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Myeloid cell-targeted miR-146a mimic inhibits NF-κB-driven inflammation and leukemia progression in vivo.

Su YL, Wang X, Mann M, Adamus TP, Wang D, Moreira DF, Zhang Z, Ouyang C, He X, Zhang B, Swiderski PM, Forman SJ, Baltimore D, Li L, Marcucci G, Boldin MP, Kortylewski M.

Blood. 2020 Jan 16;135(3):167-180. doi: 10.1182/blood.2019002045.


Alternative splicing coupled with transcript degradation modulates OAS1g antiviral activity.

Frankiw L, Mann M, Li G, Joglekar A, Baltimore D.

RNA. 2020 Feb;26(2):126-136. doi: 10.1261/rna.073825.119. Epub 2019 Nov 18.


MATE-Seq: microfluidic antigen-TCR engagement sequencing.

Ng AHC, Peng S, Xu AM, Noh WJ, Guo K, Bethune MT, Chour W, Choi J, Yang S, Baltimore D, Heath JR.

Lab Chip. 2019 Sep 10;19(18):3011-3021. doi: 10.1039/c9lc00538b.


Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood.

Peng S, Zaretsky JM, Ng AHC, Chour W, Bethune MT, Choi J, Hsu A, Holman E, Ding X, Guo K, Kim J, Xu AM, Heath JE, Noh WJ, Zhou J, Su Y, Lu Y, McLaughlin J, Cheng D, Witte ON, Baltimore D, Ribas A, Heath JR.

Cell Rep. 2019 Sep 3;28(10):2728-2738.e7. doi: 10.1016/j.celrep.2019.07.106.


Alternative mRNA splicing in cancer immunotherapy.

Frankiw L, Baltimore D, Li G.

Nat Rev Immunol. 2019 Nov;19(11):675-687. doi: 10.1038/s41577-019-0195-7. Epub 2019 Jul 30. Review.


Dual mechanisms of posttranscriptional regulation of Tet2 by Let-7 microRNA in macrophages.

Jiang S, Yan W, Wang SE, Baltimore D.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12416-12421. doi: 10.1073/pnas.1811040116. Epub 2019 Jun 3.


The Cellular Immunotherapy Revolution: Arming the Immune System for Precision Therapy.

Paucek RD, Baltimore D, Li G.

Trends Immunol. 2019 Apr;40(4):292-309. doi: 10.1016/ Epub 2019 Mar 11. Review.


T cell antigen discovery via trogocytosis.

Li G, Bethune MT, Wong S, Joglekar AV, Leonard MT, Wang JK, Kim JT, Cheng D, Peng S, Zaretsky JM, Su Y, Luo Y, Heath JR, Ribas A, Witte ON, Baltimore D.

Nat Methods. 2019 Feb;16(2):183-190. doi: 10.1038/s41592-018-0305-7. Epub 2019 Jan 28.


T cell antigen discovery via signaling and antigen-presenting bifunctional receptors.

Joglekar AV, Leonard MT, Jeppson JD, Swift M, Li G, Wong S, Peng S, Zaretsky JM, Heath JR, Ribas A, Bethune MT, Baltimore D.

Nat Methods. 2019 Feb;16(2):191-198. doi: 10.1038/s41592-018-0304-8. Epub 2019 Jan 28.


BUD13 Promotes a Type I Interferon Response by Countering Intron Retention in Irf7.

Frankiw L, Majumdar D, Burns C, Vlach L, Moradian A, Sweredoski MJ, Baltimore D.

Mol Cell. 2019 Feb 21;73(4):803-814.e6. doi: 10.1016/j.molcel.2018.11.038. Epub 2019 Jan 10.


Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age.

Mann M, Mehta A, de Boer CG, Kowalczyk MS, Lee K, Haldeman P, Rogel N, Knecht AR, Farouq D, Regev A, Baltimore D.

Cell Rep. 2018 Dec 11;25(11):2992-3005.e5. doi: 10.1016/j.celrep.2018.11.056.


IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System.

Puig-Saus C, Parisi G, Garcia-Diaz A, Krystofinski PE, Sandoval S, Zhang R, Champhekar AS, McCabe J, Cheung-Lau GC, Truong NA, Vega-Crespo A, Komenan MDS, Pang J, Macabali MH, Saco JD, Goodwin JL, Bolon B, Seet CS, Montel-Hagen A, Crooks GM, Hollis RP, Campo-Fernandez B, Bischof D, Cornetta K, Gschweng EH, Adelson C, Nguyen A, Yang L, Witte ON, Baltimore D, Comin-Anduix B, Kohn DB, Wang X, Cabrera P, Kaplan-Lefko PJ, Berent-Maoz B, Ribas A.

Clin Cancer Res. 2019 Feb 1;25(3):1000-1011. doi: 10.1158/1078-0432.CCR-18-0963. Epub 2018 Nov 8.


Functional TCR T cell screening using single-cell droplet microfluidics.

Segaliny AI, Li G, Kong L, Ren C, Chen X, Wang JK, Baltimore D, Wu G, Zhao W.

Lab Chip. 2018 Dec 4;18(24):3733-3749. doi: 10.1039/c8lc00818c.


Sixty Years of Discovery.

Baltimore D.

Annu Rev Immunol. 2019 Apr 26;37:1-17. doi: 10.1146/annurev-immunol-042718-041210. Epub 2018 Oct 31.


Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules.

Bethune MT, Li XH, Yu J, McLaughlin J, Cheng D, Mathis C, Moreno BH, Woods K, Knights AJ, Garcia-Diaz A, Wong S, Hu-Lieskovan S, Puig-Saus C, Cebon J, Ribas A, Yang L, Witte ON, Baltimore D.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10702-E10711. doi: 10.1073/pnas.1810653115. Epub 2018 Oct 22.


Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses.

Mann M, Mehta A, Zhao JL, Lee K, Marinov GK, Garcia-Flores Y, Lu LF, Rudensky AY, Baltimore D.

Nat Commun. 2018 Aug 16;9(1):3338. doi: 10.1038/s41467-018-05720-5.


Epigenetic silencing of miR-125b is required for normal B-cell development.

Li G, So AY, Sookram R, Wong S, Wang JK, Ouyang Y, He P, Su Y, Casellas R, Baltimore D.

Blood. 2018 Apr 26;131(17):1920-1930. doi: 10.1182/blood-2018-01-824540. Epub 2018 Mar 19.


Characterization of Postinfusion Phenotypic Differences in Fresh Versus Cryopreserved TCR Engineered Adoptive Cell Therapy Products.

Nowicki TS, Escuin-Ordinas H, Avramis E, Chmielowski B, Chodon T, Berent-Maoz B, Wang X, Kaplan-Lefko P, Yang L, Baltimore D, Economou JS, Ribas A, Comin-Anduix B.

J Immunother. 2018 Jun;41(5):248-259. doi: 10.1097/CJI.0000000000000216.


T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable.

Joglekar AV, Liu Z, Weber JK, Ouyang Y, Jeppson JD, Noh WJ, Lamothe-Molina PA, Chen H, Kang SG, Bethune MT, Zhou R, Walker BD, Baltimore D.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1877-1882. doi: 10.1073/pnas.1718659115. Epub 2018 Feb 7.


A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication.

Zhou J, Bethune MT, Malkova N, Sutherland AM, Comin-Anduix B, Su Y, Baltimore D, Ribas A, Heath JR.

PLoS One. 2018 Jan 23;13(1):e0191634. doi: 10.1371/journal.pone.0191634. eCollection 2018.


Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients.

Jiang S, Yan W, Wang SE, Baltimore D.

Cell Metab. 2018 Feb 6;27(2):393-403.e4. doi: 10.1016/j.cmet.2017.12.007. Epub 2018 Jan 11.


Dendritic cells efficiently transmit HIV to T Cells in a tenofovir and raltegravir insensitive manner.

Kim JT, Chang E, Sigal A, Baltimore D.

PLoS One. 2018 Jan 2;13(1):e0189945. doi: 10.1371/journal.pone.0189945. eCollection 2018.


Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.

Gee MH, Han A, Lofgren SM, Beausang JF, Mendoza JL, Birnbaum ME, Bethune MT, Fischer S, Yang X, Gomez-Eerland R, Bingham DB, Sibener LV, Fernandes RA, Velasco A, Baltimore D, Schumacher TN, Khatri P, Quake SR, Davis MM, Garcia KC.

Cell. 2018 Jan 25;172(3):549-563.e16. doi: 10.1016/j.cell.2017.11.043. Epub 2017 Dec 21.


The Pathway to a Universal Influenza Vaccine.

Paules CI, Marston HD, Eisinger RW, Baltimore D, Fauci AS.

Immunity. 2017 Oct 17;47(4):599-603. doi: 10.1016/j.immuni.2017.09.007.


An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses.

Mann M, Mehta A, Zhao JL, Lee K, Marinov GK, Garcia-Flores Y, Lu LF, Rudensky AY, Baltimore D.

Nat Commun. 2017 Oct 11;8(1):851. doi: 10.1038/s41467-017-00972-z. Erratum in: Nat Commun. 2018 Aug 16;9(1):3338.


Human Embryo Editing: Opportunities and Importance of Transnational Cooperation.

Pei D, Beier DW, Levy-Lahad E, Marchant G, Rossant J, Izpisua Belmonte JC, Lovell-Badge R, Jaenisch R, Charo A, Baltimore D.

Cell Stem Cell. 2017 Oct 5;21(4):423-426. doi: 10.1016/j.stem.2017.09.010.


Photon-Induced Near-Field Electron Microscopy of Eukaryotic Cells.

Kaplan M, Yoo BK, Tang J, Karam TE, Liao B, Majumdar D, Baltimore D, Jensen GJ, Zewail AH.

Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11498-11501. doi: 10.1002/anie.201706120. Epub 2017 Aug 10.


Dendritic cell-targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation.

Kim JT, Liu Y, Kulkarni RP, Lee KK, Dai B, Lovely G, Ouyang Y, Wang P, Yang L, Baltimore D.

Sci Immunol. 2017 Jul 21;2(13). pii: eaal1329. doi: 10.1126/sciimmunol.aal1329.


Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids.

Seet CS, He C, Bethune MT, Li S, Chick B, Gschweng EH, Zhu Y, Kim K, Kohn DB, Baltimore D, Crooks GM, Montel-Hagen A.

Nat Methods. 2017 May;14(5):521-530. doi: 10.1038/nmeth.4237. Epub 2017 Apr 3.


Preparation of peptide-MHC and T-cell receptor dextramers by biotinylated dextran doping.

Bethune MT, Comin-Anduix B, Hwang Fu YH, Ribas A, Baltimore D.

Biotechniques. 2017 Mar 1;62(3):123-130. doi: 10.2144/000114525.


HIV-1 Conserved Mosaics Delivered by Regimens with Integration-Deficient DC-Targeting Lentiviral Vector Induce Robust T Cells.

Wee EG, Ondondo B, Berglund P, Archer J, McMichael AJ, Baltimore D, Ter Meulen JH, Hanke T.

Mol Ther. 2017 Feb 1;25(2):494-503. doi: 10.1016/j.ymthe.2016.12.004.


Antibody gene transfer with adeno-associated viral vectors as a method for HIV prevention.

Brady JM, Baltimore D, Balazs AB.

Immunol Rev. 2017 Jan;275(1):324-333. doi: 10.1111/imr.12478. Review.


30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology.

Zhang Q, Lenardo MJ, Baltimore D.

Cell. 2017 Jan 12;168(1-2):37-57. doi: 10.1016/j.cell.2016.12.012. Epub 2017 Jan 12. Review.


Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1.

Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh KH, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J, Gupta V.

J Biol Chem. 2017 Jan 13;292(2):732-747. doi: 10.1074/jbc.M116.753822. Epub 2016 Dec 2.


Domain-swapped T cell receptors improve the safety of TCR gene therapy.

Bethune MT, Gee MH, Bunse M, Lee MS, Gschweng EH, Pagadala MS, Zhou J, Cheng D, Heath JR, Kohn DB, Kuhns MS, Uckert W, Baltimore D.

Elife. 2016 Nov 8;5. pii: e19095. doi: 10.7554/eLife.19095.


The boldness of philanthropists.

Baltimore D.

Science. 2016 Sep 30;353(6307):1473. Epub 2016 Sep 21. No abstract available.


A path toward understanding neurodegeneration.

Kosik KS, Sejnowski TJ, Raichle ME, Ciechanover A, Baltimore D.

Science. 2016 Aug 26;353(6302):872-3. doi: 10.1126/science.aai7622. No abstract available.


Deficiency of Nuclear Factor-κB c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice.

Ramakrishnan P, Yui MA, Tomalka JA, Majumdar D, Parameswaran R, Baltimore D.

Diabetes. 2016 Aug;65(8):2367-79. doi: 10.2337/db15-1607. Epub 2016 May 23.


Legal aids: Science primers in the courtroom.

Baltimore D, Tatel DS.

Nature. 2016 Apr 21;532(7599):313. No abstract available.


MicroRNAs as regulatory elements in immune system logic.

Mehta A, Baltimore D.

Nat Rev Immunol. 2016 Apr 28;16(5):279-94. doi: 10.1038/nri.2016.40. Review.


RNA-binding protein Lin28 in cancer and immunity.

Jiang S, Baltimore D.

Cancer Lett. 2016 May 28;375(1):108-113. doi: 10.1016/j.canlet.2016.02.050. Epub 2016 Mar 2. Review.


The microRNA-212/132 cluster regulates B cell development by targeting Sox4.

Mehta A, Mann M, Zhao JL, Marinov GK, Majumdar D, Garcia-Flores Y, Du X, Erikci E, Chowdhury K, Baltimore D.

J Exp Med. 2015 Sep 21;212(10):1679-92. doi: 10.1084/jem.20150489. Epub 2015 Sep 14.


The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression.

Mehta A, Zhao JL, Sinha N, Marinov GK, Mann M, Kowalczyk MS, Galimidi RP, Du X, Erikci E, Regev A, Chowdhury K, Baltimore D.

Immunity. 2015 Jun 16;42(6):1021-32. doi: 10.1016/j.immuni.2015.05.017.


Regulation of stress-induced hematopoiesis.

Zhao JL, Baltimore D.

Curr Opin Hematol. 2015 Jul;22(4):286-92. doi: 10.1097/MOH.0000000000000149. Review.


Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection.

Saunders KO, Wang L, Joyce MG, Yang ZY, Balazs AB, Cheng C, Ko SY, Kong WP, Rudicell RS, Georgiev IS, Duan L, Foulds KE, Donaldson M, Xu L, Schmidt SD, Todd JP, Baltimore D, Roederer M, Haase AT, Kwong PD, Rao SS, Mascola JR, Nabel GJ.

J Virol. 2015 Aug;89(16):8334-45.


The role of microRNA in nutritional control.

Nolte-'t Hoen EN, Van Rooij E, Bushell M, Zhang CY, Dashwood RH, James WP, Harris C, Baltimore D.

J Intern Med. 2015 Aug;278(2):99-109. doi: 10.1111/joim.12372. Epub 2015 May 19.


Single-molecule analysis of RAG-mediated V(D)J DNA cleavage.

Lovely GA, Brewster RC, Schatz DG, Baltimore D, Phillips R.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1715-23. doi: 10.1073/pnas.1503477112. Epub 2015 Mar 23.


Biotechnology. A prudent path forward for genomic engineering and germline gene modification.

Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR.

Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19. No abstract available.


Broadly neutralizing antibodies abrogate established hepatitis C virus infection.

de Jong YP, Dorner M, Mommersteeg MC, Xiao JW, Balazs AB, Robbins JB, Winer BY, Gerges S, Vega K, Labitt RN, Donovan BM, Giang E, Krishnan A, Chiriboga L, Charlton MR, Burton DR, Baltimore D, Law M, Rice CM, Ploss A.

Sci Transl Med. 2014 Sep 17;6(254):254ra129. doi: 10.1126/scitranslmed.3009512.


T-cell immunotherapy: looking forward.

Corrigan-Curay J, Kiem HP, Baltimore D, O'Reilly M, Brentjens RJ, Cooper L, Forman S, Gottschalk S, Greenberg P, Junghans R, Heslop H, Jensen M, Mackall C, June C, Press O, Powell D, Ribas A, Rosenberg S, Sadelain M, Till B, Patterson AP, Jambou RC, Rosenthal E, Gargiulo L, Montgomery M, Kohn DB.

Mol Ther. 2014 Sep;22(9):1564-74. doi: 10.1038/mt.2014.148. No abstract available.

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