of print]


Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor.

Giotis ES, Carnell G, Young EF, Ghanny S, Soteropoulos P, Wang LF, Barclay WS, Skinner MA, Temperton N.

Nat Microbiol. 2019 Jul 29. doi: 10.1038/s41564-019-0517-3. [Epub ahead of print]


Host Determinants of Influenza RNA Synthesis.

Peacock TP, Sheppard CM, Staller E, Barclay WS.

Annu Rev Virol. 2019 Jul 5. doi: 10.1146/annurev-virology-092917-043339. [Epub ahead of print]


ANP32 Proteins Are Essential for Influenza Virus Replication in Human Cells.

Staller E, Sheppard CM, Neasham PJ, Mistry B, Peacock TP, Goldhill DH, Long JS, Barclay WS.

J Virol. 2019 Aug 13;93(17). pii: e00217-19. doi: 10.1128/JVI.00217-19. Print 2019 Sep 1.


Influenza Virus with Increased pH of Hemagglutinin Activation Has Improved Replication in Cell Culture but at the Cost of Infectivity in Human Airway Epithelium.

Singanayagam A, Zambon M, Barclay WS.

J Virol. 2019 Aug 13;93(17). pii: e00058-19. doi: 10.1128/JVI.00058-19. Print 2019 Sep 1.


Receptor for bat influenza virus uncovers potential risk to humans.

Barclay WS.

Nature. 2019 Mar;567(7746):35-36. doi: 10.1038/d41586-019-00580-5. No abstract available.


The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells.

James J, Smith N, Ross C, Iqbal M, Goodbourn S, Digard P, Barclay WS, Shelton H.

J Gen Virol. 2019 Mar;100(3):414-430. doi: 10.1099/jgv.0.001220. Epub 2019 Jan 23.


Publisher Correction: Host and viral determinants of influenza A virus species specificity.

Long JS, Mistry B, Haslam SM, Barclay WS.

Nat Rev Microbiol. 2019 Jan;17(2):124. doi: 10.1038/s41579-018-0140-y.


Host and viral determinants of influenza A virus species specificity.

Long JS, Mistry B, Haslam SM, Barclay WS.

Nat Rev Microbiol. 2019 Jan;17(2):67-81. doi: 10.1038/s41579-018-0115-z. Review. Erratum in: Nat Rev Microbiol. 2018 Dec 18;:.


Determining the Mutation Bias of Favipiravir in Influenza Virus Using Next-Generation Sequencing.

Goldhill DH, Langat P, Xie H, Galiano M, Miah S, Kellam P, Zambon M, Lackenby A, Barclay WS.

J Virol. 2019 Jan 4;93(2). pii: e01217-18. doi: 10.1128/JVI.01217-18. Print 2019 Jan 15.


The mechanism of resistance to favipiravir in influenza.

Goldhill DH, Te Velthuis AJW, Fletcher RA, Langat P, Zambon M, Lackenby A, Barclay WS.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11613-11618. doi: 10.1073/pnas.1811345115. Epub 2018 Oct 23.


Assays to Measure the Activity of Influenza Virus Polymerase.

Te Velthuis AJW, Long JS, Barclay WS.

Methods Mol Biol. 2018;1836:343-374. doi: 10.1007/978-1-4939-8678-1_17.


Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice.

Li H, Bradley KC, Long JS, Frise R, Ashcroft JW, Hartgroves LC, Shelton H, Makris S, Johansson C, Cao B, Barclay WS.

PLoS Pathog. 2018 Jan 4;14(1):e1006821. doi: 10.1371/journal.ppat.1006821. eCollection 2018 Jan.


Influenza: a world of discoveries, outbreaks and controversy.

Barclay WS.

J Gen Virol. 2017 May;98(5):892-894. doi: 10.1099/jgv.0.000812. Epub 2017 May 24.


Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics.

Peacock TP, Benton DJ, James J, Sadeyen JR, Chang P, Sealy JE, Bryant JE, Martin SR, Shelton H, Barclay WS, Iqbal M.

J Virol. 2017 Jun 26;91(14). pii: e00218-17. doi: 10.1128/JVI.00218-17. Print 2017 Jul 15.


Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion.

Peacock TP, Benton DJ, Sadeyen JR, Chang P, Sealy JE, Bryant JE, Martin SR, Shelton H, McCauley JW, Barclay WS, Iqbal M.

Emerg Microbes Infect. 2017 Mar 22;6(3):e11. doi: 10.1038/emi.2016.139.


Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window.

James J, Howard W, Iqbal M, Nair VK, Barclay WS, Shelton H.

J Gen Virol. 2016 Oct;97(10):2516-2527. doi: 10.1099/jgv.0.000584. Epub 2016 Aug 23.


Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance.

Frise R, Bradley K, van Doremalen N, Galiano M, Elderfield RA, Stilwell P, Ashcroft JW, Fernandez-Alonso M, Miah S, Lackenby A, Roberts KL, Donnelly CA, Barclay WS.

Sci Rep. 2016 Jul 19;6:29793. doi: 10.1038/srep29793.


An engineered avian-origin influenza A virus for pancreatic ductal adenocarcinoma virotherapy.

Pizzuto MS, Silic-Benussi M, Ciminale V, Elderfield RA, Capua I, Barclay WS.

J Gen Virol. 2016 Sep;97(9):2166-2179. doi: 10.1099/jgv.0.000549. Epub 2016 Jul 14.


Computational and molecular analysis of conserved influenza A virus RNA secondary structures involved in infectious virion production.

Kobayashi Y, Dadonaite B, van Doremalen N, Suzuki Y, Barclay WS, Pybus OG.

RNA Biol. 2016 Sep;13(9):883-94. doi: 10.1080/15476286.2016.1208331. Epub 2016 Jul 11.


Species difference in ANP32A underlies influenza A virus polymerase host restriction.

Long JS, Giotis ES, Moncorgé O, Frise R, Mistry B, James J, Morisson M, Iqbal M, Vignal A, Skinner MA, Barclay WS.

Nature. 2016 Jan 7;529(7584):101-4. doi: 10.1038/nature16474.


NB protein does not affect influenza B virus replication in vitro and is not required for replication in or transmission between ferrets.

Elderfield RA, Koutsakos M, Frise R, Bradley K, Ashcroft J, Miah S, Lackenby A, Barclay WS.

J Gen Virol. 2016 Mar;97(3):593-601. doi: 10.1099/jgv.0.000386. Epub 2015 Dec 24.


Knowns and unknowns of influenza B viruses.

Koutsakos M, Nguyen TH, Barclay WS, Kedzierska K.

Future Microbiol. 2016;11(1):119-35. doi: 10.2217/fmb.15.120. Epub 2015 Dec 18. Review.


The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein.

Liu M, Lam MK, Zhang Q, Elderfield R, Barclay WS, Shaw PC.

PLoS One. 2015 Sep 14;10(9):e0137802. doi: 10.1371/journal.pone.0137802. eCollection 2015.


Amino acid substitution D222N from fatal influenza infection affects receptor-binding properties of the influenza A(H1N1)pdm09 virus.

Matos-Patrón A, Byrd-Leotis L, Steinhauer DA, Barclay WS, Ayora-Talavera G.

Virology. 2015 Oct;484:15-21. doi: 10.1016/j.virol.2015.05.012. Epub 2015 Jun 5.


Ferret airway epithelial cell cultures support efficient replication of influenza B virus but not mumps virus.

Elderfield RA, Parker L, Stilwell P, Roberts KL, Schepelmann S, Barclay WS.

J Gen Virol. 2015 Aug;96(8):2092-8. doi: 10.1099/vir.0.000176. Epub 2015 May 6.


One-way trip: influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential.

Long JS, Benfield CT, Barclay WS.

Bioessays. 2015 Feb;37(2):204-12. doi: 10.1002/bies.201400133. Epub 2014 Dec 28. Erratum in: Bioessays. 2015 Apr;37(4):463.


Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.

Elderfield RA, Watson SJ, Godlee A, Adamson WE, Thompson CI, Dunning J, Fernandez-Alonso M, Blumenkrantz D, Hussell T; MOSAIC Investigators, Zambon M, Openshaw P, Kellam P, Barclay WS.

J Virol. 2014 Nov;88(22):13269-83. doi: 10.1128/JVI.01636-14. Epub 2014 Sep 10.


Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies.

Jia N, Barclay WS, Roberts K, Yen HL, Chan RW, Lam AK, Air G, Peiris JS, Dell A, Nicholls JM, Haslam SM.

J Biol Chem. 2014 Oct 10;289(41):28489-504. doi: 10.1074/jbc.M114.588541. Epub 2014 Aug 18.


Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor.

Goujon C, Moncorgé O, Bauby H, Doyle T, Barclay WS, Malim MH.

J Virol. 2014 Aug;88(16):9017-26. doi: 10.1128/JVI.01269-14. Epub 2014 Jun 4.


Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir.

Marriott AC, Dove BK, Whittaker CJ, Bruce C, Ryan KA, Bean TJ, Rayner E, Pearson G, Taylor I, Dowall S, Plank J, Newman E, Barclay WS, Dimmock NJ, Easton AJ, Hallis B, Silman NJ, Carroll MW.

PLoS One. 2014 Apr 7;9(4):e94090. doi: 10.1371/journal.pone.0094090. eCollection 2014.


Viral determinants of influenza A virus host range.

Cauldwell AV, Long JS, Moncorgé O, Barclay WS.

J Gen Virol. 2014 Jun;95(Pt 6):1193-210. doi: 10.1099/vir.0.062836-0. Epub 2014 Feb 28. Review.


Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.

Goujon C, Moncorgé O, Bauby H, Doyle T, Ward CC, Schaller T, Hué S, Barclay WS, Schulz R, Malim MH.

Nature. 2013 Oct 24;502(7472):559-62. doi: 10.1038/nature12542. Epub 2013 Sep 18.


The short stalk length of highly pathogenic avian influenza H5N1 virus neuraminidase limits transmission of pandemic H1N1 virus in ferrets.

Blumenkrantz D, Roberts KL, Shelton H, Lycett S, Barclay WS.

J Virol. 2013 Oct;87(19):10539-51. doi: 10.1128/JVI.00967-13. Epub 2013 Jul 17.


The effect of the PB2 mutation 627K on highly pathogenic H5N1 avian influenza virus is dependent on the virus lineage.

Long JS, Howard WA, Núñez A, Moncorgé O, Lycett S, Banks J, Barclay WS.

J Virol. 2013 Sep;87(18):9983-96. doi: 10.1128/JVI.01399-13. Epub 2013 Jul 10.


Harnessing alveolar macrophages for sustained mucosal T-cell recall confers long-term protection to mice against lethal influenza challenge without clinical disease.

Macdonald DC, Singh H, Whelan MA, Escors D, Arce F, Bottoms SE, Barclay WS, Maini M, Collins MK, Rosenberg WM.

Mucosal Immunol. 2014 Jan;7(1):89-100. doi: 10.1038/mi.2013.27. Epub 2013 May 29.


Obesity and susceptibility to severe outcomes following respiratory viral infection.

Almond MH, Edwards MR, Barclay WS, Johnston SL.

Thorax. 2013 Jul;68(7):684-6. doi: 10.1136/thoraxjnl-2012-203009. Epub 2013 Feb 22. Review.


Transmission studies resume for avian flu.

Fouchier RA, García-Sastre A, Kawaoka Y, Barclay WS, Bouvier NM, Brown IH, Capua I, Chen H, Compans RW, Couch RB, Cox NJ, Doherty PC, Donis RO, Feldmann H, Guan Y, Katz JM, Kiselev OI, Klenk HD, Kobinger G, Liu J, Liu X, Lowen A, Mettenleiter TC, Osterhaus AD, Palese P, Peiris JS, Perez DR, Richt JA, Schultz-Cherry S, Steel J, Subbarao K, Swayne DE, Takimoto T, Tashiro M, Taubenberger JK, Thomas PG, Tripp RA, Tumpey TM, Webby RJ, Webster RG.

Science. 2013 Feb 1;339(6119):520-1. doi: 10.1126/science.1235140. Epub 2013 Jan 23. No abstract available.


Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cells.

Cauldwell AV, Moncorgé O, Barclay WS.

J Virol. 2013 Jan;87(2):1278-84. doi: 10.1128/JVI.02597-12. Epub 2012 Oct 31.


Investigation of influenza virus polymerase activity in pig cells.

Moncorgé O, Long JS, Cauldwell AV, Zhou H, Lycett SJ, Barclay WS.

J Virol. 2013 Jan;87(1):384-94. doi: 10.1128/JVI.01633-12. Epub 2012 Oct 17.


Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model.

Roberts KL, Shelton H, Stilwell P, Barclay WS.

PLoS One. 2012;7(8):e43303. doi: 10.1371/journal.pone.0043303. Epub 2012 Aug 29.


Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults.

Sridhar S, Begom S, Bermingham A, Ziegler T, Roberts KL, Barclay WS, Openshaw P, Lalvani A.

Eur J Immunol. 2012 Nov;42(11):2913-24. doi: 10.1002/eji.201242504. Epub 2012 Aug 15.


Immune responses in pigs vaccinated with adjuvanted and non-adjuvanted A(H1N1)pdm/09 influenza vaccines used in human immunization programmes.

Lefevre EA, Carr BV, Inman CF, Prentice H, Brown IH, Brookes SM, Garcon F, Hill ML, Iqbal M, Elderfield RA, Barclay WS, Gubbins S, Bailey M, Charleston B; COSI.

PLoS One. 2012;7(3):e32400. doi: 10.1371/journal.pone.0032400. Epub 2012 Mar 9.


Pause on avian flu transmission research.

Fouchier RA, García-Sastre A, Kawaoka Y, Barclay WS, Bouvier NM, Brown IH, Capua I, Chen H, Compans RW, Couch RB, Cox NJ, Doherty PC, Donis RO, Feldmann H, Guan Y, Katz J, Klenk HD, Kobinger G, Liu J, Liu X, Lowen A, Mettenleiter TC, Osterhaus AD, Palese P, Peiris JS, Perez DR, Richt JA, Schultz-Cherry S, Steel J, Subbarao K, Swayne DE, Takimoto T, Tashiro M, Taubenberger JK, Thomas PG, Tripp RA, Tumpey TM, Webby RJ, Webster RG.

Science. 2012 Jan 27;335(6067):400-1. doi: 10.1126/science.335.6067.400. No abstract available.


A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets.

van Doremalen N, Shelton H, Roberts KL, Jones IM, Pickles RJ, Thompson CI, Barclay WS.

PLoS One. 2011;6(10):e25755. doi: 10.1371/journal.pone.0025755. Epub 2011 Oct 5.


Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo.

Roberts KL, Shelton H, Scull M, Pickles R, Barclay WS.

J Gen Virol. 2011 Aug;92(Pt 8):1822-31. doi: 10.1099/vir.0.031203-0. Epub 2011 Apr 20.


Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase.

Foeglein Á, Loucaides EM, Mura M, Wise HM, Barclay WS, Digard P.

J Gen Virol. 2011 Jul;92(Pt 7):1650-61. doi: 10.1099/vir.0.031492-0. Epub 2011 Apr 6.


Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines.

Loureiro S, Ren J, Phapugrangkul P, Colaco CA, Bailey CR, Shelton H, Molesti E, Temperton NJ, Barclay WS, Jones IM.

J Virol. 2011 Mar;85(6):3010-4. doi: 10.1128/JVI.01241-10. Epub 2010 Dec 29.


Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness.

Brookes DW, Miah S, Lackenby A, Hartgroves L, Barclay WS.

J Antimicrob Chemother. 2011 Mar;66(3):466-70. doi: 10.1093/jac/dkq486. Epub 2010 Dec 16.

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