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Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW II, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O'Brien KD, O'Rourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L.

Circulation. 2019 Oct 1;140(14):1205-1216.


Mitochondrial genetics regulate nuclear gene expression through metabolites.

Fetterman JL, Ballinger SW.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15763-15765. doi: 10.1073/pnas.1909996116. Epub 2019 Jul 15. No abstract available.


Mitochondrial - nuclear genetic interaction modulates whole body metabolism, adiposity and gene expression in vivo.

Dunham-Snary KJ, Sandel MW, Sammy MJ, Westbrook DG, Xiao R, McMonigle RJ, Ratcliffe WF, Penn A, Young ME, Ballinger SW.

EBioMedicine. 2018 Oct;36:316-328. doi: 10.1016/j.ebiom.2018.08.036. Epub 2018 Sep 16.


Reply to Shah et al.: Mitochondrial Dysfunction in Bronchopulmonary Dysplasia.

Kandasamy J, Olave N, Ballinger SW, Ambalavanan N.

Am J Respir Crit Care Med. 2018 May 15;197(10):1363-1364. doi: 10.1164/rccm.201712-2429LE. No abstract available.


Mitochondrial toxicity of tobacco smoke and air pollution.

Fetterman JL, Sammy MJ, Ballinger SW.

Toxicology. 2017 Nov 1;391:18-33. doi: 10.1016/j.tox.2017.08.002. Epub 2017 Aug 22. Review. No abstract available.


Vascular Endothelial Mitochondrial Function Predicts Death or Pulmonary Outcomes in Preterm Infants.

Kandasamy J, Olave N, Ballinger SW, Ambalavanan N.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):1040-1049. doi: 10.1164/rccm.201702-0353OC.


Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass.

Andres AM, Tucker KC, Thomas A, Taylor DJ, Sengstock D, Jahania SM, Dabir R, Pourpirali S, Brown JA, Westbrook DG, Ballinger SW, Mentzer RM Jr, Gottlieb RA.

JCI Insight. 2017 Feb 23;2(4):e89303. doi: 10.1172/jci.insight.89303.


Mitochondrial DNA mutations and cardiovascular disease.

Bray AW, Ballinger SW.

Curr Opin Cardiol. 2017 Feb 4. doi: 10.1097/HCO.0000000000000383. [Epub ahead of print]


Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer.

Kesterson RA, Johnson LW, Lambert LJ, Vivian JL, Welch DR, Ballinger SW.

Bio Protoc. 2016 Oct 20;6(20). pii: e1976.


Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease.

Fetterman JL, Holbrook M, Westbrook DG, Brown JA, Feeley KP, Bretón-Romero R, Linder EA, Berk BD, Weisbrod RM, Widlansky ME, Gokce N, Ballinger SW, Hamburg NM.

Cardiovasc Diabetol. 2016 Mar 31;15:53. doi: 10.1186/s12933-016-0372-y.


Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry.

Krzywanski DM, Moellering DR, Westbrook DG, Dunham-Snary KJ, Brown J, Bray AW, Feeley KP, Sammy MJ, Smith MR, Schurr TG, Vita JA, Ambalavanan N, Calhoun D, Dell'Italia L, Ballinger SW.

Circ Cardiovasc Genet. 2016 Feb;9(1):26-36. doi: 10.1161/CIRCGENETICS.115.001308. Epub 2016 Jan 19.


Mitochondrial Genetics Regulate Breast Cancer Tumorigenicity and Metastatic Potential.

Feeley KP, Bray AW, Westbrook DG, Johnson LW, Kesterson RA, Ballinger SW, Welch DR.

Cancer Res. 2015 Oct 15;75(20):4429-36. doi: 10.1158/0008-5472.CAN-15-0074.


GENETICS. Mitochondrial-nuclear DNA mismatch matters.

Dunham-Snary KJ, Ballinger SW.

Science. 2015 Sep 25;349(6255):1449-50. doi: 10.1126/science.aac5271. No abstract available.


Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4F.

Datta G, Kramer PA, Johnson MS, Sawada H, Smythies LE, Crossman DK, Chacko B, Ballinger SW, Westbrook DG, Mayakonda P, Anantharamaiah GM, Darley-Usmar VM, White CR.

Biochem J. 2015 May 1;467(3):517-27. doi: 10.1042/BJ20131635.


An ex-vivo model for evaluating bioenergetics in aortic rings.

Feeley KP, Westbrook DG, Bray AW, Ballinger SW.

Redox Biol. 2014;2:1003-7. doi: 10.1016/j.redox.2014.08.008. Epub 2014 Sep 3.


Aging and energetics' 'Top 40' future research opportunities 2010-2013.

Allison DB, Antoine LH, Ballinger SW, Bamman MM, Biga P, Darley-Usmar VM, Fisher G, Gohlke JM, Halade GV, Hartman JL, Hunter GR, Messina JL, Nagy TR, Plaisance EP, Powell ML, Roth KA, Sandel MW, Schwartz TS, Smith DL, Sweatt JD, Tollefsbol TO, Watts SA, Yang Y, Zhang J, Austad SN.

F1000Res. 2014 Sep 12;3:219. doi: 10.12688/f1000research.5212.1. eCollection 2014. Review.


A method for assessing mitochondrial bioenergetics in whole white adipose tissues.

Dunham-Snary KJ, Sandel MW, Westbrook DG, Ballinger SW.

Redox Biol. 2014 Apr 18;2:656-60. doi: 10.1016/j.redox.2014.04.005. eCollection 2014.


The Bioenergetic Health Index: a new concept in mitochondrial translational research.

Chacko BK, Kramer PA, Ravi S, Benavides GA, Mitchell T, Dranka BP, Ferrick D, Singal AK, Ballinger SW, Bailey SM, Hardy RW, Zhang J, Zhi D, Darley-Usmar VM.

Clin Sci (Lond). 2014 Sep;127(6):367-73. doi: 10.1042/CS20140101. Review.


Mitochondrial-nuclear genome interactions in non-alcoholic fatty liver disease in mice.

Betancourt AM, King AL, Fetterman JL, Millender-Swain T, Finley RD, Oliva CR, Crowe DR, Ballinger SW, Bailey SM.

Biochem J. 2014 Jul 15;461(2):223-32. doi: 10.1042/BJ20131433.


Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.

Liu W, Beck BH, Vaidya KS, Nash KT, Feeley KP, Ballinger SW, Pounds KM, Denning WL, Diers AR, Landar A, Dhar A, Iwakuma T, Welch DR.

Cancer Res. 2014 Feb 1;74(3):954-63. doi: 10.1158/0008-5472.CAN-13-1183. Epub 2013 Dec 18.


Mitochondrial genetics and obesity: evolutionary adaptation and contemporary disease susceptibility.

Dunham-Snary KJ, Ballinger SW.

Free Radic Biol Med. 2013 Dec;65:1229-1237. doi: 10.1016/j.freeradbiomed.2013.09.007. Epub 2013 Sep 25. Review.


Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload.

Fetterman JL, Zelickson BR, Johnson LW, Moellering DR, Westbrook DG, Pompilius M, Sammy MJ, Johnson M, Dunham-Snary KJ, Cao X, Bradley WE, Zhang J, Wei CC, Chacko B, Schurr TG, Kesterson RA, Dell'italia LJ, Darley-Usmar VM, Welch DR, Ballinger SW.

Biochem J. 2013 Oct 15;455(2):157-67. doi: 10.1042/BJ20130029. Erratum in: Biochem J. 2013 Oct 1;455(1):147.


Developmental exposure to second-hand smoke increases adult atherogenesis and alters mitochondrial DNA copy number and deletions in apoE(-/-) mice.

Fetterman JL, Pompilius M, Westbrook DG, Uyeminami D, Brown J, Pinkerton KE, Ballinger SW.

PLoS One. 2013 Jun 25;8(6):e66835. doi: 10.1371/journal.pone.0066835. Print 2013.


Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood.

Chacko BK, Kramer PA, Ravi S, Johnson MS, Hardy RW, Ballinger SW, Darley-Usmar VM.

Lab Invest. 2013 Jun;93(6):690-700. doi: 10.1038/labinvest.2013.53. Epub 2013 Mar 25.


Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics.

Mitchell T, Chacko B, Ballinger SW, Bailey SM, Zhang J, Darley-Usmar V.

Biochem Soc Trans. 2013 Feb 1;41(1):127-33. doi: 10.1042/BST20120231. Review.


The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics.

Krzywanski DM, Moellering DR, Fetterman JL, Dunham-Snary KJ, Sammy MJ, Ballinger SW.

Lab Invest. 2011 Aug;91(8):1122-35. doi: 10.1038/labinvest.2011.95. Epub 2011 Jun 6. Review.


Role of reactive oxygen species in injury-induced insulin resistance.

Zhai L, Ballinger SW, Messina JL.

Mol Endocrinol. 2011 Mar;25(3):492-502. doi: 10.1210/me.2010-0224. Epub 2011 Jan 14.


Mitochondrial oxidative stress significantly influences atherogenic risk and cytokine-induced oxidant production.

Harrison CM, Pompilius M, Pinkerton KE, Ballinger SW.

Environ Health Perspect. 2011 May;119(5):676-81. doi: 10.1289/ehp.1002857. Epub 2010 Dec 17.


Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overload.

Ulasova E, Gladden JD, Chen Y, Zheng J, Pat B, Bradley W, Powell P, Zmijewski JW, Zelickson BR, Ballinger SW, Darley-Usmar V, Dell'italia LJ.

J Mol Cell Cardiol. 2011 Jan;50(1):147-56. doi: 10.1016/j.yjmcc.2010.10.034. Epub 2010 Nov 6.


Perinatal tobacco smoke exposure increases vascular oxidative stress and mitochondrial damage in non-human primates.

Westbrook DG, Anderson PG, Pinkerton KE, Ballinger SW.

Cardiovasc Toxicol. 2010 Sep;10(3):216-26. doi: 10.1007/s12012-010-9085-8.


Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis.

Chuang GC, Yang Z, Westbrook DG, Pompilius M, Ballinger CA, White CR, Krzywanski DM, Postlethwait EM, Ballinger SW.

Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L209-16. doi: 10.1152/ajplung.00102.2009. Epub 2009 Apr 24.


Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE(-/-) mouse: implications for a "multihit" hypothesis of fatty liver disease.

Bailey SM, Mantena SK, Millender-Swain T, Cakir Y, Jhala NC, Chhieng D, Pinkerton KE, Ballinger SW.

Free Radic Biol Med. 2009 Apr 1;46(7):928-38.


Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis.

Cakir Y, Yang Z, Knight CA, Pompilius M, Westbrook D, Bailey SM, Pinkerton KE, Ballinger SW.

Free Radic Biol Med. 2007 Nov 1;43(9):1279-88. Epub 2007 Jul 19.


The role of tobacco smoke induced mitochondrial damage in vascular dysfunction and atherosclerosis.

Yang Z, Harrison CM, Chuang GC, Ballinger SW.

Mutat Res. 2007 Aug 1;621(1-2):61-74. Epub 2007 Mar 1. Review.


Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells.

Gutierrez J, Ballinger SW, Darley-Usmar VM, Landar A.

Circ Res. 2006 Oct 27;99(9):924-32. Review.


Pathogenesis of osteopenia/osteoporosis induced by highly active anti-retroviral therapy for AIDS.

Pan G, Yang Z, Ballinger SW, McDonald JM.

Ann N Y Acad Sci. 2006 Apr;1068:297-308. Review.


The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.

Vartanian V, Lowell B, Minko IG, Wood TG, Ceci JD, George S, Ballinger SW, Corless CL, McCullough AK, Lloyd RS.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1864-9. Epub 2006 Jan 30.


Reactive species-mediated regulation of cell signaling and the cell cycle: the role of MAPK.

Cakir Y, Ballinger SW.

Antioxid Redox Signal. 2005 May-Jun;7(5-6):726-40. Review.


Mitochondrial dysfunction in cardiovascular disease.

Ballinger SW.

Free Radic Biol Med. 2005 May 15;38(10):1278-95. Review.


Prenatal environmental tobacco smoke exposure promotes adult atherogenesis and mitochondrial damage in apolipoprotein E-/- mice fed a chow diet.

Yang Z, Knight CA, Mamerow MM, Vickers K, Penn A, Postlethwait EM, Ballinger SW.

Circulation. 2004 Dec 14;110(24):3715-20. Epub 2004 Nov 29.


Differential effects of exercise on aortic mitochondria.

Young CG, Knight CA, Vickers KC, Westbrook D, Madamanchi NR, Runge MS, Ischiropoulos H, Ballinger SW.

Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1683-9. Epub 2004 Nov 18.


Mitochondrial integrity and function in atherogenesis.

Ballinger SW, Patterson C, Knight-Lozano CA, Burow DL, Conklin CA, Hu Z, Reuf J, Horaist C, Lebovitz R, Hunter GC, McIntyre K, Runge MS.

Circulation. 2002 Jul 30;106(5):544-9.


Cigarette smoke exposure and hypercholesterolemia increase mitochondrial damage in cardiovascular tissues.

Knight-Lozano CA, Young CG, Burow DL, Hu ZY, Uyeminami D, Pinkerton KE, Ischiropoulos H, Ballinger SW.

Circulation. 2002 Feb 19;105(7):849-54.


Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells.

Ballinger SW, Patterson C, Yan CN, Doan R, Burow DL, Young CG, Yakes FM, Van Houten B, Ballinger CA, Freeman BA, Runge MS.

Circ Res. 2000 May 12;86(9):960-6.


Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells.

Ballinger SW, Van Houten B, Jin GF, Conklin CA, Godley BF.

Exp Eye Res. 1999 Jun;68(6):765-72.


Mitochondrial genome damage associated with cigarette smoking.

Ballinger SW, Bouder TG, Davis GS, Judice SA, Nicklas JA, Albertini RJ.

Cancer Res. 1996 Dec 15;56(24):5692-7.


Mitochondrial DNA mutations in human degenerative diseases and aging.

Wallace DC, Shoffner JM, Trounce I, Brown MD, Ballinger SW, Corral-Debrinski M, Horton T, Jun AS, Lott MT.

Biochim Biophys Acta. 1995 May 24;1271(1):141-51. Review.


Mitochondrial diabetes revisited.

Ballinger SW, Shoffner JM, Gebhart S, Koontz DA, Wallace DC.

Nat Genet. 1994 Aug;7(4):458-9. No abstract available.


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