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Items: 22


Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump Locus.

Rouquette-Loughlin CE, Reimche JL, Balthazar JT, Dhulipala V, Gernert KM, Kersh EN, Pham CD, Pettus K, Abrams AJ, Trees DL, St Cyr S, Shafer WM.

MBio. 2018 Nov 27;9(6). pii: e02281-18. doi: 10.1128/mBio.02281-18.


Control of gdhR Expression in Neisseria gonorrhoeae via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon.

Rouquette-Loughlin CE, Zalucki YM, Dhulipala VL, Balthazar JT, Doyle RG, Nicholas RA, Begum AA, Raterman EL, Jerse AE, Shafer WM.

MBio. 2017 Apr 11;8(2). pii: e00449-17. doi: 10.1128/mBio.00449-17.


The MisR Response Regulator Is Necessary for Intrinsic Cationic Antimicrobial Peptide and Aminoglycoside Resistance in Neisseria gonorrhoeae.

Kandler JL, Holley CL, Reimche JL, Dhulipala V, Balthazar JT, MuszyƄski A, Carlson RW, Shafer WM.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4690-700. doi: 10.1128/AAC.00823-16. Print 2016 Aug.


Phosphoethanolamine Modification of Neisseria gonorrhoeae Lipid A Reduces Autophagy Flux in Macrophages.

Zughaier SM, Kandler JL, Balthazar JT, Shafer WM.

PLoS One. 2015 Dec 7;10(12):e0144347. doi: 10.1371/journal.pone.0144347. eCollection 2015.


Phase-variable expression of lptA modulates the resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides.

Kandler JL, Joseph SJ, Balthazar JT, Dhulipala V, Read TD, Jerse AE, Shafer WM.

Antimicrob Agents Chemother. 2014 Jul;58(7):4230-3. doi: 10.1128/AAC.03108-14. Epub 2014 May 12.


Lipid A's structure mediates Neisseria gonorrhoeae fitness during experimental infection of mice and men.

Hobbs MM, Anderson JE, Balthazar JT, Kandler JL, Carlson RW, Ganguly J, Begum AA, Duncan JA, Lin JT, Sparling PF, Jerse AE, Shafer WM.

MBio. 2013 Nov 19;4(6):e00892-13. doi: 10.1128/mBio.00892-13.


Lipooligosaccharide Structure is an Important Determinant in the Resistance of Neisseria Gonorrhoeae to Antimicrobial Agents of Innate Host Defense.

Balthazar JT, Gusa A, Martin LE, Choudhury B, Carlson R, Shafer WM.

Front Microbiol. 2011 Feb 18;2:30. doi: 10.3389/fmicb.2011.00030. eCollection 2011.


Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum.

Lewis LA, Choudhury B, Balthazar JT, Martin LE, Ram S, Rice PA, Stephens DS, Carlson R, Shafer WM.

Infect Immun. 2009 Mar;77(3):1112-20. doi: 10.1128/IAI.01280-08. Epub 2008 Dec 29.


Characterization of the MacA-MacB efflux system in Neisseria gonorrhoeae.

Rouquette-Loughlin CE, Balthazar JT, Shafer WM.

J Antimicrob Chemother. 2005 Nov;56(5):856-60. Epub 2005 Sep 14.


Modulation of the mtrCDE-encoded efflux pump gene complex of Neisseria meningitidis due to a Correia element insertion sequence.

Rouquette-Loughlin CE, Balthazar JT, Hill SA, Shafer WM.

Mol Microbiol. 2004 Nov;54(3):731-41.


The NorM efflux pump of Neisseria gonorrhoeae and Neisseria meningitidis recognizes antimicrobial cationic compounds.

Rouquette-Loughlin C, Dunham SA, Kuhn M, Balthazar JT, Shafer WM.

J Bacteriol. 2003 Feb;185(3):1101-6.


Phase variable changes in genes lgtA and lgtC within the lgtABCDE operon of Neisseria gonorrhoeae can modulate gonococcal susceptibility to normal human serum.

Shafer WM, Datta A, Kolli VS, Rahman MM, Balthazar JT, Martin LE, Veal WL, Stephens DS, Carlson R.

J Endotoxin Res. 2002;8(1):47-58.


Inducible, but not constitutive, resistance of gonococci to hydrophobic agents due to the MtrC-MtrD-MtrE efflux pump requires TonB-ExbB-ExbD proteins.

Rouquette-Loughlin C, Stojiljkovic I, Hrobowski T, Balthazar JT, Shafer WM.

Antimicrob Agents Chemother. 2002 Feb;46(2):561-5.


Genetic organization and regulation of antimicrobial efflux systems possessed by Neisseria gonorrhoeae and Neisseria meningitidis.

Shafer WM, Veal WL, Lee EH, Zarantonelli L, Balthazar JT, Rouquette C.

J Mol Microbiol Biotechnol. 2001 Apr;3(2):219-24. Review.


Loss-of-function mutations in the mtr efflux system of Neisseria gonorrhoeae.

Veal WL, Yellen A, Balthazar JT, Pan W, Spratt BG, Shafer WM.

Microbiology. 1998 Mar;144 ( Pt 3):621-7.


Involvement of the gonococcal MtrE protein in the resistance of Neisseria gonorrhoeae to toxic hydrophobic agents.

Delahay RM, Robertson BD, Balthazar JT, Shafer WM, Ison CA.

Microbiology. 1997 Jul;143 ( Pt 7):2127-33.


The MtrD protein of Neisseria gonorrhoeae is a member of the resistance/nodulation/division protein family constituting part of an efflux system.

Hagman KE, Lucas CE, Balthazar JT, Snyder L, Nilles M, Judd RC, Shafer WM.

Microbiology. 1997 Jul;143 ( Pt 7):2117-25.


The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae.

Lucas CE, Balthazar JT, Hagman KE, Shafer WM.

J Bacteriol. 1997 Jul;179(13):4123-8.


Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system.

Hagman KE, Pan W, Spratt BG, Balthazar JT, Judd RC, Shafer WM.

Microbiology. 1995 Mar;141 ( Pt 3):611-22.


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