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RNA structure and splicing regulation.

Baralle FE, Singh RN, Stamm S.

Biochim Biophys Acta Gene Regul Mech. 2019 Nov - Dec;1862(11-12):194448. doi: 10.1016/j.bbagrm.2019.194448. Epub 2019 Nov 12. No abstract available.


RhoGAPp190: A potential player in tbph-mediated neurodegeneration in Drosophila.

Langellotti S, Romano G, Feiguin F, Baralle FE, Romano M.

PLoS One. 2018 Apr 13;13(4):e0195845. doi: 10.1371/journal.pone.0195845. eCollection 2018.


The splicing code.

Baralle M, Baralle FE.

Biosystems. 2018 Feb;164:39-48. doi: 10.1016/j.biosystems.2017.11.002. Epub 2017 Nov 6. Review.


Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.

Mompeán M, Romano V, Pantoja-Uceda D, Stuani C, Baralle FE, Buratti E, Laurents DV.

J Biol Chem. 2017 Jul 14;292(28):11992-12006. doi: 10.1074/jbc.M117.775965. Epub 2017 May 31.


Alternative splicing as a regulator of development and tissue identity.

Baralle FE, Giudice J.

Nat Rev Mol Cell Biol. 2017 Jul;18(7):437-451. doi: 10.1038/nrm.2017.27. Epub 2017 May 10. Review.


A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects.

Langellotti S, Romano V, Romano G, Klima R, Feiguin F, Cragnaz L, Romano M, Baralle FE.

Dis Model Mech. 2016 Jun 1;9(6):659-69. doi: 10.1242/dmm.023382. Epub 2016 Apr 21.


The TDP-43 N-terminal domain structure at high resolution.

Mompeán M, Romano V, Pantoja-Uceda D, Stuani C, Baralle FE, Buratti E, Laurents DV.

FEBS J. 2016 Apr;283(7):1242-60. doi: 10.1111/febs.13651. Epub 2016 Feb 11.


Absence of TDP-43 is difficult to digest.

Skoko N, Baralle M, Baralle FE.

EMBO J. 2016 Jan 18;35(2):115-7. doi: 10.15252/embj.201593603. Epub 2015 Dec 23. No abstract available.


An age-related reduction of brain TBPH/TDP-43 levels precedes the onset of locomotion defects in a Drosophila ALS model.

Cragnaz L, Klima R, De Conti L, Romano G, Feiguin F, Buratti E, Baralle M, Baralle FE.

Neuroscience. 2015 Dec 17;311:415-21. doi: 10.1016/j.neuroscience.2015.10.037. Epub 2015 Oct 27.


From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.

Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A.

Biochim Biophys Acta. 2015 Dec;1849(12):1398-410. doi: 10.1016/j.bbagrm.2015.10.015. Epub 2015 Oct 26.


Glial TDP-43 regulates axon wrapping, GluRIIA clustering and fly motility by autonomous and non-autonomous mechanisms.

Romano G, Appocher C, Scorzeto M, Klima R, Baralle FE, Megighian A, Feiguin F.

Hum Mol Genet. 2015 Nov 1;24(21):6134-45. doi: 10.1093/hmg/ddv330. Epub 2015 Aug 13.


The structural integrity of TDP-43 N-terminus is required for efficient aggregate entrapment and consequent loss of protein function.

Romano V, Quadri Z, Baralle FE, Buratti E.

Prion. 2015;9(1):1-9. doi: 10.1080/19336896.2015.1011885.


TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain.

Budini M, Romano V, Quadri Z, Buratti E, Baralle FE.

Hum Mol Genet. 2015 Jan 1;24(1):9-20. doi: 10.1093/hmg/ddu415. Epub 2014 Aug 13.


Chronological requirements of TDP-43 function in synaptic organization and locomotive control.

Romano G, Klima R, Buratti E, Verstreken P, Baralle FE, Feiguin F.

Neurobiol Dis. 2014 Nov;71:95-109. doi: 10.1016/j.nbd.2014.07.007. Epub 2014 Aug 1.


Aggregate formation prevents dTDP-43 neurotoxicity in the Drosophila melanogaster eye.

Cragnaz L, Klima R, Skoko N, Budini M, Feiguin F, Baralle FE.

Neurobiol Dis. 2014 Nov;71:74-80. doi: 10.1016/j.nbd.2014.07.009. Epub 2014 Jul 31.


Targeting TDP-43 in neurodegenerative diseases.

Budini M, Baralle FE, Buratti E.

Expert Opin Ther Targets. 2014 Jun;18(6):617-32. doi: 10.1517/14728222.2014.896905. Epub 2014 Mar 20. Review.


Exon first nucleotide mutations in splicing: evaluation of in silico prediction tools.

Grodecká L, Lockerová P, Ravčuková B, Buratti E, Baralle FE, Dušek L, Freiberger T.

PLoS One. 2014 Feb 21;9(2):e89570. doi: 10.1371/journal.pone.0089570. eCollection 2014.


A novel anti-aldolase C antibody specifically interacts with residues 85-102 of the protein.

Langellotti S, Romano M, Guarnaccia C, Granata V, Orrù S, Zagari A, Baralle FE, Salvatore F.

MAbs. 2014 May-Jun;6(3):708-17. doi: 10.4161/mabs.28191. Epub 2014 Feb 13.


"Structural characterization of the minimal segment of TDP-43 competent for aggregation".

Mompeán M, Buratti E, Guarnaccia C, Brito RM, Chakrabartty A, Baralle FE, Laurents DV.

Arch Biochem Biophys. 2014 Mar 1;545:53-62. doi: 10.1016/ Epub 2014 Jan 15.


Predominance of spliceosomal complex formation over polyadenylation site selection in TDP-43 autoregulation.

Bembich S, Herzog JS, De Conti L, Stuani C, Avendaño-Vázquez SE, Buratti E, Baralle M, Baralle FE.

Nucleic Acids Res. 2014 Mar;42(5):3362-71. doi: 10.1093/nar/gkt1343. Epub 2013 Dec 24.


The role of TDP-43 in the pathogenesis of ALS and FTLD.

Baralle M, Buratti E, Baralle FE.

Biochem Soc Trans. 2013 Dec;41(6):1536-40. doi: 10.1042/BST20130186. Review.


Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43.

Lukavsky PJ, Daujotyte D, Tollervey JR, Ule J, Stuani C, Buratti E, Baralle FE, Damberger FF, Allain FH.

Nat Struct Mol Biol. 2013 Dec;20(12):1443-9. doi: 10.1038/nsmb.2698. Epub 2013 Nov 17.


Functional characterization of the common c.-32-13T>G mutation of GAA gene: identification of potential therapeutic agents.

Dardis A, Zanin I, Zampieri S, Stuani C, Pianta A, Romanello M, Baralle FE, Bembi B, Buratti E.

Nucleic Acids Res. 2014 Jan;42(2):1291-302. doi: 10.1093/nar/gkt987. Epub 2013 Oct 22.


RNA and splicing regulation in neurodegeneration.

Baralle FE, Buratti E.

Mol Cell Neurosci. 2013 Sep;56:404-5. doi: 10.1016/j.mcn.2013.09.001. No abstract available.


HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition.

Bonomi S, di Matteo A, Buratti E, Cabianca DS, Baralle FE, Ghigna C, Biamonti G.

Nucleic Acids Res. 2013 Oct;41(18):8665-79. doi: 10.1093/nar/gkt579. Epub 2013 Jul 17.


Characterizing TDP-43 interaction with its RNA targets.

Bhardwaj A, Myers MP, Buratti E, Baralle FE.

Nucleic Acids Res. 2013 May;41(9):5062-74. doi: 10.1093/nar/gkt189. Epub 2013 Mar 21.


TDP-43 high throughput screening analyses in neurodegeneration: advantages and pitfalls.

Buratti E, Romano M, Baralle FE.

Mol Cell Neurosci. 2013 Sep;56:465-74. doi: 10.1016/j.mcn.2013.03.001. Epub 2013 Mar 14. Review.


From single splicing events to thousands: the ambiguous step forward in splicing research.

Buratti E, Baralle M, Baralle FE.

Brief Funct Genomics. 2013 Jan;12(1):3-12. doi: 10.1093/bfgp/els048. Epub 2012 Nov 18. Review.


Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.

Avendaño-Vázquez SE, Dhir A, Bembich S, Buratti E, Proudfoot N, Baralle FE.

Genes Dev. 2012 Aug 1;26(15):1679-84. doi: 10.1101/gad.194829.112.


TDP-43: gumming up neurons through protein-protein and protein-RNA interactions.

Buratti E, Baralle FE.

Trends Biochem Sci. 2012 Jun;37(6):237-47. doi: 10.1016/j.tibs.2012.03.003. Epub 2012 Apr 24. Review.


TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.

Colombrita C, Onesto E, Megiorni F, Pizzuti A, Baralle FE, Buratti E, Silani V, Ratti A.

J Biol Chem. 2012 May 4;287(19):15635-47. doi: 10.1074/jbc.M111.333450. Epub 2012 Mar 16.


Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.

Budini M, Romano V, Avendaño-Vázquez SE, Bembich S, Buratti E, Baralle FE.

Brain Res. 2012 Jun 26;1462:139-50. doi: 10.1016/j.brainres.2012.02.031. Epub 2012 Feb 22.


Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region.

Budini M, Buratti E, Stuani C, Guarnaccia C, Romano V, De Conti L, Baralle FE.

J Biol Chem. 2012 Mar 2;287(10):7512-25. doi: 10.1074/jbc.M111.288720. Epub 2012 Jan 10.


Stam2 expression pattern during embryo development.

Curlin M, Kapuralin K, Muro AF, Baralle FE, Chowdhury K, Gajović S.

Gene Expr Patterns. 2012 Jan-Feb;12(1-2):68-76. doi: 10.1016/j.gep.2011.11.005. Epub 2011 Nov 28.


TDP-43: Overview of the series.

Baralle FE, Buratti E.

FEBS J. 2011 Oct;278(19):3529. doi: 10.1111/j.1742-4658.2011.08278.x. Epub 2011 Sep 6. No abstract available.


TDP-43: new aspects of autoregulation mechanisms in RNA binding proteins and their connection with human disease.

Buratti E, Baralle FE.

FEBS J. 2011 Oct;278(19):3530-8. doi: 10.1111/j.1742-4658.2011.08257.x. Epub 2011 Aug 24. Review.


Evolutionary connections between coding and splicing regulatory regions in the fibronectin EDA exon.

Zago P, Buratti E, Stuani C, Baralle FE.

J Mol Biol. 2011 Aug 5;411(1):1-15. doi: 10.1016/j.jmb.2011.05.031. Epub 2011 Jun 1.


TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization.

Godena VK, Romano G, Romano M, Appocher C, Klima R, Buratti E, Baralle FE, Feiguin F.

PLoS One. 2011 Mar 11;6(3):e17808. doi: 10.1371/journal.pone.0017808.


Regulation of gene expression by TDP-43 and FUS/TLS in frontotemporal lobar degeneration.

Budini M, Baralle FE, Buratti E.

Curr Alzheimer Res. 2011 May;8(3):237-45. Review.


TDP-43 regulates its mRNA levels through a negative feedback loop.

Ayala YM, De Conti L, Avendaño-Vázquez SE, Dhir A, Romano M, D'Ambrogio A, Tollervey J, Ule J, Baralle M, Buratti E, Baralle FE.

EMBO J. 2011 Jan 19;30(2):277-88. doi: 10.1038/emboj.2010.310. Epub 2010 Dec 3.


Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene.

Valacca C, Bonomi S, Buratti E, Pedrotti S, Baralle FE, Sette C, Ghigna C, Biamonti G.

J Cell Biol. 2010 Oct 4;191(1):87-99. doi: 10.1083/jcb.201001073. Epub 2010 Sep 27.


Neurons don't appreciate FUSsing in the cytoplasm.

Buratti E, Baralle FE.

EMBO J. 2010 Aug 18;29(16):2769-71. doi: 10.1038/emboj.2010.163. No abstract available.


The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation.

Buratti E, Baralle FE.

RNA Biol. 2010 Jul-Aug;7(4):420-9. Epub 2010 Jul 1. Review.


The intronic splicing code: multiple factors involved in ATM pseudoexon definition.

Dhir A, Buratti E, van Santen MA, Lührmann R, Baralle FE.

EMBO J. 2010 Feb 17;29(4):749-60. doi: 10.1038/emboj.2009.397. Epub 2010 Jan 21.


Functional properties and evolutionary splicing constraints on a composite exonic regulatory element of splicing in CFTR exon 12.

Haque A, Buratti E, Baralle FE.

Nucleic Acids Res. 2010 Jan;38(2):647-59. doi: 10.1093/nar/gkp1040. Epub 2009 Nov 12.


The molecular links between TDP-43 dysfunction and neurodegeneration.

Buratti E, Baralle FE.

Adv Genet. 2009;66:1-34. doi: 10.1016/S0065-2660(09)66001-6. Review.


Italy leads the way in supporting African biotechnology.

Baralle FE.

Nature. 2009 Aug 27;460(7259):1079. doi: 10.1038/4601079a. No abstract available.


Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo.

D'Ambrogio A, Buratti E, Stuani C, Guarnaccia C, Romano M, Ayala YM, Baralle FE.

Nucleic Acids Res. 2009 Jul;37(12):4116-26. doi: 10.1093/nar/gkp342. Epub 2009 May 8.


Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior.

Feiguin F, Godena VK, Romano G, D'Ambrogio A, Klima R, Baralle FE.

FEBS Lett. 2009 May 19;583(10):1586-92. doi: 10.1016/j.febslet.2009.04.019. Epub 2009 Apr 19.

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