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Items: 42

1.

The relative contributions of CYP3A4 and CYP3A5 to the metabolism of vinorelbine.

Topletz AR, Dennison JB, Barbuch RJ, Hadden CE, Hall SD, Renbarger JL.

Drug Metab Dispos. 2013 Sep;41(9):1651-61. doi: 10.1124/dmd.113.051094. Epub 2013 Jun 18.

2.

Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.

Zamek-Gliszczynski MJ, Abraham TL, Alberts JJ, Kulanthaivel P, Jackson KA, Chow KH, McCann DJ, Hu H, Anderson S, Furr NA, Barbuch RJ, Cassidy KC.

Drug Metab Dispos. 2013 Apr;41(4):714-26. doi: 10.1124/dmd.112.048488. Epub 2013 Jan 10.

PMID:
23305709
3.

Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway.

Layer JV, Barnes BM, Yamasaki Y, Barbuch R, Li L, Taramino S, Balliano G, Bard M.

Biochim Biophys Acta. 2013 Feb;1831(2):361-9. doi: 10.1016/j.bbalip.2012.09.012. Epub 2012 Sep 27.

PMID:
23022663
4.

The fate of 4-hydroxycarbazole metabolite: metabolism and carcinogenicity assessment of a β-adrenergic receptor modulator containing carbazole structure.

He MM, Ji T, Barbuch RJ, Campanale K, Lantz R, Hadden C, Wilke A.

Xenobiotica. 2011 Dec;41(12):1108-21. doi: 10.3109/00498254.2011.604744. Epub 2011 Sep 5.

PMID:
21892880
5.

Metabolism of LY654322, a growth hormone secretagogue, to an unusual diimidazopyridine metabolite.

Borel AG, Jones TM, Barbuch RJ, Jackson DA, Kulanthaivel P, Mattiuz E, Klimkowski VJ, Wheeler WJ, Rener GA.

Drug Metab Dispos. 2011 May;39(5):740-9. doi: 10.1124/dmd.110.037598. Epub 2011 Feb 23.

PMID:
21346003
6.

Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans.

Yi P, Hadden C, Kulanthaivel P, Calvert N, Annes W, Brown T, Barbuch RJ, Chaudhary A, Ayan-Oshodi MA, Ring BJ.

Drug Metab Dispos. 2010 Apr;38(4):554-65. doi: 10.1124/dmd.109.030841. Epub 2010 Jan 14.

PMID:
20075192
7.

A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus.

Willger SD, Puttikamonkul S, Kim KH, Burritt JB, Grahl N, Metzler LJ, Barbuch R, Bard M, Lawrence CB, Cramer RA Jr.

PLoS Pathog. 2008 Nov;4(11):e1000200. doi: 10.1371/journal.ppat.1000200. Epub 2008 Nov 7.

8.

Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes.

Dennison JB, Mohutsky MA, Barbuch RJ, Wrighton SA, Hall SD.

J Pharmacol Exp Ther. 2008 Oct;327(1):248-57. doi: 10.1124/jpet.108.139998. Epub 2008 Jul 23.

PMID:
18650247
9.

Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae.

Teske B, Taramino S, Bhuiyan MS, Kumaraswami NS, Randall SK, Barbuch R, Eckstein J, Balliano G, Bard M.

Biochim Biophys Acta. 2008 Aug;1781(8):359-66. doi: 10.1016/j.bbalip.2008.04.017. Epub 2008 May 15.

10.

Synthetically lethal interactions involving loss of the yeast ERG24: the sterol C-14 reductase gene.

Shah Alam Bhuiyan M, Eckstein J, Barbuch R, Bard M.

Lipids. 2007 Feb;42(1):69-76. Epub 2006 Dec 19.

11.

Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.

Hughes AL, Powell DW, Bard M, Eckstein J, Barbuch R, Link AJ, Espenshade PJ.

Cell Metab. 2007 Feb;5(2):143-9.

12.

Disposition of [14C]ruboxistaurin in humans.

Burkey JL, Campanale KM, Barbuch R, O'Bannon D, Rash J, Benson C, Small D.

Drug Metab Dispos. 2006 Nov;34(11):1909-17. Epub 2006 Aug 8.

PMID:
16896067
13.

Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles.

Valachovic M, Bareither BM, Shah Alam Bhuiyan M, Eckstein J, Barbuch R, Balderes D, Wilcox L, Sturley SL, Dickson RC, Bard M.

Genetics. 2006 Aug;173(4):1893-908. Epub 2006 May 15.

14.

Selective metabolism of vincristine in vitro by CYP3A5.

Dennison JB, Kulanthaivel P, Barbuch RJ, Renbarger JL, Ehlhardt WJ, Hall SD.

Drug Metab Dispos. 2006 Aug;34(8):1317-27. Epub 2006 May 5.

PMID:
16679390
15.

In vivo metabolism of [14C]ruboxistaurin in dogs, mice, and rats following oral administration and the structure determination of its metabolites by liquid chromatography/mass spectrometry and NMR spectroscopy.

Barbuch RJ, Campanale K, Hadden CE, Zmijewski M, Yi P, O'Bannon DD, Burkey JL, Kulanthaivel P.

Drug Metab Dispos. 2006 Feb;34(2):213-24. Epub 2005 Oct 28.

PMID:
16258078
16.

Sterol uptake in Candida glabrata: rescue of sterol auxotrophic strains.

Bard M, Sturm AM, Pierson CA, Brown S, Rogers KM, Nabinger S, Eckstein J, Barbuch R, Lees ND, Howell SA, Hazen KC.

Diagn Microbiol Infect Dis. 2005 Aug;52(4):285-93.

PMID:
15893902
17.

Ergosterol gene expression in wild-type and ergosterol-deficient mutants of Candida albicans.

Pierson CA, Eckstein J, Barbuch R, Bard M.

Med Mycol. 2004 Aug;42(4):385-9.

PMID:
15473366
18.

Disruption of the Candida albicans CYB5 gene results in increased azole sensitivity.

Rogers KM, Pierson CA, Culbertson NT, Mo C, Sturm AM, Eckstein J, Barbuch R, Lees ND, Bard M.

Antimicrob Agents Chemother. 2004 Sep;48(9):3425-35.

19.

Selective reduction of N-oxides to amines: application to drug metabolism.

Kulanthaivel P, Barbuch RJ, Davidson RS, Yi P, Rener GA, Mattiuz EL, Hadden CE, Goodwin LA, Ehlhardt WJ.

Drug Metab Dispos. 2004 Sep;32(9):966-72.

PMID:
15319338
20.

Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans.

Barker KS, Crisp S, Wiederhold N, Lewis RE, Bareither B, Eckstein J, Barbuch R, Bard M, Rogers PD.

J Antimicrob Chemother. 2004 Aug;54(2):376-85. Epub 2004 Jun 16.

PMID:
15201233
21.

Characterization of dark liver pigment observed in rats after subchronic dosing of the beta3-adrenergic receptor agonist LY368842.

He MM, Barbuch RJ, Abraham TL, Lindsay TJ, Jackson DA, Ackermann BL, Wilke AV, Jensen CB.

Chem Res Toxicol. 2003 Jul;16(7):912-9.

PMID:
12870894
22.

Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog.

Mattiuz EL, Ponsler GD, Barbuch RJ, Wood PG, Mullen JH, Shugert RL, Li Q, Wheeler WJ, Kuo F, Conrad PC, Sauer JM.

Drug Metab Dispos. 2003 Jan;31(1):88-97.

PMID:
12485957
23.

Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site.

Jia N, Arthington-Skaggs B, Lee W, Pierson CA, Lees ND, Eckstein J, Barbuch R, Bard M.

Antimicrob Agents Chemother. 2002 Apr;46(4):947-57.

24.

A novel gene conserved from yeast to humans is involved in sterol biosynthesis.

Gachotte D, Eckstein J, Barbuch R, Hughes T, Roberts C, Bard M.

J Lipid Res. 2001 Jan;42(1):150-4.

25.
26.

Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.

Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12655-60.

27.

Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae.

Kennedy MA, Barbuch R, Bard M.

Biochim Biophys Acta. 1999 Apr 14;1445(1):110-22.

PMID:
10209263
28.

Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis.

Gachotte D, Barbuch R, Gaylor J, Nickel E, Bard M.

Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13794-9. Erratum in: Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1810.

29.

Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants.

Jensen-Pergakes KL, Kennedy MA, Lees ND, Barbuch R, Koegel C, Bard M.

Antimicrob Agents Chemother. 1998 May;42(5):1160-7.

30.

A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme.

Gachotte D, Pierson CA, Lees ND, Barbuch R, Koegel C, Bard M.

Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11173-8.

31.

Evidence for a novel pentyl radical adduct of the cyclic nitrone spin trap MDL 101,002.

Dage JL, Ackermann BL, Barbuch RJ, Bernotas RC, Ohlweiler DF, Haegele KD, Thomas CE.

Free Radic Biol Med. 1997;22(5):807-12.

PMID:
9119249
32.

Cloning and characterization of the Saccharomyces cerevisiae C-22 sterol desaturase gene, encoding a second cytochrome P-450 involved in ergosterol biosynthesis.

Skaggs BA, Alexander JF, Pierson CA, Schweitzer KS, Chun KT, Koegel C, Barbuch R, Bard M.

Gene. 1996 Feb 22;169(1):105-9.

PMID:
8635732
33.

Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.

Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, Koegel C, Barbuch R.

Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):186-90.

34.

Spectral analysis and structural identification of a major deflazacort metabolite in man.

Huber EW, Barbuch RJ.

Xenobiotica. 1995 Feb;25(2):175-83.

PMID:
7618345
35.

Sterol synthesis and viability of erg11 (cytochrome P450 lanosterol demethylase) mutations in Saccharomyces cerevisiae and Candida albicans.

Bard M, Lees ND, Turi T, Craft D, Cofrin L, Barbuch R, Koegel C, Loper JC.

Lipids. 1993 Nov;28(11):963-7.

PMID:
8277826
36.

A simple method for the isolation of zymosterol from a sterol mutant of Saccharomyces cerevisiae.

Heiderpriem RW, Livant PD, Parish EJ, Barbuch RJ, Broaddus MG, Bard M.

J Steroid Biochem Mol Biol. 1992 Dec;43(7):741-3.

PMID:
1472465
37.

Evidence for a lysine-specific fragmentation in fast-atom bombardment mass spectra of peptides.

Ackermann BL, Barbuch RJ, Coutant JE, Krstenansky JL, Owen TJ.

Rapid Commun Mass Spectrom. 1992 Apr;6(4):257-64.

PMID:
1373977
38.

Cloning and disruption of the yeast C-8 sterol isomerase gene.

Ashman WH, Barbuch RJ, Ulbright CE, Jarrett HW, Bard M.

Lipids. 1991 Aug;26(8):628-32.

PMID:
1779709
39.

Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase.

Arthington BA, Bennett LG, Skatrud PL, Guynn CJ, Barbuch RJ, Ulbright CE, Bard M.

Gene. 1991 Jun 15;102(1):39-44.

PMID:
1864507
40.
41.

Characterization of a cytochrome P450 deficient mutant of Candida albicans.

Bard M, Lees ND, Barbuch RJ, Sanglard D.

Biochem Biophys Res Commun. 1987 Sep 15;147(2):794-800.

PMID:
3307785
42.

Identification in man of urinary metabolites of a new bronchodilator, MDL 257, using triple stage quadrupole mass spectrometry-mass spectrometry.

Coutant JE, Barbuch RJ, Satonin DK, Cregge RJ.

Biomed Environ Mass Spectrom. 1987 Jul;14(7):325-30.

PMID:
2959339

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