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Blocking CRH receptors in adults mitigates age-related memory impairments provoked by early-life adversity.

Short AK, Maras PM, Pham AL, Ivy AS, Baram TZ.

Neuropsychopharmacology. 2019 Nov 7. doi: 10.1038/s41386-019-0562-x. [Epub ahead of print]


Dexamethasone attenuates hyperexcitability provoked by experimental febrile status epilepticus.

Garcia-Curran MM, Hall AM, Patterson KP, Shao M, Eltom N, Chen K, Dubé CM, Baram TZ.

eNeuro. 2019 Nov 4. pii: ENEURO.0430-19.2019. doi: 10.1523/ENEURO.0430-19.2019. [Epub ahead of print]


Early-life adversity and neurological disease: age-old questions and novel answers.

Short AK, Baram TZ.

Nat Rev Neurol. 2019 Nov;15(11):657-669. doi: 10.1038/s41582-019-0246-5. Epub 2019 Sep 17. Review.


Intra-individual changes in methylome profiles: an epigenetic 'scar' of early-life adversity?

Mortazavi A, Baram TZ.

Neuropsychopharmacology. 2019 Aug 30. doi: 10.1038/s41386-019-0496-3. [Epub ahead of print] No abstract available.


Across continents and demographics, unpredictable maternal signals are associated with children's cognitive function.

Davis EP, Korja R, Karlsson L, Glynn LM, Sandman CA, Vegetabile B, Kataja EL, Nolvi S, Sinervä E, Pelto J, Karlsson H, Stern HS, Baram TZ.

EBioMedicine. 2019 Aug;46:256-263. doi: 10.1016/j.ebiom.2019.07.025. Epub 2019 Jul 27.


Construction and disruption of spatial memory networks during development.

Baram TZ, Donato F, Holmes GL.

Learn Mem. 2019 Jun 17;26(7):206-218. doi: 10.1101/lm.049239.118. Print 2019 Jul.


Intra-individual methylomics detects the impact of early-life adversity.

Jiang S, Kamei N, Bolton JL, Ma X, Stern HS, Baram TZ, Mortazavi A.

Life Sci Alliance. 2019 Apr 1;2(2). pii: e201800204. doi: 10.26508/lsa.201800204. Print 2019 Apr.


New viral-genetic mapping uncovers an enrichment of corticotropin-releasing hormone-expressing neuronal inputs to the nucleus accumbens from stress-related brain regions.

Itoga CA, Chen Y, Fateri C, Echeverry PA, Lai JM, Delgado J, Badhon S, Short A, Baram TZ, Xu X.

J Comp Neurol. 2019 Oct 15;527(15):2474-2487. doi: 10.1002/cne.24676. Epub 2019 Mar 30.


Programming of Stress-Sensitive Neurons and Circuits by Early-Life Experiences.

Bolton JL, Short AK, Simeone KA, Daglian J, Baram TZ.

Front Behav Neurosci. 2019 Feb 18;13:30. doi: 10.3389/fnbeh.2019.00030. eCollection 2019.


The influence of unpredictable, fragmented parental signals on the developing brain.

Glynn LM, Baram TZ.

Front Neuroendocrinol. 2019 Apr;53:100736. doi: 10.1016/j.yfrne.2019.01.002. Epub 2019 Jan 31. Review.


Measuring novel antecedents of mental illness: the Questionnaire of Unpredictability in Childhood.

Glynn LM, Stern HS, Howland MA, Risbrough VB, Baker DG, Nievergelt CM, Baram TZ, Davis EP.

Neuropsychopharmacology. 2019 Apr;44(5):876-882. doi: 10.1038/s41386-018-0280-9. Epub 2018 Nov 23.


Hyper-diversity of CRH interneurons in mouse hippocampus.

Gunn BG, Sanchez GA, Lynch G, Baram TZ, Chen Y.

Brain Struct Funct. 2019 Mar;224(2):583-598. doi: 10.1007/s00429-018-1793-z. Epub 2018 Nov 20.


Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic?

Curran MM, Haddad E, Patterson KP, Choy M, Dubé CM, Baram TZ, Obenaus A.

Epilepsia. 2018 Nov;59(11):2005-2018. doi: 10.1111/epi.14561. Epub 2018 Sep 6.


Parental smartphone use and children's mental outcomes: a neuroscience perspective.

Baram TZ, Bolton JL.

Neuropsychopharmacology. 2019 Jan;44(2):239-240. doi: 10.1038/s41386-018-0184-8. Epub 2018 Aug 21. Review. No abstract available.


Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia.

Bolton JL, Ruiz CM, Rismanchi N, Sanchez GA, Castillo E, Huang J, Cross C, Baram TZ, Mahler SV.

Neurobiol Stress. 2018 Jan 12;8:57-67. doi: 10.1016/j.ynstr.2018.01.002. eCollection 2018 Feb.


Does Anhedonia Presage Increased Risk of Posttraumatic Stress Disorder? : Adolescent Anhedonia and Posttraumatic Disorders.

Risbrough VB, Glynn LM, Davis EP, Sandman CA, Obenaus A, Stern HS, Keator DB, Yassa MA, Baram TZ, Baker DG.

Curr Top Behav Neurosci. 2018;38:249-265. doi: 10.1007/7854_2018_51.


Network specialization during adolescence: Hippocampal effective connectivity in boys and girls.

Riley JD, Chen EE, Winsell J, Davis EP, Glynn LM, Baram TZ, Sandman CA, Small SL, Solodkin A.

Neuroimage. 2018 Jul 15;175:402-412. doi: 10.1016/j.neuroimage.2018.04.013. Epub 2018 Apr 9.


Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches.

Vogel Ciernia A, Laufer BI, Dunaway KW, Mordaunt CE, Coulson RL, Totah TS, Stolzenberg DS, Frahm JC, Singh-Taylor A, Baram TZ, LaSalle JM, Yasui DH.

Epigenetics. 2018;13(3):318-330. doi: 10.1080/15592294.2018.1451720. Epub 2018 May 10.


Cortical Thinning and Neuropsychiatric Outcomes in Children Exposed to Prenatal Adversity: A Role for Placental CRH?

Sandman CA, Curran MM, Davis EP, Glynn LM, Head K, Baram TZ.

Am J Psychiatry. 2018 May 1;175(5):471-479. doi: 10.1176/appi.ajp.2017.16121433. Epub 2018 Mar 2.


Prenatal maternal mood patterns predict child temperament and adolescent mental health.

Glynn LM, Howland MA, Sandman CA, Davis EP, Phelan M, Baram TZ, Stern HS.

J Affect Disord. 2018 Mar 1;228:83-90. doi: 10.1016/j.jad.2017.11.065. Epub 2017 Nov 14.


Anhedonia Following Early-Life Adversity Involves Aberrant Interaction of Reward and Anxiety Circuits and Is Reversed by Partial Silencing of Amygdala Corticotropin-Releasing Hormone Gene.

Bolton JL, Molet J, Regev L, Chen Y, Rismanchi N, Haddad E, Yang DZ, Obenaus A, Baram TZ.

Biol Psychiatry. 2018 Jan 15;83(2):137-147. doi: 10.1016/j.biopsych.2017.08.023. Epub 2017 Sep 7.


Stress and Seizures: Space, Time and Hippocampal Circuits.

Gunn BG, Baram TZ.

Trends Neurosci. 2017 Nov;40(11):667-679. doi: 10.1016/j.tins.2017.08.004. Epub 2017 Sep 12. Review.


Exposure to unpredictable maternal sensory signals influences cognitive development across species.

Davis EP, Stout SA, Molet J, Vegetabile B, Glynn LM, Sandman CA, Heins K, Stern H, Baram TZ.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10390-10395. doi: 10.1073/pnas.1703444114. Epub 2017 Sep 11.


Neuroinflammation imaging markers for epileptogenesis.

Koepp MJ, Årstad E, Bankstahl JP, Dedeurwaerdere S, Friedman A, Potschka H, Ravizza T, Theodore WH, Baram TZ.

Epilepsia. 2017 Jul;58 Suppl 3:11-19. doi: 10.1111/epi.13778.


Abnormal dendritic maturation of developing cortical neurons exposed to corticotropin releasing hormone (CRH): Insights into effects of prenatal adversity?

Curran MM, Sandman CA, Poggi Davis E, Glynn LM, Baram TZ.

PLoS One. 2017 Jun 28;12(6):e0180311. doi: 10.1371/journal.pone.0180311. eCollection 2017.


Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential.

Walker CD, Bath KG, Joels M, Korosi A, Larauche M, Lucassen PJ, Morris MJ, Raineki C, Roth TL, Sullivan RM, Taché Y, Baram TZ.

Stress. 2017 Sep;20(5):421-448. doi: 10.1080/10253890.2017.1343296. Epub 2017 Jul 12.


The Endogenous Stress Hormone CRH Modulates Excitatory Transmission and Network Physiology in Hippocampus.

Gunn BG, Cox CD, Chen Y, Frotscher M, Gall CM, Baram TZ, Lynch G.

Cereb Cortex. 2017 Aug 1;27(8):4182-4198. doi: 10.1093/cercor/bhx103.


New insights into early-life stress and behavioral outcomes.

Bolton JL, Molet J, Ivy A, Baram TZ.

Curr Opin Behav Sci. 2017 Apr;14:133-139. doi: 10.1016/j.cobeha.2016.12.012.


Enduring Memory Impairments Provoked by Developmental Febrile Seizures Are Mediated by Functional and Structural Effects of Neuronal Restrictive Silencing Factor.

Patterson KP, Barry JM, Curran MM, Singh-Taylor A, Brennan G, Rismanchi N, Page M, Noam Y, Holmes GL, Baram TZ.

J Neurosci. 2017 Apr 5;37(14):3799-3812. doi: 10.1523/JNEUROSCI.3748-16.2017. Epub 2017 Mar 8.


The Role of Sirt1 in Epileptogenesis.

Hall AM, Brennan GP, Nguyen TM, Singh-Taylor A, Mun HS, Sargious MJ, Baram TZ.

eNeuro. 2017 Feb 10;4(1). pii: ENEURO.0301-16.2017. doi: 10.1523/ENEURO.0301-16.2017. eCollection 2017 Jan-Feb.


NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience.

Singh-Taylor A, Molet J, Jiang S, Korosi A, Bolton JL, Noam Y, Simeone K, Cope J, Chen Y, Mortazavi A, Baram TZ.

Mol Psychiatry. 2018 Mar;23(3):648-657. doi: 10.1038/mp.2016.240. Epub 2017 Jan 10.


Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses.

Chen Y, Molet J, Lauterborn JC, Trieu BH, Bolton JL, Patterson KP, Gall CM, Lynch G, Baram TZ.

J Neurosci. 2016 Nov 2;36(44):11295-11307.


MRI uncovers disrupted hippocampal microstructure that underlies memory impairments after early-life adversity.

Molet J, Maras PM, Kinney-Lang E, Harris NG, Rashid F, Ivy AS, Solodkin A, Obenaus A, Baram TZ.

Hippocampus. 2016 Dec;26(12):1618-1632. doi: 10.1002/hipo.22661. Epub 2016 Oct 11.


Temporal Coordination of Hippocampal Neurons Reflects Cognitive Outcome Post-febrile Status Epilepticus.

Barry JM, Sakkaki S, Barriere SJ, Patterson KP, Lenck-Santini PP, Scott RC, Baram TZ, Holmes GL.

EBioMedicine. 2016 May;7:175-90. doi: 10.1016/j.ebiom.2016.03.039. Epub 2016 Apr 6.


Dual and Opposing Roles of MicroRNA-124 in Epilepsy Are Mediated through Inflammatory and NRSF-Dependent Gene Networks.

Brennan GP, Dey D, Chen Y, Patterson KP, Magnetta EJ, Hall AM, Dube CM, Mei YT, Baram TZ.

Cell Rep. 2016 Mar 15;14(10):2402-12. doi: 10.1016/j.celrep.2016.02.042. Epub 2016 Mar 3.


Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in Epilepsy.

Brennan GP, Baram TZ, Poolos NP.

Cold Spring Harb Perspect Med. 2016 Mar 1;6(3):a022384. doi: 10.1101/cshperspect.a022384. Review.


Fragmentation and high entropy of neonatal experience predict adolescent emotional outcome.

Molet J, Heins K, Zhuo X, Mei YT, Regev L, Baram TZ, Stern H.

Transl Psychiatry. 2016 Jan 5;6:e702. doi: 10.1038/tp.2015.200.


Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis.

Patterson KP, Brennan GP, Curran M, Kinney-Lang E, Dubé C, Rashid F, Ly C, Obenaus A, Baram TZ.

eNeuro. 2015 Nov 9;2(5). pii: ENEURO.0034-15.2015. doi: 10.1523/ENEURO.0034-15.2015. eCollection 2015 Sep-Oct.


Diversity of Reporter Expression Patterns in Transgenic Mouse Lines Targeting Corticotropin-Releasing Hormone-Expressing Neurons.

Chen Y, Molet J, Gunn BG, Ressler K, Baram TZ.

Endocrinology. 2015 Dec;156(12):4769-80. doi: 10.1210/en.2015-1673. Epub 2015 Sep 24.


Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks.

Chen Y, Baram TZ.

Neuropsychopharmacology. 2016 Jan;41(1):197-206. doi: 10.1038/npp.2015.181. Epub 2015 Jun 24. Review.


Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice.

Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM.

J Neurochem. 2015 Sep;134(5):915-26. doi: 10.1111/jnc.13195. Epub 2015 Jul 14.


T2 relaxation time post febrile status epilepticus predicts cognitive outcome.

Barry JM, Choy M, Dube C, Robbins A, Obenaus A, Lenck-Santini PP, Scott RC, Baram TZ, Holmes GL.

Exp Neurol. 2015 Jul;269:242-52. doi: 10.1016/j.expneurol.2015.04.015. Epub 2015 May 1.


Hyper-excitability and epilepsy generated by chronic early-life stress.

Dubé CM, Molet J, Singh-Taylor A, Ivy A, Maras PM, Baram TZ.

Neurobiol Stress. 2015;2:10-19.


Synaptic rewiring of stress-sensitive neurons by early-life experience: a mechanism for resilience?

Singh-Taylor A, Korosi A, Molet J, Gunn BG, Baram TZ.

Neurobiol Stress. 2015 Jan 1;1:109-115.


The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes.

McClelland S, Brennan GP, Dubé C, Rajpara S, Iyer S, Richichi C, Bernard C, Baram TZ.

Elife. 2014 Aug 12;3:e01267. doi: 10.7554/eLife.01267.


Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multi-modal stress.

Maras PM, Molet J, Chen Y, Rice C, Ji SG, Solodkin A, Baram TZ.

Mol Psychiatry. 2014 Jul;19(7):745. doi: 10.1038/mp.2014.64. No abstract available.


A novel, noninvasive, predictive epilepsy biomarker with clinical potential.

Choy M, Dubé CM, Patterson K, Barnes SR, Maras P, Blood AB, Hasso AN, Obenaus A, Baram TZ.

J Neurosci. 2014 Jun 25;34(26):8672-84. doi: 10.1523/JNEUROSCI.4806-13.2014.


Inflammatory processes, febrile seizures, and subsequent epileptogenesis.

Choy M, Dubé CM, Ehrengruber M, Baram TZ.

Epilepsy Curr. 2014 Jan;14(1 Suppl):15-22. doi: 10.5698/1535-7511-14.s2.15.


Naturalistic rodent models of chronic early-life stress.

Molet J, Maras PM, Avishai-Eliner S, Baram TZ.

Dev Psychobiol. 2014 Dec;56(8):1675-88. doi: 10.1002/dev.21230. Epub 2014 Jun 9. Review.


Origins of temporal lobe epilepsy: febrile seizures and febrile status epilepticus.

Patterson KP, Baram TZ, Shinnar S.

Neurotherapeutics. 2014 Apr;11(2):242-50. doi: 10.1007/s13311-014-0263-4. Review.

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