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Items: 24


An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors.

Indarte M, Puentes R, Maruggi M, Ihle NT, Grandjean G, Scott M, Ahmed Z, Meuillet EJ, Zang S, Lemos R Jr, Du-Cuny L, Layng FIAL, Correa RG, Bankston LA, Liddington RC, Kirkpatrick L, Powis G.

Cancer Res. 2019 Jun 15;79(12):3100-3111. doi: 10.1158/0008-5472.CAN-18-2372. Epub 2019 Apr 30.


Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells.

Feng Y, Sessions EH, Zhang F, Ban F, Placencio-Hickok V, Ma CT, Zeng FY, Pass I, Terry DB, Cadwell G, Bankston LA, Liddington RC, Chung TDY, Pinkerton AB, Sergienko E, Gleave M, Bhowmick NA, Jackson MR, Cherkasov A, Ronai ZA.

Cancer Lett. 2019 May 1;449:145-162. doi: 10.1016/j.canlet.2019.02.012. Epub 2019 Feb 14.


Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N.

Nat Chem Biol. 2017 Jun;13(6):624-632. doi: 10.1038/nchembio.2344. Epub 2017 Mar 27.


Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target.

Grandjean G, de Jong PR, James B, Koh MY, Lemos R, Kingston J, Aleshin A, Bankston LA, Miller CP, Cho EJ, Edupuganti R, Devkota A, Stancu G, Liddington RC, Dalby K, Powis G.

Cancer Res. 2016 Jul 15;76(14):4259-4269. doi: 10.1158/0008-5472.CAN-16-0401. Epub 2016 Jun 3.


Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses.

Avnir Y, Tallarico AS, Zhu Q, Bennett AS, Connelly G, Sheehan J, Sui J, Fahmy A, Huang CY, Cadwell G, Bankston LA, McGuire AT, Stamatatos L, Wagner G, Liddington RC, Marasco WA.

PLoS Pathog. 2014 May 1;10(5):e1004103. doi: 10.1371/journal.ppat.1004103. eCollection 2014 May.


αE-catenin is an autoinhibited molecule that coactivates vinculin.

Choi HJ, Pokutta S, Cadwell GW, Bobkov AA, Bankston LA, Liddington RC, Weis WI.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8576-81. doi: 10.1073/pnas.1203906109. Epub 2012 May 14.


Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC).

Aleshin AE, Schraufstatter IU, Stec B, Bankston LA, Liddington RC, DiScipio RG.

J Biol Chem. 2012 Mar 23;287(13):10210-22. doi: 10.1074/jbc.M111.327809. Epub 2012 Jan 20.


Wide prevalence of heterosubtypic broadly neutralizing human anti-influenza A antibodies.

Sui J, Sheehan J, Hwang WC, Bankston LA, Burchett SK, Huang CY, Liddington RC, Beigel JH, Marasco WA.

Clin Infect Dis. 2011 Apr 15;52(8):1003-9. doi: 10.1093/cid/cir121.


Structural insights into inhibition of Bacillus anthracis sporulation by a novel class of non-heme globin sensor domains.

Stranzl GR, Santelli E, Bankston LA, La Clair C, Bobkov A, Schwarzenbacher R, Godzik A, Perego M, Grynberg M, Liddington RC.

J Biol Chem. 2011 Mar 11;286(10):8448-58. doi: 10.1074/jbc.M110.207126. Epub 2011 Jan 7.


Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs).

Premkumar L, Bobkov AA, Patel M, Jaroszewski L, Bankston LA, Stec B, Vuori K, Côté JF, Liddington RC.

J Biol Chem. 2010 Apr 23;285(17):13211-22. doi: 10.1074/jbc.M110.102517. Epub 2010 Feb 18.


Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses.

Sui J, Hwang WC, Perez S, Wei G, Aird D, Chen LM, Santelli E, Stec B, Cadwell G, Ali M, Wan H, Murakami A, Yammanuru A, Han T, Cox NJ, Bankston LA, Donis RO, Liddington RC, Marasco WA.

Nat Struct Mol Biol. 2009 Mar;16(3):265-73. doi: 10.1038/nsmb.1566. Epub 2009 Feb 22.


Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells.

Chen KH, Liu S, Bankston LA, Liddington RC, Leppla SH.

J Biol Chem. 2007 Mar 30;282(13):9834-45. Epub 2007 Jan 24.


Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing.

Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M.

Science. 2005 Feb 4;307(5710):734-8. Erratum in: Science. 2005 Apr 29;308(5722):633. Science. 2011 Jul 15;333(6040):288.


Crystal structure of a complex between anthrax toxin and its host cell receptor.

Santelli E, Bankston LA, Leppla SH, Liddington RC.

Nature. 2004 Aug 19;430(7002):905-8. Epub 2004 Jul 4.


Structural basis for vinculin activation at sites of cell adhesion.

Bakolitsa C, Cohen DM, Bankston LA, Bobkov AA, Cadwell GW, Jennings L, Critchley DR, Craig SW, Liddington RC.

Nature. 2004 Jul 29;430(6999):583-6. Epub 2004 Jun 13.


Cell adhesion: a FERM grasp of membrane dynamics.

Liddington RC, Bankston LA, de Pereda JM.

Curr Biol. 2003 Feb 4;13(3):R94-5.


Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation.

Lipton SA, Choi YB, Takahashi H, Zhang D, Li W, Godzik A, Bankston LA.

Trends Neurosci. 2002 Sep;25(9):474-80. Review.


Structural basis of von Willebrand factor activation by the snake toxin botrocetin.

Fukuda K, Doggett TA, Bankston LA, Cruz MA, Diacovo TG, Liddington RC.

Structure. 2002 Jul;10(7):943-50.


The structural basis of dynamic cell adhesion: heads, tails, and allostery.

Liddington RC, Bankston LA.

Exp Cell Res. 2000 Nov 25;261(1):37-43. Review. No abstract available.


Crystal structure of the apoptotic suppressor CrmA in its cleaved form.

Renatus M, Zhou Q, Stennicke HR, Snipas SJ, Turk D, Bankston LA, Liddington RC, Salvesen GS.

Structure. 2000 Jul 15;8(7):789-97.


Mapping the collagen-binding site in the I domain of the glycoprotein Ia/IIa (integrin alpha(2)beta(1)).

Smith C, Estavillo D, Emsley J, Bankston LA, Liddington RC, Cruz MA.

J Biol Chem. 2000 Feb 11;275(6):4205-9.


14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.

Petosa C, Masters SC, Bankston LA, Pohl J, Wang B, Fu H, Liddington RC.

J Biol Chem. 1998 Jun 26;273(26):16305-10.


Two conformations of the integrin A-domain (I-domain): a pathway for activation?

Lee JO, Bankston LA, Arnaout MA, Liddington RC.

Structure. 1995 Dec 15;3(12):1333-40.

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