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Measuring the impact of a mandatory province-wide vaccinate-or-mask policy on healthcare worker absenteeism in British Columbia, Canada.

Murti M, Otterstatter M, Orth A, Balshaw R, Halani K, Brown PD, Hejazi S, Thompson D, Allison S, Bharmal A, Dawar M, Hoyano D, Lee V, Naus M, Pollock S, Bevanda J, Coughlin S, Fitzgerald J, Keen D, Maracle M, Sprague S, Henry B.

Vaccine. 2019 Jul 9;37(30):4008-4014. doi: 10.1016/j.vaccine.2019.06.007. Epub 2019 Jun 14.


Measuring the impact of influenza vaccination on healthcare worker absenteeism in the context of a province-wide mandatory vaccinate-or-mask policy.

Murti M, Otterstatter M, Orth A, Balshaw R, Halani K, Brown PD, Hejazi S, Thompson D, Allison S, Bharmal A, Dawar M, Hoyano D, Lee V, Naus M, Pollock S, Bevanda J, Coughlin S, Fitzgerald J, Keen D, Maracle M, Sprague S, Henry B.

Vaccine. 2019 Jul 9;37(30):4001-4007. doi: 10.1016/j.vaccine.2019.06.014. Epub 2019 Jun 14.


Modelling the combined impact of interventions in averting deaths during a synthetic-opioid overdose epidemic.

Irvine MA, Kuo M, Buxton JA, Balshaw R, Otterstatter M, Macdougall L, Milloy MJ, Bharmal A, Henry B, Tyndall M, Coombs D, Gilbert M.

Addiction. 2019 Sep;114(9):1602-1613. doi: 10.1111/add.14664. Epub 2019 Jun 28.


Sex Differences in Presentation and Outcome After an Acute Transient or Minor Neurologic Event.

Yu AYX, Penn AM, Lesperance ML, Croteau NS, Balshaw RF, Votova K, Bibok MB, Penn M, Saly V, Hegedus J, Zerna C, Klourfeld E, Bilston L, Hong ZM, Coutts SB; SpecTRA Study Group.

JAMA Neurol. 2019 May 22. doi: 10.1001/jamaneurol.2019.1305. [Epub ahead of print]


Estimated impact of World Health Organization latent tuberculosis screening guidelines in a low TB incidence region: retrospective cohort study.

Ronald LA, Campbell JR, Rose C, Balshaw R, Romanowski K, Roth D, Marra F, Schwartzman K, Cook VJ, Johnston JC.

Clin Infect Dis. 2019 Mar 11. pii: ciz188. doi: 10.1093/cid/ciz188. [Epub ahead of print]


What can we learn by examining variations in the use of urine culture in the management of acute cystitis? A retrospective cohort study with linked administrative data in British Columbia, Canada, 2005-2011.

McKay R, Law M, McGrail K, Balshaw R, Reyes R, Patrick DM.

PLoS One. 2019 Mar 8;14(3):e0213534. doi: 10.1371/journal.pone.0213534. eCollection 2019.


Development and Validation of Apolipoprotein AI-Associated Lipoprotein Proteome Panel for the Prediction of Cholesterol Efflux Capacity and Coronary Artery Disease.

Jin Z, Collier TS, Dai DLY, Chen V, Hollander Z, Ng RT, McManus BM, Balshaw R, Apostolidou S, Penn MS, Bystrom C.

Clin Chem. 2019 Feb;65(2):282-290. doi: 10.1373/clinchem.2018.291922. Epub 2018 Nov 21.


Predicting tuberculosis relapse in patients treated with the standard 6-month regimen: an individual patient data meta-analysis.

Romanowski K, Balshaw RF, Benedetti A, Campbell JR, Menzies D, Ahmad Khan F, Johnston JC.

Thorax. 2019 Mar;74(3):291-297. doi: 10.1136/thoraxjnl-2017-211120. Epub 2018 Nov 12.


Considerations for adaptive design in pediatric clinical trials: study protocol for a systematic review, mixed-methods study, and integrated knowledge translation plan.

Kelly LE, Dyson MP, Butcher NJ, Balshaw R, London AJ, Neilson CJ, Junker A, Mahmud SM, Driedger SM, Wang X.

Trials. 2018 Oct 19;19(1):572. doi: 10.1186/s13063-018-2934-7.


Retrospective evaluation of a clinical decision support tool for effective computed tomography angiography utilization in urgent brain imaging of suspected TIA/minor stroke in the emergency department.

Bibok MB, Votova K, Balshaw RF, Penn M, Lesperance ML, Harris DR, Sedgwick C, Nealis M, Farrell B, Mathieson JR, Penn AM.

CJEM. 2019 May;21(3):343-351. doi: 10.1017/cem.2018.449. Epub 2018 Oct 2.


Screening for Latent Tuberculosis Infection in Migrants With CKD: A Cost-effectiveness Analysis.

Campbell JR, Johnston JC, Ronald LA, Sadatsafavi M, Balshaw RF, Cook VJ, Levin A, Marra F.

Am J Kidney Dis. 2019 Jan;73(1):39-50. doi: 10.1053/j.ajkd.2018.07.014. Epub 2018 Sep 28.


Effect of opioid-substitution therapy and mental health counseling on HIV risk among hepatitis C-infected individuals.

Butt ZA, Shrestha N, Gesink D, Murti M, Buxton JA, Gilbert M, Balshaw RF, Wong S, Kuo M, Wong J, Yu A, Alvarez M, Samji H, Roth D, Consolacion T, Hull MW, Ogilvie G, Tyndall MW, Krajden M, Janjua NZ.

Clin Epidemiol. 2018 Aug 31;10:1127-1145. doi: 10.2147/CLEP.S173449. eCollection 2018.


Validation of a proteomic biomarker panel to diagnose minor-stroke and transient ischaemic attack: phase 2 of SpecTRA, a large scale translational study.

Penn AM, Bibok MB, Saly VK, Coutts SB, Lesperance ML, Balshaw RF, Votova K, Croteau NS, Trivedi A, Jackson AM, Hegedus J, Klourfeld E, Yu AYX, Zerna C, Modi J, Barber PA, Hoag G, Borchers CH; SpecTRA study group.

Biomarkers. 2018 Dec;23(8):793-803. doi: 10.1080/1354750X.2018.1499130. Epub 2018 Aug 23.


Distribution of take-home opioid antagonist kits during a synthetic opioid epidemic in British Columbia, Canada: a modelling study.

Irvine MA, Buxton JA, Otterstatter M, Balshaw R, Gustafson R, Tyndall M, Kendall P, Kerr T, Gilbert M, Coombs D.

Lancet Public Health. 2018 May;3(5):e218-e225. doi: 10.1016/S2468-2667(18)30044-6. Epub 2018 Apr 18.


A novel Bayesian approach to predicting reductions in HIV incidence following increased testing interventions among gay, bisexual and other men who have sex with men in Vancouver, Canada.

Irvine MA, Konrad BP, Michelow W, Balshaw R, Gilbert M, Coombs D.

J R Soc Interface. 2018 Mar;15(140). pii: 20170849. doi: 10.1098/rsif.2017.0849.


Demographic predictors of active tuberculosis in people migrating to British Columbia, Canada: a retrospective cohort study.

Ronald LA, Campbell JR, Balshaw RF, Romanowski K, Roth DZ, Marra F, Cook VJ, Johnston JC.

CMAJ. 2018 Feb 26;190(8):E209-E216. doi: 10.1503/cmaj.170817.


Reducing time-to-unit among patients referred to an outpatient stroke assessment unit with a novel triage process: a prospective cohort study.

Bibok MB, Votova K, Balshaw RF, Lesperance ML, Croteau NS, Trivedi A, Morrison J, Sedgwick C, Penn AM.

BMC Health Serv Res. 2018 Feb 27;18(1):142. doi: 10.1186/s12913-018-2952-x.


Pharmacogenomic biomarkers do not predict response to drotrecogin alfa in patients with severe sepsis.

Annane D, Mira JP, Ware LB, Gordon AC, Hinds CJ, Christiani DC, Sevransky J, Barnes K, Buchman TG, Heagerty PJ, Balshaw R, Lesnikova N, de Nobrega K, Wellman HF, Neira M, Mancini ADJ, Walley KR, Russell JA.

Ann Intensive Care. 2018 Jan 31;8(1):16. doi: 10.1186/s13613-018-0353-2.


Verification of a proteomic biomarker panel to diagnose minor stroke and transient ischaemic attack: phase 1 of SpecTRA, a large scale translational study.

Penn AM, Bibok MB, Saly VK, Coutts SB, Lesperance ML, Balshaw RF, Votova K, Croteau NS, Trivedi A, Jackson AM, Hegedus J, Klourfeld E, Yu AYX, Zerna C, Borchers CH; SpecTRA study group.

Biomarkers. 2018 May - Jun;23(4):392-405. doi: 10.1080/1354750X.2018.1434681. Epub 2018 Feb 12.


Differential Proteomics for Distinguishing Ischemic Stroke from Controls: a Pilot Study of the SpecTRA Project.

Penn AM, Saly V, Trivedi A, Lesperance ML, Votova K, Jackson AM, Croteau NS, Balshaw RF, Bibok MB, Smith DS, Lam KK, Morrison J, Lu L, Coutts SB, Borchers CH.

Transl Stroke Res. 2018 Dec;9(6):590-599. doi: 10.1007/s12975-018-0609-z. Epub 2018 Jan 24.


Validation of a multivariate clinical prediction model for the diagnosis of mild stroke/transient ischemic attack in physician first-contact patient settings.

Bibok MB, Penn AM, Lesperance ML, Votova K, Balshaw R.

Health Informatics J. 2019 Sep;25(3):1148-1157. doi: 10.1177/1460458217747111. Epub 2017 Dec 17.


Associations between extreme precipitation and acute gastro-intestinal illness due to cryptosporidiosis and giardiasis in an urban Canadian drinking water system (1997-2009).

Chhetri BK, Takaro TK, Balshaw R, Otterstatter M, Mak S, Lem M, Zubel M, Lysyshyn M, Clarkson L, Edwards J, Fleury MD, Henderson SB, Galanis E.

J Water Health. 2017 Oct;15(6):898-907. doi: 10.2166/wh.2017.100.


Novel Blood-based Transcriptional Biomarker Panels Predict the Late-Phase Asthmatic Response.

Singh A, Shannon CP, Kim YW, Yang CX, Balshaw R, Cohen Freue GV, Gauvreau GM, FitzGerald JM, Boulet LP, O'Byrne PM, Tebbutt SJ.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):450-462. doi: 10.1164/rccm.201701-0110OC.


A syndemic approach to assess the effect of substance use and social disparities on the evolution of HIV/HCV infections in British Columbia.

Butt ZA, Shrestha N, Wong S, Kuo M, Gesink D, Gilbert M, Wong J, Yu A, Alvarez M, Samji H, Buxton JA, Johnston JC, Cook VJ, Roth D, Consolacion T, Murti M, Hottes TS, Ogilvie G, Balshaw R, Tyndall MW, Krajden M, Janjua NZ; BC Hepatitis Testers Cohort.

PLoS One. 2017 Aug 22;12(8):e0183609. doi: 10.1371/journal.pone.0183609. eCollection 2017.


A Targeted Proteomics Analysis of Cerebrospinal Fluid after Acute Human Spinal Cord Injury.

Streijger F, Skinnider MA, Rogalski JC, Balshaw R, Shannon CP, Prudova A, Belanger L, Ritchie L, Tsang A, Christie S, Parent S, Mac-Thiong JM, Bailey C, Urquhart J, Ailon T, Paquette S, Boyd M, Street J, Fisher CG, Dvorak MF, Borchers CH, Foster LJ, Kwon BK.

J Neurotrauma. 2017 Jun 15;34(12):2054-2068. doi: 10.1089/neu.2016.4879. Epub 2017 Apr 7.


Interim estimates of 2016/17 vaccine effectiveness against influenza A(H3N2), Canada, January 2017.

Skowronski DM, Chambers C, Sabaiduc S, Dickinson JA, Winter AL, De Serres G, Drews SJ, Jassem A, Gubbay JB, Charest H, Balshaw R, Bastien N, Li Y, Krajden M.

Euro Surveill. 2017 Feb 9;22(6). pii: 30460. doi: 10.2807/1560-7917.ES.2017.22.6.30460.


Sustained Reduction in Sexual Behavior that May Pose a Risk of HIV Transmission Following Diagnosis During Early HIV Infection Among Gay Men in Vancouver, British Columbia.

Gilbert M, Taylor D, Michelow W, Grace D, Balshaw R, Kwag M, Lim E, Fischer B, Patrick D, Ogilvie G, Coombs D, Steinberg M, Rekart M.

AIDS Behav. 2018 Jul;22(7):2068-2078. doi: 10.1007/s10461-017-1702-0.


Enumerateblood - an R package to estimate the cellular composition of whole blood from Affymetrix Gene ST gene expression profiles.

Shannon CP, Balshaw R, Chen V, Hollander Z, Toma M, McManus BM, FitzGerald JM, Sin DD, Ng RT, Tebbutt SJ.

BMC Genomics. 2017 Jan 6;18(1):43. doi: 10.1186/s12864-016-3460-1.


Predicting tuberculosis risk in the foreign-born population of British Columbia, Canada: study protocol for a retrospective population-based cohort study.

Ronald LA, Campbell JR, Balshaw RF, Roth DZ, Romanowski K, Marra F, Cook VJ, Johnston JC.

BMJ Open. 2016 Nov 25;6(11):e013488. doi: 10.1136/bmjopen-2016-013488.


SABRE: a method for assessing the stability of gene modules in complex tissues and subject populations.

Shannon CP, Chen V, Takhar M, Hollander Z, Balshaw R, McManus BM, Tebbutt SJ, Sin DD, Ng RT.

BMC Bioinformatics. 2016 Nov 14;17(1):460.


Excess medical costs in patients with asthma and the role of comorbidity.

Chen W, Lynd LD, FitzGerald JM, Marra CA, Balshaw R, To T, Tavakoli H, Sadatsafavi M; Canadian Respiratory Research Network.

Eur Respir J. 2016 Dec;48(6):1584-1592. doi: 10.1183/13993003.01141-2016. Epub 2016 Oct 6.


Exploring phlebotomy technique as a pre-analytical factor in proteomic analyses by mass spectrometry.

Penn AM, Lu L, Chambers AG, Balshaw RF, Morrison JL, Votova K, Wood E, Smith DS, Lesperance M, del Zoppo GJ, Borchers CH; SpecTRA Study Group.

Genome. 2015 Dec;58(12):569-76. doi: 10.1139/gen-2015-0036. Epub 2015 Jul 10.


Risk Factors for Progression of Alzheimer Disease in a Canadian Population: The Canadian Outcomes Study in Dementia (COSID).

Herrmann N, Harimoto T, Balshaw R, Lanctôt KL; Canadian Outcomes Study in Dementia (COSID) Investigators.

Can J Psychiatry. 2015 Apr;60(4):189-99.


Longitudinal clinical findings and outcome among patients with Cryptococcus gattii infection in British Columbia.

Phillips P, Galanis E, MacDougall L, Chong MY, Balshaw R, Cook VJ, Bowie W, Steiner T, Hoang L, Morshed M, Ghesquiere W, Forrest DM, Roscoe D, Doyle P, Kibsey PC, Connolly T, Mirzanejad Y, Thompson D; British Columbia Cryptococcus gattii Study Group.

Clin Infect Dis. 2015 May 1;60(9):1368-76. doi: 10.1093/cid/civ041. Epub 2015 Jan 28.


Two-stage, in silico deconvolution of the lymphocyte compartment of the peripheral whole blood transcriptome in the context of acute kidney allograft rejection.

Shannon CP, Balshaw R, Ng RT, Wilson-McManus JE, Keown P, McMaster R, McManus BM, Landsberg D, Isbel NM, Knoll G, Tebbutt SJ.

PLoS One. 2014 Apr 14;9(4):e95224. doi: 10.1371/journal.pone.0095224. eCollection 2014.


Variation in RNA-Seq transcriptome profiles of peripheral whole blood from healthy individuals with and without globin depletion.

Shin H, Shannon CP, Fishbane N, Ruan J, Zhou M, Balshaw R, Wilson-McManus JE, Ng RT, McManus BM, Tebbutt SJ; PROOF Centre of Excellence Team.

PLoS One. 2014 Mar 7;9(3):e91041. doi: 10.1371/journal.pone.0091041. eCollection 2014.


Proteomic biomarkers of recovered heart function.

Hollander Z, Lazárová M, Lam KK, Ignaszewski A, Oudit GY, Dyck JR, Schreiner G, Pauwels J, Chen V, Cohen Freue GV, Ng RT, Wilson-McManus JE, Balshaw R, Tebbutt SJ, McMaster RW, Keown PA, McManus BM; NCE CECR PROOF Prevention of Organ Failure (PROOF) Centre of Excellence.

Eur J Heart Fail. 2014 May;16(5):551-9. doi: 10.1002/ejhf.65. Epub 2014 Feb 23.


Longitudinal analysis of whole blood transcriptomes to explore molecular signatures associated with acute renal allograft rejection.

Shin H, Günther O, Hollander Z, Wilson-McManus JE, Ng RT, Balshaw R, Keown PA, McMaster R, McManus BM, Isbel NM, Knoll G, Tebbutt SJ.

Bioinform Biol Insights. 2014 Jan 22;8:17-33. doi: 10.4137/BBI.S13376.. eCollection 2014.


Randomized controlled ferret study to assess the direct impact of 2008-09 trivalent inactivated influenza vaccine on A(H1N1)pdm09 disease risk.

Skowronski DM, Hamelin ME, De Serres G, Janjua NZ, Li G, Sabaiduc S, Bouhy X, Couture C, Leung A, Kobasa D, Embury-Hyatt C, de Bruin E, Balshaw R, Lavigne S, Petric M, Koopmans M, Boivin G.

PLoS One. 2014 Jan 27;9(1):e86555. doi: 10.1371/journal.pone.0086555. eCollection 2014.


Efficient panel designs for longitudinal recurrent event studies recording panel counts.

Juarez-Colunga E, Dean CB, Balshaw R.

Biostatistics. 2014 Apr;15(2):234-50. doi: 10.1093/biostatistics/kxt054. Epub 2013 Dec 3.


Prevalence and predictors of burden in caregivers of people with dementia.

Brodaty H, Woodward M, Boundy K, Ames D, Balshaw R; PRIME Study Group.

Am J Geriatr Psychiatry. 2014 Aug;22(8):756-65. doi: 10.1016/j.jagp.2013.05.004. Epub 2013 Sep 5.


Interferon-gamma release assays are a better tuberculosis screening test for hemodialysis patients: A study and review of the literature.

Grant J, Jastrzebski J, Johnston J, Stefanovic A, Jastrabesky J, Elwood K, Roscoe D, Balshaw R, Bryce E.

Can J Infect Dis Med Microbiol. 2012 Fall;23(3):114-6.


Alteration of human blood cell transcriptome in uremia.

Scherer A, Günther OP, Balshaw RF, Hollander Z, Wilson-McManus J, Ng R, McMaster WR, McManus BM, Keown PA.

BMC Med Genomics. 2013 Jun 28;6:23. doi: 10.1186/1755-8794-6-23.


Plasma protein biosignatures for detection of cardiac allograft vasculopathy.

Lin D, Cohen Freue G, Hollander Z, John Mancini GB, Sasaki M, Mui A, Wilson-McManus J, Ignaszewski A, Imai C, Meredith A, Balshaw R, Ng RT, Keown PA, Robert McMaster W, Carere R, Webb JG, McManus BM; Biomarkers in Transplantation Team; Networks of Centres of Excellence, Centres of Excellence for Commercialization and Research-Prevention of Organ Failure Centre of Excellence.

J Heart Lung Transplant. 2013 Jul;32(7):723-33. doi: 10.1016/j.healun.2013.04.011.


Computational biomarker pipeline from discovery to clinical implementation: plasma proteomic biomarkers for cardiac transplantation.

Cohen Freue GV, Meredith A, Smith D, Bergman A, Sasaki M, Lam KK, Hollander Z, Opushneva N, Takhar M, Lin D, Wilson-McManus J, Balshaw R, Keown PA, Borchers CH, McManus B, Ng RT, McMaster WR; Biomarkers in Transplantation and the NCE CECR Prevention of Organ Failure Centre of Excellence Teams.

PLoS Comput Biol. 2013 Apr;9(4):e1002963. doi: 10.1371/journal.pcbi.1002963. Epub 2013 Apr 4.


Predicting acute cardiac rejection from donor heart and pre-transplant recipient blood gene expression.

Hollander Z, Chen V, Sidhu K, Lin D, Ng RT, Balshaw R, Cohen-Freue GV, Ignaszewski A, Imai C, Kaan A, Tebbutt SJ, Wilson-McManus JE, McMaster RW, Keown PA, McManus BM; NCE CECR PROOF Centre of Excellence.

J Heart Lung Transplant. 2013 Feb;32(2):259-65. doi: 10.1016/j.healun.2012.11.008. Epub 2012 Dec 21.


A computational pipeline for the development of multi-marker bio-signature panels and ensemble classifiers.

Günther OP, Chen V, Freue GC, Balshaw RF, Tebbutt SJ, Hollander Z, Takhar M, McMaster WR, McManus BM, Keown PA, Ng RT.

BMC Bioinformatics. 2012 Dec 8;13:326. doi: 10.1186/1471-2105-13-326.


White blood cell differentials enrich whole blood expression data in the context of acute cardiac allograft rejection.

Shannon CP, Hollander Z, Wilson-McManus J, Balshaw R, Ng RT, McMaster R, McManus BM, Keown PA, Tebbutt SJ.

Bioinform Biol Insights. 2012;6:49-61. doi: 10.4137/BBI.S9197. Epub 2012 Apr 10.


Randomised clinical trial: the efficacy of treatment, guided by a shorter duration of response, using peginterferon alfa-2a plus ribavirin for hepatitis C virus other than genotypes 2 or 3.

Lee SS, Sherman M, Ramji A, Greenbloom S, Elkashab M, Pluta H, Hilzenrat N, Balshaw R, Usaty C, Myers RP.

Aliment Pharmacol Ther. 2012 Jan;35(1):37-47. doi: 10.1111/j.1365-2036.2011.04911.x. Epub 2011 Nov 2.


Molecular signatures of end-stage heart failure.

Lin D, Hollander Z, Meredith A, Stadnick E, Sasaki M, Cohen Freue G, Qasimi P, Mui A, Ng RT, Balshaw R, Wilson-McManus JE, Wishart D, Hau D, Keown PA, McMaster R, McManus BM; Biomarkers in Transplantation Team; NCE CECR PROOF Centre of Excellence.

J Card Fail. 2011 Oct;17(10):867-74. doi: 10.1016/j.cardfail.2011.07.001. Epub 2011 Sep 3.


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