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Items: 47

1.

Attenuation of epileptogenesis by 2-deoxy-d-glucose is accompanied by increased cerebral glucose supply, microglial activation and reduced astrocytosis.

Leiter I, Bascuñana P, Bengel FM, Bankstahl JP, Bankstahl M.

Neurobiol Dis. 2019 Jun 15;130:104510. doi: 10.1016/j.nbd.2019.104510. [Epub ahead of print]

PMID:
31212069
2.

Anesthesia and Preconditioning Induced Changes in Mouse Brain [18F] FDG Uptake and Kinetics.

Bascuñana P, Thackeray JT, Bankstahl M, Bengel FM, Bankstahl JP.

Mol Imaging Biol. 2019 Mar 11. doi: 10.1007/s11307-019-01314-9. [Epub ahead of print]

PMID:
30859471
3.

Divergent metabolic substrate utilization in brain during epileptogenesis precedes chronic hypometabolism.

Bascuñana P, Brackhan M, Leiter I, Keller H, Jahreis I, Ross TL, Bengel FM, Bankstahl M, Bankstahl JP.

J Cereb Blood Flow Metab. 2018 Oct 30:271678X18809886. doi: 10.1177/0271678X18809886. [Epub ahead of print]

PMID:
30375913
4.

Blood-Brain Barrier Leakage during Early Epileptogenesis Is Associated with Rapid Remodeling of the Neurovascular Unit.

Bankstahl M, Breuer H, Leiter I, Märkel M, Bascuñana P, Michalski D, Bengel FM, Löscher W, Meier M, Bankstahl JP, Härtig W.

eNeuro. 2018 May 30;5(3). pii: ENEURO.0123-18.2018. doi: 10.1523/ENEURO.0123-18.2018. eCollection 2018 May-Jun.

5.

[18 F]GE180 positron emission tomographic imaging indicates a potential double-hit insult in the intrahippocampal kainate mouse model of temporal lobe epilepsy.

Brackhan M, Bascuñana P, Ross TL, Bengel FM, Bankstahl JP, Bankstahl M.

Epilepsia. 2018 Mar;59(3):617-626. doi: 10.1111/epi.14009. Epub 2018 Jan 24.

6.

Recent Advances in Radiotracer Imaging Hold Potential for Future Refined Evaluation of Epilepsy in Veterinary Neurology.

Bankstahl M, Bankstahl JP.

Front Vet Sci. 2017 Dec 13;4:218. doi: 10.3389/fvets.2017.00218. eCollection 2017. Review.

7.

A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy.

Schidlitzki A, Twele F, Klee R, Waltl I, Römermann K, Bröer S, Meller S, Gerhauser I, Rankovic V, Li D, Brandt C, Bankstahl M, Töllner K, Löscher W.

Sci Rep. 2017 Sep 22;7(1):12191. doi: 10.1038/s41598-017-12368-6.

8.

Abnormal neurobehaviour and impaired memory function as a consequence of Toxocara canis- as well as Toxocara cati-induced neurotoxocarosis.

Janecek E, Waindok P, Bankstahl M, Strube C.

PLoS Negl Trop Dis. 2017 May 8;11(5):e0005594. doi: 10.1371/journal.pntd.0005594. eCollection 2017 May.

9.

Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy.

Bar-Klein G, Klee R, Brandt C, Bankstahl M, Bascuñana P, Töllner K, Dalipaj H, Bankstahl JP, Friedman A, Löscher W.

Ann Neurol. 2016 Dec;80(6):896-908. doi: 10.1002/ana.24804.

PMID:
27761920
10.

The effects of carbamazepine in the intrahippocampal kainate model of temporal lobe epilepsy depend on seizure definition and mouse strain.

Twele F, Töllner K, Bankstahl M, Löscher W.

Epilepsia Open. 2016 Jul 27;1(1-2):45-60. doi: 10.1002/epi4.2. eCollection 2016 Sep.

11.

Multimodality imaging of blood-brain barrier impairment during epileptogenesis.

Breuer H, Meier M, Schneefeld S, Härtig W, Wittneben A, Märkel M, Ross TL, Bengel FM, Bankstahl M, Bankstahl JP.

J Cereb Blood Flow Metab. 2017 Jun;37(6):2049-2061. doi: 10.1177/0271678X16659672. Epub 2016 Jan 1.

12.

The pilocarpine model of temporal lobe epilepsy: Marked intrastrain differences in female Sprague-Dawley rats and the effect of estrous cycle.

Brandt C, Bankstahl M, Töllner K, Klee R, Löscher W.

Epilepsy Behav. 2016 Aug;61:141-152. doi: 10.1016/j.yebeh.2016.05.020. Epub 2016 Jun 23.

PMID:
27344503
13.

Knockout of P-glycoprotein does not alter antiepileptic drug efficacy in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.

Bankstahl M, Klein S, Römermann K, Löscher W.

Neuropharmacology. 2016 Oct;109:183-195. doi: 10.1016/j.neuropharm.2016.06.007. Epub 2016 Jun 7.

PMID:
27288003
14.

Serial Quantitative TSPO-Targeted PET Reveals Peak Microglial Activation up to 2 Weeks After an Epileptogenic Brain Insult.

Brackhan M, Bascuñana P, Postema JM, Ross TL, Bengel FM, Bankstahl M, Bankstahl JP.

J Nucl Med. 2016 Aug;57(8):1302-8. doi: 10.2967/jnumed.116.172494. Epub 2016 Apr 7.

15.

Brain inflammation, neurodegeneration and seizure development following picornavirus infection markedly differ among virus and mouse strains and substrains.

Bröer S, Käufer C, Haist V, Li L, Gerhauser I, Anjum M, Bankstahl M, Baumgärtner W, Löscher W.

Exp Neurol. 2016 May;279:57-74. doi: 10.1016/j.expneurol.2016.02.011. Epub 2016 Feb 15.

PMID:
26892877
16.

Network pharmacology for antiepileptogenesis: Tolerability of multitargeted drug combinations in nonepileptic vs. post-status epilepticus mice.

Klee R, Töllner K, Rankovic V, Römermann K, Schidlitzki A, Bankstahl M, Löscher W.

Epilepsy Res. 2015 Dec;118:34-48. doi: 10.1016/j.eplepsyres.2015.11.003. Epub 2015 Nov 10.

PMID:
26600369
17.

Development and performance test of an online blood sampling system for determination of the arterial input function in rats.

Roehrbacher F, Bankstahl JP, Bankstahl M, Wanek T, Stanek J, Sauberer M, Muellauer J, Schroettner T, Langer O, Kuntner C.

EJNMMI Phys. 2015 Dec;2(1):1. doi: 10.1186/s40658-014-0106-8. Epub 2015 Jan 14.

18.

The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.

Twele F, Bankstahl M, Klein S, Römermann K, Löscher W.

Neuropharmacology. 2015 Aug;95:234-42. doi: 10.1016/j.neuropharm.2015.03.014. Epub 2015 Mar 31.

PMID:
25839899
19.

[(18)F]FDG is not transported by P-glycoprotein and breast cancer resistance protein at the rodent blood-brain barrier.

Wanek T, Traxl A, Bankstahl JP, Bankstahl M, Sauberer M, Langer O, Kuntner C.

Nucl Med Biol. 2015 Jul;42(7):585-9. doi: 10.1016/j.nucmedbio.2015.03.004. Epub 2015 Mar 18.

PMID:
25823393
20.

Pilocarpine-induced convulsive activity is limited by multidrug transporters at the rodent blood-brain barrier.

Römermann K, Bankstahl JP, Löscher W, Bankstahl M.

J Pharmacol Exp Ther. 2015 May;353(2):351-9. doi: 10.1124/jpet.114.221952. Epub 2015 Mar 9.

PMID:
25755207
21.

Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.

Klein S, Bankstahl M, Löscher W.

Neuropharmacology. 2015 Mar;90:53-62. doi: 10.1016/j.neuropharm.2014.11.008. Epub 2014 Nov 22.

PMID:
25460186
22.

Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.

Klein S, Bankstahl M, Gramer M, Hausknecht M, Löscher W.

Epilepsy Res. 2014 Dec;108(10):1719-27. doi: 10.1016/j.eplepsyres.2014.10.002. Epub 2014 Oct 15.

PMID:
25458535
23.

Sucrose consumption test reveals pharmacoresistant depression-associated behavior in two mouse models of temporal lobe epilepsy.

Klein S, Bankstahl JP, Löscher W, Bankstahl M.

Exp Neurol. 2015 Jan;263:263-71. doi: 10.1016/j.expneurol.2014.09.004. Epub 2014 Sep 16.

PMID:
25220610
24.

Pilocarpine-induced epilepsy in mice alters seizure thresholds and the efficacy of antiepileptic drugs in the 6-Hertz psychomotor seizure model.

Bankstahl M, Bankstahl JP, Löscher W.

Epilepsy Res. 2013 Dec;107(3):205-16. doi: 10.1016/j.eplepsyres.2013.09.014. Epub 2013 Oct 5.

PMID:
24161515
26.

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy.

Noe FM, Polascheck N, Frigerio F, Bankstahl M, Ravizza T, Marchini S, Beltrame L, Banderó CR, Löscher W, Vezzani A.

Neurobiol Dis. 2013 Nov;59:183-93. doi: 10.1016/j.nbd.2013.07.015. Epub 2013 Aug 9.

PMID:
23938763
27.

(R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood-brain barrier, and not by MRP1 and BCRP.

Römermann K, Wanek T, Bankstahl M, Bankstahl JP, Fedrowitz M, Müller M, Löscher W, Kuntner C, Langer O.

Nucl Med Biol. 2013 Oct;40(7):873-8. doi: 10.1016/j.nucmedbio.2013.05.012. Epub 2013 Jul 8.

28.

Assessment of cerebral P-glycoprotein expression and function with PET by combined [11C]inhibitor and [11C]substrate scans in rats.

Müllauer J, Karch R, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Mairinger S, Müller M, Löscher W, Langer O, Kuntner C.

Nucl Med Biol. 2013 Aug;40(6):755-63. doi: 10.1016/j.nucmedbio.2013.05.005. Epub 2013 Jun 15.

PMID:
23774004
29.

Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study.

Bankstahl JP, Bankstahl M, Römermann K, Wanek T, Stanek J, Windhorst AD, Fedrowitz M, Erker T, Müller M, Löscher W, Langer O, Kuntner C.

Drug Metab Dispos. 2013 Apr;41(4):754-62. doi: 10.1124/dmd.112.049148. Epub 2013 Jan 10.

PMID:
23305710
30.

A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier.

Wanek T, Kuntner C, Bankstahl JP, Mairinger S, Bankstahl M, Stanek J, Sauberer M, Filip T, Erker T, Müller M, Löscher W, Langer O.

J Cereb Blood Flow Metab. 2012 Nov;32(11):2002-11. doi: 10.1038/jcbfm.2012.112. Epub 2012 Jul 25.

31.

Generation and characterization of pilocarpine-sensitive C57BL/6 mice as a model of temporal lobe epilepsy.

Bankstahl M, Müller CJ, Wilk E, Schughart K, Löscher W.

Behav Brain Res. 2012 Apr 21;230(1):182-91. doi: 10.1016/j.bbr.2012.02.004. Epub 2012 Feb 10.

PMID:
22348894
32.

Vigabatrin for focal drug delivery in epilepsy: bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model.

Bröer S, Backofen-Wehrhahn B, Bankstahl M, Gey L, Gernert M, Löscher W.

Neurobiol Dis. 2012 May;46(2):362-76. doi: 10.1016/j.nbd.2012.01.017. Epub 2012 Feb 9.

PMID:
22342648
33.

The antiepileptic drug mephobarbital is not transported by P-glycoprotein or multidrug resistance protein 1 at the blood-brain barrier: a positron emission tomography study.

Mairinger S, Bankstahl JP, Kuntner C, Römermann K, Bankstahl M, Wanek T, Stanek J, Löscher W, Müller M, Erker T, Langer O.

Epilepsy Res. 2012 Jun;100(1-2):93-103. doi: 10.1016/j.eplepsyres.2012.01.012. Epub 2012 Feb 17.

34.

Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.

Bankstahl M, Bankstahl JP, Bloms-Funke P, Löscher W.

Neurotoxicology. 2012 Jan;33(1):127-37. doi: 10.1016/j.neuro.2011.12.011. Epub 2011 Dec 21.

PMID:
22209701
35.

Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy.

Bankstahl M, Bankstahl JP, Löscher W.

Exp Neurol. 2012 Mar;234(1):70-84. doi: 10.1016/j.expneurol.2011.12.014. Epub 2011 Dec 19.

PMID:
22201552
36.

A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.

Wanek T, Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Sauberer M, Mairinger S, Strommer S, Wacheck V, Löscher W, Erker T, Müller M, Langer O.

Eur J Nucl Med Mol Imaging. 2012 Jan;39(1):149-59. doi: 10.1007/s00259-011-1941-7. Epub 2011 Oct 8.

37.

A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier.

Bankstahl JP, Bankstahl M, Kuntner C, Stanek J, Wanek T, Meier M, Ding XQ, Müller M, Langer O, Löscher W.

J Neurosci. 2011 Jun 15;31(24):8803-11. doi: 10.1523/JNEUROSCI.6616-10.2011.

38.

Radiosynthesis and in vivo evaluation of 1-[18F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein.

Dörner B, Kuntner C, Bankstahl JP, Wanek T, Bankstahl M, Stanek J, Müllauer J, Bauer F, Mairinger S, Löscher W, Miller DW, Chiba P, Müller M, Erker T, Langer O.

Bioorg Med Chem. 2011 Apr 1;19(7):2190-8. doi: 10.1016/j.bmc.2011.02.039. Epub 2011 Feb 26.

39.

Enhanced susceptibility to the GABA antagonist pentylenetetrazole during the latent period following a pilocarpine-induced status epilepticus in rats.

Rattka M, Brandt C, Bankstahl M, Bröer S, Löscher W.

Neuropharmacology. 2011 Feb-Mar;60(2-3):505-12. doi: 10.1016/j.neuropharm.2010.11.005. Epub 2010 Nov 12.

PMID:
21075125
40.

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor.

Bauer F, Kuntner C, Bankstahl JP, Wanek T, Bankstahl M, Stanek J, Mairinger S, Dörner B, Löscher W, Müller M, Erker T, Langer O.

Bioorg Med Chem. 2010 Aug 1;18(15):5489-97. doi: 10.1016/j.bmc.2010.06.057. Epub 2010 Jun 22.

41.

Synthesis and in vivo evaluation of the putative breast cancer resistance protein inhibitor [11C]methyl 4-((4-(2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)phenyl)amino-carbonyl)-2-(quinoline-2-carbonylamino)benzoate.

Mairinger S, Langer O, Kuntner C, Wanek T, Bankstahl JP, Bankstahl M, Stanek J, Dörner B, Bauer F, Baumgartner C, Löscher W, Erker T, Müller M.

Nucl Med Biol. 2010 Jul;37(5):637-44. doi: 10.1016/j.nucmedbio.2010.02.008. Epub 2010 Apr 8.

42.

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy.

Polascheck N, Bankstahl M, Löscher W.

Exp Neurol. 2010 Jul;224(1):219-33. doi: 10.1016/j.expneurol.2010.03.014. Epub 2010 Mar 29.

PMID:
20353773
43.

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Stundner G, Karch R, Brauner R, Meier M, Ding X, Müller M, Löscher W, Langer O.

Eur J Nucl Med Mol Imaging. 2010 May;37(5):942-53. doi: 10.1007/s00259-009-1332-5. Epub 2009 Dec 17.

44.

Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier.

Dörner B, Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Stundner G, Mairinger S, Löscher W, Müller M, Langer O, Erker T.

J Med Chem. 2009 Oct 8;52(19):6073-82. doi: 10.1021/jm900940f.

45.

In vivo down-regulation of mouse brain capillary P-glycoprotein: a preliminary investigation.

Fuest C, Bankstahl M, Winter P, Helm M, Pekcec A, Potschka H.

Neurosci Lett. 2009 Oct 16;464(1):47-51. doi: 10.1016/j.neulet.2009.08.014. Epub 2009 Aug 11.

PMID:
19679165
46.

Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage.

Müller CJ, Bankstahl M, Gröticke I, Löscher W.

Eur J Pharmacol. 2009 Oct 1;619(1-3):15-24. doi: 10.1016/j.ejphar.2009.07.020. Epub 2009 Jul 24.

PMID:
19632220
47.

Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice.

Müller CJ, Gröticke I, Bankstahl M, Löscher W.

Exp Neurol. 2009 Sep;219(1):284-97. doi: 10.1016/j.expneurol.2009.05.035. Epub 2009 Jun 3.

PMID:
19500573

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