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Items: 1 to 50 of 165

1.

STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity.

Falahat R, Perez-Villarroel P, Mailloux AW, Zhu G, Pilon-Thomas S, Barber GN, Mulé JJ.

Cancer Immunol Res. 2019 Aug 28. doi: 10.1158/2326-6066.CIR-19-0229. [Epub ahead of print]

PMID:
31462408
2.

Brucella abortus Cyclic Dinucleotides Trigger STING-Dependent Unfolded Protein Response That Favors Bacterial Replication.

Guimarães ES, Gomes MTR, Campos PC, Mansur DS, Dos Santos AA, Harms J, Splitter G, Smith JA, Barber GN, Oliveira SC.

J Immunol. 2019 May 1;202(9):2671-2681. doi: 10.4049/jimmunol.1801233. Epub 2019 Mar 20.

PMID:
30894428
3.

Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.

Imanishi T, Unno M, Kobayashi W, Yoneda N, Matsuda S, Ikeda K, Hoshii T, Hirao A, Miyake K, Barber GN, Arita M, Ishii KJ, Akira S, Saito T.

Life Sci Alliance. 2019 Jan 25;2(1). pii: e201800282. doi: 10.26508/lsa.201800282. Print 2019 Feb.

4.

Ovarian Cancer Cells Commonly Exhibit Defective STING Signaling Which Affects Sensitivity to Viral Oncolysis.

de Queiroz NMGP, Xia T, Konno H, Barber GN.

Mol Cancer Res. 2019 Apr;17(4):974-986. doi: 10.1158/1541-7786.MCR-18-0504. Epub 2018 Dec 26.

PMID:
30587523
5.

Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.

Sato R, Kato A, Chimura T, Saitoh SI, Shibata T, Murakami Y, Fukui R, Liu K, Zhang Y, Arii J, Sun-Wada GH, Wada Y, Ikenoue T, Barber GN, Manabe T, Kawaguchi Y, Miyake K.

Nat Immunol. 2018 Oct;19(10):1071-1082. doi: 10.1038/s41590-018-0203-2. Epub 2018 Sep 10.

PMID:
30201994
6.

Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose.

Araujo AM, Antunes MM, Mattos MS, Diniz AB, Alvarenga DM, Nakagaki BN, Carvalho É, Lacerda VAS, Carvalho-Gontijo R, Goulart J, Mafra K, Freitas-Lopes MA, Oliveira HMC, Dutra CM, David BA, Mendes Silva A, Quesniaux V, Ryffel B, Oliveira SC, Barber GN, Mansur DS, Cunha TM, Rezende RM, Oliveira AG, Menezes GB.

Cells. 2018 Jul 27;7(8). pii: E88. doi: 10.3390/cells7080088.

7.

Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells.

Ahn J, Xia T, Rabasa Capote A, Betancourt D, Barber GN.

Cancer Cell. 2018 May 14;33(5):862-873.e5. doi: 10.1016/j.ccell.2018.03.027. Epub 2018 Apr 26.

8.

Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING.

Konno H, Chinn IK, Hong D, Orange JS, Lupski JR, Mendoza A, Pedroza LA, Barber GN.

Cell Rep. 2018 Apr 24;23(4):1112-1123. doi: 10.1016/j.celrep.2018.03.115.

9.

Oncolytic Viruses as Antigen-Agnostic Cancer Vaccines.

Russell SJ, Barber GN.

Cancer Cell. 2018 Apr 9;33(4):599-605. doi: 10.1016/j.ccell.2018.03.011. Review.

10.

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.

Takahashi A, Loo TM, Okada R, Kamachi F, Watanabe Y, Wakita M, Watanabe S, Kawamoto S, Miyata K, Barber GN, Ohtani N, Hara E.

Nat Commun. 2018 Mar 28;9(1):1249. doi: 10.1038/s41467-018-03555-8.

11.

Epidemiology, clinical features, and outcome of HTLV-1-related ATLL in an area of prevalence in the United States.

Malpica L, Pimentel A, Reis IM, Gotuzzo E, Lekakis L, Komanduri K, Harrington T, Barber GN, Ramos JC.

Blood Adv. 2018 Mar 27;2(6):607-620. doi: 10.1182/bloodadvances.2017011106.

12.

Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production.

Konno H, Yamauchi S, Berglund A, Putney RM, Mulé JJ, Barber GN.

Oncogene. 2018 Apr;37(15):2037-2051. doi: 10.1038/s41388-017-0120-0. Epub 2018 Jan 25.

13.

The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation.

Canesso MCC, Lemos L, Neves TC, Marim FM, Castro TBR, Veloso ÉS, Queiroz CP, Ahn J, Santiago HC, Martins FS, Alves-Silva J, Ferreira E, Cara DC, Vieira AT, Barber GN, Oliveira SC, Faria AMC.

Mucosal Immunol. 2018 May;11(3):820-834. doi: 10.1038/mi.2017.88. Epub 2017 Dec 20.

PMID:
29346345
14.

STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis.

Ahn J, Son S, Oliveira SC, Barber GN.

Cell Rep. 2017 Dec 26;21(13):3873-3884. doi: 10.1016/j.celrep.2017.11.101.

15.

Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.

Costa Franco MM, Marim F, Guimarães ES, Assis NRG, Cerqueira DM, Alves-Silva J, Harms J, Splitter G, Smith J, Kanneganti TD, de Queiroz NMGP, Gutman D, Barber GN, Oliveira SC.

J Immunol. 2018 Jan 15;200(2):607-622. doi: 10.4049/jimmunol.1700725. Epub 2017 Dec 4.

16.

A noncanonical function of cGAMP in inflammasome priming and activation.

Swanson KV, Junkins RD, Kurkjian CJ, Holley-Guthrie E, Pendse AA, El Morabiti R, Petrucelli A, Barber GN, Benedict CA, Ting JP.

J Exp Med. 2017 Dec 4;214(12):3611-3626. doi: 10.1084/jem.20171749. Epub 2017 Oct 13.

17.

Cytoplasmic chromatin triggers inflammation in senescence and cancer.

Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.

Nature. 2017 Oct 19;550(7676):402-406. doi: 10.1038/nature24050. Epub 2017 Oct 4.

18.

Ubiquitination of STING at lysine 224 controls IRF3 activation.

Ni G, Konno H, Barber GN.

Sci Immunol. 2017 May 5;2(11). pii: eaah7119. doi: 10.1126/sciimmunol.aah7119.

19.

Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques.

Martins MA, Shin YC, Gonzalez-Nieto L, Domingues A, Gutman MJ, Maxwell HS, Castro I, Magnani DM, Ricciardi M, Pedreño-Lopez N, Bailey V, Betancourt D, Altman JD, Pauthner M, Burton DR, von Bredow B, Evans DT, Yuan M, Parks CL, Ejima K, Allison DB, Rakasz E, Barber GN, Capuano S 3rd, Lifson JD, Desrosiers RC, Watkins DI.

PLoS Pathog. 2017 Jul 21;13(7):e1006529. doi: 10.1371/journal.ppat.1006529. eCollection 2017 Jul.

20.

Simian T Lymphotropic Virus 1 Infection of Papio anubis: tax Sequence Heterogeneity and T Cell Recognition.

Termini JM, Magnani DM, Maxwell HS, Lauer W, Castro I, Pecotte J, Barber GN, Watkins DI, Desrosiers RC.

J Virol. 2017 Sep 27;91(20). pii: e00950-17. doi: 10.1128/JVI.00950-17. Print 2017 Oct 15.

21.

The Birds, the Bees, and Innate Immunity.

Barber GN.

Immunity. 2017 Apr 18;46(4):521-522. doi: 10.1016/j.immuni.2017.04.002.

22.

Cutting Edge: Innate Immune Augmenting Vesicular Stomatitis Virus Expressing Zika Virus Proteins Confers Protective Immunity.

Betancourt D, de Queiroz NM, Xia T, Ahn J, Barber GN.

J Immunol. 2017 Apr 15;198(8):3023-3028. doi: 10.4049/jimmunol.1602180. Epub 2017 Mar 13.

23.

Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis.

Xia T, Konno H, Barber GN.

Cancer Res. 2016 Nov 15;76(22):6747-6759. doi: 10.1158/0008-5472.CAN-16-1404. Epub 2016 Sep 28.

24.

The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection.

Komuro A, Homma Y, Negoro T, Barber GN, Horvath CM.

Biochem Biophys Res Commun. 2016 Nov 11;480(2):187-193. doi: 10.1016/j.bbrc.2016.10.023. Epub 2016 Oct 13.

PMID:
27743889
25.

Activation of STING requires palmitoylation at the Golgi.

Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, Barber GN, Arai H, Taguchi T.

Nat Commun. 2016 Jun 21;7:11932. doi: 10.1038/ncomms11932.

26.

Cellular Immune Responses against Simian T-Lymphotropic Virus Type 1 Target Tax in Infected Baboons.

Castro I, Giret TM, Magnani DM, Maxwell HS, Umland O, Perry JK, Pecotte JK, Brasky KM, Barber GN, Desrosiers RC, Watkins DI.

J Virol. 2016 May 12;90(11):5280-5291. doi: 10.1128/JVI.00281-16. Print 2016 Jun 1.

27.

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis.

Xia T, Konno H, Ahn J, Barber GN.

Cell Rep. 2016 Jan 12;14(2):282-97. doi: 10.1016/j.celrep.2015.12.029. Epub 2015 Dec 31.

28.

STING: infection, inflammation and cancer.

Barber GN.

Nat Rev Immunol. 2015 Dec;15(12):760-70. doi: 10.1038/nri3921. Review.

29.

Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma.

Agarwal NK, Kim CH, Kunkalla K, Konno H, Tjendra Y, Kwon D, Blonska M, Kozloski GA, Moy VT, Verdun RE, Barber GN, Lossos IS, Vega F.

Blood. 2016 Feb 4;127(5):605-15. doi: 10.1182/blood-2015-07-658781. Epub 2015 Nov 24.

30.

Retargeting Oncolytic Vesicular Stomatitis Virus to Human T-Cell Lymphotropic Virus Type 1-Associated Adult T-Cell Leukemia.

Betancourt D, Ramos JC, Barber GN.

J Virol. 2015 Dec;89(23):11786-800. doi: 10.1128/JVI.01356-15. Epub 2015 Sep 16.

31.

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses.

Ma Z, Jacobs SR, West JA, Stopford C, Zhang Z, Davis Z, Barber GN, Glaunsinger BA, Dittmer DP, Damania B.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4306-15. doi: 10.1073/pnas.1503831112. Epub 2015 Jul 21.

32.

Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING.

Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, Takubo K.

Cell Rep. 2015 Apr 7;11(1):71-84. doi: 10.1016/j.celrep.2015.02.066. Epub 2015 Apr 2.

33.

Oncogenic human T-cell lymphotropic virus type 1 tax suppression of primary innate immune signaling pathways.

Hyun J, Ramos JC, Toomey N, Balachandran S, Lavorgna A, Harhaj E, Barber GN.

J Virol. 2015 May;89(9):4880-93. doi: 10.1128/JVI.02493-14. Epub 2015 Feb 18.

34.

Diverse roles of STING-dependent signaling on the development of cancer.

Ahn J, Konno H, Barber GN.

Oncogene. 2015 Oct 8;34(41):5302-8. doi: 10.1038/onc.2014.457. Epub 2015 Feb 2.

35.

DNase II-dependent DNA digestion is required for DNA sensing by TLR9.

Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh S, Ohto U, Shimizu T, Barber GN, Miyake K.

Nat Commun. 2015 Jan 20;6:5853. doi: 10.1038/ncomms6853.

PMID:
25600358
36.

STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.

Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, Duggan R, Wang Y, Barber GN, Fitzgerald KA, Alegre ML, Gajewski TF.

Immunity. 2014 Nov 20;41(5):830-42. doi: 10.1016/j.immuni.2014.10.017. Epub 2014 Nov 5. Erratum in: Immunity. 2015 Jan 20;42(1):199.

37.

Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease.

Ahn J, Barber GN.

Curr Opin Immunol. 2014 Dec;31:121-6. doi: 10.1016/j.coi.2014.10.009. Epub 2014 Nov 4. Review.

PMID:
25459004
38.

The STING controlled cytosolic-DNA activated innate immune pathway and microbial disease.

Konno H, Barber GN.

Microbes Infect. 2014 Dec;16(12):998-1001. doi: 10.1016/j.micinf.2014.10.002. Epub 2014 Oct 18. Review.

39.

Inflammation-driven carcinogenesis is mediated through STING.

Ahn J, Xia T, Konno H, Konno K, Ruiz P, Barber GN.

Nat Commun. 2014 Oct 10;5:5166. doi: 10.1038/ncomms6166.

40.

Intrinsic self-DNA triggers inflammatory disease dependent on STING.

Ahn J, Ruiz P, Barber GN.

J Immunol. 2014 Nov 1;193(9):4634-42. doi: 10.4049/jimmunol.1401337. Epub 2014 Sep 26.

41.

Primate-specific miR-576-3p sets host defense signalling threshold.

Yarbrough ML, Zhang K, Sakthivel R, Forst CV, Posner BA, Barber GN, White MA, Fontoura BM.

Nat Commun. 2014 Sep 18;5:4963. doi: 10.1038/ncomms5963.

42.

Activation of the STING adaptor attenuates experimental autoimmune encephalitis.

Lemos H, Huang L, Chandler PR, Mohamed E, Souza GR, Li L, Pacholczyk G, Barber GN, Hayakawa Y, Munn DH, Mellor AL.

J Immunol. 2014 Jun 15;192(12):5571-8. doi: 10.4049/jimmunol.1303258. Epub 2014 May 5.

43.

Nucleic acid sensing by T cells initiates Th2 cell differentiation.

Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T.

Nat Commun. 2014 Apr 10;5:3566. doi: 10.1038/ncomms4566.

PMID:
24717539
44.

Vesiculovirus neutralization by natural IgM and complement.

Tesfay MZ, Ammayappan A, Federspiel MJ, Barber GN, Stojdl D, Peng KW, Russell SJ.

J Virol. 2014 Jun;88(11):6148-57. doi: 10.1128/JVI.00074-14. Epub 2014 Mar 19. Erratum in: J Virol. 2015 Feb;89(3):1945-6.

45.

Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1.

Abe T, Barber GN.

J Virol. 2014 May;88(10):5328-41. doi: 10.1128/JVI.00037-14. Epub 2014 Mar 5.

46.

STING-dependent cytosolic DNA sensing pathways.

Barber GN.

Trends Immunol. 2014 Feb;35(2):88-93. doi: 10.1016/j.it.2013.10.010. Epub 2013 Dec 2. Review.

PMID:
24309426
47.

DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling.

Ma Z, Moore R, Xu X, Barber GN.

PLoS Pathog. 2013 Oct;9(10):e1003721. doi: 10.1371/journal.ppat.1003721. Epub 2013 Oct 31.

48.

Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling.

Konno H, Konno K, Barber GN.

Cell. 2013 Oct 24;155(3):688-98. doi: 10.1016/j.cell.2013.09.049. Epub 2013 Oct 10.

49.

Innate immunity in an in vitro murine blastocyst model using embryonic and trophoblast stem cells.

Aikawa H, Tamai M, Mitamura K, Itmainati F, Barber GN, Tagawa Y.

J Biosci Bioeng. 2014 Mar;117(3):358-65. doi: 10.1016/j.jbiosc.2013.09.001. Epub 2013 Oct 7.

PMID:
24113362
50.

Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses.

Huang L, Li L, Lemos H, Chandler PR, Pacholczyk G, Baban B, Barber GN, Hayakawa Y, McGaha TL, Ravishankar B, Munn DH, Mellor AL.

J Immunol. 2013 Oct 1;191(7):3509-13. doi: 10.4049/jimmunol.1301419. Epub 2013 Aug 28.

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