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Items: 20

1.

The relative contributions of CYP3A4 and CYP3A5 to the metabolism of vinorelbine.

Topletz AR, Dennison JB, Barbuch RJ, Hadden CE, Hall SD, Renbarger JL.

Drug Metab Dispos. 2013 Sep;41(9):1651-61. doi: 10.1124/dmd.113.051094. Epub 2013 Jun 18.

2.

Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.

Zamek-Gliszczynski MJ, Abraham TL, Alberts JJ, Kulanthaivel P, Jackson KA, Chow KH, McCann DJ, Hu H, Anderson S, Furr NA, Barbuch RJ, Cassidy KC.

Drug Metab Dispos. 2013 Apr;41(4):714-26. doi: 10.1124/dmd.112.048488. Epub 2013 Jan 10.

PMID:
23305709
3.

The fate of 4-hydroxycarbazole metabolite: metabolism and carcinogenicity assessment of a β-adrenergic receptor modulator containing carbazole structure.

He MM, Ji T, Barbuch RJ, Campanale K, Lantz R, Hadden C, Wilke A.

Xenobiotica. 2011 Dec;41(12):1108-21. doi: 10.3109/00498254.2011.604744. Epub 2011 Sep 5.

PMID:
21892880
4.

Metabolism of LY654322, a growth hormone secretagogue, to an unusual diimidazopyridine metabolite.

Borel AG, Jones TM, Barbuch RJ, Jackson DA, Kulanthaivel P, Mattiuz E, Klimkowski VJ, Wheeler WJ, Rener GA.

Drug Metab Dispos. 2011 May;39(5):740-9. doi: 10.1124/dmd.110.037598. Epub 2011 Feb 23.

PMID:
21346003
5.

Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans.

Yi P, Hadden C, Kulanthaivel P, Calvert N, Annes W, Brown T, Barbuch RJ, Chaudhary A, Ayan-Oshodi MA, Ring BJ.

Drug Metab Dispos. 2010 Apr;38(4):554-65. doi: 10.1124/dmd.109.030841. Epub 2010 Jan 14.

PMID:
20075192
6.

Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes.

Dennison JB, Mohutsky MA, Barbuch RJ, Wrighton SA, Hall SD.

J Pharmacol Exp Ther. 2008 Oct;327(1):248-57. doi: 10.1124/jpet.108.139998. Epub 2008 Jul 23.

PMID:
18650247
7.

Selective metabolism of vincristine in vitro by CYP3A5.

Dennison JB, Kulanthaivel P, Barbuch RJ, Renbarger JL, Ehlhardt WJ, Hall SD.

Drug Metab Dispos. 2006 Aug;34(8):1317-27. Epub 2006 May 5.

PMID:
16679390
8.

In vivo metabolism of [14C]ruboxistaurin in dogs, mice, and rats following oral administration and the structure determination of its metabolites by liquid chromatography/mass spectrometry and NMR spectroscopy.

Barbuch RJ, Campanale K, Hadden CE, Zmijewski M, Yi P, O'Bannon DD, Burkey JL, Kulanthaivel P.

Drug Metab Dispos. 2006 Feb;34(2):213-24. Epub 2005 Oct 28.

PMID:
16258078
9.

Selective reduction of N-oxides to amines: application to drug metabolism.

Kulanthaivel P, Barbuch RJ, Davidson RS, Yi P, Rener GA, Mattiuz EL, Hadden CE, Goodwin LA, Ehlhardt WJ.

Drug Metab Dispos. 2004 Sep;32(9):966-72.

PMID:
15319338
10.

Characterization of dark liver pigment observed in rats after subchronic dosing of the beta3-adrenergic receptor agonist LY368842.

He MM, Barbuch RJ, Abraham TL, Lindsay TJ, Jackson DA, Ackermann BL, Wilke AV, Jensen CB.

Chem Res Toxicol. 2003 Jul;16(7):912-9.

PMID:
12870894
11.

Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog.

Mattiuz EL, Ponsler GD, Barbuch RJ, Wood PG, Mullen JH, Shugert RL, Li Q, Wheeler WJ, Kuo F, Conrad PC, Sauer JM.

Drug Metab Dispos. 2003 Jan;31(1):88-97.

PMID:
12485957
12.

Evidence for a novel pentyl radical adduct of the cyclic nitrone spin trap MDL 101,002.

Dage JL, Ackermann BL, Barbuch RJ, Bernotas RC, Ohlweiler DF, Haegele KD, Thomas CE.

Free Radic Biol Med. 1997;22(5):807-12.

PMID:
9119249
13.

Spectral analysis and structural identification of a major deflazacort metabolite in man.

Huber EW, Barbuch RJ.

Xenobiotica. 1995 Feb;25(2):175-83.

PMID:
7618345
14.

A simple method for the isolation of zymosterol from a sterol mutant of Saccharomyces cerevisiae.

Heiderpriem RW, Livant PD, Parish EJ, Barbuch RJ, Broaddus MG, Bard M.

J Steroid Biochem Mol Biol. 1992 Dec;43(7):741-3.

PMID:
1472465
15.

Evidence for a lysine-specific fragmentation in fast-atom bombardment mass spectra of peptides.

Ackermann BL, Barbuch RJ, Coutant JE, Krstenansky JL, Owen TJ.

Rapid Commun Mass Spectrom. 1992 Apr;6(4):257-64.

PMID:
1373977
16.

Cloning and disruption of the yeast C-8 sterol isomerase gene.

Ashman WH, Barbuch RJ, Ulbright CE, Jarrett HW, Bard M.

Lipids. 1991 Aug;26(8):628-32.

PMID:
1779709
17.

Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase.

Arthington BA, Bennett LG, Skatrud PL, Guynn CJ, Barbuch RJ, Ulbright CE, Bard M.

Gene. 1991 Jun 15;102(1):39-44.

PMID:
1864507
18.
19.

Characterization of a cytochrome P450 deficient mutant of Candida albicans.

Bard M, Lees ND, Barbuch RJ, Sanglard D.

Biochem Biophys Res Commun. 1987 Sep 15;147(2):794-800.

PMID:
3307785
20.

Identification in man of urinary metabolites of a new bronchodilator, MDL 257, using triple stage quadrupole mass spectrometry-mass spectrometry.

Coutant JE, Barbuch RJ, Satonin DK, Cregge RJ.

Biomed Environ Mass Spectrom. 1987 Jul;14(7):325-30.

PMID:
2959339

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