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In vivo programming of endogenous antibodies via oral administration of adaptor ligands.

Nagano M, Carrillo N, Otsubo N, Hakamata W, Ban H, Fuller RP, Bashiruddin NK, Barbas CF 3rd.

Bioorg Med Chem. 2017 Nov 1;25(21):5952-5961. doi: 10.1016/j.bmc.2017.09.010. Epub 2017 Sep 23.


Human Serum Albumin Domain I Fusion Protein for Antibody Conjugation.

Patterson JT, Wilson HD, Asano S, Nilchan N, Fuller RP, Roush WR, Rader C, Barbas CF 3rd.

Bioconjug Chem. 2016 Oct 19;27(10):2271-2275. Epub 2016 Sep 26.


Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.

Perdigão P, Gaj T, Santa-Marta M, Barbas CF 3rd, Goncalves J.

PLoS One. 2016 Mar 2;11(3):e0150037. doi: 10.1371/journal.pone.0150037. eCollection 2016.


Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells.

Liu J, Gaj T, Yang Y, Wang N, Shui S, Kim S, Kanchiswamy CN, Kim JS, Barbas CF 3rd.

Nat Protoc. 2015 Nov;10(11):1842-59. doi: 10.1038/nprot.2015.117. Epub 2015 Oct 22.


Redesigning Recombinase Specificity for Safe Harbor Sites in the Human Genome.

Wallen MC, Gaj T, Barbas CF 3rd.

PLoS One. 2015 Sep 28;10(9):e0139123. doi: 10.1371/journal.pone.0139123. eCollection 2015.


N-Sulfonyl-β-lactam hapten as an effective labeling reagent for aldolase mAb.

Inokuma T, Fuller RP, Barbas CF 3rd.

Bioorg Med Chem Lett. 2015 Apr 15;25(8):1684-1687. doi: 10.1016/j.bmcl.2015.03.011. Epub 2015 Mar 10.


Improved cell-penetrating zinc-finger nuclease proteins for precision genome engineering.

Liu J, Gaj T, Wallen MC, Barbas CF 3rd.

Mol Ther Nucleic Acids. 2015 Mar 10;4:e232. doi: 10.1038/mtna.2015.6.


Selective arylthiolane deprotection by singlet oxygen: a promising tool for sensors and prodrugs.

Lamb BM, Barbas CF 3rd.

Chem Commun (Camb). 2015 Feb 21;51(15):3196-9. doi: 10.1039/c4cc09040c.


Genome engineering with custom recombinases.

Gaj T, Barbas CF 3rd.

Methods Enzymol. 2014;546:79-91. doi: 10.1016/B978-0-12-801185-0.00004-0.


Site-selective labeling of a lysine residue in human serum albumin.

Asano S, Patterson JT, Gaj T, Barbas CF 3rd.

Angew Chem Int Ed Engl. 2014 Oct 27;53(44):11783-6. doi: 10.1002/anie.201405924. Epub 2014 Sep 4.


Improving the serum stability of site-specific antibody conjugates with sulfone linkers.

Patterson JT, Asano S, Li X, Rader C, Barbas CF 3rd.

Bioconjug Chem. 2014 Aug 20;25(8):1402-7. doi: 10.1021/bc500276m. Epub 2014 Aug 6.


Protein delivery using Cys2-His2 zinc-finger domains.

Gaj T, Liu J, Anderson KE, Sirk SJ, Barbas CF 3rd.

ACS Chem Biol. 2014 Aug 15;9(8):1662-7. doi: 10.1021/cb500282g. Epub 2014 Jun 19.


Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies.

Gersbach CA, Gaj T, Barbas CF 3rd.

Acc Chem Res. 2014 Aug 19;47(8):2309-18. doi: 10.1021/ar500039w. Epub 2014 May 30.


Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign.

Gaj T, Sirk SJ, Tingle RD, Mercer AC, Wallen MC, Barbas CF 3rd.

J Am Chem Soc. 2014 Apr 2;136(13):5047-56. doi: 10.1021/ja4130059. Epub 2014 Mar 20.


Preparation and activities of macromolecule conjugates of the CCR5 antagonist Maraviroc.

Asano S, Gavrilyuk J, Burton DR, Barbas CF 3rd.

ACS Med Chem Lett. 2014 Feb 13;5(2):133-137.


Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering.

Liu J, Gaj T, Patterson JT, Sirk SJ, Barbas CF 3rd.

PLoS One. 2014 Jan 20;9(1):e85755. doi: 10.1371/journal.pone.0085755. eCollection 2014.


Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants.

Sirk SJ, Gaj T, Jonsson A, Mercer AC, Barbas CF 3rd.

Nucleic Acids Res. 2014 Apr;42(7):4755-66. doi: 10.1093/nar/gkt1389. Epub 2014 Jan 21.


Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors.

Mercer AC, Gaj T, Sirk SJ, Lamb BM, Barbas CF 3rd.

ACS Synth Biol. 2014 Oct 17;3(10):723-30. doi: 10.1021/sb400114p. Epub 2013 Nov 22.


Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation.

Toda N, Asano S, Barbas CF 3rd.

Angew Chem Int Ed Engl. 2013 Nov 25;52(48):12592-6. doi: 10.1002/anie.201306241. Epub 2013 Oct 2. No abstract available.


Expanding the scope of site-specific recombinases for genetic and metabolic engineering.

Gaj T, Sirk SJ, Barbas CF 3rd.

Biotechnol Bioeng. 2014 Jan;111(1):1-15. doi: 10.1002/bit.25096. Epub 2013 Sep 13. Review.


Directed evolution of the TALE N-terminal domain for recognition of all 5' bases.

Lamb BM, Mercer AC, Barbas CF 3rd.

Nucleic Acids Res. 2013 Nov;41(21):9779-85. doi: 10.1093/nar/gkt754. Epub 2013 Aug 26.


Core-structure-motivated design of iminium-enolate organocascade reactions: enantioselective syntheses of 5,6-dihydroindolizines.

Jiang X, Tan B, Barbas CF 3rd.

Angew Chem Int Ed Engl. 2013 Aug 26;52(35):9261-5. doi: 10.1002/anie.201303300. Epub 2013 Jul 10. No abstract available.


Chemically Programmed Antibodies AS HIV-1 Attachment Inhibitors.

Sato S, Inokuma T, Otsubo N, Burton DR, Barbas CF 3rd.

ACS Med Chem Lett. 2013 May 9;4(5):460-465.


Asymmetric construction of spirocyclopentenebenzofuranone core structures via highly selective phosphine-catalyzed [3 + 2] cycloaddition reactions.

Albertshofer K, Tan B, Barbas CF 3rd.

Org Lett. 2013 Jun 21;15(12):2958-61. doi: 10.1021/ol401087a. Epub 2013 Jun 3.


ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.

Gaj T, Gersbach CA, Barbas CF 3rd.

Trends Biotechnol. 2013 Jul;31(7):397-405. doi: 10.1016/j.tibtech.2013.04.004. Epub 2013 May 9. Review.


Monoclonal antibody therapeutics with up to five specificities: functional enhancement through fusion of target-specific peptides.

LaFleur DW, Abramyan D, Kanakaraj P, Smith RG, Shah RR, Wang G, Yao XT, Kankanala S, Boyd E, Zaritskaya L, Nam V, Puffer BA, Buasen P, Kaithamana S, Burnette AF, Krishnamurthy R, Patel D, Roschke VV, Kiener PA, Hilbert DM, Barbas CF 3rd.

MAbs. 2013 Mar-Apr;5(2):208-18. doi: 10.4161/mabs.23043.


Facile and stabile linkages through tyrosine: bioconjugation strategies with the tyrosine-click reaction.

Ban H, Nagano M, Gavrilyuk J, Hakamata W, Inokuma T, Barbas CF 3rd.

Bioconjug Chem. 2013 Apr 17;24(4):520-32. doi: 10.1021/bc300665t. Epub 2013 Mar 27.


Antibody conjugation approach enhances breadth and potency of neutralization of anti-HIV-1 antibodies and CD4-IgG.

Gavrilyuk J, Ban H, Uehara H, Sirk SJ, Saye-Francisco K, Cuevas A, Zablowsky E, Oza A, Seaman MS, Burton DR, Barbas CF 3rd.

J Virol. 2013 May;87(9):4985-93. doi: 10.1128/JVI.03146-12. Epub 2013 Feb 20.


A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells.

Gaj T, Mercer AC, Sirk SJ, Smith HL, Barbas CF 3rd.

Nucleic Acids Res. 2013 Apr 1;41(6):3937-46. doi: 10.1093/nar/gkt071. Epub 2013 Feb 7.


Formylbenzene diazonium hexafluorophosphate reagent for tyrosine-selective modification of proteins and the introduction of a bioorthogonal aldehyde.

Gavrilyuk J, Ban H, Nagano M, Hakamata W, Barbas CF 3rd.

Bioconjug Chem. 2012 Dec 19;23(12):2321-8. doi: 10.1021/bc300410p. Epub 2012 Nov 29.


Assembly of spirooxindole derivatives via organocatalytic iminium-enamine cascade reactions.

Albertshofer K, Anderson KE, Barbas CF 3rd.

Org Lett. 2012 Dec 7;14(23):5968-71. doi: 10.1021/ol302876c. Epub 2012 Nov 14.


Organocatalytic amidation and esterification of aldehydes with activating reagents by a cross-coupling strategy.

Tan B, Toda N, Barbas CF 3rd.

Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12538-41. doi: 10.1002/anie.201205921. Epub 2012 Nov 7.


Chimeric TALE recombinases with programmable DNA sequence specificity.

Mercer AC, Gaj T, Fuller RP, Barbas CF 3rd.

Nucleic Acids Res. 2012 Nov;40(21):11163-72. doi: 10.1093/nar/gks875. Epub 2012 Sep 26.


A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.

Hayakawa M, Toda N, Carrillo N, Thornburg NJ, Crowe JE Jr, Barbas CF 3rd.

Chembiochem. 2012 Oct 15;13(15):2191-5. doi: 10.1002/cbic.201200439. Epub 2012 Sep 10.


Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.

Kanakaraj P, Puffer BA, Yao XT, Kankanala S, Boyd E, Shah RR, Wang G, Patel D, Krishnamurthy R, Kaithamana S, Smith RG, LaFleur DW, Barbas CF 3rd, Hilbert DM, Kiener PA, Roschke VV.

MAbs. 2012 Sep-Oct;4(5):600-13. doi: 10.4161/mabs.21227. Epub 2012 Aug 6.


Induction of Fetal Hemoglobin In Vivo Mediated by a Synthetic γ-Globin Zinc Finger Activator.

Costa FC, Fedosyuk H, Neades R, de Los Rios JB, Barbas CF 3rd, Peterson KR.

Anemia. 2012;2012:507894. doi: 10.1155/2012/507894. Epub 2012 Jun 15.


Targeted gene knockout by direct delivery of zinc-finger nuclease proteins.

Gaj T, Guo J, Kato Y, Sirk SJ, Barbas CF 3rd.

Nat Methods. 2012 Jul 1;9(8):805-7. doi: 10.1038/nmeth.2030.


Rationally designed amide donors for organocatalytic asymmetric Michael reactions.

Tan B, Hernández-Torres G, Barbas CF 3rd.

Angew Chem Int Ed Engl. 2012 May 29;51(22):5381-5. doi: 10.1002/anie.201200996. Epub 2012 Apr 13. No abstract available.


Organocatalysis as a safe practical method for the stereospecific dibromination of unsaturated compounds.

Hernández-Torres G, Tan B, Barbas CF 3rd.

Org Lett. 2012 Apr 6;14(7):1858-61. doi: 10.1021/ol300456x. Epub 2012 Mar 23.


Assembly of spirooxindole derivatives containing four consecutive stereocenters via organocatalytic Michael-Henry cascade reactions.

Albertshofer K, Tan B, Barbas CF 3rd.

Org Lett. 2012 Apr 6;14(7):1834-7. doi: 10.1021/ol300441z. Epub 2012 Mar 22.


Zinc finger protein designed to target 2-long terminal repeat junctions interferes with human immunodeficiency virus integration.

Sakkhachornphop S, Barbas CF 3rd, Keawvichit R, Wongworapat K, Tayapiwatana C.

Hum Gene Ther. 2012 Sep;23(9):932-42. doi: 10.1089/hum.2011.124. Epub 2012 May 8.


Core structure-based design of organocatalytic [3+2]-cycloaddition reactions: highly efficient and stereocontrolled syntheses of 3,3'-pyrrolidonyl spirooxindoles.

Tan B, Zeng X, Leong WW, Shi Z, Barbas CF 3rd, Zhong G.

Chemistry. 2012 Jan 2;18(1):63-7. doi: 10.1002/chem.201103449. Epub 2011 Dec 9. No abstract available. Erratum in: Chemistry. 2012 May 21;18(21):6414.


Generation of human Fab antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences.

Andris-Widhopf J, Steinberger P, Fuller R, Rader C, Barbas CF 3rd.

Cold Spring Harb Protoc. 2011 Sep 1;2011(9). pii: pdb.prot065565. doi: 10.1101/pdb.prot065565.


Generation of human scFv antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences.

Andris-Widhopf J, Steinberger P, Fuller R, Rader C, Barbas CF 3rd.

Cold Spring Harb Protoc. 2011 Sep 1;2011(9). pii: pdb.prot065573. doi: 10.1101/pdb.prot065573.


Benzoate X receptor zinc-finger gene switches for drug-inducible regulation of transcription.

Schwimmer LJ, Gonzalez B, Barbas CF 3rd.

Gene Ther. 2012 Apr;19(4):458-62. doi: 10.1038/gt.2011.112. Epub 2011 Jul 28.


Highly efficient hydrogen-bonding catalysis of the Diels-Alder reaction of 3-vinylindoles and methyleneindolinones provides carbazolespirooxindole skeletons.

Tan B, Hernández-Torres G, Barbas CF.

J Am Chem Soc. 2011 Aug 17;133(32):12354-7. doi: 10.1021/ja203812h. Epub 2011 Jul 22.


Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase.

Gersbach CA, Gaj T, Gordley RM, Mercer AC, Barbas CF 3rd.

Nucleic Acids Res. 2011 Sep 1;39(17):7868-78. doi: 10.1093/nar/gkr421. Epub 2011 Jun 7.


Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst.

Tan B, Candeias NR, Barbas CF 3rd.

Nat Chem. 2011 Jun;3(6):473-7. doi: 10.1038/nchem.1039. Epub 2011 May 8.


Core-structure-motivated design of a phosphine-catalyzed [3+2] cycloaddition reaction: enantioselective syntheses of spirocyclopenteneoxindoles.

Tan B, Candeias NR, Barbas CF 3rd.

J Am Chem Soc. 2011 Apr 6;133(13):4672-5. doi: 10.1021/ja110147w. Epub 2011 Mar 11.


Structure-guided reprogramming of serine recombinase DNA sequence specificity.

Gaj T, Mercer AC, Gersbach CA, Gordley RM, Barbas CF 3rd.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):498-503. doi: 10.1073/pnas.1014214108. Epub 2010 Dec 27.

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