Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 200

1.

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas.

Dodagatta-Marri E, Meyer DS, Reeves MQ, Paniagua R, To MD, Binnewies M, Broz ML, Mori H, Wu D, Adoumie M, Del Rosario R, Li O, Buchmann T, Liang B, Malato J, Arce Vargus F, Sheppard D, Hann BC, Mirza A, Quezada SA, Rosenblum MD, Krummel MF, Balmain A, Akhurst RJ.

J Immunother Cancer. 2019 Mar 4;7(1):62. doi: 10.1186/s40425-018-0493-9.

2.

A model for RAS mutation patterns in cancers: finding the sweet spot.

Li S, Balmain A, Counter CM.

Nat Rev Cancer. 2018 Dec;18(12):767-777. doi: 10.1038/s41568-018-0076-6. Review.

PMID:
30420765
3.

Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis.

Reeves MQ, Kandyba E, Harris S, Del Rosario R, Balmain A.

Nat Cell Biol. 2018 Jun;20(6):699-709. doi: 10.1038/s41556-018-0109-0. Epub 2018 May 25.

4.

Age, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue.

Quigley DA, Tahiri A, Lüders T, Riis MH, Balmain A, Børresen-Dale AL, Bukholm I, Kristensen V.

Oncoimmunology. 2017 Aug 10;6(11):e1356142. doi: 10.1080/2162402X.2017.1356142. eCollection 2017.

5.

Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma.

Huang PY, Kandyba E, Jabouille A, Sjolund J, Kumar A, Halliwill K, McCreery M, DelRosario R, Kang HC, Wong CE, Seibler J, Beuger V, Pellegrino M, Sciambi A, Eastburn DJ, Balmain A.

Nat Genet. 2017 Nov;49(11):1624-1632. doi: 10.1038/ng.3957. Epub 2017 Sep 25.

6.

Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer.

Halliwill KD, Quigley DA, Kang HC, Del Rosario R, Ginzinger D, Balmain A.

Genome Med. 2016 Aug 9;8(1):83. doi: 10.1186/s13073-016-0334-8.

7.

Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer.

Quigley DA, Kandyba E, Huang P, Halliwill KD, Sjölund J, Pelorosso F, Wong CE, Hirst GL, Wu D, Delrosario R, Kumar A, Balmain A.

Cell Rep. 2016 Jul 26;16(4):1153-1165. doi: 10.1016/j.celrep.2016.06.061. Epub 2016 Jul 14.

8.

K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.

Wang MT, Holderfield M, Galeas J, Delrosario R, To MD, Balmain A, McCormick F.

Cell. 2015 Nov 19;163(5):1237-1251. doi: 10.1016/j.cell.2015.10.041.

9.

Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers.

McCreery MQ, Halliwill KD, Chin D, Delrosario R, Hirst G, Vuong P, Jen KY, Hewinson J, Adams DJ, Balmain A.

Nat Med. 2015 Dec;21(12):1514-20. doi: 10.1038/nm.3979. Epub 2015 Nov 2.

10.

The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development.

Adams CJ, Yu JS, Mao JH, Jen KY, Costes SV, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl GM, Balmain A.

Mol Carcinog. 2016 Sep;55(9):1387-96. doi: 10.1002/mc.22377. Epub 2015 Aug 27.

11.

Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.

Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H.

Nat Commun. 2015 Apr 27;6:6706. doi: 10.1038/ncomms7706.

PMID:
25913614
12.

Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14.

Letteboer TG, Benzinou M, Merrick CB, Quigley DA, Zhau K, Kim IJ, To MD, Jablons DM, van Amstel JK, Westermann CJ, Giraud S, Dupuis-Girod S, Lesca G, Berg JH, Balmain A, Akhurst RJ.

Front Genet. 2015 Mar 12;6:67. doi: 10.3389/fgene.2015.00067. eCollection 2015.

13.

The genetics of splicing in neuroblastoma.

Chen J, Hackett CS, Zhang S, Song YK, Bell RJ, Molinaro AM, Quigley DA, Balmain A, Song JS, Costello JF, Gustafson WC, Van Dyke T, Kwok PY, Khan J, Weiss WA.

Cancer Discov. 2015 Apr;5(4):380-95. doi: 10.1158/2159-8290.CD-14-0892. Epub 2015 Jan 30.

14.

Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.

Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, Khan J, Balmain A, Fan Q, Weiss WA.

Cell Rep. 2014 Nov 6;9(3):1034-46. doi: 10.1016/j.celrep.2014.09.046. Epub 2014 Oct 23.

15.

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.

Westcott PM, Halliwill KD, To MD, Rashid M, Rust AG, Keane TM, Delrosario R, Jen KY, Gurley KE, Kemp CJ, Fredlund E, Quigley DA, Adams DJ, Balmain A.

Nature. 2015 Jan 22;517(7535):489-92. doi: 10.1038/nature13898. Epub 2014 Nov 2.

16.

Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53.

Quigley D, Silwal-Pandit L, Dannenfelser R, Langerød A, Vollan HK, Vaske C, Siegel JU, Troyanskaya O, Chin SF, Caldas C, Balmain A, Børresen-Dale AL, Kristensen V.

Mol Cancer Res. 2015 Mar;13(3):493-501. doi: 10.1158/1541-7786.MCR-14-0387. Epub 2014 Oct 28.

17.

Milestones in skin carcinogenesis: the biology of multistage carcinogenesis.

Balmain A, Yuspa SH.

J Invest Dermatol. 2014 Oct 10;134(e1):E2-7. doi: 10.1038/skinbio.2014.2. Review. No abstract available.

18.

Modeling cutaneous squamous carcinoma development in the mouse.

Huang PY, Balmain A.

Cold Spring Harb Perspect Med. 2014 Sep 2;4(9):a013623. doi: 10.1101/cshperspect.a013623. Review.

19.

A multilevel model of postmenopausal breast cancer incidence.

Hiatt RA, Porco TC, Liu F, Balke K, Balmain A, Barlow J, Braithwaite D, Diez-Roux AV, Kushi LH, Moasser MM, Werb Z, Windham GC, Rehkopf DH.

Cancer Epidemiol Biomarkers Prev. 2014 Oct;23(10):2078-92. doi: 10.1158/1055-9965.EPI-14-0403. Epub 2014 Jul 13.

20.

Identification of Hipk2 as an essential regulator of white fat development.

Sjölund J, Pelorosso FG, Quigley DA, DelRosario R, Balmain A.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7373-8. doi: 10.1073/pnas.1322275111. Epub 2014 Apr 30.

21.

Cellular reprogramming in skin cancer.

Song IY, Balmain A.

Semin Cancer Biol. 2015 Jun;32:32-9. doi: 10.1016/j.semcancer.2014.03.006. Epub 2014 Apr 8. Review.

22.

The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.

Quigley DA, Fiorito E, Nord S, Van Loo P, Alnæs GG, Fleischer T, Tost J, Moen Vollan HK, Tramm T, Overgaard J, Bukholm IR, Hurtado A, Balmain A, Børresen-Dale AL, Kristensen V.

Mol Oncol. 2014 Mar;8(2):273-84. doi: 10.1016/j.molonc.2013.11.008. Epub 2013 Dec 3.

23.

Keratin 16 regulates innate immunity in response to epidermal barrier breach.

Lessard JC, Piña-Paz S, Rotty JD, Hickerson RP, Kaspar RL, Balmain A, Coulombe PA.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19537-42. doi: 10.1073/pnas.1309576110. Epub 2013 Nov 11.

24.

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.

Saunders SP, Goh CS, Brown SJ, Palmer CN, Porter RM, Cole C, Campbell LE, Gierlinski M, Barton GJ, Schneider G, Balmain A, Prescott AR, Weidinger S, Baurecht H, Kabesch M, Gieger C, Lee YA, Tavendale R, Mukhopadhyay S, Turner SW, Madhok VB, Sullivan FM, Relton C, Burn J, Meggitt S, Smith CH, Allen MA, Barker JN, Reynolds NJ, Cordell HJ, Irvine AD, McLean WH, Sandilands A, Fallon PG.

J Allergy Clin Immunol. 2013 Nov;132(5):1121-9. doi: 10.1016/j.jaci.2013.08.046. Epub 2013 Sep 29. Erratum in: J Allergy Clin Immunol. 2015 Dec;136(6):1710.

25.

Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas.

Kim IJ, Quigley D, To MD, Pham P, Lin K, Jo B, Jen KY, Raz D, Kim J, Mao JH, Jablons D, Balmain A.

Nat Commun. 2013;4:1701. doi: 10.1038/ncomms2660.

26.

Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.

Wong CE, Yu JS, Quigley DA, To MD, Jen KY, Huang PY, Del Rosario R, Balmain A.

Genes Dev. 2013 Mar 15;27(6):670-82. doi: 10.1101/gad.210427.112.

27.

Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology.

Kang HC, Quigley DA, Kim IJ, Wakabayashi Y, Ferguson-Smith MA, D'Alessandro M, Birgitte Lane E, Akhurst RJ, Goudie DR, Balmain A.

J Invest Dermatol. 2013 Jul;133(7):1907-10. doi: 10.1038/jid.2013.45. Epub 2013 Jan 28. No abstract available.

28.

Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes.

Nguyen DH, Fredlund E, Zhao W, Perou CM, Balmain A, Mao JH, Barcellos-Hoff MH.

Clin Cancer Res. 2013 Mar 15;19(6):1353-62. doi: 10.1158/1078-0432.CCR-12-3554. Epub 2013 Jan 21.

29.

Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice.

Kang HC, Wakabayashi Y, Jen KY, Mao JH, Zoumpourlis V, Del Rosario R, Balmain A.

J Invest Dermatol. 2013 May;133(5):1311-20. doi: 10.1038/jid.2012.419. Epub 2012 Dec 6.

30.

Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis.

To MD, Rosario RD, Westcott PM, Banta KL, Balmain A.

Oncogene. 2013 Aug 22;32(34):4028-33. doi: 10.1038/onc.2012.404. Epub 2012 Sep 3.

31.

Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.

Kwon YW, Kim IJ, Wu D, Lu J, Stock WA Jr, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH.

Mol Cancer Res. 2012 Jun;10(6):834-44. doi: 10.1158/1541-7786.MCR-12-0025. Epub 2012 Apr 18.

32.

Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility.

Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH.

PLoS One. 2012;7(2):e31301. doi: 10.1371/journal.pone.0031301. Epub 2012 Feb 13.

33.

Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.

Jen KY, Song IY, Banta KL, Wu D, Mao JH, Balmain A.

Blood. 2012 Jan 19;119(3):805-9. doi: 10.1182/blood-2011-01-327619. Epub 2011 Nov 23.

34.

Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer.

To MD, Quigley DA, Mao JH, Del Rosario R, Hsu J, Hodgson G, Jacks T, Balmain A.

Mol Cancer Res. 2011 Oct;9(10):1339-45. doi: 10.1158/1541-7786.MCR-11-0219. Epub 2011 Aug 1.

35.

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma.

Mao JH, Wu D, Kim IJ, Kang HC, Wei G, Climent J, Kumar A, Pelorosso FG, DelRosario R, Huang EJ, Balmain A.

Oncogene. 2012 Mar 1;31(9):1176-80. doi: 10.1038/onc.2011.306. Epub 2011 Jul 25.

36.

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity.

Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM.

Genes Dev. 2011 Jul 1;25(13):1426-38. doi: 10.1101/gad.2024411.

37.

Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility.

Quigley DA, To MD, Kim IJ, Lin KK, Albertson DG, Sjolund J, Pérez-Losada J, Balmain A.

Genome Biol. 2011;12(1):R5. doi: 10.1186/gb-2011-12-1-r5. Epub 2011 Jan 18.

38.

C/EBPδ: friend or foe? a novel role for C/EBPδ in metastasis.

Pelorosso FG, Balmain A.

EMBO J. 2010 Dec 15;29(24):4063-5. doi: 10.1038/emboj.2010.308. No abstract available.

39.

Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis.

Chun MG, Mao JH, Chiu CW, Balmain A, Hanahan D.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17268-73. doi: 10.1073/pnas.1012705107. Epub 2010 Sep 20.

40.

Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer.

Climent J, Perez-Losada J, Quigley DA, Kim IJ, Delrosario R, Jen KY, Bosch A, Lluch A, Mao JH, Balmain A.

J Clin Oncol. 2010 Aug 10;28(23):3770-8. doi: 10.1200/JCO.2009.27.0215. Epub 2010 Jul 12.

41.

Guidelines for the welfare and use of animals in cancer research.

Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DA, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles SA; Committee of the National Cancer Research Institute.

Br J Cancer. 2010 May 25;102(11):1555-77. doi: 10.1038/sj.bjc.6605642.

42.

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7.

Rocher-Ros V, Marco S, Mao JH, Gines S, Metzger D, Chambon P, Balmain A, Saura CA.

Oncogene. 2010 May 20;29(20):2950-61. doi: 10.1038/onc.2010.57. Epub 2010 Mar 8.

43.

An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis.

Li Z, Zhang Q, Mao JH, Weise A, Mrasek K, Fan X, Zhang X, Liehr T, Lu KH, Balmain A, Cai WW.

Oncogene. 2010 May 6;29(18):2659-71. doi: 10.1038/onc.2010.19. Epub 2010 Feb 15.

PMID:
20154723
44.

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.

Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T.

Am J Med Genet A. 2010 Jan;152A(1):4-24. doi: 10.1002/ajmg.a.33183.

45.

Systems genetics analysis of cancer susceptibility: from mouse models to humans.

Quigley D, Balmain A.

Nat Rev Genet. 2009 Sep;10(9):651-7. doi: 10.1038/nrg2617. Epub 2009 Jul 28. Review.

PMID:
19636343
46.

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis.

Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Bobisse S, Rondina MB, Guzzardo V, Parenti AR, Rosato A, Bicciato S, Balmain A, Piccolo S.

Cell. 2009 Apr 3;137(1):87-98. doi: 10.1016/j.cell.2009.01.039.

47.

Genetic architecture of mouse skin inflammation and tumour susceptibility.

Quigley DA, To MD, Pérez-Losada J, Pelorosso FG, Mao JH, Nagase H, Ginzinger DG, Balmain A.

Nature. 2009 Mar 26;458(7237):505-8. doi: 10.1038/nature07683. Epub 2009 Jan 11.

48.

Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus.

Mahler KL, Fleming JL, Dworkin AM, Gladman N, Cho HY, Mao JH, Balmain A, Toland AE.

BMC Genomics. 2008 Dec 23;9:626. doi: 10.1186/1471-2164-9-626.

49.

FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.

Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A.

Science. 2008 Sep 12;321(5895):1499-502. doi: 10.1126/science.1162981.

50.

Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.

To MD, Wong CE, Karnezis AN, Del Rosario R, Di Lauro R, Balmain A.

Nat Genet. 2008 Oct;40(10):1240-4. doi: 10.1038/ng.211. Epub 2008 Aug 31.

Supplemental Content

Loading ...
Support Center