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Kinetics of HTLV-1 reactivation from latency quantified by single-molecule RNA FISH and stochastic modelling.

Miura M, Dey S, Ramanayake S, Singh A, Rueda DS, Bangham CRM.

PLoS Pathog. 2019 Nov 18;15(11):e1008164. doi: 10.1371/journal.ppat.1008164. eCollection 2019 Nov.


Regulation of Latency in the Human T Cell Leukemia Virus, HTLV-1.

Bangham CRM, Miura M, Kulkarni A, Matsuoka M.

Annu Rev Virol. 2019 Sep 29;6(1):365-385. doi: 10.1146/annurev-virology-092818-015501. Epub 2019 Jul 5.


Molecular remissions are observed in chronic adult T-cell leukemia/lymphoma in patients treated with mogamulizumab.

Cook LBM, Demontis MA, Sagawe S, Witkover A, Melamed A, Turpin J, Dillon R, Haddow J, Marks AJ, Bangham CRM, Fields P, Taylor GP, Rowan AG.

Haematologica. 2019 Dec;104(12):e566-e569. doi: 10.3324/haematol.2019.219253. Epub 2019 Apr 19. No abstract available.


Epigenetic changes around the pX region and spontaneous HTLV-1 transcription are CTCF-independent.

Miura M, Miyazato P, Satou Y, Tanaka Y, Bangham CRM.

Version 2. Wellcome Open Res. 2018 Dec 11 [revised 2018 Jan 1];3:105. doi: 10.12688/wellcomeopenres.14741.2. eCollection 2018.


Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1.

Kulkarni A, Taylor GP, Klose RJ, Schofield CJ, Bangham CR.

JCI Insight. 2018 Oct 18;3(20). pii: 123196. doi: 10.1172/jci.insight.123196.


Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia.

Turpin J, Yurick D, Khoury G, Pham H, Locarnini S, Melamed A, Witkover A, Wilson K, Purcell D, Bangham CRM, Einsiedel L.

J Infect Dis. 2019 Jan 29;219(4):562-567. doi: 10.1093/infdis/jiy546.


Phosphatidylinositol 3-kinase-δ (PI3K-δ) is a potential therapeutic target in adult T-cell leukemia-lymphoma.

Katsuya H, Cook LBM, Rowan AG, Satou Y, Taylor GP, Bangham CRM.

Biomark Res. 2018 Jul 18;6:24. doi: 10.1186/s40364-018-0138-7. eCollection 2018.


The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis.

Melamed A, Yaguchi H, Miura M, Witkover A, Fitzgerald TW, Birney E, Bangham CR.

Elife. 2018 Jun 26;7. pii: e36245. doi: 10.7554/eLife.36245.


Author Correction: Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model.

Satou Y, Katsuya H, Fukuda A, Misawa N, Ito J, Uchiyama Y, Miyazato P, Islam S, Fassati A, Melamed A, Bangham CRM, Koyanagi Y, Sato K.

Sci Rep. 2018 Apr 25;8(1):6770. doi: 10.1038/s41598-018-24607-5.


HTLV-1: Regulating the Balance Between Proviral Latency and Reactivation.

Kulkarni A, Bangham CRM.

Front Microbiol. 2018 Mar 19;9:449. doi: 10.3389/fmicb.2018.00449. eCollection 2018. Review.


Quantification of HTLV-1 reverse transcriptase activity in ATL patients treated with zidovudine and interferon-α.

Macchi B, Balestrieri E, Frezza C, Grelli S, Valletta E, Marçais A, Marino-Merlo F, Turpin J, Bangham CR, Hermine O, Mastino A, Bazarbachi A.

Blood Adv. 2017 May 5;1(12):748-752. doi: 10.1182/bloodadvances.2016001370. eCollection 2017 May 9.


Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo.

Furuta R, Yasunaga JI, Miura M, Sugata K, Saito A, Akari H, Ueno T, Takenouchi N, Fujisawa JI, Koh KR, Higuchi Y, Mahgoub M, Shimizu M, Matsuda F, Melamed A, Bangham CR, Matsuoka M.

PLoS Pathog. 2017 Nov 29;13(11):e1006722. doi: 10.1371/journal.ppat.1006722. eCollection 2017 Nov.


Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis.

Bangham CRM.

Annu Rev Immunol. 2018 Apr 26;36:43-71. doi: 10.1146/annurev-immunol-042617-053222. Epub 2017 Nov 16. Review.


Long-term clinical remission maintained after cessation of zidovudine and interferon-α therapy in chronic adult T-cell leukemia/lymphoma.

Cook LB, Rowan AG, Demontis MA, Sagawe S, Gillet NA, Melamed A, Greiller C, Witkover A, Bangham CRM, Taylor GP.

Int J Hematol. 2018 Mar;107(3):378-382. doi: 10.1007/s12185-017-2361-7. Epub 2017 Oct 31.


Single-cell heterogeneity and cell-cycle-related viral gene bursts in the human leukaemia virus HTLV-1.

Billman MR, Rueda D, Bangham CRM.

Wellcome Open Res. 2017 Sep 22;2:87. doi: 10.12688/wellcomeopenres.12469.2. eCollection 2017.


Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1.

Kulkarni A, Mateus M, Thinnes CC, McCullagh JS, Schofield CJ, Taylor GP, Bangham CRM.

Cell Chem Biol. 2017 Nov 16;24(11):1377-1387.e3. doi: 10.1016/j.chembiol.2017.08.016. Epub 2017 Sep 28.


Human T-cell leukaemia virus type 1: parasitism and pathogenesis.

Bangham CRM, Matsuoka M.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732). pii: 20160272. doi: 10.1098/rstb.2016.0272. Review.


The impact of HTLV-1 on the cellular genome.

Cook L, Melamed A, Yaguchi H, Bangham CR.

Curr Opin Virol. 2017 Oct;26:125-131. doi: 10.1016/j.coviro.2017.07.013. Epub 2017 Aug 18. Review.


Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model.

Satou Y, Katsuya H, Fukuda A, Misawa N, Ito J, Uchiyama Y, Miyazato P, Islam S, Fassati A, Melamed A, Bangham CRM, Koyanagi Y, Sato K.

Sci Rep. 2017 Jul 31;7(1):6913. doi: 10.1038/s41598-017-07307-4. Erratum in: Sci Rep. 2018 Apr 25;8(1):6770.


Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation.

Zhyvoloup A, Melamed A, Anderson I, Planas D, Lee CH, Kriston-Vizi J, Ketteler R, Merritt A, Routy JP, Ancuta P, Bangham CRM, Fassati A.

PLoS Pathog. 2017 Jul 20;13(7):e1006460. doi: 10.1371/journal.ppat.1006460. eCollection 2017 Jul.


High-Throughput Mapping and Clonal Quantification of Retroviral Integration Sites.

Gillet NA, Melamed A, Bangham CR.

Methods Mol Biol. 2017;1582:127-141. doi: 10.1007/978-1-4939-6872-5_10.


Risk stratification of adult T-cell leukemia/lymphoma using immunophenotyping.

Kagdi HH, Demontis MA, Fields PA, Ramos JC, Bangham CR, Taylor GP.

Cancer Med. 2017 Jan;6(1):298-309. doi: 10.1002/cam4.928. Epub 2016 Dec 30.


Whole body clonality analysis in an aggressive STLV-1 associated leukemia (ATLL) reveals an unexpected clonal complexity.

Turpin J, Alais S, Marçais A, Bruneau J, Melamed A, Gadot N, Tanaka Y, Hermine O, Melot S, Lacoste R, Bangham CR, Mahieux R.

Cancer Lett. 2017 Mar 28;389:78-85. doi: 10.1016/j.canlet.2016.12.022. Epub 2016 Dec 26.


Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis.

Lewin A, Hamilton S, Witkover A, Langford P, Nicholas R, Chataway J, Bangham CRM.

Wellcome Open Res. 2016 Nov 15;1:10. doi: 10.12688/wellcomeopenres.9967.2.


T Cell Receptor Vβ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8+ T cells.

Rowan AG, Witkover A, Melamed A, Tanaka Y, Cook LB, Fields P, Taylor GP, Bangham CR.

PLoS Pathog. 2016 Nov 28;12(11):e1006030. doi: 10.1371/journal.ppat.1006030. eCollection 2016 Nov.


Retroviruses integrate into a shared, non-palindromic DNA motif.

Kirk PD, Huvet M, Melamed A, Maertens GN, Bangham CR.

Nat Microbiol. 2016 Nov 14;2:16212. doi: 10.1038/nmicrobiol.2016.212.


CADM1/TSLC1 Identifies HTLV-1-Infected Cells and Determines Their Susceptibility to CTL-Mediated Lysis.

Manivannan K, Rowan AG, Tanaka Y, Taylor GP, Bangham CR.

PLoS Pathog. 2016 Apr 22;12(4):e1005560. doi: 10.1371/journal.ppat.1005560. eCollection 2016 Apr.


The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome.

Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan AG, Nakao M, Bangham CR.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3054-9. doi: 10.1073/pnas.1423199113. Epub 2016 Feb 29.


Rapid dissemination of human T-lymphotropic virus type 1 during primary infection in transplant recipients.

Cook LB, Melamed A, Demontis MA, Laydon DJ, Fox JM, Tosswill JH, de Freitas D, Price AD, Medcalf JF, Martin F, Neuberger JM, Bangham CR, Taylor GP.

Retrovirology. 2016 Jan 8;13:3. doi: 10.1186/s12977-015-0236-7.


Immune Compromise in HIV-1/HTLV-1 Coinfection With Paradoxical Resolution of CD4 Lymphocytosis During Antiretroviral Therapy: A Case Report.

Rockwood N, Cook L, Kagdi H, Basnayake S, Bangham CR, Pozniak AL, Taylor GP.

Medicine (Baltimore). 2015 Dec;94(50):e2275. doi: 10.1097/MD.0000000000002275.


HTLV-1 drives vigorous clonal expansion of infected CD8(+) T cells in natural infection.

Melamed A, Laydon DJ, Al Khatib H, Rowan AG, Taylor GP, Bangham CR.

Retrovirology. 2015 Nov 9;12:91. doi: 10.1186/s12977-015-0221-1.


How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?

Bangham CR, Ratner L.

Curr Opin Virol. 2015 Oct;14:93-100. doi: 10.1016/j.coviro.2015.09.004. Epub 2015 Sep 27. Review.


Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach.

Laydon DJ, Bangham CR, Asquith B.

Philos Trans R Soc Lond B Biol Sci. 2015 Aug 19;370(1675). pii: 20140291. doi: 10.1098/rstb.2014.0291. Review.


HTLV-1-associated myelopathy/tropical spastic paraparesis.

Bangham CR, Araujo A, Yamano Y, Taylor GP.

Nat Rev Dis Primers. 2015 Jun 18;1:15012. doi: 10.1038/nrdp.2015.12. Review.


Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression.

Rowan AG, Suemori K, Fujiwara H, Yasukawa M, Tanaka Y, Taylor GP, Bangham CR.

Retrovirology. 2014 Dec 14;11:116. doi: 10.1186/s12977-014-0116-6.


Integration site and clonal expansion in human chronic retroviral infection and gene therapy.

Niederer HA, Bangham CR.

Viruses. 2014 Oct 31;6(11):4140-64. doi: 10.3390/v6114140. Review.


HTLV-1 proviral integration sites differ between asymptomatic carriers and patients with HAM/TSP.

Niederer HA, Laydon DJ, Melamed A, Elemans M, Asquith B, Matsuoka M, Bangham CR.

Virol J. 2014 Sep 30;11:172. doi: 10.1186/1743-422X-11-172.


Quantification of HTLV-1 clonality and TCR diversity.

Laydon DJ, Melamed A, Sim A, Gillet NA, Sim K, Darko S, Kroll JS, Douek DC, Price DA, Bangham CR, Asquith B.

PLoS Comput Biol. 2014 Jun 19;10(6):e1003646. doi: 10.1371/journal.pcbi.1003646. eCollection 2014 Jun.


The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma.

Cook LB, Melamed A, Niederer H, Valganon M, Laydon D, Foroni L, Taylor GP, Matsuoka M, Bangham CR.

Blood. 2014 Jun 19;123(25):3925-31. doi: 10.1182/blood-2014-02-553602. Epub 2014 Apr 15.


Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial.

Chataway J, Schuerer N, Alsanousi A, Chan D, MacManus D, Hunter K, Anderson V, Bangham CR, Clegg S, Nielsen C, Fox NC, Wilkie D, Nicholas JM, Calder VL, Greenwood J, Frost C, Nicholas R.

Lancet. 2014 Jun 28;383(9936):2213-21. doi: 10.1016/S0140-6736(13)62242-4. Epub 2014 Mar 19.


Clonality of HTLV-2 in natural infection.

Melamed A, Witkover AD, Laydon DJ, Brown R, Ladell K, Miners K, Rowan AG, Gormley N, Price DA, Taylor GP, Murphy EL, Bangham CR.

PLoS Pathog. 2014 Mar 13;10(3):e1004006. doi: 10.1371/journal.ppat.1004006. eCollection 2014 Mar.


HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection.

Bangham CR, Cook LB, Melamed A.

Semin Cancer Biol. 2014 Jun;26:89-98. doi: 10.1016/j.semcancer.2013.11.003. Epub 2013 Dec 6. Review.


Balancing the robustness and predictive performance of biomarkers.

Kirk P, Witkover A, Bangham CR, Richardson S, Lewin AM, Stumpf MP.

J Comput Biol. 2013 Dec;20(12):979-89. doi: 10.1089/cmb.2013.0018. Epub 2013 Aug 2.


Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo.

Gillet NA, Cook L, Laydon DJ, Hlela C, Verdonck K, Alvarez C, Gotuzzo E, Clark D, Farré L, Bittencourt A, Asquith B, Taylor GP, Bangham CR.

PLoS Pathog. 2013;9(4):e1003263. doi: 10.1371/journal.ppat.1003263. Epub 2013 Apr 4.


Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection.

Melamed A, Laydon DJ, Gillet NA, Tanaka Y, Taylor GP, Bangham CR.

PLoS Pathog. 2013 Mar;9(3):e1003271. doi: 10.1371/journal.ppat.1003271. Epub 2013 Mar 21.


Is There a Role for HTLV-1-Specific CTL in Adult T-Cell Leukemia/Lymphoma?

Rowan AG, Bangham CR.

Leuk Res Treatment. 2012;2012:391953. doi: 10.1155/2012/391953. Epub 2011 Nov 30.


Immunopathogenesis of human T-cell leukemia virus type-1-associated myelopathy/tropical spastic paraparesis: recent perspectives.

Saito M, Bangham CR.

Leuk Res Treatment. 2012;2012:259045. doi: 10.1155/2012/259045. Epub 2012 Feb 6.


HTLV-1 Infection and Its Associated Diseases.

Saito M, Jain P, Tsukasaki K, Bangham CR.

Leuk Res Treatment. 2012;2012:123637. doi: 10.1155/2012/123637. Epub 2012 May 7. No abstract available.


HTLV-1-infected T cells contain a single integrated provirus in natural infection.

Cook LB, Rowan AG, Melamed A, Taylor GP, Bangham CR.

Blood. 2012 Oct 25;120(17):3488-90. doi: 10.1182/blood-2012-07-445593. Epub 2012 Sep 6.


HTLV-1 infection: what determines the risk of inflammatory disease?

Tattermusch S, Bangham CR.

Trends Microbiol. 2012 Oct;20(10):494-500. doi: 10.1016/j.tim.2012.07.004. Epub 2012 Aug 21. Review.


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