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Items: 41


A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal.

Grim TW, Schmid CL, Stahl EL, Pantouli F, Ho JH, Acevedo-Canabal A, Kennedy NM, Cameron MD, Bannister TD, Bohn LM.

Neuropsychopharmacology. 2019 Aug 23. doi: 10.1038/s41386-019-0491-8. [Epub ahead of print]


The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo.

Kim J, Wang C, de Sabando AR, Cole HL, Huang TJ, Yang J, Bannister TD, Yang VW, Bialkowska AB.

Mol Cancer Ther. 2019 Nov;18(11):1973-1984. doi: 10.1158/1535-7163.MCT-18-1366. Epub 2019 Jul 29.


Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias.

Kennedy NM, Schmid CL, Ross NC, Lovell KM, Yue Z, Chen YT, Cameron MD, Bohn LM, Bannister TD.

J Med Chem. 2018 Oct 11;61(19):8895-8907. doi: 10.1021/acs.jmedchem.8b01136. Epub 2018 Sep 24.


Chemical validation and optimization of pharmacoperones targeting vasopressin type 2 receptor mutant.

Janovick JA, Spicer TP, Bannister TD, Smith E, Ganapathy V, Scampavia L.

Biochem J. 2018 Sep 25;475(18):2941-2953. doi: 10.1042/BCJ20180065.


Site-Selective γ-C(sp3 )-H and γ-C(sp2 )-H Arylation of Free Amino Esters Promoted by a Catalytic Transient Directing Group.

Lin H, Wang C, Bannister TD, Kamenecka TM.

Chemistry. 2018 Jul 5;24(38):9535-9541. doi: 10.1002/chem.201802465. Epub 2018 Jun 6.


Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.

Schmid CL, Kennedy NM, Ross NC, Lovell KM, Yue Z, Morgenweck J, Cameron MD, Bannister TD, Bohn LM.

Cell. 2017 Nov 16;171(5):1165-1175.e13. doi: 10.1016/j.cell.2017.10.035.


A Rapid Phenotypic Whole-Cell Screening Approach for the Identification of Small-Molecule Inhibitors That Counter β-Lactamase Resistance in Pseudomonas aeruginosa.

Collia D, Bannister TD, Tan H, Jin S, Langaee T, Shumate J, Scampavia L, Spicer TP.

SLAS Discov. 2018 Jan;23(1):55-64. doi: 10.1177/2472555217728489. Epub 2017 Aug 29.


Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.

Janovick JA, Spicer TP, Bannister TD, Scampavia L, Conn PM.

PLoS One. 2017 Aug 2;12(8):e0181830. doi: 10.1371/journal.pone.0181830. eCollection 2017.


Receptor antagonism/agonism can be uncoupled from pharmacoperone activity.

Janovick JA, Spicer TP, Smith E, Bannister TD, Kenakin T, Scampavia L, Conn PM.

Mol Cell Endocrinol. 2016 Oct 15;434:176-85. doi: 10.1016/j.mce.2016.07.003. Epub 2016 Jul 4.


Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors.

Nair RN, Mishra JK, Li F, Tortosa M, Yang C, Doherty JR, Cameron M, Cleveland JL, Roush WR, Bannister TD.

Medchemcomm. 2016 May 1;7(5):900-905. Epub 2016 Feb 23.


Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus.

Smith E, Janovick JA, Bannister TD, Shumate J, Scampavia L, Conn PM, Spicer TP.

J Biomol Screen. 2016 Sep;21(8):824-31. doi: 10.1177/1087057116653925. Epub 2016 Jun 8.


Preparation of tetrasubstituted pyrimido[4,5-d]pyrimidine diones.

Wang H, Wang C, Bannister TD.

Tetrahedron Lett. 2015 Apr 8;56(15):1949-4952.


Synthesis and Cytoxicity of Sempervirine and Analogues.

Pan X, Yang C, Cleveland JL, Bannister TD.

J Org Chem. 2016 Mar 4;81(5):2194-200. doi: 10.1021/acs.joc.6b00022. Epub 2016 Feb 10.


ML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer.

Ruiz de Sabando A, Wang C, He Y, García-Barros M, Kim J, Shroyer KR, Bannister TD, Yang VW, Bialkowska AB.

Mol Cancer Ther. 2016 Jan;15(1):72-83. doi: 10.1158/1535-7163.MCT-15-0600. Epub 2015 Nov 30.


Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors.

Abdul-Hay SO, Bannister TD, Wang H, Cameron MD, Caulfield TR, Masson A, Bertrand J, Howard EA, McGuire MP, Crisafulli U, Rosenberry TR, Topper CL, Thompson CR, Schürer SC, Madoux F, Hodder P, Leissring MA.

ACS Chem Biol. 2015 Dec 18;10(12):2716-24. doi: 10.1021/acschembio.5b00334. Epub 2015 Sep 30.


Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.

Ting PY, Damoiseaux R, Titz B, Bradley KA, Graeber TG, Fernández-Vega V, Bannister TD, Chase P, Nair R, Scampavia L, Hodder P, Spicer TP, Colicelli J.

PLoS One. 2015 Mar 26;10(3):e0121833. doi: 10.1371/journal.pone.0121833. eCollection 2015.


Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors.

Wang H, Yang C, Doherty JR, Roush WR, Cleveland JL, Bannister TD.

J Med Chem. 2014 Sep 11;57(17):7317-24. doi: 10.1021/jm500640x. Epub 2014 Aug 22.


ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE).

Bannister TD, Wang H, Abdul-Hay SO, Masson A, Madoux F, Ferguson J, Mercer BA, Schurer S, Zuhl A, Cravatt BF, Leissring MA, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 17 [updated 2014 May 13].


Grubbs cross-metathesis pathway for a scalable synthesis of γ-keto-α,β-unsaturated esters.

Nair RN, Bannister TD.

J Org Chem. 2014 Feb 7;79(3):1467-72. doi: 10.1021/jo4023606. Epub 2014 Jan 21.


Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.

Doherty JR, Yang C, Scott KE, Cameron MD, Fallahi M, Li W, Hall MA, Amelio AL, Mishra JK, Li F, Tortosa M, Genau HM, Rounbehler RJ, Lu Y, Dang CV, Kumar KG, Butler AA, Bannister TD, Hooper AT, Unsal-Kacmaz K, Roush WR, Cleveland JL.

Cancer Res. 2014 Feb 1;74(3):908-20. doi: 10.1158/0008-5472.CAN-13-2034. Epub 2013 Nov 27.


ML328: A Novel Dual Inhibitor of Bacterial AddAB and RecBCD Helicase-nuclease DNA Repair Enzymes.

Bannister TD, Nair R, Spicer T, Fernandez Vega V, Eberhart C, Mercer BA, Cameron M, Schurer S, Amundsen SK, Karabulut A, Londoño LM, Smith GR, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 17 [updated 2013 Apr 5].


ML264: An Antitumor Agent that Potently and Selectively Inhibits Krüppel-like Factor Five (KLF5) Expression: A Probe for Studying Colon Cancer Development and Progression.

Bialkowska A, Crisp M, Madoux F, Spicer T, Knapinska A, Mercer B, Bannister TD, He Y, Chowdhury S, Cameron M, Yang VW, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Oct 31 [updated 2013 Mar 7].


Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD.

Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ.

Sci Transl Med. 2013 Jun 5;5(188):188ra73. doi: 10.1126/scitranslmed.3005656.


Amino acid derived quinazolines as Rock/PKA inhibitors.

Chowdhury S, Chen YT, Fang X, Grant W, Pocas J, Cameron MD, Ruiz C, Lin L, Park H, Schröter T, Bannister TD, Lograsso PV, Feng Y.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1592-9. doi: 10.1016/j.bmcl.2013.01.109. Epub 2013 Jan 31.


Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes.

Amundsen SK, Spicer T, Karabulut AC, Londoño LM, Eberhart C, Fernandez Vega V, Bannister TD, Hodder P, Smith GR.

ACS Chem Biol. 2012 May 18;7(5):879-91. doi: 10.1021/cb300018x. Epub 2012 Mar 23.


Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II).

Sessions EH, Chowdhury S, Yin Y, Pocas JR, Grant W, Schröter T, Lin L, Ruiz C, Cameron MD, LoGrasso P, Bannister TD, Feng Y.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7113-8. doi: 10.1016/j.bmcl.2011.09.084. Epub 2011 Oct 1.


Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).

Chowdhury S, Sessions EH, Pocas JR, Grant W, Schröter T, Lin L, Ruiz C, Cameron MD, Schürer S, LoGrasso P, Bannister TD, Feng Y.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7107-12. doi: 10.1016/j.bmcl.2011.09.083. Epub 2011 Sep 24.


Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors.

Fang X, Chen YT, Sessions EH, Chowdhury S, Vojkovsky T, Yin Y, Pocas JR, Grant W, Schröter T, Lin L, Ruiz C, Cameron MD, LoGrasso P, Bannister TD, Feng Y.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1844-8. doi: 10.1016/j.bmcl.2011.01.039. Epub 2011 Jan 14.


The development of benzimidazoles as selective rho kinase inhibitors.

Sessions EH, Smolinski M, Wang B, Frackowiak B, Chowdhury S, Yin Y, Chen YT, Ruiz C, Lin L, Pocas J, Schröter T, Cameron MD, LoGrasso P, Feng Y, Bannister TD.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1939-43. doi: 10.1016/j.bmcl.2010.01.124. Epub 2010 Feb 1.


Benzimidazole- and benzoxazole-based inhibitors of Rho kinase.

Sessions EH, Yin Y, Bannister TD, Weiser A, Griffin E, Pocas J, Cameron MD, Ruiz C, Lin L, Schürer SC, Schröter T, LoGrasso P, Feng Y.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6390-3. doi: 10.1016/j.bmcl.2008.10.095. Epub 2008 Oct 25.


Chroman-3-amides as potent Rho kinase inhibitors.

Chen YT, Bannister TD, Weiser A, Griffin E, Lin L, Ruiz C, Cameron MD, Schürer S, Duckett D, Schröter T, LoGrasso P, Feng Y.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6406-9. doi: 10.1016/j.bmcl.2008.10.080. Epub 2008 Oct 22.


Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.

Lin J, Deng H, Jin L, Pandey P, Quinn J, Cantin S, Rynkiewicz MJ, Gorga JC, Bibbins F, Celatka CA, Nagafuji P, Bannister TD, Meyers HV, Babine RE, Hayward NJ, Weaver D, Benjamin H, Stassen F, Abdel-Meguid SS, Strickler JE.

J Med Chem. 2006 Dec 28;49(26):7781-91.


Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine.

Deng H, Bannister TD, Jin L, Babine RE, Quinn J, Nagafuji P, Celatka CA, Lin J, Lazarova TI, Rynkiewicz MJ, Bibbins F, Pandey P, Gorga J, Meyers HV, Abdel-Meguid SS, Strickler JE.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):3049-54. Epub 2006 Mar 9.


Total synthesis of (-)-bafilomycin A(1).

Scheidt KA, Bannister TD, Tasaka A, Wendt MD, Savall BM, Fegley GJ, Roush WR.

J Am Chem Soc. 2002 Jun 19;124(24):6981-90.


An NMR method for assigning relative stereochemistry to beta-hydroxy ketones deriving from aldol reactions of methyl ketones.

Roush WR, Bannister TD, Wendt MD, VanNieuwenhze MS, Gustin DJ, Dilley GJ, Lane GC, Scheidt KA, Smith WJ 3rd.

J Org Chem. 2002 Jun 14;67(12):4284-9.


Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment.

Roush WR, Bannister TD, Wendt MD, Jablonowski JA, Scheidt KA.

J Org Chem. 2002 Jun 14;67(12):4275-83.


The Treponema denticola major sheath protein is predominantly periplasmic and has only limited surface exposure.

Caimano MJ, Bourell KW, Bannister TD, Cox DL, Radolf JD.

Infect Immun. 1999 Aug;67(8):4072-83.


Total Synthesis of (-)-Bafilomycin A1 : Application of Diastereoselective Crotylboration and Methyl Ketone Aldol Reactions.

Scheidt KA, Tasaka A, Bannister TD, Wendt MD, Roush WR.

Angew Chem Int Ed Engl. 1999 Jun 1;38(11):1652-1655. doi: 10.1002/(SICI)1521-3773(19990601)38:11<1652::AID-ANIE1652>3.0.CO;2-K.


Hydrogen peroxide and hydroxyl radical formation by methylene blue in the presence of ascorbic acid.

Buettner GR, Doherty TP, Bannister TD.

Radiat Environ Biophys. 1984;23(4):235-43.


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