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Items: 12

1.

Caspase-1 interdomain linker cleavage is required for pyroptosis.

Ball DP, Taabazuing CY, Griswold AR, Orth EL, Rao SD, Kotliar IB, Vostal LE, Johnson DC, Bachovchin DA.

Life Sci Alliance. 2020 Feb 12;3(3). pii: e202000664. doi: 10.26508/lsa.202000664. Print 2020 Mar.

2.

DPP9's Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation.

Griswold AR, Ball DP, Bhattacharjee A, Chui AJ, Rao SD, Taabazuing CY, Bachovchin DA.

ACS Chem Biol. 2019 Nov 15;14(11):2424-2429. doi: 10.1021/acschembio.9b00462. Epub 2019 Sep 20.

3.

DPP8/9 inhibitors are universal activators of functional NLRP1 alleles.

Gai K, Okondo MC, Rao SD, Chui AJ, Ball DP, Johnson DC, Bachovchin DA.

Cell Death Dis. 2019 Aug 5;10(8):587. doi: 10.1038/s41419-019-1817-5.

4.

N-terminal degradation activates the NLRP1B inflammasome.

Chui AJ, Okondo MC, Rao SD, Gai K, Griswold AR, Johnson DC, Ball DP, Taabazuing CY, Orth EL, Vittimberga BA, Bachovchin DA.

Science. 2019 Apr 5;364(6435):82-85. doi: 10.1126/science.aau1208. Epub 2019 Mar 14.

PMID:
30872531
5.

Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities.

Ali AM, Gómez-Biagi RF, Rosa DA, Lai PS, Heaton WL, Park JS, Eiring AM, Vellore NA, de Araujo ED, Ball DP, Shouksmith AE, Patel AB, Deininger MW, O'Hare T, Gunning PT.

ChemMedChem. 2016 Apr 19;11(8):850-61. doi: 10.1002/cmdc.201600021. Epub 2016 Mar 30.

6.

Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent.

Ball DP, Lewis AM, Williams D, Resetca D, Wilson DJ, Gunning PT.

Oncotarget. 2016 Apr 12;7(15):20669-79. doi: 10.18632/oncotarget.7838.

7.

Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics.

Arpin CC, Mac S, Jiang Y, Cheng H, Grimard M, Page BD, Kamocka MM, Haftchenary S, Su H, Ball DP, Rosa DA, Lai PS, Gómez-Biagi RF, Ali AM, Rana R, Hanenberg H, Kerman K, McElyea KC, Sandusky GE, Gunning PT, Fishel ML.

Mol Cancer Ther. 2016 May;15(5):794-805. doi: 10.1158/1535-7163.MCT-15-0003. Epub 2016 Feb 12.

8.

Identification of Bidentate Salicylic Acid Inhibitors of PTP1B.

Haftchenary S, Jouk AO, Aubry I, Lewis AM, Landry M, Ball DP, Shouksmith AE, Collins CV, Tremblay ML, Gunning PT.

ACS Med Chem Lett. 2015 Jul 22;6(9):982-6. doi: 10.1021/acsmedchemlett.5b00171. eCollection 2015 Sep 10.

9.

A STAT inhibitor patent review: progress since 2011.

Lai PS, Rosa DA, Magdy Ali A, Gómez-Biagi RF, Ball DP, Shouksmith AE, Gunning PT.

Expert Opin Ther Pat. 2015;25(12):1397-421. doi: 10.1517/13543776.2015.1086749. Epub 2015 Sep 22. Review. Erratum in: Expert Opin Ther Pat. 2015;25(12):1495.

PMID:
26394986
10.

Electrochemical detection of the Fc-STAT3 phosphorylation and STAT3-Fc-STAT3 dimerization and inhibition.

Martic S, Rains MK, Haftchenary S, Shahani VM, Kraskouskaya D, Ball DP, Gunning PT, Kraatz HB.

Mol Biosyst. 2014 Mar 4;10(3):576-80. doi: 10.1039/c3mb70493a. Epub 2014 Jan 8.

PMID:
24402062
11.

A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells.

Shahani VM, Ball DP, Ramos AV, Li Z, Spagnuolo PA, Haftchenary S, Schimmer AD, Trudel S, Gunning PT.

Bioorg Med Chem. 2013 Sep 1;21(17):5618-28. doi: 10.1016/j.bmc.2013.04.080. Epub 2013 May 9.

PMID:
23810672
12.

Signal transducer and activator of transcription 3 inhibitors: a patent review.

Page BD, Ball DP, Gunning PT.

Expert Opin Ther Pat. 2011 Jan;21(1):65-83. doi: 10.1517/13543776.2011.539205. Epub 2010 Nov 29. Review.

PMID:
21114420

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