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Effects of neuromedin U-8 on stress responsiveness and hypothalamus-pituitary-adrenal axis activity in male C57BL/6J mice.

De Prins A, Allaoui W, Medrano Moya M, Van Eeckhaut A, Ballet S, Smolders I, De Bundel D.

Horm Behav. 2019 Dec 30:104666. doi: 10.1016/j.yhbeh.2019.104666. [Epub ahead of print]


Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.

Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han GW, Holleran BJ, Van der Poorten O, White KL, Hanson MA, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu ZJ, Müller CE, Stevens RC.

Sci Adv. 2019 Nov 27;5(11):eaax9115. doi: 10.1126/sciadv.aax9115. eCollection 2019 Nov.


Contrast-to-Dose Relationship of Gadopiclenol, an MRI Macrocyclic Gadolinium-based Contrast Agent, Compared with Gadoterate, Gadobenate, and Gadobutrol in a Rat Brain Tumor Model.

Robert P, Vives V, Grindel AL, Kremer S, Bierry G, Louin G, Ballet S, Corot C.

Radiology. 2020 Jan;294(1):117-126. doi: 10.1148/radiol.2019182953. Epub 2019 Oct 29.


Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia.

Eiselt E, Gonzalez S, Martin C, Chartier M, Betti C, Longpré JM, Cavelier F, Tourwé D, Gendron L, Ballet S, Sarret P.

ACS Chem Neurosci. 2019 Nov 20;10(11):4535-4544. doi: 10.1021/acschemneuro.9b00390. Epub 2019 Oct 21.


Neuromedin U and Structural Analogs: an Overview of Their Structure, Function and Selectivity.

De Prins A, Van Eeckhaut A, Smolders I, Tourwé D, Ballet S.

Curr Med Chem. 2019 Sep 16. doi: 10.2174/0929867326666190916143028. [Epub ahead of print]


Primary hepatocytes and their cultures for the testing of drug-induced liver injury.

Vilas-Boas V, Cooreman A, Gijbels E, Van Campenhout R, Gustafson E, Ballet S, Annaert P, Cogliati B, Vinken M.

Adv Pharmacol. 2019;85:1-30. doi: 10.1016/bs.apha.2018.08.001. Epub 2018 Sep 1.


The 1,3-diyne linker as a rigid "i,i+7" staple for α-helix stabilization: Stereochemistry at work.

Verlinden S, Geudens N, Van Holsbeeck K, Mannes M, Martins JC, Verniest G, Ballet S.

J Pept Sci. 2019 Jul;25(7):e3194. doi: 10.1002/psc.3194. Epub 2019 Jun 18.


Trifluoromethylated Proline Surrogates as Part of "Pro-Pro" Turn-Inducing Templates.

Gadais C, Van Holsbeeck K, Moors SLC, Buyst D, Fehér K, Van Hecke K, Tourwé D, Brigaud T, Martin C, De Proft F, Pytkowicz J, Martins JC, Chaume G, Ballet S.

Chembiochem. 2019 Oct 1;20(19):2513-2518. doi: 10.1002/cbic.201900294. Epub 2019 Jul 15.


Solid-Phase Azopeptide Diels-Alder Chemistry for Aza-pipecolyl Residue Synthesis To Study Peptide Conformation.

Chingle R, Mulumba M, Chung NN, Nguyen TM, Ong H, Ballet S, Schiller PW, Lubell WD.

J Org Chem. 2019 May 17;84(10):6006-6016. doi: 10.1021/acs.joc.8b03283. Epub 2019 Apr 26.


Persistence at the final stage of volcanic island ontogeny: Abiotic predictors explain native plant species richness on 111 remote Pacific atolls.

Larrue S, Butaud JF, Daehler CC, Ballet S, Chadeyron J, Oyono R.

Ecol Evol. 2018 Nov 20;8(23):12208-12220. doi: 10.1002/ece3.4680. eCollection 2018 Dec.


Biodegradable Amphipathic Peptide Hydrogels as Extended-Release System for Opioid Peptides.

Martin C, Dumitrascuta M, Mannes M, Lantero A, Bucher D, Walker K, Van Wanseele Y, Oyen E, Hernot S, Van Eeckhaut A, Madder A, Hoogenboom R, Spetea M, Ballet S.

J Med Chem. 2018 Nov 8;61(21):9784-9789. doi: 10.1021/acs.jmedchem.8b01282. Epub 2018 Oct 26.


Connexin and Pannexin (Hemi)Channels: Emerging Targets in the Treatment of Liver Disease.

Cooreman A, Van Campenhout R, Ballet S, Annaert P, Van Den Bossche B, Colle I, Cogliati B, Vinken M.

Hepatology. 2019 Mar;69(3):1317-1323. doi: 10.1002/hep.30306. Epub 2019 Feb 23. Review.


Radiometal-labeled anti-VCAM-1 nanobodies as molecular tracers for atherosclerosis - impact of radiochemistry on pharmacokinetics.

Bala G, Crauwels M, Blykers A, Remory I, Marschall ALJ, Dübel S, Dumas L, Broisat A, Martin C, Ballet S, Cosyns B, Caveliers V, Devoogdt N, Xavier C, Hernot S.

Biol Chem. 2019 Feb 25;400(3):323-332. doi: 10.1515/hsz-2018-0330.


The Neurokinins: Peptidomimetic Ligand Design and Therapeutic Applications.

Gadais C, Ballet S.

Curr Med Chem. 2018 Sep 12. doi: 10.2174/0929867325666180913095918. [Epub ahead of print]


Site-Specific Radioactive Labeling of Nanobodies.

Crauwels M, Massa S, Martin C, Betti C, Ballet S, Devoogdt N, Xavier C, Muyldermans S.

Methods Mol Biol. 2018;1827:505-540. doi: 10.1007/978-1-4939-8648-4_26.


Corrigendum to "Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings" [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320-2323].

Willemse T, Eiselt E, Hollanders K, Schepens W, van Vlijmen HWT, Chung NN, Blais V, Holleran B, Longpré JM, Schiller PW, Maes BUW, Sarret P, Gendron L, Ballet S.

Bioorg Med Chem Lett. 2018 Nov 1;28(20):3418. doi: 10.1016/j.bmcl.2018.08.023. Epub 2018 Sep 5. No abstract available.


Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility.

Machiela MJ, Grünewald TGP, Surdez D, Reynaud S, Mirabeau O, Karlins E, Rubio RA, Zaidi S, Grossetete-Lalami S, Ballet S, Lapouble E, Laurence V, Michon J, Pierron G, Kovar H, Gaspar N, Kontny U, González-Neira A, Picci P, Alonso J, Patino-Garcia A, Corradini N, Bérard PM, Freedman ND, Rothman N, Dagnall CL, Burdett L, Jones K, Manning M, Wyatt K, Zhou W, Yeager M, Cox DG, Hoover RN, Khan J, Armstrong GT, Leisenring WM, Bhatia S, Robison LL, Kulozik AE, Kriebel J, Meitinger T, Metzler M, Hartmann W, Strauch K, Kirchner T, Dirksen U, Morton LM, Mirabello L, Tucker MA, Tirode F, Chanock SJ, Delattre O.

Nat Commun. 2018 Aug 9;9(1):3184. doi: 10.1038/s41467-018-05537-2.


Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings.

Willemse T, Eiselt E, Hollanders K, Schepens W, van Vlijmen HWT, Chung NN, Blais V, Holleran B, Longpré JM, Schiller PW, Maes BUW, Sarret P, Gendron L, Ballet S.

Bioorg Med Chem Lett. 2018 Jul 15;28(13):2320-2323. doi: 10.1016/j.bmcl.2018.05.015. Epub 2018 May 12. Erratum in: Bioorg Med Chem Lett. 2018 Nov 1;28(20):3418.


Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.

De Prins A, Martin C, Van Wanseele Y, Tömböly C, Tourwé D, Caveliers V, Holst B, Van Eeckhaut A, Rosenkilde MM, Smolders I, Ballet S.

ACS Med Chem Lett. 2018 Apr 23;9(5):496-501. doi: 10.1021/acsmedchemlett.8b00105. eCollection 2018 May 10.


One-year Retention of Gadolinium in the Brain: Comparison of Gadodiamide and Gadoterate Meglumine in a Rodent Model.

Robert P, Fingerhut S, Factor C, Vives V, Letien J, Sperling M, Rasschaert M, Santus R, Ballet S, Idée JM, Corot C, Karst U.

Radiology. 2018 Aug;288(2):424-433. doi: 10.1148/radiol.2018172746. Epub 2018 May 22.


A bifunctional-biased mu-opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects.

Drieu la Rochelle A, Guillemyn K, Dumitrascuta M, Martin C, Utard V, Quillet R, Schneider S, Daubeuf F, Willemse T, Mampuys P, Maes BUW, Frossard N, Bihel F, Spetea M, Simonin F, Ballet S.

Pain. 2018 Sep;159(9):1705-1718. doi: 10.1097/j.pain.0000000000001262.


Bromotryptophans and their incorporation in cyclic and bicyclic privileged peptides.

García-Pindado J, Willemse T, Goss R, Maes BUW, Giralt E, Ballet S, Teixidó M.

Biopolymers. 2018 Aug;109(10):e23112. doi: 10.1002/bip.23112. Epub 2018 Mar 12.


Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors.

Pardon E, Betti C, Laeremans T, Chevillard F, Guillemyn K, Kolb P, Ballet S, Steyaert J.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5292-5295. doi: 10.1002/anie.201712581. Epub 2018 Mar 30.


Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR - Ullmann cross-coupling sequence.

Van der Poorten O, Van Den Hauwe R, Hollanders K, Maes BUW, Tourwé D, Jida M, Ballet S.

Org Biomol Chem. 2018 Feb 21;16(8):1242-1246. doi: 10.1039/c7ob03094k.


Indoloazepinone-Constrained Oligomers as Cell-Penetrating and Blood-Brain-Barrier-Permeating Compounds.

Van der Poorten O, Legrand B, Vezenkov LL, García-Pindado J, Bettache N, Knuhtsen A, Pedersen DS, Sánchez-Navarro M, Martinez J, Teixidó M, Garcia M, Tourwé D, Amblard M, Ballet S.

Chembiochem. 2018 Apr 4;19(7):696-705. doi: 10.1002/cbic.201700678. Epub 2018 Feb 28.


Binding-Site Compatible Fragment Growing Applied to the Design of β2-Adrenergic Receptor Ligands.

Chevillard F, Rimmer H, Betti C, Pardon E, Ballet S, van Hilten N, Steyaert J, Diederich WE, Kolb P.

J Med Chem. 2018 Feb 8;61(3):1118-1129. doi: 10.1021/acs.jmedchem.7b01558. Epub 2018 Jan 24.


Development of potent and proteolytically stable human neuromedin U receptor agonists.

De Prins A, Martin C, Van Wanseele Y, Skov LJ, Tömböly C, Tourwé D, Caveliers V, Van Eeckhaut A, Holst B, Rosenkilde MM, Smolders I, Ballet S.

Eur J Med Chem. 2018 Jan 20;144:887-897. doi: 10.1016/j.ejmech.2017.12.035. Epub 2017 Dec 14.


Mechanism of Action, Pharmacokinetics, Efficacy, and Safety of Transarterial Therapies Using Ethiodized Oil: Preclinical Review in Liver Cancer Models.

Gaba RC, Schwind RM, Ballet S.

J Vasc Interv Radiol. 2018 Mar;29(3):413-424. doi: 10.1016/j.jvir.2017.09.025. Epub 2017 Dec 28. Review.


Comment on "In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma".

González W, Idée JM, Ballet S.

Mol Pharm. 2018 Jan 2;15(1):332-335. doi: 10.1021/acs.molpharmaceut.7b00138. Epub 2017 Dec 1. No abstract available.


χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.

Van der Poorten O, Van Den Hauwe R, Eiselt E, Betti C, Guillemyn K, Chung NN, Hallé F, Bihel F, Schiller PW, Tourwé D, Sarret P, Gendron L, Ballet S.

ACS Med Chem Lett. 2017 Oct 4;8(11):1177-1182. doi: 10.1021/acsmedchemlett.7b00347. eCollection 2017 Nov 9.


Antimicrobial peptides in frog poisons constitute a molecular toxin delivery system against predators.

Raaymakers C, Verbrugghe E, Hernot S, Hellebuyck T, Betti C, Peleman C, Claeys M, Bert W, Caveliers V, Ballet S, Martel A, Pasmans F, Roelants K.

Nat Commun. 2017 Nov 14;8(1):1495. doi: 10.1038/s41467-017-01710-1.


Efficient One-Pot Access to Trisubstituted 2-Benzazepin-3-ones as Constrained Pseudopeptide Analogues and Privileged Scaffolds.

der Poorten OV, Jida M, Tourwe D, Ballet S.

Med Chem. 2018;14(4):400-408. doi: 10.2174/1573406413666171002122233.


Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.

Starnowska J, Costante R, Guillemyn K, Popiolek-Barczyk K, Chung NN, Lemieux C, Keresztes A, Van Duppen J, Mollica A, Streicher J, Vanden Broeck J, Schiller PW, Tourwé D, Mika J, Ballet S, Przewlocka B.

ACS Chem Neurosci. 2017 Oct 18;8(10):2315-2324. doi: 10.1021/acschemneuro.7b00226. Epub 2017 Jul 26.


Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β2 Adrenergic Receptor Ligands.

Martin C, Moors SLC, Danielsen M, Betti C, Fabris C, Sejer Pedersen D, Pardon E, Peyressatre M, Fehér K, Martins JC, Mosolff Mathiesen J, Morris MC, Devoogdt N, Caveliers V, De Proft F, Steyaert J, Ballet S.

Chemistry. 2017 Jul 18;23(40):9632-9640. doi: 10.1002/chem.201701321. Epub 2017 Jun 29.


Bifunctional opioid/nociceptin hybrid KGNOP1 effectively attenuates pain-related behaviour in a rat model of neuropathy.

Starnowska J, Guillemyn K, Makuch W, Mika J, Ballet S, Przewlocka B.

Eur J Pharm Sci. 2017 Jun 15;104:221-229. doi: 10.1016/j.ejps.2017.03.029. Epub 2017 Mar 24.


In Vivo Imaging of the Stability and Sustained Cargo Release of an Injectable Amphipathic Peptide-Based Hydrogel.

Oyen E, Martin C, Caveliers V, Madder A, Van Mele B, Hoogenboom R, Hernot S, Ballet S.

Biomacromolecules. 2017 Mar 13;18(3):994-1001. doi: 10.1021/acs.biomac.6b01840. Epub 2017 Feb 20.


Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain.

Lagard C, Chevillard L, Guillemyn K, Risède P, Laplanche JL, Spetea M, Ballet S, Mégarbane B.

Pain. 2017 Mar;158(3):505-515. doi: 10.1097/j.pain.0000000000000790.


Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds.

Dyniewicz J, Lipiński PF, Kosson P, Leśniak A, Bochyńska-Czyż M, Muchowska A, Tourwé D, Ballet S, Misicka A, Lipkowski AW.

ACS Med Chem Lett. 2016 Nov 1;8(1):73-77. doi: 10.1021/acsmedchemlett.6b00381. eCollection 2017 Jan 12.


Moderate Renal Failure Accentuates T1 Signal Enhancement in the Deep Cerebellar Nuclei of Gadodiamide-Treated Rats.

Rasschaert M, Idée JM, Robert P, Fretellier N, Vives V, Violas X, Ballet S, Corot C.

Invest Radiol. 2017 May;52(5):255-264. doi: 10.1097/RLI.0000000000000339.


Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities.

Massa S, Vikani N, Betti C, Ballet S, Vanderhaegen S, Steyaert J, Descamps B, Vanhove C, Bunschoten A, van Leeuwen FW, Hernot S, Caveliers V, Lahoutte T, Muyldermans S, Xavier C, Devoogdt N.

Contrast Media Mol Imaging. 2016 Sep;11(5):328-339. doi: 10.1002/cmmi.1696. Epub 2016 May 5.


Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design.

Van der Poorten O, Knuhtsen A, Sejer Pedersen D, Ballet S, Tourwé D.

J Med Chem. 2016 Dec 22;59(24):10865-10890. doi: 10.1021/acs.jmedchem.6b01029. Epub 2016 Oct 12. Review.


Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases.

Knuhtsen A, Legrand B, Van der Poorten O, Amblard M, Martinez J, Ballet S, Kristensen JL, Pedersen DS.

Chemistry. 2016 Sep 19;22(39):14022-14028. doi: 10.1002/chem.201602518. Epub 2016 Aug 12.


Biological evaluation and molecular docking studies of AA3052, a compound containing a μ-selective opioid peptide agonist DALDA and d-Phe-Phe-d-Phe-Leu-Leu-NH2, a substance P analogue.

Kowalczyk A, Kleczkowska P, Rękawek M, Kulik K, Lesniak A, Erdei A, Borics A, Martin C, Pawlik K, Lipkowski AW, Benyhe S, Makulska-Nowak H, Ballet S, Bujalska-Zadrozny M.

Eur J Pharm Sci. 2016 Oct 10;93:11-20. doi: 10.1016/j.ejps.2016.07.009. Epub 2016 Jul 14.


Efficient one-pot synthesis of amino-benzotriazolodiazocinone scaffolds via catalyst-free tandem Ugi-Huisgen reactions.

Barlow TM, Jida M, Guillemyn K, Tourwé D, Caveliers V, Ballet S.

Org Biomol Chem. 2016 May 18;14(20):4669-77. doi: 10.1039/c6ob00438e.


Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.

Guillemyn K, Starnowska J, Lagard C, Dyniewicz J, Rojewska E, Mika J, Chung NN, Utard V, Kosson P, Lipkowski AW, Chevillard L, Arranz-Gibert P, Teixidó M, Megarbane B, Tourwé D, Simonin F, Przewlocka B, Schiller PW, Ballet S.

J Med Chem. 2016 Apr 28;59(8):3777-92. doi: 10.1021/acs.jmedchem.5b01976. Epub 2016 Apr 14.


Early detection of colonic dysplasia by magnetic resonance molecular imaging with a contrast agent raised against the colon cancer marker MUC5AC.

Rossez Y, Burtea C, Laurent S, Gosset P, Léonard R, Gonzalez W, Ballet S, Raynal I, Rousseaux O, Dugué T, Vander Elst L, Michalski JC, Muller RN, Robbe-Masselot C.

Contrast Media Mol Imaging. 2016 May;11(3):211-21. doi: 10.1002/cmmi.1682. Epub 2016 Jan 14.


Mixed α/β-Peptides as a Class of Short Amphipathic Peptide Hydrogelators with Enhanced Proteolytic Stability.

Mangelschots J, Bibian M, Gardiner J, Waddington L, Van Wanseele Y, Van Eeckhaut A, Acevedo MM, Van Mele B, Madder A, Hoogenboom R, Ballet S.

Biomacromolecules. 2016 Feb 8;17(2):437-45. doi: 10.1021/acs.biomac.5b01319. Epub 2016 Jan 25.


Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.

Betti C, Starnowska J, Mika J, Dyniewicz J, Frankiewicz L, Novoa A, Bochynska M, Keresztes A, Kosson P, Makuch W, Van Duppen J, Chung NN, Vanden Broeck J, Lipkowski AW, Schiller PW, Janssens F, Ceusters M, Sommen F, Meert T, Przewlocka B, Tourwé D, Ballet S.

ACS Med Chem Lett. 2015 Oct 31;6(12):1209-14. doi: 10.1021/acsmedchemlett.5b00359. eCollection 2015 Dec 10.


Synthesis and binding characteristics of [(3)H]neuromedin N, a NTS2 receptor ligand.

Tóth F, Mallareddy JR, Tourwé D, Lipkowski AW, Bujalska-Zadrozny M, Benyhe S, Ballet S, Tóth G, Kleczkowska P.

Neuropeptides. 2016 Jun;57:15-20. doi: 10.1016/j.npep.2015.12.004. Epub 2015 Dec 8.


Linear Gadolinium-Based Contrast Agents Are Associated With Brain Gadolinium Retention in Healthy Rats.

Robert P, Violas X, Grand S, Lehericy S, Idée JM, Ballet S, Corot C.

Invest Radiol. 2016 Feb;51(2):73-82. doi: 10.1097/RLI.0000000000000241.

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