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Items: 28


Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darién.

Tayler NM, Boya CA, Herrera L, Moy J, Ng M, Pineda L, Almanza A, Rosero S, Coronado LM, Correa R, Santamaría R, Caballero Z, Durant-Archibold AA, Tidgewell KJ, Balunas MJ, Gerwick WH, Spadafora A, Gutiérrez M, Spadafora C.

PLoS One. 2019 Apr 2;14(4):e0214193. doi: 10.1371/journal.pone.0214193. eCollection 2019.


Electrocardiographic effects of hawthorn (Crataegus oxyacantha) in healthy volunteers: A randomized controlled trial.

Trexler SE, Nguyen E, Gromek SM, Balunas MJ, Baker WL.

Phytother Res. 2018 Aug;32(8):1642-1646. doi: 10.1002/ptr.6094. Epub 2018 Apr 19.


Propagating annotations of molecular networks using in silico fragmentation.

da Silva RR, Wang M, Nothias LF, van der Hooft JJJ, Caraballo-Rodríguez AM, Fox E, Balunas MJ, Klassen JL, Lopes NP, Dorrestein PC.

PLoS Comput Biol. 2018 Apr 18;14(4):e1006089. doi: 10.1371/journal.pcbi.1006089. eCollection 2018 Apr.


Upregulation and Identification of Antibiotic Activity of a Marine-Derived Streptomyces sp. via Co-Cultures with Human Pathogens.

Sung AA, Gromek SM, Balunas MJ.

Mar Drugs. 2017 Aug 11;15(8). pii: E250. doi: 10.3390/md15080250.


Exploration of the Innate Immune System of Styela clava: Zn2+ Binding Enhances the Antimicrobial Activity of the Tunicate Peptide Clavanin A.

Juliano SA, Pierce S, deMayo JA, Balunas MJ, Angeles-Boza AM.

Biochemistry. 2017 Mar 14;56(10):1403-1414. doi: 10.1021/acs.biochem.6b01046. Epub 2017 Mar 3.


Draft Genome Sequence of Streptomyces sp. AVP053U2 Isolated from Styela clava, a Tunicate Collected in Long Island Sound.

deMayo JA, Maas KR, Klassen JL, Balunas MJ.

Genome Announc. 2016 Oct 13;4(5). pii: e00874-16. doi: 10.1128/genomeA.00874-16.


Leisingera sp. JC1, a Bacterial Isolate from Hawaiian Bobtail Squid Eggs, Produces Indigoidine and Differentially Inhibits Vibrios.

Gromek SM, Suria AM, Fullmer MS, Garcia JL, Gogarten JP, Nyholm SV, Balunas MJ.

Front Microbiol. 2016 Sep 8;7:1342. doi: 10.3389/fmicb.2016.01342. eCollection 2016.


Draft Genome Sequence of Streptomyces sp. Strain PTY087I2, Isolated from Styela canopus, a Panamanian Tunicate.

Gromek SM, Sung AA, Klassen JL, Balunas MJ.

Genome Announc. 2016 Sep 15;4(5). pii: e00856-16. doi: 10.1128/genomeA.00856-16.


Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity.

Gromek SM, deMayo JA, Maxwell AT, West AM, Pavlik CM, Zhao Z, Li J, Wiemer AJ, Zweifach A, Balunas MJ.

Bioorg Med Chem. 2016 Nov 1;24(21):5183-5196. doi: 10.1016/j.bmc.2016.08.040. Epub 2016 Aug 24.


Development of an Enhanced Phenotypic Screen of Cytotoxic T-Lymphocyte Lytic Granule Exocytosis Suitable for Use with Synthetic Compound and Natural Product Collections.

Zhao Z, deMayo JA, West AM, Balunas MJ, Zweifach A.

J Biomol Screen. 2016 Jul;21(6):556-66. doi: 10.1177/1087057116643260. Epub 2016 Apr 5.


Flow Cytometry Enables Multiplexed Measurements of Genetically Encoded Intramolecular FRET Sensors Suitable for Screening.

Doucette J, Zhao Z, Geyer RJ, Barra MM, Balunas MJ, Zweifach A.

J Biomol Screen. 2016 Jul;21(6):535-47. doi: 10.1177/1087057116634007. Epub 2016 Feb 23.


Current therapeutic role and medicinal potential of Scutellaria barbata in Traditional Chinese Medicine and Western research.

Tao G, Balunas MJ.

J Ethnopharmacol. 2016 Apr 22;182:170-80. doi: 10.1016/j.jep.2016.02.012. Epub 2016 Feb 10.


Medusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple β-Amino Acids.

Fenner AM, Engene N, Spadafora C, Gerwick WH, Balunas MJ.

Org Lett. 2016 Feb 5;18(3):352-5. doi: 10.1021/acs.orglett.5b03110. Epub 2016 Jan 19.


Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta.

Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick WH.

J Org Chem. 2015 Aug 21;80(16):7849-55. doi: 10.1021/acs.joc.5b01264. Epub 2015 Aug 5.


Natural products as exquisitely potent cytotoxic payloads for antibody- drug conjugates.

Gromek SM, Balunas MJ.

Curr Top Med Chem. 2015;14(24):2822-34. Review.


Coibacins A and B: total synthesis and stereochemical revision.

Carneiro VM, Avila CM, Balunas MJ, Gerwick WH, Pilli RA.

J Org Chem. 2014 Jan 17;79(2):630-42. doi: 10.1021/jo402339y. Epub 2014 Jan 9.


Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.

Pavlik CM, Wong CY, Ononye S, Lopez DD, Engene N, McPhail KL, Gerwick WH, Balunas MJ.

J Nat Prod. 2013 Nov 22;76(11):2026-33. doi: 10.1021/np400198r. Epub 2013 Oct 28.


Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins.

Balunas MJ, Grosso MF, Villa FA, Engene N, McPhail KL, Tidgewell K, Pineda LM, Gerwick L, Spadafora C, Kyle DE, Gerwick WH.

Org Lett. 2012 Aug 3;14(15):3878-81. Epub 2012 Jul 13.


Natural compounds with aromatase inhibitory activity: an update.

Balunas MJ, Kinghorn AD.

Planta Med. 2010 Aug;76(11):1087-93. doi: 10.1055/s-0030-1250169. Epub 2010 Jul 15. Review.


Isolation and Characterization of Aromatase Inhibitors from Brassaiopsis glomerulata (Araliaceae).

Balunas MJ, Su B, Riswan S, Fong HH, Brueggemeier RW, Pezzuto JM, Kinghorn AD.

Phytochem Lett. 2009 Feb 19;2(1):29-33.


Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity.

Balunas MJ, Linington RG, Tidgewell K, Fenner AM, Ureña LD, Togna GD, Kyle DE, Gerwick WH.

J Nat Prod. 2010 Jan;73(1):60-6. doi: 10.1021/np900622m.


Bioactive 5,6-dihydro-alpha-pyrone derivatives from Hyptis brevipes.

Deng Y, Balunas MJ, Kim JA, Lantvit DD, Chin YW, Chai H, Sugiarso S, Kardono LB, Fong HH, Pezzuto JM, Swanson SM, de Blanco EJ, Kinghorn AD.

J Nat Prod. 2009 Jun;72(6):1165-9. doi: 10.1021/np9001724.


Natural products as aromatase inhibitors.

Balunas MJ, Su B, Brueggemeier RW, Kinghorn AD.

Anticancer Agents Med Chem. 2008 Aug;8(6):646-82. Review.


Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.

Balunas MJ, Su B, Brueggemeier RW, Kinghorn AD.

J Nat Prod. 2008 Jul;71(7):1161-6. doi: 10.1021/np8000255. Epub 2008 Jun 18.


Relationships between inhibitory activity against a cancer cell line panel, profiles of plants collected, and compound classes isolated in an anticancer drug discovery project.

Balunas MJ, Jones WP, Chin YW, Mi Q, Farnsworth NR, Soejarto DD, Cordell GA, Swanson SM, Pezzuto JM, Chai HB, Kinghorn AD.

Chem Biodivers. 2006 Aug;3(8):897-915.


Drug discovery from natural sources.

Chin YW, Balunas MJ, Chai HB, Kinghorn AD.

AAPS J. 2006 Apr 14;8(2):E239-53.


Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay.

Balunas MJ, Su B, Landini S, Brueggemeier RW, Kinghorn AD.

J Nat Prod. 2006 Apr;69(4):700-3.


Drug discovery from medicinal plants.

Balunas MJ, Kinghorn AD.

Life Sci. 2005 Dec 22;78(5):431-41. Epub 2005 Sep 29. Review.


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