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Items: 22

1.

Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.

Scanio MJC, Searle XB, Liu B, Koenig JR, Altenbach R, Gfesser GA, Bogdan A, Greszler S, Zhao G, Singh A, Fan Y, Swensen AM, Vortherms T, Manelli A, Balut C, Jia Y, Gao W, Yong H, Schrimpf M, Tse C, Kym P, Wang X.

ACS Med Chem Lett. 2019 Oct 31;10(11):1543-1548. doi: 10.1021/acsmedchemlett.9b00377. eCollection 2019 Nov 14.

PMID:
31749908
2.

Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222.

Singh AK, Fan Y, Balut C, Alani S, Manelli AM, Swensen AM, Jia Y, Neelands TR, Vortherms TA, Liu B, Searle XB, Wang X, Gao W, Hwang TC, Ren HY, Cyr D, Kym PR, Conrath K, Tse C.

J Pharmacol Exp Ther. 2020 Jan;372(1):107-118. doi: 10.1124/jpet.119.261800. Epub 2019 Nov 15.

PMID:
31732698
3.

Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.

Wang X, Liu B, Searle X, Yeung C, Bogdan A, Greszler S, Singh A, Fan Y, Swensen AM, Vortherms T, Balut C, Jia Y, Desino K, Gao W, Yong H, Tse C, Kym P.

J Med Chem. 2018 Feb 22;61(4):1436-1449. doi: 10.1021/acs.jmedchem.7b01339. Epub 2018 Jan 5.

PMID:
29251932
4.

Glycan-Mediated, Ligand-Controlled Click Chemistry for Drug-Target Identification.

Stöckmann H, Marin VL, Nimmer P, Balut CM, Davidson DJ, Richardson PL, Vasudevan A.

Chembiochem. 2016 Jan;17(2):150-4. doi: 10.1002/cbic.201500590. Epub 2015 Dec 23.

PMID:
26574896
5.

Dynamin- and Rab5-dependent endocytosis of a Ca2+ -activated K+ channel, KCa2.3.

Gao Y, Bertuccio CA, Balut CM, Watkins SC, Devor DC.

PLoS One. 2012;7(8):e44150. doi: 10.1371/journal.pone.0044150. Epub 2012 Aug 28.

6.

Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?

Balut CM, Hamilton KL, Devor DC.

ChemMedChem. 2012 Oct;7(10):1741-55. doi: 10.1002/cmdc.201200226. Epub 2012 Aug 7. Review.

7.

Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1.

Balut CM, Loch CM, Devor DC.

FASEB J. 2011 Nov;25(11):3938-48. doi: 10.1096/fj.11-187005. Epub 2011 Aug 9.

8.

Calcium-activated K+ channels increase cell proliferation independent of K+ conductance.

Millership JE, Devor DC, Hamilton KL, Balut CM, Bruce JI, Fearon IM.

Am J Physiol Cell Physiol. 2011 Apr;300(4):C792-802. doi: 10.1152/ajpcell.00274.2010. Epub 2010 Dec 1.

9.

ESCRT-dependent targeting of plasma membrane localized KCa3.1 to the lysosomes.

Balut CM, Gao Y, Murray SA, Thibodeau PH, Devor DC.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C1015-27. doi: 10.1152/ajpcell.00120.2010. Epub 2010 Aug 18.

10.

Immunofluorescence-based assay to identify modulators of the number of plasma membrane KCa3.1 channels.

Balut CM, Gao Y, Luke C, Devor DC.

Future Med Chem. 2010 May;2(5):707-13. doi: 10.4155/fmc.10.182.

11.

Recycling of the Ca2+-activated K+ channel, KCa2.3, is dependent upon RME-1, Rab35/EPI64C, and an N-terminal domain.

Gao Y, Balut CM, Bailey MA, Patino-Lopez G, Shaw S, Devor DC.

J Biol Chem. 2010 Jun 4;285(23):17938-53. doi: 10.1074/jbc.M109.086553. Epub 2010 Apr 1.

12.

Analysis of mitochondrial pH and ion concentrations.

vandeVen M, Balut C, Baron S, Smets I, Steels P, Ameloot M.

Methods Mol Biol. 2010;591:275-309. doi: 10.1007/978-1-60761-404-3_17.

PMID:
19957137
13.

Role of S3 and S4 transmembrane domain charged amino acids in channel biogenesis and gating of KCa2.3 and KCa3.1.

Gao Y, Chotoo CK, Balut CM, Sun F, Bailey MA, Devor DC.

J Biol Chem. 2008 Apr 4;283(14):9049-59. doi: 10.1074/jbc.M708022200. Epub 2008 Jan 28.

14.

Measurement of cytosolic and mitochondrial pH in living cells during reversible metabolic inhibition.

Balut C, vandeVen M, Despa S, Lambrichts I, Ameloot M, Steels P, Smets I.

Kidney Int. 2008 Jan;73(2):226-32. Epub 2007 Oct 31.

15.

Investigation of the Ba2+-sensitive NH4+ transport pathways in the apical cell membrane of primary cultured rabbit MTAL cells.

Jans F, Balut C, Ameloot M, Wouters P, Steels P.

Nephron Physiol. 2007;106(3):p45-53. Epub 2007 Jun 15.

PMID:
17570948
16.

Membrane cholesterol extraction decreases Na+ transport in A6 renal epithelia.

Balut C, Steels P, Radu M, Ameloot M, Driessche WV, Jans D.

Am J Physiol Cell Physiol. 2006 Jan;290(1):C87-94. Epub 2005 Aug 17.

17.

Experimental determination of blood permittivity and conductivity in simple shear flow.

Balan C, Balut C, Gheorghe L, Gheorghe C, Gheorghiu E, Ursu G.

Clin Hemorheol Microcirc. 2004;30(3-4):359-64.

PMID:
15258367
18.

Differential impedance spectroscopy for monitoring protein immobilization and antibody-antigen reactions.

Sadik OA, Xu H, Gheorghiu E, Andreescu D, Balut C, Gheorghiu M, Bratu D.

Anal Chem. 2002 Jul 1;74(13):3142-50.

PMID:
12141675
19.

Dielectric behaviour of gap junction connected cells: a microscopic approach.

Gheorghiu E, Balut C, Gheorghiu M.

Phys Med Biol. 2002 Jan 21;47(2):341-8.

PMID:
11837622
20.

Comparative effects of low- and high-osmolar contrast media on the renal function during early degenerative gentamicin-induced nephropathy in rats.

Idée JM, Santus R, Beaufils H, Balut C, Huntsman AM, Bourbouze R, Koeltz B, Jouanneau C, Bonnemain B.

Am J Nephrol. 1995;15(1):66-74.

PMID:
7872367
21.

Iobitridol, a new nonionic low-osmolality contrast agent, and iohexol. Impact on renal histology in the rat.

Beaufils H, Idée JM, Berthommier C, Balut C, Bourbouze R, Nimier K, Chicandre-Jouanneau C, Bonnemain B.

Invest Radiol. 1995 Jan;30(1):33-9.

PMID:
7759214
22.

Modulation of the renal effects of contrast media by endothelium-derived nitric oxide in the rat.

Touati C, Idee JM, Deray G, Santus R, Balut C, Beaufils H, Jouanneau C, Bourbouze R, Doucet D, Bonnemain B.

Invest Radiol. 1993 Sep;28(9):814-20.

PMID:
8225887

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