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Items: 1 to 50 of 53

1.

Modeling and mutational analysis of the binding mode for the multimodal antidepressant drug vortioxetine to the human 5-HT3A receptor.

Ladefoged LK, Munro L, Pedersen AJ, Balle T, Bang-Andersen B, Lummis SCR, Schiott B, Kristensen AS.

Mol Pharmacol. 2018 Sep 26. pii: mol.118.113530. doi: 10.1124/mol.118.113530. [Epub ahead of print]

2.

Mapping the Binding Site for Escitalopram and Paroxetine in the Human Serotonin Transporter Using Genetically Encoded Photo-Cross-Linkers.

Rannversson H, Andersen J, Bang-Andersen B, Strømgaard K.

ACS Chem Biol. 2017 Oct 20;12(10):2558-2562. doi: 10.1021/acschembio.7b00338. Epub 2017 Sep 26.

PMID:
28910072
3.

X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.

Topiol S, Bang-Andersen B, Sanchez C, Plenge P, Loland CJ, Juhl K, Larsen K, Bregnedal P, Bøgesø KP.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):470-478. doi: 10.1016/j.bmcl.2016.12.037. Epub 2016 Dec 21.

PMID:
28041833
4.

Synthesis and selective 2 H-, 13 C-, and 15 N-labeling of the Tau protein binder THK-523.

Neumann KT, Lindhardt AT, Bang-Andersen B, Skrydstrup T.

J Labelled Comp Radiopharm. 2017 Jan;60(1):30-35. doi: 10.1002/jlcr.3470. Epub 2016 Nov 13.

PMID:
27862198
5.

Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain.

Yang KC, Stepanov V, Amini N, Martinsson S, Takano A, Nielsen J, Bundgaard C, Bang-Andersen B, Grimwood S, Halldin C, Farde L, Finnema SJ.

Eur J Nucl Med Mol Imaging. 2017 Feb;44(2):308-320. doi: 10.1007/s00259-016-3544-9. Epub 2016 Nov 5.

6.

Exploration of insights, opportunities and caveats provided by the X-ray structures of hSERT.

Topiol S, Bang-Andersen B, Sanchez C, Bøgesø KP.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):5058-5064. doi: 10.1016/j.bmcl.2016.08.087. Epub 2016 Aug 28.

PMID:
27624075
7.

Discriminative stimulus properties of 1.25mg/kg clozapine in rats: Mediation by serotonin 5-HT2 and dopamine D4 receptors.

Prus AJ, Wise LE, Pehrson AL, Philibin SD, Bang-Andersen B, Arnt J, Porter JH.

Brain Res. 2016 Oct 1;1648(Pt A):298-305. doi: 10.1016/j.brainres.2016.08.004. Epub 2016 Aug 5.

PMID:
27502027
8.

Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter.

Rannversson H, Andersen J, Sørensen L, Bang-Andersen B, Park M, Huber T, Sakmar TP, Strømgaard K.

Nat Commun. 2016 Apr 19;7:11261. doi: 10.1038/ncomms11261.

9.

Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628.

Varnäs K, Finnema SJ, Stepanov V, Takano A, Tóth M, Svedberg M, Møller Nielsen S, Khanzhin NA, Juhl K, Bang-Andersen B, Halldin C, Farde L.

Int J Neuropsychopharmacol. 2016 Aug 12;19(8). pii: pyw023. doi: 10.1093/ijnp/pyw023. Print 2016 Aug.

10.

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter.

Larsen MA, Plenge P, Andersen J, Eildal JN, Kristensen AS, Bøgesø KP, Gether U, Strømgaard K, Bang-Andersen B, Loland CJ.

Br J Pharmacol. 2016 Mar;173(5):925-36. doi: 10.1111/bph.13411. Epub 2016 Feb 8.

11.

Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter.

Andersen J, Ringsted KB, Bang-Andersen B, Strømgaard K, Kristensen AS.

Sci Rep. 2015 Oct 27;5:15650. doi: 10.1038/srep15650.

12.

Binding of the multimodal antidepressant drug vortioxetine to the human serotonin transporter.

Andersen J, Ladefoged LK, Wang D, Kristensen TN, Bang-Andersen B, Kristensen AS, Schiøtt B, Strømgaard K.

ACS Chem Neurosci. 2015 Nov 18;6(11):1892-900. doi: 10.1021/acschemneuro.5b00225. Epub 2015 Oct 11.

PMID:
26389667
13.

Serotonin transporter occupancy by escitalopram and citalopram in the non-human primate brain: a [(11)C]MADAM PET study.

Finnema SJ, Halldin C, Bang-Andersen B, Bundgaard C, Farde L.

Psychopharmacology (Berl). 2015 Nov;232(21-22):4159-67. doi: 10.1007/s00213-015-3961-7. Epub 2015 May 17.

PMID:
25980484
14.

Correction to Palladium-catalyzed carbonylative Sonogashira coupling of aryl bromides using near stoichiometric carbon monoxide.

Neumann KT, Laursen SR, Lindhardt AT, Bang-Andersen B, Skrydstrup T.

Org Lett. 2015 May 15;17(10):2566. doi: 10.1021/acs.orglett.5b01250. Epub 2015 May 5. No abstract available.

PMID:
25941837
15.

Application of cross-species PET imaging to assess neurotransmitter release in brain.

Finnema SJ, Scheinin M, Shahid M, Lehto J, Borroni E, Bang-Andersen B, Sallinen J, Wong E, Farde L, Halldin C, Grimwood S.

Psychopharmacology (Berl). 2015 Nov;232(21-22):4129-57. doi: 10.1007/s00213-015-3938-6. Epub 2015 Apr 30. Review.

16.

Access to 2-(Het)aryl and 2-Styryl Benzoxazoles via Palladium-Catalyzed Aminocarbonylation of Aryl and Vinyl Bromides.

Neumann KT, Lindhardt AT, Bang-Andersen B, Skrydstrup T.

Org Lett. 2015 May 1;17(9):2094-7. doi: 10.1021/acs.orglett.5b00642. Epub 2015 Apr 16.

PMID:
25879769
17.

Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs.

Dale E, Bang-Andersen B, Sánchez C.

Biochem Pharmacol. 2015 May 15;95(2):81-97. doi: 10.1016/j.bcp.2015.03.011. Epub 2015 Mar 24.

18.

Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.

Mikkelsen GK, Langgård M, Schrøder TJ, Kreilgaard M, Jørgensen EB, Brandt G, Griffon Y, Boffey R, Bang-Andersen B.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1212-6. doi: 10.1016/j.bmcl.2015.01.062. Epub 2015 Feb 7.

PMID:
25701253
19.

Discovery and development of 11C-Lu AE92686 as a radioligand for PET imaging of phosphodiesterase10A in the brain.

Kehler J, Kilburn JP, Estrada S, Christensen SR, Wall A, Thibblin A, Lubberink M, Bundgaard C, Brennum LT, Steiniger-Brach B, Christoffersen CT, Timmermann S, Kreilgaard M, Antoni G, Bang-Andersen B, Nielsen J.

J Nucl Med. 2014 Sep;55(9):1513-8. doi: 10.2967/jnumed.114.140178. Epub 2014 Jul 3.

20.

Palladium-catalyzed carbonylative sonogashira coupling of aryl bromides using near stoichiometric carbon monoxide.

Neumann KT, Laursen SR, Lindhardt AT, Bang-Andersen B, Skrydstrup T.

Org Lett. 2014 Apr 18;16(8):2216-9. doi: 10.1021/ol5007289. Epub 2014 Apr 4. Erratum in: Org Lett. 2015 May 15;17(10):2566.

PMID:
24702025
21.

Synthesis and SAR study of a novel series of dopamine receptor agonists.

Risgaard R, Jensen M, Jørgensen M, Bang-Andersen B, Christoffersen CT, Jensen KG, Kristensen JL, Püschl A.

Bioorg Med Chem. 2014 Jan 1;22(1):381-92. doi: 10.1016/j.bmc.2013.11.012. Epub 2013 Nov 15.

PMID:
24296012
22.

Radiosynthesis and evaluation of new α1-adrenoceptor antagonists as PET radioligands for brain imaging.

Airaksinen AJ, Finnema SJ, Balle T, Varnäs K, Bang-Andersen B, Gulyás B, Farde L, Halldin C.

Nucl Med Biol. 2013 Aug;40(6):747-54. doi: 10.1016/j.nucmedbio.2013.05.007. Epub 2013 Jun 27.

PMID:
23810488
23.

The dopamine D₁ receptor agonist (S)-[¹¹C]N-methyl-NNC 01-0259 is not sensitive to changes in dopamine concentration--a positron emission tomography examination in the monkey brain.

Finnema SJ, Bang-Andersen B, Jørgensen M, Christoffersen CT, Gulyás B, Wikström HV, Farde L, Halldin C.

Synapse. 2013 Sep;67(9):586-95. doi: 10.1002/syn.21664. Epub 2013 Apr 18.

PMID:
23504964
24.

Discovery of novel α₁-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands.

Jørgensen M, Jørgensen PN, Christoffersen CT, Jensen KG, Balle T, Bang-Andersen B.

Bioorg Med Chem. 2013 Jan 1;21(1):196-204. doi: 10.1016/j.bmc.2012.10.049. Epub 2012 Nov 15.

PMID:
23218776
25.

Radiolabelling and PET brain imaging of the α₁-adrenoceptor antagonist Lu AE43936.

Risgaard R, Ettrup A, Balle T, Dyssegaard A, Hansen HD, Lehel S, Madsen J, Pedersen H, Püschl A, Badolo L, Bang-Andersen B, Knudsen GM, Kristensen JL.

Nucl Med Biol. 2013 Jan;40(1):135-40. doi: 10.1016/j.nucmedbio.2012.09.010. Epub 2012 Nov 17.

PMID:
23165140
26.

Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential.

Sams AG, Larsen K, Mikkelsen GK, Hentzer M, Christoffersen CT, Jensen KG, Frederiksen K, Bang-Andersen B.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5134-40. doi: 10.1016/j.bmcl.2012.05.048. Epub 2012 May 18.

PMID:
22677319
27.

Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004.

Hvenegaard MG, Bang-Andersen B, Pedersen H, Jørgensen M, Püschl A, Dalgaard L.

Drug Metab Dispos. 2012 Jul;40(7):1357-65. doi: 10.1124/dmd.112.044610. Epub 2012 Apr 11.

28.

Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder.

Mørk A, Pehrson A, Brennum LT, Nielsen SM, Zhong H, Lassen AB, Miller S, Westrich L, Boyle NJ, Sánchez C, Fischer CW, Liebenberg N, Wegener G, Bundgaard C, Hogg S, Bang-Andersen B, Stensbøl TB.

J Pharmacol Exp Ther. 2012 Mar;340(3):666-75. doi: 10.1124/jpet.111.189068. Epub 2011 Dec 9.

29.

Characterization of [³H]Lu AE60157 ([³H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine₆ (5-HT₆) receptors in vivo.

Witten L, Bang-Andersen B, Nielsen SM, Miller S, Christoffersen CT, Stensbøl TB, Brennum LT, Arnt J.

Eur J Pharmacol. 2012 Feb 15;676(1-3):6-11. doi: 10.1016/j.ejphar.2011.11.029. Epub 2011 Dec 4.

PMID:
22155399
30.

Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters.

Andersen J, Stuhr-Hansen N, Zachariassen L, Toubro S, Hansen SM, Eildal JN, Bond AD, Bøgesø KP, Bang-Andersen B, Kristensen AS, Strømgaard K.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12137-42. doi: 10.1073/pnas.1103060108. Epub 2011 Jul 5.

31.

Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.

Bang-Andersen B, Ruhland T, Jørgensen M, Smith G, Frederiksen K, Jensen KG, Zhong H, Nielsen SM, Hogg S, Mørk A, Stensbøl TB.

J Med Chem. 2011 May 12;54(9):3206-21. doi: 10.1021/jm101459g. Epub 2011 Apr 12.

PMID:
21486038
32.

Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist.

Sams AG, Mikkelsen GK, Larsen M, Langgård M, Howells ME, Schrøder TJ, Brennum LT, Torup L, Jørgensen EB, Bundgaard C, Kreilgård M, Bang-Andersen B.

J Med Chem. 2011 Feb 10;54(3):751-64. Epub 2011 Jan 6.

PMID:
21210664
33.

Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors.

Kristensen JL, Püschl A, Jensen M, Risgaard R, Christoffersen CT, Bang-Andersen B, Balle T.

J Med Chem. 2010 Oct 14;53(19):7021-34. doi: 10.1021/jm100652h.

PMID:
20857909
34.

Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.

Sams AG, Hentzer M, Mikkelsen GK, Larsen K, Bundgaard C, Plath N, Christoffersen CT, Bang-Andersen B.

J Med Chem. 2010 Sep 9;53(17):6386-97. doi: 10.1021/jm100697g.

PMID:
20684563
35.

Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists.

Sams AG, Mikkelsen GK, Larsen M, Torup L, Brennum LT, Schrøder TJ, Bang-Andersen B.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5241-4. doi: 10.1016/j.bmcl.2010.06.138. Epub 2010 Jul 24.

PMID:
20659802
36.

Current state of agonist radioligands for imaging of brain dopamine D2/D3 receptors in vivo with positron emission tomography.

Finnema SJ, Bang-Andersen B, Wikström HV, Halldin C.

Curr Top Med Chem. 2010;10(15):1477-98. Review.

PMID:
20583987
37.

Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.

Arnt J, Bang-Andersen B, Grayson B, Bymaster FP, Cohen MP, DeLapp NW, Giethlen B, Kreilgaard M, McKinzie DL, Neill JC, Nelson DL, Nielsen SM, Poulsen MN, Schaus JM, Witten LM.

Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33. doi: 10.1017/S1461145710000659. Epub 2010 Jun 23.

PMID:
20569520
38.

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

Andersen J, Olsen L, Hansen KB, Taboureau O, Jørgensen FS, Jørgensen AM, Bang-Andersen B, Egebjerg J, Strømgaard K, Kristensen AS.

J Biol Chem. 2010 Jan 15;285(3):2051-63. doi: 10.1074/jbc.M109.072587. Epub 2009 Nov 5.

39.

Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms.

Idris N, Neill J, Grayson B, Bang-Andersen B, Witten LM, Brennum LT, Arnt J.

Psychopharmacology (Berl). 2010 Jan;208(1):23-36. doi: 10.1007/s00213-009-1702-5. Epub 2009 Oct 23.

PMID:
19851757
40.

Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters.

Andersen J, Kristensen AS, Bang-Andersen B, Strømgaard K.

Chem Commun (Camb). 2009 Jul 7;(25):3677-92. doi: 10.1039/b903035m. Epub 2009 May 7. Review.

PMID:
19557250
41.

Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain--a comparative PET study with [11C]raclopride and [11C]MNPA.

Finnema SJ, Halldin C, Bang-Andersen B, Gulyás B, Bundgaard C, Wikström HV, Farde L.

Synapse. 2009 May;63(5):378-89. doi: 10.1002/syn.20615.

PMID:
19173265
42.

From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies.

Eildal JN, Andersen J, Kristensen AS, Jørgensen AM, Bang-Andersen B, Jørgensen M, Strømgaard K.

J Med Chem. 2008 May 22;51(10):3045-8. doi: 10.1021/jm701602g. Epub 2008 Apr 23.

PMID:
18429609
43.

Palladium-catalyzed three-component approach to promazine with formation of one carbon-sulfur and two carbon-nitrogen bonds.

Dahl T, Tornøe CW, Bang-Andersen B, Nielsen P, Jørgensen M.

Angew Chem Int Ed Engl. 2008;47(9):1726-8. doi: 10.1002/anie.200705209. No abstract available.

PMID:
18213669
44.

Palladium-catalyzed aryl amination-heck cyclization cascade: a one-flask approach to 3-substituted indoles.

Jensen T, Pedersen H, Bang-Andersen B, Madsen R, Jørgensen M.

Angew Chem Int Ed Engl. 2008;47(5):888-90. No abstract available.

PMID:
18081116
45.

Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole), a dopamine D4 receptor antagonist and serotonin reuptake inhibitor: characterisation of its in vitro profile and pre-clinical antipsychotic potential.

Hertel P, Didriksen M, Pouzet B, Brennum LT, Søby KK, Larsen AK, Christoffersen CT, Ramirez T, Marcus MM, Svensson TH, Di Matteo V, Esposito E, Bang-Andersen B, Arnt J.

Eur J Pharmacol. 2007 Nov 14;573(1-3):148-60. Epub 2007 Jul 4.

PMID:
17689529
46.

5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.

Madsen C, Jensen AA, Liljefors T, Kristiansen U, Nielsen B, Hansen CP, Larsen M, Ebert B, Bang-Andersen B, Krogsgaard-Larsen P, Frølund B.

J Med Chem. 2007 Aug 23;50(17):4147-61. Epub 2007 Jul 26.

PMID:
17655213
47.
48.

2-(2,3-Dihydro-1H-indol-3-yl)ethanol: synthesis, separation of enantiomers, and assignment of absolute stereochemistry by X-ray structure analysis.

Frydenvang K, Sommer MB, Heckmann D, Nielsen O, Bang-Andersen B.

Chirality. 2004 Feb;16(2):126-30.

PMID:
14712476
49.

Structural determinants of AMPA agonist activity in analogues of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid: synthesis and pharmacology.

Bang-Andersen B, Ahmadian H, Lenz SM, Stensbøl TB, Madsen U, Bøgesø KP, Krogsgaard-Larsen P.

J Med Chem. 2000 Dec 14;43(25):4910-8.

PMID:
11124000
50.

Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist.

Vogensen SB, Jensen HS, Stensbøl TB, Frydenvang K, Bang-Andersen B, Johansen TN, Egebjerg J, Krogsgaard-Larsen P.

Chirality. 2000 Nov;12(10):705-13.

PMID:
11054828

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