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Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus.

Chamberlain JM, Sortino K, Sethna P, Bae A, Lanier R, Bambara RA, Dewhurst S.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01925-18. doi: 10.1128/AAC.01925-18. Print 2019 Jan.


Modelling the effect of a mass radio campaign on child mortality using facility utilisation data and the Lives Saved Tool (LiST): findings from a cluster randomised trial in Burkina Faso.

Murray J, Head R, Sarrassat S, Hollowell J, Remes P, Lavoie M, Borghi J, Kasteng F, Meda N, Badolo H, Ouedraogo M, Bambara R, Cousens S.

BMJ Glob Health. 2018 Jul 16;3(4):e000808. doi: 10.1136/bmjgh-2018-000808. eCollection 2018.


Effect of a mass radio campaign on family behaviours and child survival in Burkina Faso: a repeated cross-sectional, cluster-randomised trial.

Sarrassat S, Meda N, Badolo H, Ouedraogo M, Some H, Bambara R, Murray J, Remes P, Lavoie M, Cousens S, Head R.

Lancet Glob Health. 2018 Mar;6(3):e330-e341. doi: 10.1016/S2214-109X(18)30004-4.


Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1.

Piekna-Przybylska D, Sharma G, Maggirwar SB, Bambara RA.

Cell Cycle. 2017 May 19;16(10):968-978. doi: 10.1080/15384101.2017.1312225. Epub 2017 Apr 7.


Acetylation regulates DNA repair mechanisms in human cells.

Piekna-Przybylska D, Bambara RA, Balakrishnan L.

Cell Cycle. 2016 Jun 2;15(11):1506-17. doi: 10.1080/15384101.2016.1176815. Epub 2016 Apr 22.


Behavior Change After 20 Months of a Radio Campaign Addressing Key Lifesaving Family Behaviors for Child Survival: Midline Results From a Cluster Randomized Trial in Rural Burkina Faso.

Sarrassat S, Meda N, Ouedraogo M, Some H, Bambara R, Head R, Murray J, Remes P, Cousens S.

Glob Health Sci Pract. 2015 Nov 3;3(4):557-76. doi: 10.9745/GHSP-D-15-00153.


U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence.

Piekna-Przybylska D, Sullivan MA, Sharma G, Bambara RA.

Biochemistry. 2014 Apr 29;53(16):2581-93. doi: 10.1021/bi4016692. Epub 2014 Apr 15.


GTP is the primary activator of the anti-HIV restriction factor SAMHD1.

Amie SM, Bambara RA, Kim B.

J Biol Chem. 2013 Aug 30;288(35):25001-6. doi: 10.1074/jbc.C113.493619. Epub 2013 Jul 23.


Mechanism of HIV-1 RNA dimerization in the central region of the genome and significance for viral evolution.

Piekna-Przybylska D, Sharma G, Bambara RA.

J Biol Chem. 2013 Aug 16;288(33):24140-50. doi: 10.1074/jbc.M113.477265. Epub 2013 Jul 9.


Efavirenz stimulates HIV-1 reverse transcriptase RNase H activity by a mechanism involving increased substrate binding and secondary cleavage activity.

Muchiri JM, Li D, Dykes C, Bambara RA.

Biochemistry. 2013 Jul 23;52(29):4981-90. doi: 10.1021/bi400618q. Epub 2013 Jul 9.


Reverse transcriptase backbone can alter the polymerization and RNase activities of non-nucleoside reverse transcriptase mutants K101E+G190S.

Wang J, Li D, Bambara RA, Dykes C.

J Gen Virol. 2013 Oct;94(Pt 10):2297-308. doi: 10.1099/vir.0.054999-0. Epub 2013 Jun 26.


Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.

Amie SM, Daly MB, Noble E, Schinazi RF, Bambara RA, Kim B.

J Biol Chem. 2013 Jul 12;288(28):20683-91. doi: 10.1074/jbc.M113.472159. Epub 2013 Jun 5.


Flap endonuclease 1.

Balakrishnan L, Bambara RA.

Annu Rev Biochem. 2013;82:119-38. doi: 10.1146/annurev-biochem-072511-122603. Epub 2013 Feb 28. Review.


Okazaki fragment metabolism.

Balakrishnan L, Bambara RA.

Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a010173. doi: 10.1101/cshperspect.a010173. Review.


Msh2-Msh3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions.

Kantartzis A, Williams GM, Balakrishnan L, Roberts RL, Surtees JA, Bambara RA.

Cell Rep. 2012 Aug 30;2(2):216-22. doi: 10.1016/j.celrep.2012.06.020. Epub 2012 Aug 2.


Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1.

Gloor JW, Balakrishnan L, Campbell JL, Bambara RA.

Nucleic Acids Res. 2012 Aug;40(14):6774-86. doi: 10.1093/nar/gks388. Epub 2012 May 7.


Frequent incorporation of ribonucleotides during HIV-1 reverse transcription and their attenuated repair in macrophages.

Kennedy EM, Amie SM, Bambara RA, Kim B.

J Biol Chem. 2012 Apr 20;287(17):14280-8. doi: 10.1074/jbc.M112.348482. Epub 2012 Mar 1.


Telomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro.

Miller AS, Balakrishnan L, Buncher NA, Opresko PL, Bambara RA.

Cell Cycle. 2012 Mar 1;11(5):998-1007. doi: 10.4161/cc.11.5.19483. Epub 2012 Mar 1.


Altered strand transfer activity of a multiple-drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutant with a dipeptide fingers domain insertion.

Nguyen LA, Daddacha W, Rigby S, Bambara RA, Kim B.

J Mol Biol. 2012 Jan 13;415(2):248-62. doi: 10.1016/j.jmb.2011.11.014. Epub 2011 Nov 12.


Nonnucleoside reverse transcriptase inhibitor-resistant HIV is stimulated by efavirenz during early stages of infection.

Wang J, Zhang G, Bambara RA, Li D, Liang H, Wu H, Smith HM, Lowe NR, Demeter LM, Dykes C.

J Virol. 2011 Oct;85(20):10861-73. doi: 10.1128/JVI.05116-11. Epub 2011 Aug 10.


The changing view of Dna2.

Balakrishnan L, Bambara RA.

Cell Cycle. 2011 Aug 15;10(16):2620-1. Epub 2011 Aug 15. No abstract available.


HIV-1 reverse transcriptase dissociates during strand transfer.

Muchiri JM, Rigby ST, Nguyen LA, Kim B, Bambara RA.

J Mol Biol. 2011 Sep 23;412(3):354-64. doi: 10.1016/j.jmb.2011.07.055. Epub 2011 Jul 29.


HIV-1 nucleocapsid protein increases strand transfer recombination by promoting dimeric G-quartet formation.

Shen W, Gorelick RJ, Bambara RA.

J Biol Chem. 2011 Aug 26;286(34):29838-47. doi: 10.1074/jbc.M111.262352. Epub 2011 Jul 7.


The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA.

Gewandter JS, Bambara RA, O'Reilly MA.

Cell Cycle. 2011 Aug 1;10(15):2561-7. Epub 2011 Aug 1.


Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.

Fortini BK, Pokharel S, Polaczek P, Balakrishnan L, Bambara RA, Campbell JL.

J Biol Chem. 2011 Jul 8;286(27):23763-70. doi: 10.1074/jbc.M111.243071. Epub 2011 May 13.


Requirements for efficient minus strand strong-stop DNA transfer in human immunodeficiency virus 1.

Piekna-Przybylska D, Bambara RA.

RNA Biol. 2011 Mar-Apr;8(2):230-6. Epub 2011 Mar 1. Review.


Sequences in the U3 region of human immunodeficiency virus 1 improve efficiency of minus strand transfer in infected cells.

Piekna-Przybylska D, Dykes C, Demeter LM, Bambara RA.

Virology. 2011 Feb 20;410(2):368-74. doi: 10.1016/j.virol.2010.11.026. Epub 2010 Dec 30.


Eukaryotic lagging strand DNA replication employs a multi-pathway mechanism that protects genome integrity.

Balakrishnan L, Bambara RA.

J Biol Chem. 2011 Mar 4;286(9):6865-70. doi: 10.1074/jbc.R110.209502. Epub 2010 Dec 21. Review.


An alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicase.

Pike JE, Henry RA, Burgers PM, Campbell JL, Bambara RA.

J Biol Chem. 2010 Dec 31;285(53):41712-23. doi: 10.1074/jbc.M110.146894. Epub 2010 Oct 19.


Dna2 exhibits a unique strand end-dependent helicase function.

Balakrishnan L, Polaczek P, Pokharel S, Campbell JL, Bambara RA.

J Biol Chem. 2010 Dec 10;285(50):38861-8. doi: 10.1074/jbc.M110.165191. Epub 2010 Oct 6.


Flap endonuclease 1 mechanism analysis indicates flap base binding prior to threading.

Gloor JW, Balakrishnan L, Bambara RA.

J Biol Chem. 2010 Nov 5;285(45):34922-31. doi: 10.1074/jbc.M110.165902. Epub 2010 Aug 25.


Components of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processing.

Henry RA, Balakrishnan L, Ying-Lin ST, Campbell JL, Bambara RA.

J Biol Chem. 2010 Sep 10;285(37):28496-505. doi: 10.1074/jbc.M110.131870. Epub 2010 Jul 13.


Reconstitution of eukaryotic lagging strand DNA replication.

Balakrishnan L, Gloor JW, Bambara RA.

Methods. 2010 Jul;51(3):347-57. doi: 10.1016/j.ymeth.2010.02.017. Epub 2010 Feb 21. Review.


Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates.

Balakrishnan L, Stewart J, Polaczek P, Campbell JL, Bambara RA.

J Biol Chem. 2010 Feb 12;285(7):4398-404. doi: 10.1074/jbc.M109.086397. Epub 2009 Dec 17.


A sequence similar to tRNA 3 Lys gene is embedded in HIV-1 U3-R and promotes minus-strand transfer.

Piekna-Przybylska D, DiChiacchio L, Mathews DH, Bambara RA.

Nat Struct Mol Biol. 2010 Jan;17(1):83-9. doi: 10.1038/nsmb.1687. Epub 2009 Dec 6.


Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates.

Stewart JA, Campbell JL, Bambara RA.

Nucleic Acids Res. 2010 Jan;38(3):920-30. doi: 10.1093/nar/gkp1055. Epub 2009 Nov 24.


Factors that determine the efficiency of HIV-1 strand transfer initiated at a specific site.

Rigby ST, Van Nostrand KP, Rose AE, Gorelick RJ, Mathews DH, Bambara RA.

J Mol Biol. 2009 Dec 11;394(4):694-707. doi: 10.1016/j.jmb.2009.10.036. Epub 2009 Oct 21.


A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro.

Shen W, Gao L, Balakrishnan M, Bambara RA.

J Biol Chem. 2009 Dec 4;284(49):33883-93. doi: 10.1074/jbc.M109.055368. Epub 2009 Oct 12.


Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway.

Pike JE, Burgers PM, Campbell JL, Bambara RA.

J Biol Chem. 2009 Sep 11;284(37):25170-80. doi: 10.1074/jbc.M109.023325. Epub 2009 Jul 15.


Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex.

Balakrishnan L, Brandt PD, Lindsey-Boltz LA, Sancar A, Bambara RA.

J Biol Chem. 2009 May 29;284(22):15158-72. doi: 10.1074/jbc.M109.000505. Epub 2009 Mar 27.


A succession of mechanisms stimulate efficient reconstituted HIV-1 minus strand strong stop DNA transfer.

Song M, Balakrishnan M, Gorelick RJ, Bambara RA.

Biochemistry. 2009 Mar 3;48(8):1810-9. doi: 10.1021/bi802149j.


Significance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae.

Stewart JA, Campbell JL, Bambara RA.

J Biol Chem. 2009 Mar 27;284(13):8283-91. doi: 10.1074/jbc.M809189200. Epub 2009 Jan 29.


Dynamic removal of replication protein A by Dna2 facilitates primer cleavage during Okazaki fragment processing in Saccharomyces cerevisiae.

Stewart JA, Miller AS, Campbell JL, Bambara RA.

J Biol Chem. 2008 Nov 14;283(46):31356-65. doi: 10.1074/jbc.M805965200. Epub 2008 Sep 17.


Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal.

Rossi ML, Pike JE, Wang W, Burgers PM, Campbell JL, Bambara RA.

J Biol Chem. 2008 Oct 10;283(41):27483-93. doi: 10.1074/jbc.M804550200. Epub 2008 Aug 9.


Catalysis of strand annealing by replication protein A derives from its strand melting properties.

Bartos JD, Willmott LJ, Binz SK, Wold MS, Bambara RA.

J Biol Chem. 2008 Aug 1;283(31):21758-68. doi: 10.1074/jbc.M800856200. Epub 2008 Jun 3.


hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.

Gehen SC, Staversky RJ, Bambara RA, Keng PC, O'Reilly MA.

Oncogene. 2008 Jul 3;27(29):4065-74. doi: 10.1038/onc.2008.48. Epub 2008 Mar 10.

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