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Items: 23

1.

Novel N-acetyl-Glycol-split heparin biotin-conjugates endowed with anti-heparanase activity.

Esposito E, Vlodavsky I, Barash U, Roscilli G, Milazzo FM, Giannini G, Naggi A.

Eur J Med Chem. 2019 Oct 30:111831. doi: 10.1016/j.ejmech.2019.111831. [Epub ahead of print]

PMID:
31740052
2.

Heparanase and chemotherapy synergize to drive macrophage activation and enhance tumor growth.

Bhattacharya U, Gutter-Kapon L, Kan T, Boyango I, Barash U, Yang SM, Liu J, Gross-Cohen M, Sanderson RD, Shaked Y, Ilan N, Vlodavsky I.

Cancer Res. 2019 Nov 5. pii: canres.1676.2019. doi: 10.1158/0008-5472.CAN-19-1676. [Epub ahead of print]

PMID:
31690669
3.

Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds.

Mohan CD, Hari S, Preetham HD, Rangappa S, Barash U, Ilan N, Nayak SC, Gupta VK, Basappa, Vlodavsky I, Rangappa KS.

iScience. 2019 May 31;15:360-390. doi: 10.1016/j.isci.2019.04.034. Epub 2019 May 3. Review.

4.

Heparanase promotes glioma progression via enhancing CD24 expression.

Barash U, Spyrou A, Liu P, Vlodavsky E, Zhu C, Luo J, Su D, Ilan N, Forsberg-Nilsson K, Vlodavsky I, Yang X.

Int J Cancer. 2019 Sep 15;145(6):1596-1608. doi: 10.1002/ijc.32375. Epub 2019 May 14.

PMID:
31032901
5.

Heparanase inhibitors restrain mesothelioma.

Lapidot M, Barash U, Vlodavsky I, Pass H.

Oncotarget. 2018 Dec 7;9(96):36830-36832. doi: 10.18632/oncotarget.26243. eCollection 2018 Dec 7.

6.

Specific Inhibition of Heparanase by a Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice.

Loka RS, Sletten ET, Barash U, Vlodavsky I, Nguyen HM.

ACS Appl Mater Interfaces. 2019 Jan 9;11(1):244-254. doi: 10.1021/acsami.8b17625. Epub 2018 Dec 31.

7.

Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer.

Katz A, Barash U, Boyango I, Feld S, Zohar Y, Hammond E, Ilan N, Kremer R, Vlodavsky I.

Oncotarget. 2018 Apr 10;9(27):19294-19306. doi: 10.18632/oncotarget.25022. eCollection 2018 Apr 10.

8.

Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.

Barash U, Lapidot M, Zohar Y, Loomis C, Moreira A, Feld S, Goparaju C, Yang H, Hammond E, Zhang G, Li JP, Ilan N, Nagler A, Pass HI, Vlodavsky I.

J Natl Cancer Inst. 2018 Oct 1;110(10):1102-1114. doi: 10.1093/jnci/djy032.

9.

Targeting heparanase to the mammary epithelium enhances mammary gland development and promotes tumor growth and metastasis.

Boyango I, Barash U, Fux L, Naroditsky I, Ilan N, Vlodavsky I.

Matrix Biol. 2018 Jan;65:91-103. doi: 10.1016/j.matbio.2017.08.005. Epub 2017 Sep 13.

PMID:
28916201
10.

Inhibition of Heparanase in Pediatric Brain Tumor Cells Attenuates their Proliferation, Invasive Capacity, and In Vivo Tumor Growth.

Spyrou A, Kundu S, Haseeb L, Yu D, Olofsson T, Dredge K, Hammond E, Barash U, Vlodavsky I, Forsberg-Nilsson K.

Mol Cancer Ther. 2017 Aug;16(8):1705-1716. doi: 10.1158/1535-7163.MCT-16-0900. Epub 2017 Jul 17.

11.

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity.

Baburajeev CP, Mohan CD, Rangappa S, Mason DJ, Fuchs JE, Bender A, Barash U, Vlodavsky I, Basappa, Rangappa KS.

BMC Cancer. 2017 Mar 31;17(1):235. doi: 10.1186/s12885-017-3214-8.

12.

Overexpression of heparanase attenuated TGF-β-stimulated signaling in tumor cells.

Batool T, Fang J, Barash U, Moustakas A, Vlodavsky I, Li JP.

FEBS Open Bio. 2017 Feb 11;7(3):405-413. doi: 10.1002/2211-5463.12190. eCollection 2017 Mar.

13.

The cardiac maladaptive ATF3-dependent cross-talk between cardiomyocytes and macrophages is mediated by the IFNγ-CXCL10-CXCR3 axis.

Koren L, Barash U, Zohar Y, Karin N, Aronheim A.

Int J Cardiol. 2017 Feb 1;228:394-400. doi: 10.1016/j.ijcard.2016.11.159. Epub 2016 Nov 10.

PMID:
27870968
14.

Heparanase 2 Attenuates Head and Neck Tumor Vascularity and Growth.

Gross-Cohen M, Feld S, Doweck I, Neufeld G, Hasson P, Arvatz G, Barash U, Naroditsky I, Ilan N, Vlodavsky I.

Cancer Res. 2016 May 1;76(9):2791-801. doi: 10.1158/0008-5472.CAN-15-1975. Epub 2016 Mar 24.

15.

Correction: Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock.

Arad G, Levy R, Nasie I, Hillman D, Rotfogel Z, Barash U, Supper E, Shpilka T, Minis A, Kaempfer R.

PLoS Biol. 2015 Aug 21;13(8):e1002237. doi: 10.1371/journal.pbio.1002237. eCollection 2015 Aug. No abstract available.

16.

Involvement of Heparanase in Empyema: Implication for Novel Therapeutic Approaches.

Lapidot M, Barash U, Zohar Y, Geffen Y, Naroditsky I, Ilan N, Best LA, Vlodavsky I.

J Clin Cell Immunol. 2015 Feb;6(1). pii: 290.

17.

Heparanase cooperates with Ras to drive breast and skin tumorigenesis.

Boyango I, Barash U, Naroditsky I, Li JP, Hammond E, Ilan N, Vlodavsky I.

Cancer Res. 2014 Aug 15;74(16):4504-14. doi: 10.1158/0008-5472.CAN-13-2962. Epub 2014 Jun 26.

18.

Heparanase enhances myeloma progression via CXCL10 downregulation.

Barash U, Zohar Y, Wildbaum G, Beider K, Nagler A, Karin N, Ilan N, Vlodavsky I.

Leukemia. 2014 Nov;28(11):2178-87. doi: 10.1038/leu.2014.121. Epub 2014 Apr 4.

19.

Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibody.

Barash U, Arvatz G, Farfara R, Naroditsky I, Doweck I, Feld S, Ben-Izhak O, Ilan N, Nativ O, Vlodavsky I.

PLoS One. 2012;7(12):e51494. doi: 10.1371/journal.pone.0051494. Epub 2012 Dec 12.

20.

Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock.

Arad G, Levy R, Nasie I, Hillman D, Rotfogel Z, Barash U, Supper E, Shpilka T, Minis A, Kaempfer R.

PLoS Biol. 2011 Sep;9(9):e1001149. doi: 10.1371/journal.pbio.1001149. Epub 2011 Sep 13. Erratum in: PLoS Biol. 2015 Aug;13(8):e1002237.

21.

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.

Barash U, Cohen-Kaplan V, Dowek I, Sanderson RD, Ilan N, Vlodavsky I.

FEBS J. 2010 Oct;277(19):3890-903. doi: 10.1111/j.1742-4658.2010.07799.x. Epub 2010 Aug 31. Review.

22.

Post-transcriptional regulation of heparanase gene expression by a 3' AU-rich element.

Arvatz G, Barash U, Nativ O, Ilan N, Vlodavsky I.

FASEB J. 2010 Dec;24(12):4969-76. doi: 10.1096/fj.10-156372. Epub 2010 Aug 26.

23.

A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.

Barash U, Cohen-Kaplan V, Arvatz G, Gingis-Velitski S, Levy-Adam F, Nativ O, Shemesh R, Ayalon-Sofer M, Ilan N, Vlodavsky I.

FASEB J. 2010 Apr;24(4):1239-48. doi: 10.1096/fj.09-147074. Epub 2009 Dec 9.

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