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Items: 1 to 50 of 145

1.

Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End-Joining.

Liu Q, Ma L, Jones T, Palomero L, Pujana MA, Martinez-Ruiz H, Ha PK, Murnane J, Cuartas I, Seoane J, Baumann M, Linge A, Barcellos-Hoff MH.

Clin Cancer Res. 2018 Aug 7. pii: clincanres.1346.2018. doi: 10.1158/1078-0432.CCR-18-1346. [Epub ahead of print]

PMID:
30087144
2.

Evaluation of Radioresponse and Radiosensitizers in Glioblastoma Organotypic Cultures.

Bayin NS, Ma L, Placantonakis DG, Barcellos-Hoff MH.

Methods Mol Biol. 2018;1741:171-182. doi: 10.1007/978-1-4939-7659-1_13.

PMID:
29392699
3.

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells.

Bayin NS, Frenster JD, Sen R, Si S, Modrek AS, Galifianakis N, Dolgalev I, Ortenzi V, Illa-Bochaca I, Khahera A, Serrano J, Chiriboga L, Zagzag D, Golfinos JG, Doyle W, Tsirigos A, Heguy A, Chesler M, Barcellos-Hoff MH, Snuderl M, Placantonakis DG.

Oncotarget. 2017 May 23;8(39):64932-64953. doi: 10.18632/oncotarget.18117. eCollection 2017 Sep 12.

4.

Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016.

Citrin DE, Prasanna PGS, Walker AJ, Freeman ML, Eke I, Barcellos-Hoff MH, Arankalayil MJ, Cohen EP, Wilkins RC, Ahmed MM, Anscher MS, Movsas B, Buchsbaum JC, Mendonca MS, Wynn TA, Coleman CN.

Radiat Res. 2017 Jul;188(1):1-20. doi: 10.1667/RR14784.1. Epub 2017 May 10.

5.

Hydrogen Peroxide Enhances TGFβ-mediated Epithelial-to-Mesenchymal Transition in Human Mammary Epithelial MCF-10A Cells.

Iizuka D, Sasatani M, Barcellos-Hoff MH, Kamiya K.

Anticancer Res. 2017 Mar;37(3):987-995.

PMID:
28314256
6.

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

Mateo F, Arenas EJ, Aguilar H, Serra-Musach J, de Garibay GR, Boni J, Maicas M, Du S, Iorio F, Herranz-Ors C, Islam A, Prado X, Llorente A, Petit A, Vidal A, Català I, Soler T, Venturas G, Rojo-Sebastian A, Serra H, Cuadras D, Blanco I, Lozano J, Canals F, Sieuwerts AM, de Weerd V, Look MP, Puertas S, García N, Perkins AS, Bonifaci N, Skowron M, Gómez-Baldó L, Hernández V, Martínez-Aranda A, Martínez-Iniesta M, Serrat X, Cerón J, Brunet J, Barretina MP, Gil M, Falo C, Fernández A, Morilla I, Pernas S, Plà MJ, Andreu X, Seguí MA, Ballester R, Castellà E, Nellist M, Morales S, Valls J, Velasco A, Matias-Guiu X, Figueras A, Sánchez-Mut JV, Sánchez-Céspedes M, Cordero A, Gómez-Miragaya J, Palomero L, Gómez A, Gajewski TF, Cohen EEW, Jesiotr M, Bodnar L, Quintela-Fandino M, López-Bigas N, Valdés-Mas R, Puente XS, Viñals F, Casanovas O, Graupera M, Hernández-Losa J, Ramón Y Cajal S, García-Alonso L, Saez-Rodriguez J, Esteller M, Sierra A, Martín-Martín N, Matheu A, Carracedo A, González-Suárez E, Nanjundan M, Cortés J, Lázaro C, Odero MD, Martens JWM, Moreno-Bueno G, Barcellos-Hoff MH, Villanueva A, Gomis RR, Pujana MA.

Oncogene. 2017 May 11;36(19):2737-2749. doi: 10.1038/onc.2016.427. Epub 2016 Dec 19.

7.

Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-β Small Molecule Inhibitor.

Bayin NS, Ma L, Thomas C, Baitalmal R, Sure A, Fansiwala K, Bustoros M, Golfinos JG, Pacione D, Snuderl M, Zagzag D, Barcellos-Hoff MH, Placantonakis D.

Neoplasia. 2016 Dec;18(12):795-805. doi: 10.1016/j.neo.2016.08.008.

8.

A TGFβ-miR-182-BRCA1 axis controls the mammary differentiation hierarchy.

Martinez-Ruiz H, Illa-Bochaca I, Omene C, Hanniford D, Liu Q, Hernando E, Barcellos-Hoff MH.

Sci Signal. 2016 Dec 6;9(457):ra118.

9.

"Praising What Is Lost. . .

Barcellos-Hoff MH, Iliakis G, Jeggo P, McKenna G, O'Neil P, Wallace S.

Radiat Res. 2015 Dec;184(6):563-4. No abstract available.

PMID:
27064149
10.

HZE Radiation Non-Targeted Effects on the Microenvironment That Mediate Mammary Carcinogenesis.

Barcellos-Hoff MH, Mao JH.

Front Oncol. 2016 Mar 11;6:57. doi: 10.3389/fonc.2016.00057. eCollection 2016. Review.

11.

Subverting misconceptions about radiation therapy.

Formenti SC, Demaria S, Barcellos-Hoff MH, McBride WH.

Nat Immunol. 2016 Apr;17(4):345. doi: 10.1038/ni.3363. No abstract available.

PMID:
27002831
12.

ICRP Publication 131: Stem cell biology with respect to carcinogenesis aspects of radiological protection.

Hendry JH, Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S.

Ann ICRP. 2016 Jun;45(1 Suppl):239-52. doi: 10.1177/0146645315621849. Epub 2016 Mar 8.

PMID:
26956677
13.

The Microenvironment of Lung Cancer and Therapeutic Implications.

Mittal V, El Rayes T, Narula N, McGraw TE, Altorki NK, Barcellos-Hoff MH.

Adv Exp Med Biol. 2016;890:75-110. doi: 10.1007/978-3-319-24932-2_5. Review.

PMID:
26703800
14.

ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection.

Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Hendry JH, Jacob P, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S; ICRP.

Ann ICRP. 2015 Dec;44(3-4):7-357. doi: 10.1177/0146645315595585. Review.

PMID:
26637346
15.

TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair.

Qiang L, Shah P, Barcellos-Hoff MH, He YY.

Oncogene. 2016 Jun 23;35(25):3293-302. doi: 10.1038/onc.2015.390. Epub 2015 Oct 19.

16.

Concepts and challenges in cancer risk prediction for the space radiation environment.

Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ Jr, Gerson S, Hlatky L, Kirsch DG, Luderer U, Shay J, Wang Y, Weil MM.

Life Sci Space Res (Amst). 2015 Jul;6:92-103. doi: 10.1016/j.lssr.2015.07.006. Epub 2015 Jul 17. Review.

17.

The effect of environmental chemicals on the tumor microenvironment.

Casey SC, Vaccari M, Al-Mulla F, Al-Temaimi R, Amedei A, Barcellos-Hoff MH, Brown DG, Chapellier M, Christopher J, Curran CS, Forte S, Hamid RA, Heneberg P, Koch DC, Krishnakumar PK, Laconi E, Maguer-Satta V, Marongiu F, Memeo L, Mondello C, Raju J, Roman J, Roy R, Ryan EP, Ryeom S, Salem HK, Scovassi AI, Singh N, Soucek L, Vermeulen L, Whitfield JR, Woodrick J, Colacci A, Bisson WH, Felsher DW.

Carcinogenesis. 2015 Jun;36 Suppl 1:S160-83. doi: 10.1093/carcin/bgv035. Review.

18.

Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells.

Decarlo L, Mestel C, Barcellos-Hoff MH, Schneider RJ.

Mol Cell Biol. 2015 Aug;35(15):2597-609. doi: 10.1128/MCB.00324-15. Epub 2015 May 18.

19.

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity.

Vanpouille-Box C, Diamond JM, Pilones KA, Zavadil J, Babb JS, Formenti SC, Barcellos-Hoff MH, Demaria S.

Cancer Res. 2015 Jun 1;75(11):2232-42. doi: 10.1158/0008-5472.CAN-14-3511. Epub 2015 Apr 9.

20.

Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo.

Du S, Bouquet S, Lo CH, Pellicciotta I, Bolourchi S, Parry R, Barcellos-Hoff MH.

Int J Radiat Oncol Biol Phys. 2015 Jan 1;91(1):91-9. doi: 10.1016/j.ijrobp.2014.09.026.

PMID:
25835621
21.

BUB1-bling over with possibilities.

Barcellos-Hoff MH.

Neoplasia. 2015 Feb;17(2):153-4. doi: 10.1016/j.neo.2015.01.002.

22.

Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment.

Zhang P, Lo A, Huang Y, Huang G, Liang G, Mott J, Karpen GH, Blakely EA, Bissell MJ, Barcellos-Hoff MH, Snijders AM, Mao JH.

Sci Rep. 2015 Mar 9;5:8919. doi: 10.1038/srep08919.

23.

Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells.

Huh SJ, Clement K, Jee D, Merlini A, Choudhury S, Maruyama R, Yoo R, Chytil A, Boyle P, Ran FA, Moses HL, Barcellos-Hoff MH, Jackson-Grusby L, Meissner A, Polyak K.

Stem Cell Reports. 2015 Feb 10;4(2):297-311. doi: 10.1016/j.stemcr.2014.12.009. Epub 2015 Jan 22.

24.

Development of a novel multiplexed assay for quantification of transforming growth factor-β (TGF-β).

Pellicciotta I, Marciscano AE, Hardee ME, Francis D, Formenti S, Barcellos-Hoff MH.

Growth Factors. 2015 Apr;33(2):79-91. doi: 10.3109/08977194.2014.999367. Epub 2015 Jan 14.

PMID:
25586866
25.

TGFβ1 protects cells from γ-IR by enhancing the activity of the NHEJ repair pathway.

Kim MR, Lee J, An YS, Jin YB, Park IC, Chung E, Shin I, Barcellos-Hoff MH, Yi JY.

Mol Cancer Res. 2015 Feb;13(2):319-29. doi: 10.1158/1541-7786.MCR-14-0098-T. Epub 2014 Oct 15.

26.

Densely ionizing radiation acts via the microenvironment to promote aggressive Trp53-null mammary carcinomas.

Illa-Bochaca I, Ouyang H, Tang J, Sebastiano C, Mao JH, Costes SV, Demaria S, Barcellos-Hoff MH.

Cancer Res. 2014 Dec 1;74(23):7137-48. doi: 10.1158/0008-5472.CAN-14-1212. Epub 2014 Oct 10.

27.

Distinct luminal-type mammary carcinomas arise from orthotopic Trp53-null mammary transplantation of juvenile versus adult mice.

Nguyen DH, Ouyang H, Mao JH, Hlatky L, Barcellos-Hoff MH.

Cancer Res. 2014 Dec 1;74(23):7149-58. doi: 10.1158/0008-5472.CAN-14-1440. Epub 2014 Oct 3.

28.

New tricks for an old fox: impact of TGFβ on the DNA damage response and genomic stability.

Barcellos-Hoff MH, Cucinotta FA.

Sci Signal. 2014 Sep 2;7(341):re5. doi: 10.1126/scisignal.2005474. Review.

PMID:
25185158
29.

Soil amendments that slow cancer growth.

Isacke CM, Barcellos-Hoff MH.

Cancer Discov. 2014 Jun;4(6):637-9. doi: 10.1158/2159-8290.CD-14-0416.

30.

Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration.

Arany PR, Cho A, Hunt TD, Sidhu G, Shin K, Hahm E, Huang GX, Weaver J, Chen AC, Padwa BL, Hamblin MR, Barcellos-Hoff MH, Kulkarni AB, J Mooney D.

Sci Transl Med. 2014 May 28;6(238):238ra69. doi: 10.1126/scitranslmed.3008234.

31.

Noninvasive diagnosis and management of spontaneous intracranial hypotension in patients with marfan syndrome: Case Report and Review of the Literature.

Bassani L, Graffeo CS, Behrooz N, Tyagi V, Wilson T, Penaranda S, Zagzag D, Rifkin DB, Barcellos-Hoff MH, Fatterpekar G, Placantonakis D.

Surg Neurol Int. 2014 Jan 21;5:8. doi: 10.4103/2152-7806.125629. eCollection 2014.

32.

Breast cancer risk in BRCA1 mutation carriers: insight from mouse models.

Barcellos-Hoff MH, Kleinberg DL.

Ann Oncol. 2013 Nov;24 Suppl 8:viii8-viii12. doi: 10.1093/annonc/mdt305. Review.

PMID:
24131977
33.

Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors.

Tang J, Fernandez-Garcia I, Vijayakumar S, Martinez-Ruis H, Illa-Bochaca I, Nguyen DH, Mao JH, Costes SV, Barcellos-Hoff MH.

Stem Cells. 2014 Mar;32(3):649-61. doi: 10.1002/stem.1533.

34.

Tumors as organs: biologically augmenting radiation therapy by inhibiting transforming growth factor β activity in carcinomas.

Du S, Barcellos-Hoff MH.

Semin Radiat Oncol. 2013 Oct;23(4):242-51. doi: 10.1016/j.semradonc.2013.05.001. Review.

35.

The evolution of the cancer niche during multistage carcinogenesis.

Barcellos-Hoff MH, Lyden D, Wang TC.

Nat Rev Cancer. 2013 Jul;13(7):511-8. doi: 10.1038/nrc3536. Epub 2013 Jun 13. Review.

PMID:
23760023
36.

Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes.

Nguyen DH, Fredlund E, Zhao W, Perou CM, Balmain A, Mao JH, Barcellos-Hoff MH.

Clin Cancer Res. 2013 Mar 15;19(6):1353-62. doi: 10.1158/1078-0432.CCR-12-3554. Epub 2013 Jan 21.

37.

Does microenvironment contribute to the etiology of estrogen receptor-negative breast cancer?

Barcellos-Hoff MH.

Clin Cancer Res. 2013 Feb 1;19(3):541-8. doi: 10.1158/1078-0432.CCR-12-2241. Epub 2013 Jan 16. Review.

38.

New biological insights on the link between radiation exposure and breast cancer risk.

Barcellos-Hoff MH.

J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):3-13. doi: 10.1007/s10911-013-9272-x. Epub 2013 Jan 17. Review.

PMID:
23325014
39.

The convergence of radiation and immunogenic cell death signaling pathways.

Golden EB, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC.

Front Oncol. 2012 Aug 7;2:88. doi: 10.3389/fonc.2012.00088. eCollection 2012.

40.

Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.

Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM, Barcellos-Hoff MH.

Cancer Res. 2012 Aug 15;72(16):4119-29. doi: 10.1158/0008-5472.CAN-12-0546. Epub 2012 Jun 12.

41.

Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.

Maxwell CA, Benítez J, Gómez-Baldó L, Osorio A, Bonifaci N, Fernández-Ramires R, Costes SV, Guinó E, Chen H, Evans GJ, Mohan P, Català I, Petit A, Aguilar H, Villanueva A, Aytes A, Serra-Musach J, Rennert G, Lejbkowicz F, Peterlongo P, Manoukian S, Peissel B, Ripamonti CB, Bonanni B, Viel A, Allavena A, Bernard L, Radice P, Friedman E, Kaufman B, Laitman Y, Dubrovsky M, Milgrom R, Jakubowska A, Cybulski C, Gorski B, Jaworska K, Durda K, Sukiennicki G, Lubiński J, Shugart YY, Domchek SM, Letrero R, Weber BL, Hogervorst FB, Rookus MA, Collee JM, Devilee P, Ligtenberg MJ, Luijt RB, Aalfs CM, Waisfisz Q, Wijnen J, Roozendaal CE; HEBON; EMBRACE, Easton DF, Peock S, Cook M, Oliver C, Frost D, Harrington P, Evans DG, Lalloo F, Eeles R, Izatt L, Chu C, Eccles D, Douglas F, Brewer C, Nevanlinna H, Heikkinen T, Couch FJ, Lindor NM, Wang X, Godwin AK, Caligo MA, Lombardi G, Loman N, Karlsson P, Ehrencrona H, Wachenfeldt Av; SWE-BRCA, Barkardottir RB, Hamann U, Rashid MU, Lasa A, Caldés T, Andrés R, Schmitt M, Assmann V, Stevens K, Offit K, Curado J, Tilgner H, Guigó R, Aiza G, Brunet J, Castellsagué J, Martrat G, Urruticoechea A, Blanco I, Tihomirova L, Goldgar DE, Buys S, John EM, Miron A, Southey M, Daly MB; BCFR, Schmutzler RK, Wappenschmidt B, Meindl A, Arnold N, Deissler H, Varon-Mateeva R, Sutter C, Niederacher D, Imyamitov E, Sinilnikova OM, Stoppa-Lyonne D, Mazoyer S, Verny-Pierre C, Castera L, de Pauw A, Bignon YJ, Uhrhammer N, Peyrat JP, Vennin P, Fert Ferrer S, Collonge-Rame MA, Mortemousque I; GEMO Study Collaborators, Spurdle AB, Beesley J, Chen X, Healey S; kConFab, Barcellos-Hoff MH, Vidal M, Gruber SB, Lázaro C, Capellá G, McGuffog L, Nathanson KL, Antoniou AC, Chenevix-Trench G, Fleisch MC, Moreno V, Pujana MA.

PLoS Biol. 2011 Nov;9(11):e1001199. doi: 10.1371/journal.pbio.1001199. Epub 2011 Nov 15.

42.

TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.

Bouquet F, Pal A, Pilones KA, Demaria S, Hann B, Akhurst RJ, Babb JS, Lonning SM, DeWyngaert JK, Formenti SC, Barcellos-Hoff MH.

Clin Cancer Res. 2011 Nov 1;17(21):6754-65. doi: 10.1158/1078-0432.CCR-11-0544. Epub 2011 Oct 25.

43.

The pivotal role of insulin-like growth factor I in normal mammary development.

Kleinberg DL, Barcellos-Hoff MH.

Endocrinol Metab Clin North Am. 2011 Sep;40(3):461-71, vii. doi: 10.1016/j.ecl.2011.06.001. Review.

PMID:
21889714
44.

What is the use of systems biology approaches in radiation biology?

Barcellos-Hoff MH.

Health Phys. 2011 Mar;100(3):272-3. No abstract available.

PMID:
21595065
45.

Consequences of epithelial or stromal TGFβ1 depletion in the mammary gland.

Nguyen DH, Martinez-Ruiz H, Barcellos-Hoff MH.

J Mammary Gland Biol Neoplasia. 2011 Jun;16(2):147-55. doi: 10.1007/s10911-011-9218-0. Epub 2011 May 17.

PMID:
21590374
46.

Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type.

Nguyen DH, Oketch-Rabah HA, Illa-Bochaca I, Geyer FC, Reis-Filho JS, Mao JH, Ravani SA, Zavadil J, Borowsky AD, Jerry DJ, Dunphy KA, Seo JH, Haslam S, Medina D, Barcellos-Hoff MH.

Cancer Cell. 2011 May 17;19(5):640-51. doi: 10.1016/j.ccr.2011.03.011.

47.

TGFβ biology in breast: 15 years on.

Barcellos-Hoff MH.

J Mammary Gland Biol Neoplasia. 2011 Jun;16(2):65-6. doi: 10.1007/s10911-011-9220-6. No abstract available.

PMID:
21534008
48.

Low-dose radiation knowledge worth the cost.

Barcellos-Hoff MH, Brenner DJ, Brooks AL, Formenti S, Hlatky L, Locke PA, Shore R, Tenforde T, Travis EL, Williams J.

Science. 2011 Apr 15;332(6027):305-6. doi: 10.1126/science.332.6027.305-b. No abstract available.

PMID:
21493843
49.

In honor of Mina J. Bissell.

Barcellos-Hoff MH.

Integr Biol (Camb). 2011 Apr;3(4):253-4. doi: 10.1039/c1ib90008k. Epub 2011 Mar 29. No abstract available.

PMID:
21448491
50.

Lack of radiation dose or quality dependence of epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor β.

Andarawewa KL, Costes SV, Fernandez-Garcia I, Chou WS, Ravani SA, Park H, Barcellos-Hoff MH.

Int J Radiat Oncol Biol Phys. 2011 Apr 1;79(5):1523-31. doi: 10.1016/j.ijrobp.2010.11.058.

PMID:
21310544

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