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Items: 1 to 50 of 71

1.

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.

Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A, Jentzsch M, Falk-Paulsen M, Stengel ST, Welz L, Schwarzer R, Rabe B, Barchet W, Krautwald S, Hartmann G, Pasparakis M, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P.

J Exp Med. 2018 Nov 5;215(11):2868-2886. doi: 10.1084/jem.20171029. Epub 2018 Sep 25.

2.

SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells.

Yu CF, Peng WM, Schlee M, Barchet W, Eis-Hübinger AM, Kolanus W, Geyer M, Schmitt S, Steinhagen F, Oldenburg J, Novak N.

J Immunol. 2018 Jun 15;200(12):4024-4035. doi: 10.4049/jimmunol.1700510. Epub 2018 Apr 30.

PMID:
29712772
3.

NAB2 is a novel immune stimulator of MDA-5 that promotes a strong type I interferon response.

Oberson A, Spagnuolo L, Puddinu V, Barchet W, Rittner K, Bourquin C.

Oncotarget. 2017 Dec 15;9(5):5641-5651. doi: 10.18632/oncotarget.23725. eCollection 2018 Jan 19.

4.

Type I interferon-mediated autoinflammation due to DNase II deficiency.

Rodero MP, Tesser A, Bartok E, Rice GI, Della Mina E, Depp M, Beitz B, Bondet V, Cagnard N, Duffy D, Dussiot M, Frémond ML, Gattorno M, Guillem F, Kitabayashi N, Porcheray F, Rieux-Laucat F, Seabra L, Uggenti C, Volpi S, Zeef LAH, Alyanakian MA, Beltrand J, Bianco AM, Boddaert N, Brouzes C, Candon S, Caorsi R, Charbit M, Fabre M, Faletra F, Girard M, Harroche A, Hartmann E, Lasne D, Marcuzzi A, Neven B, Nitschke P, Pascreau T, Pastore S, Picard C, Picco P, Piscianz E, Polak M, Quartier P, Rabant M, Stocco G, Taddio A, Uettwiller F, Valencic E, Vozzi D, Hartmann G, Barchet W, Hermine O, Bader-Meunier B, Tommasini A, Crow YJ.

Nat Commun. 2017 Dec 19;8(1):2176. doi: 10.1038/s41467-017-01932-3.

5.

Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes.

Steinhagen F, Zillinger T, Peukert K, Fox M, Thudium M, Barchet W, Putensen C, Klinman D, Latz E, Bode C.

Eur J Immunol. 2018 Apr;48(4):605-611. doi: 10.1002/eji.201747338. Epub 2017 Dec 27.

PMID:
29215161
6.

RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.

Coch C, Stümpel JP, Lilien-Waldau V, Wohlleber D, Kümmerer BM, Bekeredjian-Ding I, Kochs G, Garbi N, Herberhold S, Schuberth-Wagner C, Ludwig J, Barchet W, Schlee M, Hoerauf A, Bootz F, Staeheli P, Hartmann G, Hartmann E.

Mol Ther. 2017 Sep 6;25(9):2093-2103. doi: 10.1016/j.ymthe.2017.07.003. Epub 2017 Jul 8.

7.

Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus.

Scholtissek B, Zahn S, Maier J, Klaeschen S, Braegelmann C, Hoelzel M, Bieber T, Barchet W, Wenzel J.

J Invest Dermatol. 2017 Jul;137(7):1484-1492. doi: 10.1016/j.jid.2017.03.018. Epub 2017 Mar 27.

8.

CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.

Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W.

Immunity. 2017 Feb 21;46(2):205-219. doi: 10.1016/j.immuni.2017.01.003. Epub 2017 Feb 9.

9.

G-rich DNA-induced stress response blocks type-I-IFN but not CXCL10 secretion in monocytes.

Herzner AM, Wolter S, Zillinger T, Schmitz S, Barchet W, Hartmann G, Bartok E, Schlee M.

Sci Rep. 2016 Dec 12;6:38405. doi: 10.1038/srep38405.

10.

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites.

Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C.

Cell Host Microbe. 2016 Oct 12;20(4):443-457. doi: 10.1016/j.chom.2016.09.003.

11.

MDA-5 activation by cytoplasmic double-stranded RNA impairs endothelial function and aggravates atherosclerosis.

Asdonk T, Steinmetz M, Krogmann A, Ströcker C, Lahrmann C, Motz I, Paul-Krahe K, Flender A, Schmitz T, Barchet W, Hartmann G, Nickenig G, Zimmer S.

J Cell Mol Med. 2016 Sep;20(9):1696-705. doi: 10.1111/jcmm.12864. Epub 2016 Apr 29.

12.

Exonuclease TREX1 also Has a Sweet Tooth.

Barchet W, Zillinger T.

Immunity. 2015 Sep 15;43(3):411-3. doi: 10.1016/j.immuni.2015.08.026.

13.

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.

Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M.

Nat Immunol. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7.

14.

Translating nucleic acid-sensing pathways into therapies.

Junt T, Barchet W.

Nat Rev Immunol. 2015 Sep 15;15(9):529-44. doi: 10.1038/nri3875. Epub 2015 Aug 21. Review.

PMID:
26292638
15.

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

Schuberth-Wagner C, Ludwig J, Bruder AK, Herzner AM, Zillinger T, Goldeck M, Schmidt T, Schmid-Burgk JL, Kerber R, Wolter S, Stümpel JP, Roth A, Bartok E, Drosten C, Coch C, Hornung V, Barchet W, Kümmerer BM, Hartmann G, Schlee M.

Immunity. 2015 Jul 21;43(1):41-51. doi: 10.1016/j.immuni.2015.06.015. Epub 2015 Jul 14.

16.

Accumulation of ALDH1-positive cells after neoadjuvant chemotherapy predicts treatment resistance and prognosticates poor outcome in ovarian cancer.

Ayub TH, Keyver-Paik MD, Debald M, Rostamzadeh B, Thiesler T, Schröder L, Barchet W, Abramian A, Kaiser C, Kristiansen G, Kuhn W, Kübler K.

Oncotarget. 2015 Jun 30;6(18):16437-48.

17.

The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.

Jaeger M, van der Lee R, Cheng SC, Johnson MD, Kumar V, Ng A, Plantinga TS, Smeekens SP, Oosting M, Wang X, Barchet W, Fitzgerald K, Joosten LAB, Perfect JR, Wijmenga C, van de Veerdonk FL, Huynen MA, Xavier RJ, Kullberg BJ, Netea MG.

Eur J Clin Microbiol Infect Dis. 2015 May;34(5):963-974. doi: 10.1007/s10096-014-2309-2. Epub 2015 Jan 13.

18.

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

Gao P, Zillinger T, Wang W, Ascano M, Dai P, Hartmann G, Tuschl T, Deng L, Barchet W, Patel DJ.

Cell Rep. 2014 Sep 25;8(6):1668-1676. doi: 10.1016/j.celrep.2014.08.010. Epub 2014 Sep 4.

19.

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.

Goubau D, Schlee M, Deddouche S, Pruijssers AJ, Zillinger T, Goldeck M, Schuberth C, Van der Veen AG, Fujimura T, Rehwinkel J, Iskarpatyoti JA, Barchet W, Ludwig J, Dermody TS, Hartmann G, Reis e Sousa C.

Nature. 2014 Oct 16;514(7522):372-375. doi: 10.1038/nature13590. Epub 2014 Aug 10.

20.

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.

Liehl P, Zuzarte-Luís V, Chan J, Zillinger T, Baptista F, Carapau D, Konert M, Hanson KK, Carret C, Lassnig C, Müller M, Kalinke U, Saeed M, Chora AF, Golenbock DT, Strobl B, Prudêncio M, Coelho LP, Kappe SH, Superti-Furga G, Pichlmair A, Vigário AM, Rice CM, Fitzgerald KA, Barchet W, Mota MM.

Nat Med. 2014 Jan;20(1):47-53. doi: 10.1038/nm.3424. Epub 2013 Dec 22.

21.

Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

Niemeyer D, Zillinger T, Muth D, Zielecki F, Horvath G, Suliman T, Barchet W, Weber F, Drosten C, Müller MA.

J Virol. 2013 Nov;87(22):12489-95. doi: 10.1128/JVI.01845-13. Epub 2013 Sep 11.

22.

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

Gehrke N, Mertens C, Zillinger T, Wenzel J, Bald T, Zahn S, Tüting T, Hartmann G, Barchet W.

Immunity. 2013 Sep 19;39(3):482-95. doi: 10.1016/j.immuni.2013.08.004. Epub 2013 Aug 29.

23.

A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA.

Coch C, Lück C, Schwickart A, Putschli B, Renn M, Höller T, Barchet W, Hartmann G, Schlee M.

PLoS One. 2013 Aug 5;8(8):e71057. doi: 10.1371/journal.pone.0071057. Print 2013.

24.

Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.

Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ.

Cell. 2013 Aug 15;154(4):748-62. doi: 10.1016/j.cell.2013.07.023. Epub 2013 Aug 1.

25.

RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells.

Hagmann CA, Herzner AM, Abdullah Z, Zillinger T, Jakobs C, Schuberth C, Coch C, Higgins PG, Wisplinghoff H, Barchet W, Hornung V, Hartmann G, Schlee M.

PLoS One. 2013 Apr 30;8(4):e62872. doi: 10.1371/journal.pone.0062872. Print 2013.

26.

Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Gao P, Ascano M, Wu Y, Barchet W, Gaffney BL, Zillinger T, Serganov AA, Liu Y, Jones RA, Hartmann G, Tuschl T, Patel DJ.

Cell. 2013 May 23;153(5):1094-107. doi: 10.1016/j.cell.2013.04.046. Epub 2013 May 3.

27.

Nitrosative stress: a hallmark of the junctional inflammation in cutaneous lupus erythematosus.

Zahn S, Graef M, Barchet W, Bieber T, Tüting T, Wenzel J.

Clin Exp Dermatol. 2013 Jan;38(1):96-7. doi: 10.1111/j.1365-2230.2012.04472.x. Epub 2012 Oct 22. No abstract available.

PMID:
23083377
28.

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids.

Abdullah Z, Schlee M, Roth S, Mraheil MA, Barchet W, Böttcher J, Hain T, Geiger S, Hayakawa Y, Fritz JH, Civril F, Hopfner KP, Kurts C, Ruland J, Hartmann G, Chakraborty T, Knolle PA.

EMBO J. 2012 Nov 5;31(21):4153-64. doi: 10.1038/emboj.2012.274. Epub 2012 Oct 12.

29.

Nucleic acid adjuvants: toward an educated vaccine.

van den Boorn JG, Barchet W, Hartmann G.

Adv Immunol. 2012;114:1-32. doi: 10.1016/B978-0-12-396548-6.00001-9. Review.

PMID:
22449776
30.

Endothelial RIG-I activation impairs endothelial function.

Asdonk T, Motz I, Werner N, Coch C, Barchet W, Hartmann G, Nickenig G, Zimmer S.

Biochem Biophys Res Commun. 2012 Mar 30;420(1):66-71. doi: 10.1016/j.bbrc.2012.02.116. Epub 2012 Feb 28.

PMID:
22402283
31.

Delivery with polycations extends the immunostimulant Ribomunyl into a potent antiviral Toll-like receptor 7/8 agonist.

Herberhold S, Coch C, Zillinger T, Hommertgen B, Busch N, Schuberth C, Hartmann E, Wimmenauer V, Hagmann CA, Lüdenbach B, Schlee M, Bootz F, Hartmann G, Barchet W.

Antivir Ther. 2011;16(5):751-8. doi: 10.3851/IMP1822.

PMID:
21817197
32.

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.

Lippmann J, Müller HC, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B.

Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24.

33.

Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells.

Kübler K, tho Pesch C, Gehrke N, Riemann S, Dassler J, Coch C, Landsberg J, Wimmenauer V, Pölcher M, Rudlowski C, Tüting T, Kuhn W, Hartmann G, Barchet W.

Eur J Immunol. 2011 Oct;41(10):3028-39. doi: 10.1002/eji.201141555. Epub 2011 Aug 30.

34.

Enhanced skin expression of melanoma differentiation-associated gene 5 (MDA5) in dermatomyositis and related autoimmune diseases.

Zahn S, Barchet W, Rehkämper C, Hornung T, Bieber T, Tüting T, Wenzel J.

J Am Acad Dermatol. 2011 May;64(5):988-9. doi: 10.1016/j.jaad.2010.08.004. No abstract available.

PMID:
21496705
35.

Activation of endothelial toll-like receptor 3 impairs endothelial function.

Zimmer S, Steinmetz M, Asdonk T, Motz I, Coch C, Hartmann E, Barchet W, Wassmann S, Hartmann G, Nickenig G.

Circ Res. 2011 May 27;108(11):1358-66. doi: 10.1161/CIRCRESAHA.111.243246. Epub 2011 Apr 14.

PMID:
21493895
36.

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

Züst R, Cervantes-Barragan L, Habjan M, Maier R, Neuman BW, Ziebuhr J, Szretter KJ, Baker SC, Barchet W, Diamond MS, Siddell SG, Ludewig B, Thiel V.

Nat Immunol. 2011 Feb;12(2):137-43. doi: 10.1038/ni.1979. Epub 2011 Jan 9.

37.

Monocyte-mediated inhibition of TLR9-dependent IFN-α induction in plasmacytoid dendritic cells questions bacterial DNA as the active ingredient of bacterial lysates.

Poth JM, Coch C, Busch N, Boehm O, Schlee M, Janke M, Zillinger T, Schildgen O, Barchet W, Hartmann G.

J Immunol. 2010 Dec 15;185(12):7367-73. doi: 10.4049/jimmunol.1001798. Epub 2010 Nov 5.

38.

Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease.

Gibbert K, Dietze KK, Zelinskyy G, Lang KS, Barchet W, Kirschning CJ, Dittmer U.

J Immunol. 2010 Nov 15;185(10):6179-89. doi: 10.4049/jimmunol.1000858. Epub 2010 Oct 13.

39.

Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells.

Kübler K, Gehrke N, Riemann S, Böhnert V, Zillinger T, Hartmann E, Pölcher M, Rudlowski C, Kuhn W, Hartmann G, Barchet W.

Cancer Res. 2010 Jul 1;70(13):5293-304. doi: 10.1158/0008-5472.CAN-10-0825. Epub 2010 Jun 15.

40.

Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation.

Yu CF, Peng WM, Oldenburg J, Hoch J, Bieber T, Limmer A, Hartmann G, Barchet W, Eis-Hübinger AM, Novak N.

J Immunol. 2010 Feb 1;184(3):1159-67. doi: 10.4049/jimmunol.0901706. Epub 2009 Dec 21.

41.

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.

Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschläger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J.

Nat Immunol. 2010 Jan;11(1):63-9. doi: 10.1038/ni.1824. Epub 2009 Nov 15. Erratum in: Nat Immunol. 2014 Jan;15(1):109.

PMID:
19915568
42.

Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self-DNA based on CpG-specific recognition of phosphodiester DNA.

Coch C, Busch N, Wimmenauer V, Hartmann E, Janke M, Abdel-Mottaleb MM, Lamprecht A, Ludwig J, Barchet W, Schlee M, Hartmann G.

J Leukoc Biol. 2009 Sep;86(3):663-70. doi: 10.1189/jlb.0509314. Epub 2009 Jul 20.

PMID:
19620253
43.

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.

Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G.

Immunity. 2009 Jul 17;31(1):25-34. doi: 10.1016/j.immuni.2009.05.008. Epub 2009 Jul 2.

44.

Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus.

Anz D, Thaler R, Stephan N, Waibler Z, Trauscheid MJ, Scholz C, Kalinke U, Barchet W, Endres S, Bourquin C.

J Immunol. 2009 May 15;182(10):6044-50. doi: 10.4049/jimmunol.0803809.

45.

Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8.

Janke M, Poth J, Wimmenauer V, Giese T, Coch C, Barchet W, Schlee M, Hartmann G.

J Allergy Clin Immunol. 2009 May;123(5):1026-33. doi: 10.1016/j.jaci.2009.02.015. Epub 2009 Apr 10.

PMID:
19361845
46.

Approaching the RNA ligand for RIG-I?

Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G.

Immunol Rev. 2009 Jan;227(1):66-74. doi: 10.1111/j.1600-065X.2008.00724.x. Review.

PMID:
19120476
47.

Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation.

Ney JT, Schmidt T, Kurts C, Zhou Q, Eckert D, Felsher DW, Schorle H, Knolle P, Tüting T, Barchet W, Büttner R, Limmer A, Gütgemann I.

Hepatology. 2009 Feb;49(2):471-81. doi: 10.1002/hep.22652. Erratum in: Hepatology. 2009 Mar;49(3):1058.

PMID:
19105207
48.

Accessing the therapeutic potential of immunostimulatory nucleic acids.

Barchet W, Wimmenauer V, Schlee M, Hartmann G.

Curr Opin Immunol. 2008 Aug;20(4):389-95. doi: 10.1016/j.coi.2008.07.007. Epub 2008 Jul 30. Review.

PMID:
18652893
49.

RNA recognition via TLR7 and TLR8.

Hornung V, Barchet W, Schlee M, Hartmann G.

Handb Exp Pharmacol. 2008;(183):71-86. Review.

PMID:
18071655
50.

Beyond double-stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids.

Schlee M, Barchet W, Hornung V, Hartmann G.

Curr Top Microbiol Immunol. 2007;316:207-30. Review.

PMID:
17969450

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