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Items: 29

1.

Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates.

Ratnayake AS, Chang LP, Tumey LN, Loganzo F, Chemler JA, Wagenaar M, Musto S, Li F, Janso JE, Ballard TE, Rago B, Steele GL, Ding W, Feng X, Hosselet C, Buklan V, Lucas J, Koehn FE, O'Donnell CJ, Graziani EI.

Bioconjug Chem. 2019 Jan 16;30(1):200-209. doi: 10.1021/acs.bioconjchem.8b00843. Epub 2018 Dec 13.

PMID:
30543418
2.

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

Planken S, Behenna DC, Nair SK, Johnson TO, Nagata A, Almaden C, Bailey S, Ballard TE, Bernier L, Cheng H, Cho-Schultz S, Dalvie D, Deal JG, Dinh DM, Edwards MP, Ferre RA, Gajiwala KS, Hemkens M, Kania RS, Kath JC, Matthews J, Murray BW, Niessen S, Orr ST, Pairish M, Sach NW, Shen H, Shi M, Solowiej J, Tran K, Tseng E, Vicini P, Wang Y, Weinrich SL, Zhou R, Zientek M, Liu L, Luo Y, Xin S, Zhang C, Lafontaine J.

J Med Chem. 2017 Apr 13;60(7):3002-3019. doi: 10.1021/acs.jmedchem.6b01894. Epub 2017 Mar 29.

PMID:
28287730
3.

Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase.

Crump CJ, Murrey HE, Ballard TE, Am Ende CW, Wu X, Gertsik N, Johnson DS, Li YM.

ACS Chem Neurosci. 2016 Aug 17;7(8):1166-73. doi: 10.1021/acschemneuro.6b00127. Epub 2016 Jun 17.

4.

Determination of Antibody-Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation.

Bessire AJ, Ballard TE, Charati M, Cohen J, Green M, Lam MH, Loganzo F, Nolting B, Pierce B, Puthenveetil S, Roberts L, Schildknegt K, Subramanyam C.

Bioconjug Chem. 2016 Jul 20;27(7):1645-54. doi: 10.1021/acs.bioconjchem.6b00192. Epub 2016 Jun 13.

PMID:
27206324
5.

Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate-Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilonproteobacteria.

Kennedy AJ, Bruce AM, Gineste C, Ballard TE, Olekhnovich IN, Macdonald TL, Hoffman PS.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):3980-7. doi: 10.1128/AAC.00670-16. Print 2016 Jul.

6.

Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism.

Ballard TE, Wang S, Cox LM, Moen MA, Krzyzewski S, Ukairo O, Obach RS.

Drug Metab Dispos. 2016 Feb;44(2):172-9. doi: 10.1124/dmd.115.066688. Epub 2015 Nov 25.

PMID:
26608083
7.

A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry.

Ballard TE, Dahal UP, Bessire AJ, Schneider RP, Geoghegan KF, Vaz AD.

Rapid Commun Mass Spectrom. 2015 Nov 30;29(22):2175-83. doi: 10.1002/rcm.7375.

PMID:
26467230
8.

Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging.

Murrey HE, Judkins JC, Am Ende CW, Ballard TE, Fang Y, Riccardi K, Di L, Guilmette ER, Schwartz JW, Fox JM, Johnson DS.

J Am Chem Soc. 2015 Sep 9;137(35):11461-75. doi: 10.1021/jacs.5b06847. Epub 2015 Aug 31.

9.

Development of CBAP-BPyne, a probe for γ-secretase and presenilinase.

Gertsik N, Ballard TE, Am Ende CW, Johnson DS, Li YM.

Medchemcomm. 2014 Mar;5(3):338-341.

10.

Generation of major human excretory and circulating drug metabolites using a hepatocyte relay method.

Ballard TE, Orozco CC, Obach RS.

Drug Metab Dispos. 2014 May;42(5):899-902. doi: 10.1124/dmd.114.057026. Epub 2014 Mar 7.

PMID:
24608634
11.

An isotopically tagged azobenzene-based cleavable linker for quantitative proteomics.

Qian Y, Martell J, Pace NJ, Ballard TE, Johnson DS, Weerapana E.

Chembiochem. 2013 Aug 19;14(12):1410-4. doi: 10.1002/cbic.201300396. Epub 2013 Jul 16.

PMID:
23861326
12.

γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin.

Pozdnyakov N, Murrey HE, Crump CJ, Pettersson M, Ballard TE, Am Ende CW, Ahn K, Li YM, Bales KR, Johnson DS.

J Biol Chem. 2013 Apr 5;288(14):9710-20. doi: 10.1074/jbc.M112.398602. Epub 2013 Feb 8.

13.

BMS-708,163 targets presenilin and lacks notch-sparing activity.

Crump CJ, Castro SV, Wang F, Pozdnyakov N, Ballard TE, Sisodia SS, Bales KR, Johnson DS, Li YM.

Biochemistry. 2012 Sep 18;51(37):7209-11. doi: 10.1021/bi301137h. Epub 2012 Sep 4.

14.

O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors.

Niphakis MJ, Johnson DS, Ballard TE, Stiff C, Cravatt BF.

ACS Chem Neurosci. 2012 May 16;3(5):418-26. doi: 10.1021/cn200089j. Epub 2011 Oct 10.

15.

Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model.

Warren CA, van Opstal E, Ballard TE, Kennedy A, Wang X, Riggins M, Olekhnovich I, Warthan M, Kolling GL, Guerrant RL, Macdonald TL, Hoffman PS.

Antimicrob Agents Chemother. 2012 Aug;56(8):4103-11. doi: 10.1128/AAC.00360-12. Epub 2012 May 14.

16.

Development of clickable active site-directed photoaffinity probes for γ-secretase.

Crump CJ, am Ende CW, Ballard TE, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2997-3000. doi: 10.1016/j.bmcl.2012.02.027. Epub 2012 Feb 20.

17.

Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.

Orr ST, Ripp SL, Ballard TE, Henderson JL, Scott DO, Obach RS, Sun H, Kalgutkar AS.

J Med Chem. 2012 Jun 14;55(11):4896-933. doi: 10.1021/jm300065h. Epub 2012 Mar 27. Review. No abstract available.

PMID:
22409598
18.

Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: identification of selective and broad spectrum activity.

Ballard TE, Wang X, Olekhnovich I, Koerner T, Seymour C, Salamoun J, Warthan M, Hoffman PS, Macdonald TL.

ChemMedChem. 2011 Feb 7;6(2):362-77. doi: 10.1002/cmdc.201000475. Epub 2010 Dec 29.

19.

Biological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide.

Ballard TE, Wang X, Olekhnovich I, Koerner T, Seymour C, Hoffman PS, Macdonald TL.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3537-9. doi: 10.1016/j.bmcl.2010.04.126. Epub 2010 May 18.

20.

Nitazoxanide inhibits biofilm formation by Staphylococcus epidermidis by blocking accumulation on surfaces.

Tchouaffi-Nana F, Ballard TE, Cary CH, Macdonald TL, Sifri CD, Hoffman PS.

Antimicrob Agents Chemother. 2010 Jul;54(7):2767-74. doi: 10.1128/AAC.00901-09. Epub 2010 Apr 19.

21.

Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity.

Richards JJ, Reyes S, Stowe SD, Tucker AT, Ballard TE, Mathies LD, Cavanagh J, Melander C.

J Med Chem. 2009 Aug 13;52(15):4582-5. doi: 10.1021/jm900378s.

22.

Evaluation of dihydrooroidin as an antifouling additive in marine paint.

Melander C, Moeller PD, Ballard TE, Richards JJ, Huigens RW 3rd, Cavanagh J.

Int Biodeterior Biodegradation. 2009 Jun;63(4):529-532.

23.

Antibiofilm activity of a diverse oroidin library generated through reductive acylation.

Ballard TE, Richards JJ, Aquino A, Reed CS, Melander C.

J Org Chem. 2009 Feb 20;74(4):1755-8. doi: 10.1021/jo802260t.

PMID:
19132935
24.

Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: a structure-activity relationship study.

Ballard TE, Richards JJ, Wolfe AL, Melander C.

Chemistry. 2008;14(34):10745-61. doi: 10.1002/chem.200801419.

PMID:
18942682
25.

Inhibition of HIV fusion with multivalent gold nanoparticles.

Bowman MC, Ballard TE, Ackerson CJ, Feldheim DL, Margolis DM, Melander C.

J Am Chem Soc. 2008 Jun 4;130(22):6896-7. doi: 10.1021/ja710321g. Epub 2008 May 13.

26.

Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms.

Richards JJ, Ballard TE, Huigens RW 3rd, Melander C.

Chembiochem. 2008 May 23;9(8):1267-79. doi: 10.1002/cbic.200700774.

PMID:
18431726
27.

Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues.

Richards JJ, Ballard TE, Melander C.

Org Biomol Chem. 2008 Apr 21;6(8):1356-63. doi: 10.1039/b719082d. Epub 2008 Mar 5.

PMID:
18385842
28.

Inhibition and dispersion of proteobacterial biofilms.

Richards JJ, Huigens Iii RW, Ballard TE, Basso A, Cavanagh J, Melander C.

Chem Commun (Camb). 2008 Apr 14;(14):1698-700. doi: 10.1039/b719802g. Epub 2008 Feb 8.

PMID:
18368169
29.

Inhibition of Pseudomonas aeruginosa biofilm formation with Bromoageliferin analogues.

Huigens RW 3rd, Richards JJ, Parise G, Ballard TE, Zeng W, Deora R, Melander C.

J Am Chem Soc. 2007 Jun 6;129(22):6966-7. Epub 2007 May 15. No abstract available.

PMID:
17500516

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