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Disentangling the role of TRPM4 in hippocampus-dependent plasticity and learning: an electrophysiological, behavioral and FMRI approach.

Bovet-Carmona M, Menigoz A, Pinto S, Tambuyzer T, Krautwald K, Voets T, Aerts JM, Angenstein F, Vennekens R, Balschun D.

Brain Struct Funct. 2018 Jul 3. doi: 10.1007/s00429-018-1706-1. [Epub ahead of print]


Single mild traumatic brain injury results in transiently impaired spatial long-term memory and altered search strategies.

Marschner L, Schreurs A, Lechat B, Mogensen J, Roebroek A, Ahmed T, Balschun D.

Behav Brain Res. 2018 Feb 27. pii: S0166-4328(18)30289-4. doi: 10.1016/j.bbr.2018.02.040. [Epub ahead of print]


High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease.

Salas IH, Weerasekera A, Ahmed T, Callaerts-Vegh Z, Himmelreich U, D'Hooge R, Balschun D, Saido TC, De Strooper B, Dotti CG.

Neurobiol Dis. 2018 May;113:82-96. doi: 10.1016/j.nbd.2018.02.001. Epub 2018 Feb 7.


Transient and localized optogenetic activation of somatostatin-interneurons in mouse visual cortex abolishes long-term cortical plasticity due to vision loss.

Scheyltjens I, Vreysen S, Van den Haute C, Sabanov V, Balschun D, Baekelandt V, Arckens L.

Brain Struct Funct. 2018 Jun;223(5):2073-2095. doi: 10.1007/s00429-018-1611-7. Epub 2018 Jan 25.


Distinct Properties of Long-Term Potentiation in the Dentate Gyrus along the Dorsoventral Axis: Influence of Age and Inhibition.

Schreurs A, Sabanov V, Balschun D.

Sci Rep. 2017 Jul 11;7(1):5157. doi: 10.1038/s41598-017-05358-1.


Tau deletion promotes brain insulin resistance.

Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D.

J Exp Med. 2017 Aug 7;214(8):2257-2269. doi: 10.1084/jem.20161731. Epub 2017 Jun 26.


Impaired GABAergic inhibition in the hippocampus of Fmr1 knockout mice.

Sabanov V, Braat S, D'Andrea L, Willemsen R, Zeidler S, Rooms L, Bagni C, Kooy RF, Balschun D.

Neuropharmacology. 2017 Apr;116:71-81. doi: 10.1016/j.neuropharm.2016.12.010. Epub 2016 Dec 21.


Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.

Latif-Hernandez A, Faldini E, Ahmed T, Balschun D.

Front Cell Neurosci. 2016 Nov 7;10:252. eCollection 2016.


Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity.

Latif-Hernandez A, Shah D, Ahmed T, Lo AC, Callaerts-Vegh Z, Van der Linden A, Balschun D, D'Hooge R.

Sci Rep. 2016 Nov 7;6:36489. doi: 10.1038/srep36489.


Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons.

Palomer E, Martín-Segura A, Baliyan S, Ahmed T, Balschun D, Venero C, Martin MG, Dotti CG.

Cell Rep. 2016 Sep 13;16(11):2889-2900. doi: 10.1016/j.celrep.2016.08.028.


Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation.

Bhattacharya S, Herrera-Molina R, Sabanov V, Ahmed T, Iscru E, Stöber F, Richter K, Fischer KD, Angenstein F, Goldschmidt J, Beesley PW, Balschun D, Smalla KH, Gundelfinger ED, Montag D.

Biol Psychiatry. 2017 Jan 15;81(2):124-135. doi: 10.1016/j.biopsych.2016.03.2107. Epub 2016 Apr 11.


Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition.

Shah D, Praet J, Latif Hernandez A, Höfling C, Anckaerts C, Bard F, Morawski M, Detrez JR, Prinsen E, Villa A, De Vos WH, Maggi A, D'Hooge R, Balschun D, Rossner S, Verhoye M, Van der Linden A.

Alzheimers Dement. 2016 Sep;12(9):964-976. doi: 10.1016/j.jalz.2016.03.010. Epub 2016 Apr 21.


TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons.

Menigoz A, Ahmed T, Sabanov V, Philippaert K, Pinto S, Kerselaers S, Segal A, Freichel M, Voets T, Nilius B, Vennekens R, Balschun D.

Pflugers Arch. 2016 Apr;468(4):593-607. doi: 10.1007/s00424-015-1764-7. Epub 2015 Dec 3.


Brain endothelial TAK1 and NEMO safeguard the neurovascular unit.

Ridder DA, Wenzel J, Müller K, Töllner K, Tong XK, Assmann JC, Stroobants S, Weber T, Niturad C, Fischer L, Lembrich B, Wolburg H, Grand'Maison M, Papadopoulos P, Korpos E, Truchetet F, Rades D, Sorokin LM, Schmidt-Supprian M, Bedell BJ, Pasparakis M, Balschun D, D'Hooge R, Löscher W, Hamel E, Schwaninger M.

J Exp Med. 2015 Sep 21;212(10):1529-49. doi: 10.1084/jem.20150165. Epub 2015 Sep 7.


Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice.

Callaerts-Vegh Z, Ahmed T, Vermaercke B, Marynen P, Balschun D, Froyen G, D'Hooge R.

Front Behav Neurosci. 2015 Jul 10;9:179. doi: 10.3389/fnbeh.2015.00179. eCollection 2015.


Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.

Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, Bagni C.

Neuron. 2015 Jul 15;87(2):382-98. doi: 10.1016/j.neuron.2015.06.032. Erratum in: Neuron. 2015 Aug 19;87(4):908.


Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors.

Bollen E, Akkerman S, Puzzo D, Gulisano W, Palmeri A, D'Hooge R, Balschun D, Steinbusch HW, Blokland A, Prickaerts J.

Neuropharmacology. 2015 Aug;95:361-6. doi: 10.1016/j.neuropharm.2015.04.008. Epub 2015 Apr 17.


Rescue of impaired late-phase long-term depression in a tau transgenic mouse model.

Ahmed T, Blum D, Burnouf S, Demeyer D, Buée-Scherrer V, D'Hooge R, Buée L, Balschun D.

Neurobiol Aging. 2015 Feb;36(2):730-9. doi: 10.1016/j.neurobiolaging.2014.09.015. Epub 2014 Sep 28.


Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion.

Ahmed T, Van der Jeugd A, Blum D, Galas MC, D'Hooge R, Buee L, Balschun D.

Neurobiol Aging. 2014 Nov;35(11):2474-2478. doi: 10.1016/j.neurobiolaging.2014.05.005. Epub 2014 May 10.


Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling.

Fazzari P, Snellinx A, Sabanov V, Ahmed T, Serneels L, Gartner A, Shariati SA, Balschun D, De Strooper B.

Elife. 2014 Jun 2;3. doi: 10.7554/eLife.02196.


Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents.

Martin MG, Ahmed T, Korovaichuk A, Venero C, Menchón SA, Salas I, Munck S, Herreras O, Balschun D, Dotti CG.

EMBO Mol Med. 2014 Jul;6(7):902-17. doi: 10.15252/emmm.201303711.


Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling.

Bollen E, Puzzo D, Rutten K, Privitera L, De Vry J, Vanmierlo T, Kenis G, Palmeri A, D'Hooge R, Balschun D, Steinbusch HM, Blokland A, Prickaerts J.

Neuropsychopharmacology. 2014 Oct;39(11):2497-505. doi: 10.1038/npp.2014.106. Epub 2014 May 12.


Distinct and simultaneously active plasticity mechanisms in mouse hippocampus during different phases of Morris water maze training.

Laeremans A, Sabanov V, Ahmed T, Nys J, Van de Plas B, Vinken K, Woolley DG, Gantois I, D'Hooge R, Arckens L, Balschun D.

Brain Struct Funct. 2015;220(3):1273-90. doi: 10.1007/s00429-014-0722-z. Epub 2014 Feb 23.


Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.

Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P.

J Neurosci. 2013 Aug 7;33(32):12915-28, 12928a. doi: 10.1523/JNEUROSCI.5910-12.2013.


Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease.

Lo AC, Iscru E, Blum D, Tesseur I, Callaerts-Vegh Z, Buée L, De Strooper B, Balschun D, D'Hooge R.

J Alzheimers Dis. 2013;37(1):109-25. doi: 10.3233/JAD-122296.


A cytokine network involving brain-borne IL-1β, IL-1ra, IL-18, IL-6, and TNFα operates during long-term potentiation and learning.

del Rey A, Balschun D, Wetzel W, Randolf A, Besedovsky HO.

Brain Behav Immun. 2013 Oct;33:15-23. doi: 10.1016/j.bbi.2013.05.011. Epub 2013 Jun 6.


Improved spatial learning is associated with increased hippocampal but not prefrontal long-term potentiation in mGluR4 knockout mice.

Iscru E, Goddyn H, Ahmed T, Callaerts-Vegh Z, D'Hooge R, Balschun D.

Genes Brain Behav. 2013 Aug;12(6):615-25. doi: 10.1111/gbb.12052. Epub 2013 Jun 20.


Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS.

Trovò L, Ahmed T, Callaerts-Vegh Z, Buzzi A, Bagni C, Chuah M, Vandendriessche T, D'Hooge R, Balschun D, Dotti CG.

Nat Neurosci. 2013 Apr;16(4):449-55. doi: 10.1038/nn.3342. Epub 2013 Feb 24.


Haploinsufficiency of VGluT1 but not VGluT2 impairs extinction of spatial preference and response suppression.

Callaerts-Vegh Z, Moechars D, Van Acker N, Daneels G, Goris I, Leo S, Naert A, Meert T, Balschun D, D'Hooge R.

Behav Brain Res. 2013 May 15;245:13-21. doi: 10.1016/j.bbr.2013.01.042. Epub 2013 Feb 5.


System identification of mGluR-dependent long-term depression.

Tambuyzer T, Ahmed T, Taylor CJ, Berckmans D, Balschun D, Aerts JM.

Neural Comput. 2013 Mar;25(3):650-70. doi: 10.1162/NECO_a_00408. Epub 2012 Dec 28.


Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice.

Nuytens K, Gantois I, Stijnen P, Iscru E, Laeremans A, Serneels L, Van Eylen L, Liebhaber SA, Devriendt K, Balschun D, Arckens L, Creemers JW, D'Hooge R.

Neurobiol Dis. 2013 Mar;51:144-51. doi: 10.1016/j.nbd.2012.11.004. Epub 2012 Nov 12.


Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region.

Iscru E, Ahmed T, Coremans V, Bozzi Y, Caleo M, Conway EM, D'Hooge R, Balschun D.

Neuroscience. 2013 Feb 12;231:413-9. doi: 10.1016/j.neuroscience.2012.10.049. Epub 2012 Nov 2.


Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2.

Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, Dieck St, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM.

Nature. 2012 Apr 29;486(7402):256-60. doi: 10.1038/nature11015.


Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.

Van der Jeugd A, Hochgräfe K, Ahmed T, Decker JM, Sydow A, Hofmann A, Wu D, Messing L, Balschun D, D'Hooge R, Mandelkow EM.

Acta Neuropathol. 2012 Jun;123(6):787-805. doi: 10.1007/s00401-012-0987-3. Epub 2012 Apr 25.


Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I.

Koch D, Spiwoks-Becker I, Sabanov V, Sinning A, Dugladze T, Stellmacher A, Ahuja R, Grimm J, Schüler S, Müller A, Angenstein F, Ahmed T, Diesler A, Moser M, Tom Dieck S, Spessert R, Boeckers TM, Fässler R, Hübner CA, Balschun D, Gloveli T, Kessels MM, Qualmann B.

EMBO J. 2011 Sep 16;30(24):4955-69. doi: 10.1038/emboj.2011.339.


Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model.

Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM.

J Mol Neurosci. 2011 Nov;45(3):432-7. doi: 10.1007/s12031-011-9604-5. Epub 2011 Aug 6.


Reverse engineering of synaptic plasticity in the hippocampus.

Tambuyzer T, Ahmed T, Berckmans D, Balschun D, Aerts JM.

Commun Agric Appl Biol Sci. 2011;76(1):196-200. No abstract available.


An N-methyl-D-aspartate-receptor dependent, late-phase long-term depression in middle-aged mice identifies no GluN2-subunit bias.

Ahmed T, Sabanov V, D'Hooge R, Balschun D.

Neuroscience. 2011 Jun 30;185:27-38. doi: 10.1016/j.neuroscience.2011.04.006. Epub 2011 Apr 12.


Telencephalic histopathology and changes in behavioural and neural plasticity in a murine model for metachromatic leukodystrophy.

Faldini E, Stroobants S, Lüllmann-Rauch R, Eckhardt M, Gieselmann V, Balschun D, D'Hooge R.

Behav Brain Res. 2011 Sep 23;222(2):309-14. doi: 10.1016/j.bbr.2011.03.059. Epub 2011 Apr 1.


Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM.

J Neurosci. 2011 Feb 16;31(7):2511-25. doi: 10.1523/JNEUROSCI.5245-10.2011.


Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.

Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean ME, Humez S, Balschun D, Blum D, Buée L, D'Hooge R.

Neurobiol Learn Mem. 2011 Mar;95(3):296-304. doi: 10.1016/j.nlm.2010.12.005. Epub 2010 Dec 16.


From tau phosphorylation to tau aggregation: what about neuronal death?

Buée L, Troquier L, Burnouf S, Belarbi K, Van der Jeugd A, Ahmed T, Fernandez-Gomez F, Caillierez R, Grosjean ME, Begard S, Barbot B, Demeyer D, Obriot H, Brion I, Buée-Scherrer V, Maurage CA, Balschun D, D'hooge R, Hamdane M, Blum D, Sergeant N.

Biochem Soc Trans. 2010 Aug;38(4):967-72. doi: 10.1042/BST0380967. Review.


Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon.

Lanore F, Blanchet C, Fejtova A, Pinheiro P, Richter K, Balschun D, Gundelfinger E, Mulle C.

J Physiol. 2010 Jun 15;588(Pt 12):2133-45. doi: 10.1113/jphysiol.2009.184929. Epub 2010 Apr 26.


Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin.

Coremans V, Ahmed T, Balschun D, D'Hooge R, DeVriese A, Cremer J, Antonucci F, Moons M, Baekelandt V, Reumers V, Cremer H, Eisch A, Lagace D, Janssens T, Bozzi Y, Caleo M, Conway EM.

BMC Neurosci. 2010 Jan 5;11:2. doi: 10.1186/1471-2202-11-2.


Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning.

Balschun D, Moechars D, Callaerts-Vegh Z, Vermaercke B, Van Acker N, Andries L, D'Hooge R.

Cereb Cortex. 2010 Mar;20(3):684-93. doi: 10.1093/cercor/bhp133. Epub 2009 Jul 2.


Spred1 is required for synaptic plasticity and hippocampus-dependent learning.

Denayer E, Ahmed T, Brems H, Van Woerden G, Borgesius NZ, Callaerts-Vegh Z, Yoshimura A, Hartmann D, Elgersma Y, D'Hooge R, Legius E, Balschun D.

J Neurosci. 2008 Dec 31;28(53):14443-9. doi: 10.1523/JNEUROSCI.4698-08.2008.


The potent non-competitive mGlu1 receptor antagonist BAY 36-7620 differentially affects synaptic plasticity in area cornu ammonis 1 of rat hippocampal slices and impairs acquisition in the water maze task in mice.

Schröder UH, Müller T, Schreiber R, Stolle A, Zuschratter W, Balschun D, Jork R, Reymann KG.

Neuroscience. 2008 Nov 19;157(2):385-95. doi: 10.1016/j.neuroscience.2008.08.063. Epub 2008 Sep 9.


Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory.

Balschun D, Zuschratter W, Wetzel W.

Neuroscience. 2006 Oct 27;142(3):691-702. Epub 2006 Aug 4.


Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment.

Caeyenberghs K, Balschun D, Roces DP, Schwake M, Saftig P, D'Hooge R.

Neurobiol Dis. 2006 Aug;23(2):422-32.


Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis.

D'Hooge R, Lüllmann-Rauch R, Beckers T, Balschun D, Schwake M, Reiss K, von Figura K, Saftig P.

J Neurosci. 2005 Jul 13;25(28):6539-49.

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