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Items: 1 to 50 of 80

1.

In Vitro Characterization of the Colibactin-Activating Peptidase ClbP Enables Design of a Fluorogenic Activity Probe.

Volpe MR, Wilson MR, Brotherton CA, Winter ES, Johnson SE, Balskus EP.

ACS Chem Biol. 2019 Aug 14. doi: 10.1021/acschembio.9b00540. [Epub ahead of print] No abstract available.

PMID:
31411848
2.

Reactivity of an Unusual Amidase May Explain Colibactin's DNA Cross-Linking Activity.

Jiang Y, Stornetta A, Villalta PW, Wilson MR, Boudreau PD, Zha L, Balbo S, Balskus EP.

J Am Chem Soc. 2019 Jul 24;141(29):11489-11496. doi: 10.1021/jacs.9b02453. Epub 2019 Jul 11.

PMID:
31251062
3.

Enzymes that detoxify marine toxins.

McCallum ME, Balskus EP.

Nature. 2019 Jun;570(7761):315-316. doi: 10.1038/d41586-019-01742-1. No abstract available.

PMID:
31213676
4.

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism.

Maini Rekdal V, Bess EN, Bisanz JE, Turnbaugh PJ, Balskus EP.

Science. 2019 Jun 14;364(6445). pii: eaau6323. doi: 10.1126/science.aau6323.

PMID:
31196984
5.

In Vitro Characterization of the Colibactin-Activating Peptidase ClbP Enables Development of a Fluorogenic Activity Probe.

Volpe MR, Wilson MR, Brotherton CA, Winter ES, Johnson SE, Balskus EP.

ACS Chem Biol. 2019 Jun 21;14(6):1097-1101. doi: 10.1021/acschembio.9b00069. Epub 2019 May 13. Erratum in: ACS Chem Biol. 2019 Aug 14;:.

PMID:
31059217
6.

The human gut bacterial genotoxin colibactin alkylates DNA.

Wilson MR, Jiang Y, Villalta PW, Stornetta A, Boudreau PD, Carrá A, Brennan CA, Chun E, Ngo L, Samson LD, Engelward BP, Garrett WS, Balbo S, Balskus EP.

Science. 2019 Feb 15;363(6428). pii: eaar7785. doi: 10.1126/science.aar7785.

7.

An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin.

Ng TL, Rohac R, Mitchell AJ, Boal AK, Balskus EP.

Nature. 2019 Feb;566(7742):94-99. doi: 10.1038/s41586-019-0894-z. Epub 2019 Feb 6.

8.

A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia.

Peck SC, Denger K, Burrichter A, Irwin SM, Balskus EP, Schleheck D.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3171-3176. doi: 10.1073/pnas.1815661116. Epub 2019 Feb 4.

9.

Biocatalytic Friedel-Crafts Alkylation Using a Promiscuous Biosynthetic Enzyme.

Schultz EE, Braffman NR, Luescher MU, Hager HH, Balskus EP.

Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3151-3155. doi: 10.1002/anie.201814016. Epub 2019 Feb 14.

PMID:
30706984
10.

Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols.

Martins TP, Rouger C, Glasser NR, Freitas S, de Fraissinette NB, Balskus EP, Tasdemir D, Leão PN.

Nat Prod Rep. 2019 Jan 31. doi: 10.1039/c8np00080h. [Epub ahead of print] Review.

PMID:
30702733
11.

Structure-Guided Identification of a Small Molecule That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria.

Orman M, Bodea S, Funk MA, Campo AM, Bollenbach M, Drennan CL, Balskus EP.

J Am Chem Soc. 2019 Jan 9;141(1):33-37. doi: 10.1021/jacs.8b04883. Epub 2018 Dec 17.

PMID:
30557011
12.

Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline.

Chittim CL, Martínez Del Campo A, Balskus EP.

Nat Microbiol. 2019 Jan;4(1):155-163. doi: 10.1038/s41564-018-0294-4. Epub 2018 Nov 19.

PMID:
30455469
13.

Metabolic functions of the human gut microbiota: the role of metalloenzymes.

Rajakovich LJ, Balskus EP.

Nat Prod Rep. 2019 Apr 17;36(4):593-625. doi: 10.1039/c8np00074c. Review.

PMID:
30452039
14.

Discovering radical-dependent enzymes in the human gut microbiota.

Levin BJ, Balskus EP.

Curr Opin Chem Biol. 2018 Dec;47:86-93. doi: 10.1016/j.cbpa.2018.09.011. Epub 2018 Sep 27. Review.

PMID:
30268905
15.

Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin.

Wang KA, Ng TL, Wang P, Huang Z, Balskus EP, van der Donk WA.

Nat Commun. 2018 Sep 11;9(1):3687. doi: 10.1038/s41467-018-06083-7.

16.

Purification and Characterization of the Choline Trimethylamine-Lyase (CutC)-Activating Protein CutD.

Bodea S, Balskus EP.

Methods Enzymol. 2018;606:73-94. doi: 10.1016/bs.mie.2018.04.012. Epub 2018 Jun 1.

PMID:
30097105
17.

Announcement of 2019 Keystone Symposia Conference: "Microbiome: Chemical Mechanisms and Biological Consequences".

Balskus EP, Turnbaugh PJ, Wolan DW.

mSystems. 2018 Jul 24;3(4). pii: e00115-18. doi: 10.1128/mSystems.00115-18. eCollection 2018 Jul-Aug.

18.

Discovery of a Diazo-Forming Enzyme in Cremeomycin Biosynthesis.

Waldman AJ, Balskus EP.

J Org Chem. 2018 Jul 20;83(14):7539-7546. doi: 10.1021/acs.joc.8b00367. Epub 2018 May 29.

19.

Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins.

Koppel N, Bisanz JE, Pandelia ME, Turnbaugh PJ, Balskus EP.

Elife. 2018 May 15;7. pii: e33953. doi: 10.7554/eLife.33953.

20.

Deciphering Human Gut Microbiota-Nutrient Interactions: A Role for Biochemistry.

Chittim CL, Irwin SM, Balskus EP.

Biochemistry. 2018 May 8;57(18):2567-2577. doi: 10.1021/acs.biochem.7b01277. Epub 2018 Apr 25. Review.

PMID:
29669199
21.

Gut Microbiota: Rational Manipulation of Gut Bacterial Metalloenzymes Provides Insights into Dysbiosis and Inflammation.

M Rekdal V, Balskus EP.

Biochemistry. 2018 Apr 24;57(16):2291-2293. doi: 10.1021/acs.biochem.8b00340. Epub 2018 Apr 10. No abstract available.

PMID:
29633827
22.

Characterization of 1,2-Propanediol Dehydratases Reveals Distinct Mechanisms for B12-Dependent and Glycyl Radical Enzymes.

Levin BJ, Balskus EP.

Biochemistry. 2018 Jun 12;57(23):3222-3226. doi: 10.1021/acs.biochem.8b00164. Epub 2018 Mar 16.

PMID:
29526088
23.

Chemical signaling at the eukaryotic/prokaryotic interface.

Dorrestein PC, Balskus EP.

Chem Soc Rev. 2018 Mar 5;47(5):1572-1573. doi: 10.1039/c8cs90021c. No abstract available.

PMID:
29479607
24.

Anaerobic 4-hydroxyproline utilization: Discovery of a new glycyl radical enzyme in the human gut microbiome uncovers a widespread microbial metabolic activity.

Huang YY, Martínez-Del Campo A, Balskus EP.

Gut Microbes. 2018;9(5):437-451. doi: 10.1080/19490976.2018.1435244. Epub 2018 Jun 4.

25.

The Human Microbiome.

Balskus EP.

ACS Infect Dis. 2018 Jan 12;4(1):1-2. doi: 10.1021/acsinfecdis.7b00248. No abstract available.

PMID:
29325418
26.

Engineering chemical interactions in microbial communities.

Kenny DJ, Balskus EP.

Chem Soc Rev. 2018 Mar 5;47(5):1705-1729. doi: 10.1039/c7cs00664k. Review.

PMID:
29210396
27.

The Human Microbiota, Infectious Disease, and Global Health: Challenges and Opportunities.

Waldman AJ, Balskus EP.

ACS Infect Dis. 2018 Jan 12;4(1):14-26. doi: 10.1021/acsinfecdis.7b00232. Epub 2017 Dec 13.

PMID:
29207239
28.

Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption.

Romano KA, Martinez-Del Campo A, Kasahara K, Chittim CL, Vivas EI, Amador-Noguez D, Balskus EP, Rey FE.

Cell Host Microbe. 2017 Sep 13;22(3):279-290.e7. doi: 10.1016/j.chom.2017.07.021. Epub 2017 Aug 24.

29.

Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring.

Zha L, Jiang Y, Henke MT, Wilson MR, Wang JX, Kelleher NL, Balskus EP.

Nat Chem Biol. 2017 Oct;13(10):1063-1065. doi: 10.1038/nchembio.2448. Epub 2017 Aug 7.

30.

A new strategy for aromatic ring alkylation in cylindrocyclophane biosynthesis.

Nakamura H, Schultz EE, Balskus EP.

Nat Chem Biol. 2017 Aug;13(8):916-921. doi: 10.1038/nchembio.2421. Epub 2017 Jun 26.

PMID:
28671684
31.

Chemical transformation of xenobiotics by the human gut microbiota.

Koppel N, Maini Rekdal V, Balskus EP.

Science. 2017 Jun 23;356(6344). pii: eaag2770. doi: 10.1126/science.aag2770. Review.

32.

Interfacing Biocompatible Reactions with Engineered Escherichia coli.

Wallace S, Balskus EP.

Methods Mol Biol. 2017;1586:409-421. doi: 10.1007/978-1-4939-6887-9_27.

PMID:
28470621
33.

Natural product discovery from the human microbiome.

Wilson MR, Zha L, Balskus EP.

J Biol Chem. 2017 May 26;292(21):8546-8552. doi: 10.1074/jbc.R116.762906. Epub 2017 Apr 7. Review.

34.

Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

Waldman AJ, Ng TL, Wang P, Balskus EP.

Chem Rev. 2017 Apr 26;117(8):5784-5863. doi: 10.1021/acs.chemrev.6b00621. Epub 2017 Apr 4. Review.

35.

Production of Stealthin C Involves an S-N-Type Smiles Rearrangement.

Wang P, Hong GJ, Wilson MR, Balskus EP.

J Am Chem Soc. 2017 Mar 1;139(8):2864-2867. doi: 10.1021/jacs.6b10586. Epub 2017 Feb 16.

36.

A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline.

Levin BJ, Huang YY, Peck SC, Wei Y, Martínez-Del Campo A, Marks JA, Franzosa EA, Huttenhower C, Balskus EP.

Science. 2017 Feb 10;355(6325). pii: eaai8386. doi: 10.1126/science.aai8386.

37.

Corrigendum: Biosynthesis-Assisted Structural Elucidation of the Bartolosides, Chlorinated Aromatic Glycolipids from Cyanobacteria.

Leão PN, Nakamura H, Costa M, Pereira AR, Martins R, Vasconcelos V, Gerwick WH, Balskus EP.

Angew Chem Int Ed Engl. 2016 Nov 21;55(48):14895. doi: 10.1002/anie.201609701. No abstract available.

38.

Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase.

Bodea S, Funk MA, Balskus EP, Drennan CL.

Cell Chem Biol. 2016 Oct 20;23(10):1206-1216. doi: 10.1016/j.chembiol.2016.07.020. Epub 2016 Sep 24.

39.

Addressing Infectious Disease Challenges by Investigating Microbiomes.

Balskus EP.

ACS Infect Dis. 2016 Jul 8;2(7):453-5. doi: 10.1021/acsinfecdis.6b00100. Epub 2016 Jun 17.

PMID:
27626096
40.

Correction to Characterization of Choline Trimethylamine-Lyase Expands the Chemistry of Glycyl Radical Enzymes.

Craciun S, Marks JA, Balskus EP.

ACS Chem Biol. 2016 Jul 15;11(7):2068. doi: 10.1021/acschembio.6b00487. Epub 2016 Jun 16. No abstract available.

PMID:
27309771
41.

The Plot Thickens: Diet Microbe Interactions May Modulate Thrombosis Risk.

Martínez-Del Campo A, Romano KA, Rey FE, Balskus EP.

Cell Metab. 2016 Apr 12;23(4):573-5. doi: 10.1016/j.cmet.2016.03.017.

42.

Designer Micelles Accelerate Flux Through Engineered Metabolism in E. coli and Support Biocompatible Chemistry.

Wallace S, Balskus EP.

Angew Chem Int Ed Engl. 2016 May 10;55(20):6023-7. doi: 10.1002/anie.201600966. Epub 2016 Apr 8.

43.

Exploring and Understanding the Biochemical Diversity of the Human Microbiota.

Koppel N, Balskus EP.

Cell Chem Biol. 2016 Jan 21;23(1):18-30. doi: 10.1016/j.chembiol.2015.12.008. Review.

44.

Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin.

Zha L, Wilson MR, Brotherton CA, Balskus EP.

ACS Chem Biol. 2016 May 20;11(5):1287-95. doi: 10.1021/acschembio.6b00014. Epub 2016 Mar 1.

PMID:
26890481
45.

Colibactin: understanding an elusive gut bacterial genotoxin.

Balskus EP.

Nat Prod Rep. 2015 Nov;32(11):1534-40. doi: 10.1039/c5np00091b. Review.

PMID:
26390983
46.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

47.

The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation.

Waldman AJ, Pechersky Y, Wang P, Wang JX, Balskus EP.

Chembiochem. 2015 Oct 12;16(15):2172-5. doi: 10.1002/cbic.201500407. Epub 2015 Sep 14.

48.

Biosynthesis-assisted structural elucidation of the bartolosides, chlorinated aromatic glycolipids from cyanobacteria.

Leão PN, Nakamura H, Costa M, Pereira AR, Martins R, Vasconcelos V, Gerwick WH, Balskus EP.

Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11063-7. doi: 10.1002/anie.201503186. Epub 2015 Jul 31. Erratum in: Angew Chem Int Ed Engl. 2016 Nov 21;55(48):14895.

49.

Assembly line termination in cylindrocyclophane biosynthesis: discovery of an editing type II thioesterase domain in a type I polyketide synthase.

Nakamura H, Wang JX, Balskus EP.

Chem Sci. 2015 Jul 1;6(7):3816-3822. doi: 10.1039/c4sc03132f. Epub 2015 Apr 14.

50.

Shedding light on sunscreen biosynthesis in zebrafish.

Brotherton CA, Balskus EP.

Elife. 2015 May 12;4. doi: 10.7554/eLife.07961. No abstract available.

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