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Items: 1 to 50 of 230

1.

Hindered dialkyl ether synthesis with electrogenerated carbocations.

Xiang J, Shang M, Kawamata Y, Lundberg H, Reisberg SH, Chen M, Mykhailiuk P, Beutner G, Collins MR, Davies A, Del Bel M, Gallego GM, Spangler JE, Starr J, Yang S, Blackmond DG, Baran PS.

Nature. 2019 Sep;573(7774):398-402. doi: 10.1038/s41586-019-1539-y. Epub 2019 Sep 9.

PMID:
31501569
2.

Impact of Stereo- and Regiochemistry on Energetic Materials.

Barton LM, Edwards JT, Johnson EC, Bukowski EJ, Sausa RC, Byrd EFC, Orlicki JA, Sabatini JJ, Baran PS.

J Am Chem Soc. 2019 Aug 14;141(32):12531-12535. doi: 10.1021/jacs.9b06961. Epub 2019 Aug 5.

PMID:
31361955
3.

Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support.

Flood DT, Asai S, Zhang X, Wang J, Yoon L, Adams ZC, Dillingham BC, Sanchez BB, Vantourout JC, Flanagan ME, Piotrowski DW, Richardson P, Green SA, Shenvi RA, Chen JS, Baran PS, Dawson PE.

J Am Chem Soc. 2019 Jun 26;141(25):9998-10006. doi: 10.1021/jacs.9b03774. Epub 2019 Jun 12.

PMID:
31136164
4.

Modular, stereocontrolled Cβ-H/Cα-C activation of alkyl carboxylic acids.

Shang M, Feu KS, Vantourout JC, Barton LM, Osswald HL, Kato N, Gagaring K, McNamara CW, Chen G, Hu L, Ni S, Fernández-Canelas P, Chen M, Merchant RR, Qin T, Schreiber SL, Melillo B, Yu JQ, Baran PS.

Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8721-8727. doi: 10.1073/pnas.1903048116. Epub 2019 Apr 17.

5.

A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines.

Ni S, Padial NM, Kingston C, Vantourout JC, Schmitt DC, Edwards JT, Kruszyk MM, Merchant RR, Mykhailiuk PK, Sanchez BB, Yang S, Perry MA, Gallego GM, Mousseau JJ, Collins MR, Cherney RJ, Lebed PS, Chen JS, Qin T, Baran PS.

J Am Chem Soc. 2019 Apr 24;141(16):6726-6739. doi: 10.1021/jacs.9b02238. Epub 2019 Apr 16.

PMID:
30943023
6.

Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications.

Kawamata Y, Vantourout JC, Hickey DP, Bai P, Chen L, Hou Q, Qiao W, Barman K, Edwards MA, Garrido-Castro AF, deGruyter JN, Nakamura H, Knouse K, Qin C, Clay KJ, Bao D, Li C, Starr JT, Garcia-Irizarry C, Sach N, White HS, Neurock M, Minteer SD, Baran PS.

J Am Chem Soc. 2019 Apr 17;141(15):6392-6402. doi: 10.1021/jacs.9b01886. Epub 2019 Apr 2.

PMID:
30905151
7.

Scalable and safe synthetic organic electroreduction inspired by Li-ion battery chemistry.

Peters BK, Rodriguez KX, Reisberg SH, Beil SB, Hickey DP, Kawamata Y, Collins M, Starr J, Chen L, Udyavara S, Klunder K, Gorey TJ, Anderson SL, Neurock M, Minteer SD, Baran PS.

Science. 2019 Feb 22;363(6429):838-845. doi: 10.1126/science.aav5606.

PMID:
30792297
8.

Corrigendum: Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms.

Qin T, Malins LR, Edwards JT, Merchant RR, Novak AJE, Zhong JZ, Mills RB, Yan M, Yuan C, Eastgate MD, Baran PS.

Angew Chem Int Ed Engl. 2019 Feb 11;58(7):1866. doi: 10.1002/anie.201812580. Epub 2018 Nov 14. No abstract available.

PMID:
30714686
9.

11-Step Total Synthesis of Teleocidins B-1-B-4.

Nakamura H, Yasui K, Kanda Y, Baran PS.

J Am Chem Soc. 2019 Jan 30;141(4):1494-1497. doi: 10.1021/jacs.8b13697. Epub 2019 Jan 15.

PMID:
30636411
10.

Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents.

Chen TG, Zhang H, Mykhailiuk PK, Merchant RR, Smith CA, Qin T, Baran PS.

Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2454-2458. doi: 10.1002/anie.201814524. Epub 2019 Jan 30.

PMID:
30623547
11.

Direct Carbon Isotope Exchange through Decarboxylative Carboxylation.

Kingston C, Wallace MA, Allentoff AJ, deGruyter JN, Chen JS, Gong SX, Bonacorsi S Jr, Baran PS.

J Am Chem Soc. 2019 Jan 16;141(2):774-779. doi: 10.1021/jacs.8b12035. Epub 2019 Jan 3.

PMID:
30605319
12.

Concise Total Synthesis of Herqulines B and C.

He C, Stratton TP, Baran PS.

J Am Chem Soc. 2019 Jan 9;141(1):29-32. doi: 10.1021/jacs.8b13029. Epub 2018 Dec 24.

PMID:
30575396
13.

Cu-Catalyzed Decarboxylative Borylation.

Wang J, Shang M, Lundberg H, Feu KS, Hecker SJ, Qin T, Blackmond DG, Baran PS.

ACS Catal. 2018 Oct 5;8(10):9537-9542. doi: 10.1021/acscatal.8b02928. Epub 2018 Sep 13.

14.

Alkyl Sulfinates: Radical Precursors Enabling Drug Discovery.

Smith JM, Dixon JA, deGruyter JN, Baran PS.

J Med Chem. 2019 Mar 14;62(5):2256-2264. doi: 10.1021/acs.jmedchem.8b01303. Epub 2018 Oct 16.

PMID:
30272973
15.

A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling.

Ni S, Garrido-Castro AF, Merchant RR, de Gruyter JN, Schmitt DC, Mousseau JJ, Gallego GM, Yang S, Collins MR, Qiao JX, Yeung KS, Langley DR, Poss MA, Scola PM, Qin T, Baran PS.

Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14560-14565. doi: 10.1002/anie.201809310. Epub 2018 Oct 15.

PMID:
30212610
16.

Unlocking P(V): Reagents for chiral phosphorothioate synthesis.

Knouse KW, deGruyter JN, Schmidt MA, Zheng B, Vantourout JC, Kingston C, Mercer SE, Mcdonald IM, Olson RE, Zhu Y, Hang C, Zhu J, Yuan C, Wang Q, Park P, Eastgate MD, Baran PS.

Science. 2018 Sep 21;361(6408):1234-1238. doi: 10.1126/science.aau3369. Epub 2018 Aug 2.

17.

Radical Retrosynthesis.

Smith JM, Harwood SJ, Baran PS.

Acc Chem Res. 2018 Aug 21;51(8):1807-1817. doi: 10.1021/acs.accounts.8b00209. Epub 2018 Aug 2.

18.

Building C(sp3)-rich complexity by combining cycloaddition and C-C cross-coupling reactions.

Chen TG, Barton LM, Lin Y, Tsien J, Kossler D, Bastida I, Asai S, Bi C, Chen JS, Shan M, Fang H, Fang FG, Choi HW, Hawkins L, Qin T, Baran PS.

Nature. 2018 Aug;560(7718):350-354. doi: 10.1038/s41586-018-0391-9. Epub 2018 Jul 30.

19.

Kinetically guided radical-based synthesis of C(sp3)-C(sp3) linkages on DNA.

Wang J, Lundberg H, Asai S, Martín-Acosta P, Chen JS, Brown S, Farrell W, Dushin RG, O'Donnell CJ, Ratnayake AS, Richardson P, Liu Z, Qin T, Blackmond DG, Baran PS.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6404-E6410. doi: 10.1073/pnas.1806900115. Epub 2018 Jun 26.

20.

Divergent Synthesis of Pyrone Diterpenes via Radical Cross Coupling.

Merchant RR, Oberg KM, Lin Y, Novak AJE, Felding J, Baran PS.

J Am Chem Soc. 2018 Jun 20;140(24):7462-7465. doi: 10.1021/jacs.8b04891. Epub 2018 Jun 11.

21.

Divergent synthesis of thapsigargin analogs.

Chu H, Dünstl G, Felding J, Baran PS.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2705-2707. doi: 10.1016/j.bmcl.2018.03.065. Epub 2018 Mar 23.

22.

Natural Product Total Synthesis: As Exciting as Ever and Here To Stay.

Baran PS.

J Am Chem Soc. 2018 Apr 11;140(14):4751-4755. doi: 10.1021/jacs.8b02266. No abstract available.

PMID:
29635919
23.

Modular radical cross-coupling with sulfones enables access to sp3-rich (fluoro)alkylated scaffolds.

Merchant RR, Edwards JT, Qin T, Kruszyk MM, Bi C, Che G, Bao DH, Qiao W, Sun L, Collins MR, Fadeyi OO, Gallego GM, Mousseau JJ, Nuhant P, Baran PS.

Science. 2018 Apr 6;360(6384):75-80. doi: 10.1126/science.aar7335. Epub 2018 Feb 18.

24.

Scalable Access to Arylomycins via C-H Functionalization Logic.

Peters DS, Romesberg FE, Baran PS.

J Am Chem Soc. 2018 Feb 14;140(6):2072-2075. doi: 10.1021/jacs.8b00087. Epub 2018 Feb 6.

25.

Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs.

Parker CG, Kuttruff CA, Galmozzi A, Jørgensen L, Yeh CH, Hermanson DJ, Wang Y, Artola M, McKerrall SJ, Josyln CM, Nørremark B, Dünstl G, Felding J, Saez E, Baran PS, Cravatt BF.

ACS Cent Sci. 2017 Dec 27;3(12):1276-1285. doi: 10.1021/acscentsci.7b00420. Epub 2017 Dec 6.

26.

CITU: A Peptide and Decarboxylative Coupling Reagent.

deGruyter JN, Malins LR, Wimmer L, Clay KJ, Lopez-Ogalla J, Qin T, Cornella J, Liu Z, Che G, Bao D, Stevens JM, Qiao JX, Allen MP, Poss MA, Baran PS.

Org Lett. 2017 Nov 17;19(22):6196-6199. doi: 10.1021/acs.orglett.7b03121. Epub 2017 Nov 8.

27.

Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance.

Yan M, Kawamata Y, Baran PS.

Chem Rev. 2017 Nov 8;117(21):13230-13319. doi: 10.1021/acs.chemrev.7b00397. Epub 2017 Oct 9.

28.

Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097.

Mathur A, Wang B, Smith D, Li J, Pawluczyk J, Sun JH, Wong MK, Krishnananthan S, Wu DR, Sun D, Li P, Yip S, Chen BC, Baran PS, Chen Q, Lopez OD, Yong Z, Bender JA, Nguyen VN, Romine JL, Laurent DRS, Wang G, Kadow JF, Meanwell NA, Belema M, Zhao R.

J Org Chem. 2017 Oct 6;82(19):10376-10387. doi: 10.1021/acs.joc.7b01852. Epub 2017 Sep 14.

PMID:
28877441
29.

Electrochemically Enabled, Nickel-Catalyzed Amination.

Li C, Kawamata Y, Nakamura H, Vantourout JC, Liu Z, Hou Q, Bao D, Starr JT, Chen J, Yan M, Baran PS.

Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13088-13093. doi: 10.1002/anie.201707906. Epub 2017 Sep 14.

30.

Synthetic Organic Electrochemistry: Calling All Engineers.

Yan M, Kawamata Y, Baran PS.

Angew Chem Int Ed Engl. 2018 Apr 9;57(16):4149-4155. doi: 10.1002/anie.201707584. Epub 2017 Nov 3. Review.

31.

Decoding the Mechanism of Intramolecular Cu-Directed Hydroxylation of sp3 C-H Bonds.

Trammell R, See YY, Herrmann AT, Xie N, Díaz DE, Siegler MA, Baran PS, Garcia-Bosch I.

J Org Chem. 2017 Aug 4;82(15):7887-7904. doi: 10.1021/acs.joc.7b01069. Epub 2017 Jul 14.

32.

Residue-Specific Peptide Modification: A Chemist's Guide.

deGruyter JN, Malins LR, Baran PS.

Biochemistry. 2017 Aug 1;56(30):3863-3873. doi: 10.1021/acs.biochem.7b00536. Epub 2017 Jul 17. Review.

33.

Decarboxylative Alkynylation.

Smith JM, Qin T, Merchant RR, Edwards JT, Malins LR, Liu Z, Che G, Shen Z, Shaw SA, Eastgate MD, Baran PS.

Angew Chem Int Ed Engl. 2017 Sep 18;56(39):11906-11910. doi: 10.1002/anie.201705107. Epub 2017 Aug 1.

34.

Scalable, Electrochemical Oxidation of Unactivated C-H Bonds.

Kawamata Y, Yan M, Liu Z, Bao DH, Chen J, Starr JT, Baran PS.

J Am Chem Soc. 2017 Jun 7;139(22):7448-7451. doi: 10.1021/jacs.7b03539. Epub 2017 May 23.

35.

Decarboxylative alkenylation.

Edwards JT, Merchant RR, McClymont KS, Knouse KW, Qin T, Malins LR, Vokits B, Shaw SA, Bao DH, Wei FL, Zhou T, Eastgate MD, Baran PS.

Nature. 2017 May 11;545(7653):213-218. doi: 10.1038/nature22307. Epub 2017 Apr 19.

36.

Decarboxylative borylation.

Li C, Wang J, Barton LM, Yu S, Tian M, Peters DS, Kumar M, Yu AW, Johnson KA, Chatterjee AK, Yan M, Baran PS.

Science. 2017 Jun 9;356(6342). pii: eaam7355. doi: 10.1126/science.aam7355. Epub 2017 Apr 13.

37.

Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products.

Malins LR, deGruyter JN, Robbins KJ, Scola PM, Eastgate MD, Ghadiri MR, Baran PS.

J Am Chem Soc. 2017 Apr 12;139(14):5233-5241. doi: 10.1021/jacs.7b01624. Epub 2017 Mar 31.

38.

Alkyl-(Hetero)Aryl Bond Formation via Decarboxylative Cross-Coupling: A Systematic Analysis.

Sandfort F, O'Neill MJ, Cornella J, Wimmer L, Baran PS.

Angew Chem Int Ed Engl. 2017 Mar 13;56(12):3319-3323. doi: 10.1002/anie.201612314. Epub 2017 Feb 10.

39.

Scalable Synthesis of (-)-Thapsigargin.

Chu H, Smith JM, Felding J, Baran PS.

ACS Cent Sci. 2017 Jan 25;3(1):47-51. doi: 10.1021/acscentsci.6b00313. Epub 2016 Dec 19.

40.

Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity.

Lopchuk JM, Fjelbye K, Kawamata Y, Malins LR, Pan CM, Gianatassio R, Wang J, Prieto L, Bradow J, Brandt TA, Collins MR, Elleraas J, Ewanicki J, Farrell W, Fadeyi OO, Gallego GM, Mousseau JJ, Oliver R, Sach NW, Smith JK, Spangler JE, Zhu H, Zhu J, Baran PS.

J Am Chem Soc. 2017 Mar 1;139(8):3209-3226. doi: 10.1021/jacs.6b13229. Epub 2017 Feb 20.

41.

Fe-Catalyzed C-C Bond Construction from Olefins via Radicals.

Lo JC, Kim D, Pan CM, Edwards JT, Yabe Y, Gui J, Qin T, Gutiérrez S, Giacoboni J, Smith MW, Holland PL, Baran PS.

J Am Chem Soc. 2017 Feb 15;139(6):2484-2503. doi: 10.1021/jacs.6b13155. Epub 2017 Feb 2.

42.

Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms.

Qin T, Malins LR, Edwards JT, Merchant RR, Novak AJ, Zhong JZ, Mills RB, Yan M, Yuan C, Eastgate MD, Baran PS.

Angew Chem Int Ed Engl. 2017 Jan 2;56(1):260-265. doi: 10.1002/anie.201609662. Epub 2016 Dec 16. Erratum in: Angew Chem Int Ed Engl. 2019 Feb 11;58(7):1866.

43.

11-Step Total Synthesis of Araiosamines.

Tian M, Yan M, Baran PS.

J Am Chem Soc. 2016 Nov 2;138(43):14234-14237. Epub 2016 Oct 19.

44.

Radicals: Reactive Intermediates with Translational Potential.

Yan M, Lo JC, Edwards JT, Baran PS.

J Am Chem Soc. 2016 Oct 5;138(39):12692-12714. Epub 2016 Sep 26. Review.

45.

Redox-Active Esters in Fe-Catalyzed C-C Coupling.

Toriyama F, Cornella J, Wimmer L, Chen TG, Dixon DD, Creech G, Baran PS.

J Am Chem Soc. 2016 Sep 7;138(35):11132-5. doi: 10.1021/jacs.6b07172. Epub 2016 Aug 29.

46.

Tagging the Untaggable: A Difluoroalkyl-Sulfinate Ketone-Based Reagent for Direct C-H Functionalization of Bioactive Heteroarenes.

Gnaim S, Scomparin A, Li X, Baran PS, Rader C, Satchi-Fainaro R, Shabat D.

Bioconjug Chem. 2016 Sep 21;27(9):1965-71. doi: 10.1021/acs.bioconjchem.6b00382. Epub 2016 Aug 15.

PMID:
27494153
47.

11-Step Total Synthesis of (-)-Maoecrystal V.

Cernijenko A, Risgaard R, Baran PS.

J Am Chem Soc. 2016 Aug 3;138(30):9425-8. doi: 10.1021/jacs.6b06623. Epub 2016 Jul 26.

48.

Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids.

Wang J, Qin T, Chen TG, Wimmer L, Edwards JT, Cornella J, Vokits B, Shaw SA, Baran PS.

Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9676-9. doi: 10.1002/anie.201605463. Epub 2016 Jul 6.

49.

11-Step Total Synthesis of Pallambins C and D.

Martinez LP, Umemiya S, Wengryniuk SE, Baran PS.

J Am Chem Soc. 2016 Jun 22;138(24):7536-9. doi: 10.1021/jacs.6b04816. Epub 2016 Jun 10.

50.

Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method.

Horn EJ, Rosen BR, Baran PS.

ACS Cent Sci. 2016 May 25;2(5):302-8. doi: 10.1021/acscentsci.6b00091. Epub 2016 May 5. Review.

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