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Imaging Lymphatics in Mouse Lungs.

Baluk P, McDonald DM.

Methods Mol Biol. 2018;1846:161-180. doi: 10.1007/978-1-4939-8712-2_11.


Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread.

Ma Q, Dieterich LC, Ikenberg K, Bachmann SB, Mangana J, Proulx ST, Amann VC, Levesque MP, Dummer R, Baluk P, McDonald DM, Detmar M.

Sci Adv. 2018 Aug 8;4(8):eaat4758. doi: 10.1126/sciadv.aat4758. eCollection 2018 Aug.


Rapamycin reversal of VEGF-C-driven lymphatic anomalies in the respiratory tract.

Baluk P, Yao LC, Flores JC, Choi D, Hong YK, McDonald DM.

JCI Insight. 2017 Aug 17;2(16). pii: 90103. doi: 10.1172/jci.insight.90103. eCollection 2017 Aug 17.


Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation.

Kim M, Allen B, Korhonen EA, Nitschké M, Yang HW, Baluk P, Saharinen P, Alitalo K, Daly C, Thurston G, McDonald DM.

J Clin Invest. 2016 Sep 1;126(9):3511-25. doi: 10.1172/JCI84871. Epub 2016 Aug 22.


Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases.

Huang JL, Woolf AS, Kolatsi-Joannou M, Baluk P, Sandford RN, Peters DJ, McDonald DM, Price KL, Winyard PJ, Long DA.

J Am Soc Nephrol. 2016 Jan;27(1):69-77. doi: 10.1681/ASN.2014090856. Epub 2015 Jun 2.


Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice.

Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF.

PLoS One. 2015 Mar 19;10(3):e0118513. doi: 10.1371/journal.pone.0118513. eCollection 2015.


Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways.

Baluk P, Phillips K, Yao LC, Adams A, Nitschké M, McDonald DM.

Am J Pathol. 2014 Jun;184(6):1877-89. doi: 10.1016/j.ajpath.2014.02.010. Epub 2014 Apr 13.


Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation.

Baluk P, Adams A, Phillips K, Feng J, Hong YK, Brown MB, McDonald DM.

Am J Pathol. 2014 May;184(5):1577-92. doi: 10.1016/j.ajpath.2014.01.021. Epub 2014 Mar 11.


Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period.

Yao LC, Testini C, Tvorogov D, Anisimov A, Vargas SO, Baluk P, Pytowski B, Claesson-Welsh L, Alitalo K, McDonald DM.

Circ Res. 2014 Feb 28;114(5):806-22. doi: 10.1161/CIRCRESAHA.114.303119. Epub 2014 Jan 15.


Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis.

Xu X, Greenland J, Baluk P, Adams A, Bose O, McDonald DM, Caughey GH.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):437-44. doi: 10.1165/rcmb.2013-0016OC.


Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways.

Baluk P, Hogmalm A, Bry M, Alitalo K, Bry K, McDonald DM.

Am J Pathol. 2013 Apr;182(4):1434-47. doi: 10.1016/j.ajpath.2012.12.003. Epub 2013 Feb 4.


Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo.

Orsenigo F, Giampietro C, Ferrari A, Corada M, Galaup A, Sigismund S, Ristagno G, Maddaluno L, Koh GY, Franco D, Kurtcuoglu V, Poulikakos D, Baluk P, McDonald D, Grazia Lampugnani M, Dejana E.

Nat Commun. 2012;3:1208. doi: 10.1038/ncomms2199.


Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation.

Yao LC, Baluk P, Srinivasan RS, Oliver G, McDonald DM.

Am J Pathol. 2012 Jun;180(6):2561-75. doi: 10.1016/j.ajpath.2012.02.019. Epub 2012 Apr 23.


Dynamics of airway blood vessels and lymphatics: lessons from development and inflammation.

McDonald DM, Yao LC, Baluk P.

Proc Am Thorac Soc. 2011 Nov;8(6):504-7. doi: 10.1513/pats.201102-022MW. Review.


Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation.

Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O'Brien S, Epstein DM, Koh GY, McDonald DM.

Am J Pathol. 2011 Jun;178(6):2897-909. doi: 10.1016/j.ajpath.2011.02.008. Epub 2011 May 6.


Rapid remodeling of airway vascular architecture at birth.

Ni A, Lashnits E, Yao LC, Baluk P, McDonald DM.

Dev Dyn. 2010 Sep;239(9):2354-66. doi: 10.1002/dvdy.22379.


Lymphotoxin-alpha contributes to lymphangiogenesis.

Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH.

Blood. 2010 Sep 23;116(12):2173-82. doi: 10.1182/blood-2009-12-256065. Epub 2010 Jun 21.


Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth.

Hashizume H, Falcón BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM.

Cancer Res. 2010 Mar 15;70(6):2213-23. doi: 10.1158/0008-5472.CAN-09-1977. Epub 2010 Mar 2.


Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation.

Fuxe J, Lashnits E, O'Brien S, Baluk P, Tabruyn SP, Kuhnert F, Kuo C, Thurston G, McDonald DM.

Am J Pathol. 2010 Apr;176(4):2009-18. doi: 10.2353/ajpath.2010.090976. Epub 2010 Feb 4.


Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways.

Yao LC, Baluk P, Feng J, McDonald DM.

Am J Pathol. 2010 Mar;176(3):1525-41. doi: 10.2353/ajpath.2010.090909. Epub 2010 Jan 21.


Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.

Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin SR, McDonald DM, Schwab SR, Cyster JG.

J Exp Med. 2010 Jan 18;207(1):17-27. doi: 10.1084/jem.20091619. Epub 2009 Dec 21.


TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice.

Baluk P, Yao LC, Feng J, Romano T, Jung SS, Schreiter JL, Yan L, Shealy DJ, McDonald DM.

J Clin Invest. 2009 Oct;119(10):2954-64. doi: 10.1172/JCI37626. Epub 2009 Sep 14.


alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation.

Okazaki T, Ni A, Ayeni OA, Baluk P, Yao LC, Vossmeyer D, Zischinsky G, Zahn G, Knolle J, Christner C, McDonald DM.

Am J Pathol. 2009 Jun;174(6):2378-87. doi: 10.2353/ajpath.2009.080942. Epub 2009 May 14.


Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice.

Okazaki T, Ni A, Baluk P, Ayeni OA, Kearley J, Coyle AJ, Humbles A, McDonald DM.

Am J Pathol. 2009 Jun;174(6):2388-99. doi: 10.2353/ajpath.2009.080949. Epub 2009 May 14.


Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity.

Johnson NC, Dillard ME, Baluk P, McDonald DM, Harvey NL, Frase SL, Oliver G.

Genes Dev. 2008 Dec 1;22(23):3282-91. doi: 10.1101/gad.1727208.


Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees.

Dejana E, Orsenigo F, Molendini C, Baluk P, McDonald DM.

Cell Tissue Res. 2009 Jan;335(1):17-25. doi: 10.1007/s00441-008-0694-5. Epub 2008 Oct 15. Review.


Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels.

Korpisalo P, Karvinen H, Rissanen TT, Kilpijoki J, Marjomäki V, Baluk P, McDonald DM, Cao Y, Eriksson U, Alitalo K, Ylä-Herttuala S.

Circ Res. 2008 Nov 7;103(10):1092-9. doi: 10.1161/CIRCRESAHA.108.182287. Epub 2008 Oct 2.


Markers for microscopic imaging of lymphangiogenesis and angiogenesis.

Baluk P, McDonald DM.

Ann N Y Acad Sci. 2008;1131:1-12. doi: 10.1196/annals.1413.001. Review.


Disease-specific gene expression profiling in multiple models of lung disease.

Lewis CC, Yang JY, Huang X, Banerjee SK, Blackburn MR, Baluk P, McDonald DM, Blackwell TS, Nagabhushanam V, Peters W, Voehringer D, Erle DJ.

Am J Respir Crit Care Med. 2008 Feb 15;177(4):376-87. Epub 2007 Nov 20.


Functionally specialized junctions between endothelial cells of lymphatic vessels.

Baluk P, Fuxe J, Hashizume H, Romano T, Lashnits E, Butz S, Vestweber D, Corada M, Molendini C, Dejana E, McDonald DM.

J Exp Med. 2007 Oct 1;204(10):2349-62. Epub 2007 Sep 10.


The biologic basis of in vivo angiogenesis imaging.

Ocak I, Baluk P, Barrett T, McDonald DM, Choyke P.

Front Biosci. 2007 May 1;12:3601-16. Review.


In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin.

Kim KE, Cho CH, Kim HZ, Baluk P, McDonald DM, Koh GY.

Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):564-70. Epub 2006 Dec 28.


Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung.

Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11021-6. Epub 2006 Jul 10.


Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection.

Aurora AB, Baluk P, Zhang D, Sidhu SS, Dolganov GM, Basbaum C, McDonald DM, Killeen N.

J Immunol. 2005 Nov 15;175(10):6319-26.


Mast cells protect mice from Mycoplasma pneumonia.

Xu X, Zhang D, Lyubynska N, Wolters PJ, Killeen NP, Baluk P, McDonald DM, Hawgood S, Caughey GH.

Am J Respir Crit Care Med. 2006 Jan 15;173(2):219-25. Epub 2005 Oct 6.


Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors.

Parsons-Wingerter P, Kasman IM, Norberg S, Magnussen A, Zanivan S, Rissone A, Baluk P, Favre CJ, Jeffry U, Murray R, McDonald DM.

Am J Pathol. 2005 Jul;167(1):193-211.


Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow.

Cho CH, Kim KE, Byun J, Jang HS, Kim DK, Baluk P, Baffert F, Lee GM, Mochizuki N, Kim J, Jeon BH, McDonald DM, Koh GY.

Circ Res. 2005 Jul 8;97(1):86-94. Epub 2005 Jun 16. Erratum in: Circ Res. 2006 May 12;98(9):e69.


Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels.

Magnussen A, Kasman IM, Norberg S, Baluk P, Murray R, McDonald DM.

Cancer Res. 2005 Apr 1;65(7):2712-21.


Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.

Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, Hicklin DJ, Jeltsch M, Petrova TV, Pytowski B, Stacker SA, Ylä-Herttuala S, Jackson DG, Alitalo K, McDonald DM.

J Clin Invest. 2005 Feb;115(2):247-57.


Cellular abnormalities of blood vessels as targets in cancer.

Baluk P, Hashizume H, McDonald DM.

Curr Opin Genet Dev. 2005 Feb;15(1):102-11. Review.


Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice.

Wolters PJ, Mallen-St Clair J, Lewis CC, Villalta SA, Baluk P, Erle DJ, Caughey GH.

Clin Exp Allergy. 2005 Jan;35(1):82-8.


Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways.

Baluk P, Lee CG, Link H, Ator E, Haskell A, Elias JA, McDonald DM.

Am J Pathol. 2004 Oct;165(4):1071-85.


Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.

Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA.

Nat Med. 2004 Oct;10(10):1095-103. Epub 2004 Sep 19.


Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts.

Inai T, Mancuso M, Hashizume H, Baffert F, Haskell A, Baluk P, Hu-Lowe DD, Shalinsky DR, Thurston G, Yancopoulos GD, McDonald DM.

Am J Pathol. 2004 Jul;165(1):35-52.


Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling.

Baluk P, Raymond WW, Ator E, Coussens LM, McDonald DM, Caughey GH.

Am J Physiol Lung Cell Mol Physiol. 2004 Aug;287(2):L307-17. Epub 2004 Apr 9.


Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors.

Baluk P, Morikawa S, Haskell A, Mancuso M, McDonald DM.

Am J Pathol. 2003 Nov;163(5):1801-15.


Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung.

Favre CJ, Mancuso M, Maas K, McLean JW, Baluk P, McDonald DM.

Am J Physiol Heart Circ Physiol. 2003 Nov;285(5):H1917-38. Epub 2003 Jul 3.


Significance of blood vessel leakiness in cancer.

McDonald DM, Baluk P.

Cancer Res. 2002 Sep 15;62(18):5381-5.


Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.

Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM.

Am J Pathol. 2002 Mar;160(3):985-1000.

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