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Items: 1 to 50 of 84

1.

Coordinated Management of Academic Health Centers.

Balser JR, Stead WW.

Trans Am Clin Climatol Assoc. 2017;128:353-362.

2.

Research in academic medical centers: two threats to sustainable support.

Levine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, Rothman PB, Schwinn DA, Shapiro LJ, Spiegel AM.

Sci Transl Med. 2015 May 27;7(289):289fs22. doi: 10.1126/scitranslmed.aac5200.

PMID:
26019216
3.

Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias.

Potet F, Lorinc AN, Chaigne S, Hopkins CR, Venkataraman R, Stepanovic SZ, Lewis LM, Days E, Sidorov VY, Engers DW, Zou B, Afshartous D, George AL Jr, Campbell CM, Balser JR, Li M, Baudenbacher FJ, Lindsley CW, Weaver CD, Kupershmidt S.

J Biol Chem. 2012 Nov 16;287(47):39613-25. doi: 10.1074/jbc.M112.380162. Epub 2012 Oct 2.

4.

Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.

Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM.

Am J Hum Genet. 2010 Apr 9;86(4):560-72. doi: 10.1016/j.ajhg.2010.03.003. Epub 2010 Apr 1. Erratum in: Am J Hum Genet. 2010 Aug 13;87(2):310.

5.

Beyond Flexner: a new model for continuous learning in the health professions.

Miller BM, Moore DE Jr, Stead WW, Balser JR.

Acad Med. 2010 Feb;85(2):266-72. doi: 10.1097/ACM.0b013e3181c859fb.

PMID:
20107354
6.

Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation.

Nakajima T, Davies SS, Matafonova E, Potet F, Amarnath V, Tallman KA, Serwa RA, Porter NA, Balser JR, Kupershmidt S, Roberts LJ 3rd.

J Mol Cell Cardiol. 2010 Feb;48(2):352-9. doi: 10.1016/j.yjmcc.2009.11.016. Epub 2009 Dec 3.

7.

Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding.

Yamagishi T, Xiong W, Kondratiev A, Vélez P, Méndez-Fitzwilliam A, Balser JR, Marbán E, Tomaselli GF.

Mol Pharmacol. 2009 Oct;76(4):861-71. doi: 10.1124/mol.109.055863. Epub 2009 Jul 20.

8.

The evolutionarily conserved residue A653 plays a key role in HERG channel closing.

Stepanovic SZ, Potet F, Petersen CI, Smith JA, Meiler J, Balser JR, Kupershmidt S.

J Physiol. 2009 Jun 1;587(Pt 11):2555-66. doi: 10.1113/jphysiol.2008.166694. Epub 2009 Apr 30.

9.

Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin.

Potet F, Chagot B, Anghelescu M, Viswanathan PC, Stepanovic SZ, Kupershmidt S, Chazin WJ, Balser JR.

J Biol Chem. 2009 Mar 27;284(13):8846-54. doi: 10.1074/jbc.M806871200. Epub 2009 Jan 26.

10.

Solution NMR structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5.

Chagot B, Potet F, Balser JR, Chazin WJ.

J Biol Chem. 2009 Mar 6;284(10):6436-45. doi: 10.1074/jbc.M807747200. Epub 2008 Dec 11.

11.

Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator.

Potet F, Petersen CI, Boutaud O, Shuai W, Stepanovic SZ, Balser JR, Kupershmidt S.

J Mol Cell Cardiol. 2009 Feb;46(2):257-67. doi: 10.1016/j.yjmcc.2008.10.015. Epub 2008 Nov 5.

12.

Centralized oversight of physician-scientist faculty development at Vanderbilt: early outcomes.

Brown AM, Morrow JD, Limbird LE, Byrne DW, Gabbe SG, Balser JR, Brown NJ.

Acad Med. 2008 Oct;83(10):969-75. doi: 10.1097/ACM.0b013e3181850950.

13.

Science at the interstices: an evolution in the academy.

Balser JR, Baruchin A.

Acad Med. 2008 Sep;83(9):827-31. doi: 10.1097/ACM.0b013e318181d1ed.

PMID:
18728436
14.

Development of a large-scale de-identified DNA biobank to enable personalized medicine.

Roden DM, Pulley JM, Basford MA, Bernard GR, Clayton EW, Balser JR, Masys DR.

Clin Pharmacol Ther. 2008 Sep;84(3):362-9. doi: 10.1038/clpt.2008.89. Epub 2008 May 21.

15.

Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmias.

Boyden PA, Davies SS, Viswanathan PC, Amarnath V, Balser JR, Roberts LJ 2nd.

J Cardiovasc Pharmacol. 2007 Nov;50(5):480-6. Review.

PMID:
18030056
16.

HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function.

Nakajima T, Hayashi K, Viswanathan PC, Kim MY, Anghelescu M, Barksdale KA, Shuai W, Balser JR, Kupershmidt S.

J Biol Chem. 2007 Feb 23;282(8):5506-13. Epub 2006 Dec 21.

17.

Molecular basis of isolated cardiac conduction disease.

Viswanathan PC, Balser JR.

Handb Exp Pharmacol. 2006;(171):331-47. Review.

PMID:
16610351
18.

Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch.

Shah VN, Wingo TL, Weiss KL, Williams CK, Balser JR, Chazin WJ.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3592-7. Epub 2006 Feb 27.

19.

Anesthesiology physician scientists in academic medicine: a wake-up call.

Schwinn DA, Balser JR.

Anesthesiology. 2006 Jan;104(1):170-8. Review. No abstract available.

20.

Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels.

Fukuda K, Davies SS, Nakajima T, Ong BH, Kupershmidt S, Fessel J, Amarnath V, Anderson ME, Boyden PA, Viswanathan PC, Roberts LJ 2nd, Balser JR.

Circ Res. 2005 Dec 9;97(12):1262-9. Epub 2005 Nov 10.

PMID:
16284182
21.

A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families.

Smits JP, Koopmann TT, Wilders R, Veldkamp MW, Opthof T, Bhuiyan ZA, Mannens MM, Balser JR, Tan HL, Bezzina CR, Wilde AA.

J Mol Cell Cardiol. 2005 Jun;38(6):969-81. Epub 2005 Apr 1.

PMID:
15910881
22.

Compound-specific Na+ channel pore conformational changes induced by local anaesthetics.

Fukuda K, Nakajima T, Viswanathan PC, Balser JR.

J Physiol. 2005 Apr 1;564(Pt 1):21-31. Epub 2005 Jan 27.

23.

In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.

Petersen CI, McFarland TR, Stepanovic SZ, Yang P, Reiner DJ, Hayashi K, George AL, Roden DM, Thomas JH, Balser JR.

Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11773-8. Epub 2004 Jul 27.

24.

Functional interaction between extracellular sodium, potassium and inactivation gating in HERG channels.

Mullins FM, Stepanovic SZ, Gillani NB, George AL Jr, Balser JR.

J Physiol. 2004 Aug 1;558(Pt 3):729-44. Epub 2004 May 28.

25.

Perioperative cardiac arrhythmias.

Thompson A, Balser JR.

Br J Anaesth. 2004 Jul;93(1):86-94. Epub 2004 May 14. Review. No abstract available.

26.

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

Wingo TL, Shah VN, Anderson ME, Lybrand TP, Chazin WJ, Balser JR.

Nat Struct Mol Biol. 2004 Mar;11(3):219-25. Epub 2004 Feb 22.

PMID:
14981509
27.

Inherited sodium channelopathies: a continuum of channel dysfunction.

Viswanathan PC, Balser JR.

Trends Cardiovasc Med. 2004 Jan;14(1):28-35. Review.

PMID:
14720472
28.

New treatments for perioperative cardiac arrhythmias.

Hastings LA, Balser JR.

Anesthesiol Clin North Am. 2003 Sep;21(3):569-86. Review.

PMID:
14562566
29.

The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.

Kupershmidt S, Yang IC, Hayashi K, Wei J, Chanthaphaychith S, Petersen CI, Johns DC, George AL Jr, Roden DM, Balser JR.

FASEB J. 2003 Dec;17(15):2263-5. Epub 2003 Oct 2.

PMID:
14525949
30.

Perioperative genomics. Venturing into uncharted seas.

Donahue BS, Balser JR.

Anesthesiology. 2003 Jul;99(1):7-8. No abstract available.

PMID:
12826835
31.

A common SCN5A polymorphism modulates the biophysical effects of an SCN5A mutation.

Viswanathan PC, Benson DW, Balser JR.

J Clin Invest. 2003 Feb;111(3):341-6.

32.

Cytoskeletal disrupting agents prevent calmodulin kinase, IQ domain and voltage-dependent facilitation of L-type Ca2+ channels.

Dzhura I, Wu Y, Colbran RJ, Corbin JD, Balser JR, Anderson ME.

J Physiol. 2002 Dec 1;545(2):399-406. Erratum in: J Physiol. 2003 Feb 1;546(Pt 3):955. Retraction in: J Physiol. 2015 May 1;593(9):2247.

33.

Extracellular sodium interacts with the HERG channel at an outer pore site.

Mullins FM, Stepanovic SZ, Desai RR, George AL Jr, Balser JR.

J Gen Physiol. 2002 Oct;120(4):517-37.

34.

Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system.

Kupershmidt S, Yang IC, Sutherland M, Wells KS, Yang T, Yang P, Balser JR, Roden DM.

Cardiovasc Res. 2002 Oct;56(1):93-103.

PMID:
12237170
35.

Perioperative arrhythmias: incidence, risk assessment, evaluation, and management.

Balser JR.

Card Electrophysiol Rev. 2002 Feb;6(1-2):96-9. Review. No abstract available.

PMID:
11984026
36.

Inherited sodium channelopathies: models for acquired arrhythmias?

Balser JR.

Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1175-80. Review. No abstract available.

37.

Cardiac ion channels.

Roden DM, Balser JR, George AL Jr, Anderson ME.

Annu Rev Physiol. 2002;64:431-75. Review.

PMID:
11826275
38.

A calcium sensor in the sodium channel modulates cardiac excitability.

Tan HL, Kupershmidt S, Zhang R, Stepanovic S, Roden DM, Wilde AA, Anderson ME, Balser JR.

Nature. 2002 Jan 24;415(6870):442-7.

PMID:
11807557
39.

Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block.

Wang DW, Viswanathan PC, Balser JR, George AL Jr, Benson DW.

Circulation. 2002 Jan 22;105(3):341-6.

PMID:
11804990
40.

Intravenous amiodarone and off-pump coronary artery bypass graft procedures: a new role for intraoperative antiarrhythmic therapy?

Balser JR.

J Cardiothorac Vasc Anesth. 2001 Oct;15(5):542-4. No abstract available.

PMID:
11687990
41.

Inherited sodium channelopathies: novel therapeutic and proarrhythmic molecular mechanisms.

Balser JR.

Trends Cardiovasc Med. 2001 Aug;11(6):229-37. Review.

PMID:
11673053
42.

Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes.

Viswanathan PC, Bezzina CR, George AL Jr, Roden DM, Wilde AA, Balser JR.

Circulation. 2001 Sep 4;104(10):1200-5.

PMID:
11535580
43.

A novel extracellular calcium sensing mechanism in voltage-gated potassium ion channels.

Johnson JP Jr, Balser JR, Bennett PB.

J Neurosci. 2001 Jun 15;21(12):4143-53.

44.

The cardiac sodium channel: gating function and molecular pharmacology.

Balser JR.

J Mol Cell Cardiol. 2001 Apr;33(4):599-613. Review.

PMID:
11273715
45.

A sodium-channel mutation causes isolated cardiac conduction disease.

Tan HL, Bink-Boelkens MT, Bezzina CR, Viswanathan PC, Beaufort-Krol GC, van Tintelen PJ, van den Berg MP, Wilde AA, Balser JR.

Nature. 2001 Feb 22;409(6823):1043-7.

PMID:
11234013
46.

Probing the interaction between inactivation gating and Dd-sotalol block of HERG.

Numaguchi H, Mullins FM, Johnson JP Jr, Johns DC, Po SS, Yang IC, Tomaselli GF, Balser JR.

Circ Res. 2000 Nov 24;87(11):1012-8.

PMID:
11090546
47.
48.

Enhanced Na(+) channel intermediate inactivation in Brugada syndrome.

Wang DW, Makita N, Kitabatake A, Balser JR, George AL Jr.

Circ Res. 2000 Oct 13;87(8):E37-43.

PMID:
11029409
49.

Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel.

Veldkamp MW, Viswanathan PC, Bezzina C, Baartscheer A, Wilde AA, Balser JR.

Circ Res. 2000 May 12;86(9):E91-7.

PMID:
10807877
50.

A revised view of cardiac sodium channel "blockade" in the long-QT syndrome.

Kambouris NG, Nuss HB, Johns DC, Marbán E, Tomaselli GF, Balser JR.

J Clin Invest. 2000 Apr;105(8):1133-40.

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